Works (23)

Updated: July 5th, 2023 15:37

2021 article

Bioorthogonal catalytic patch

Chen, Z., Li, H., Bian, Y., Wang, Z., Chen, G., Zhang, X., … Gu, Z. (2021, May 10). NATURE NANOTECHNOLOGY.

By: Z. Chen*, H. Li*, Y. Bian*, Z. Wang*, G. Chen*, X. Zhang*, Y. Miao*, D. Wen* ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Catalysis; Drug Delivery Systems; Hep G2 Cells; Humans; Melanoma, Experimental; Metal Nanoparticles / chemistry; Metal Nanoparticles / therapeutic use; Mice; Palladium / chemistry; Palladium / pharmacokinetics; Palladium / pharmacology; Prodrugs / chemistry; Prodrugs / pharmacokinetics; Prodrugs / pharmacology; Titanium / chemistry; Titanium / pharmacokinetics; Titanium / pharmacology
Source: Web Of Science
Added: June 10, 2021

2020 journal article

Engineered PD-L1-Expressing Platelets Reverse New-Onset Type 1 Diabetes

ADVANCED MATERIALS, 32(26).

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: drug delivery; immune tolerance; platelets; programmed death-ligand 1 (PD-L1); type 1 diabetes (T1D)
MeSH headings : Animals; B7-H1 Antigen / genetics; B7-H1 Antigen / metabolism; Blood Glucose / analysis; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Diabetes Mellitus, Type 1 / pathology; Diabetes Mellitus, Type 1 / therapy; Diabetes Mellitus, Type 1 / veterinary; Genetic Engineering; Immune Tolerance; Insulin / blood; Insulin-Secreting Cells / cytology; Insulin-Secreting Cells / immunology; Insulin-Secreting Cells / metabolism; Megakaryocyte Progenitor Cells / cytology; Megakaryocyte Progenitor Cells / metabolism; Megakaryocyte Progenitor Cells / transplantation; Mice; Mice, Inbred NOD; T-Lymphocytes, Regulatory / cytology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism
Source: Web Of Science
Added: June 8, 2020

2019 journal article

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

ACS NANO, 13(4), 4354–4360.

By: G. Yang n, Q. Chen n, D. Wen n, Z. Chen n, J. Wang n, G. Chen n, Z. Wang*, X. Zhang n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: drug delivery; microneedle; exosome; keratin; hair regrowth; transdermal drug delivery
MeSH headings : Animals; Cell Line; Delayed-Action Preparations / chemistry; Drug Delivery Systems / instrumentation; Equipment Design; Hair / chemistry; Hair / drug effects; Hair / growth & development; Hair Follicle / drug effects; Hair Follicle / growth & development; Humans; Injections, Subcutaneous; Keratins / chemistry; Mice, Inbred C57BL; Transdermal Patch
Source: Web Of Science
Added: June 4, 2019

2019 journal article

Bioresponsive Protein Complex of aPD1 and aCD47 Antibodies for Enhanced Immunotherapy

NANO LETTERS, 19(8), 4879–4889.

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Drug delivery; immunotherapy; immune checkpoint blockade; bioresponsive; nanomedicine
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Antibodies, Monoclonal / therapeutic use; Antineoplastic Agents, Immunological / immunology; Antineoplastic Agents, Immunological / therapeutic use; CD47 Antigen / immunology; Female; Immunotherapy; Melanoma / immunology; Melanoma / therapy; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor / immunology; Reactive Oxygen Species / immunology; Tumor Microenvironment / drug effects
Source: Web Of Science
Added: September 3, 2019

2019 journal article

Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs

SCIENCE ADVANCES, 5(7).

By: J. Wang n, J. Yu n, Y. Zhang n, X. Zhang*, A. Kahkoska*, G. Chen*, Z. Wang*, W. Sun* ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Animals; Blood Glucose / drug effects; Diabetes Mellitus, Experimental / drug therapy; Drug Carriers / chemical synthesis; Drug Carriers / chemistry; Drug Delivery Systems; Insulin / administration & dosage; Mice; Molecular Structure; Polymers / chemical synthesis; Polymers / chemistry; Swine
Source: Web Of Science
Added: August 19, 2019

2019 journal article

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

NATURE NANOTECHNOLOGY, 14(1), 89-+.

By: Q. Chen n, C. Wang n, X. Zhang*, G. Chen*, Q. Hu n, H. Li*, J. Wang n, D. Wen* ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Animals; Biocompatible Materials / chemistry; Calcium Carbonate / chemistry; Female; Fibrin / chemistry; Gels / chemistry; Humans; Immunity; Immunotherapy / methods; Luminescent Measurements; Melanoma, Experimental / pathology; Mice, Inbred C57BL; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasm Recurrence, Local / pathology; Neoplasms / pathology; Neoplasms / surgery; Phagocytosis
Source: Web Of Science
Added: January 21, 2019

2019 journal article

Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy

NANO RESEARCH, 12(6), 1313–1320.

By: J. Yan n, X. Zhang n, Y. Liu n, Y. Ye n, J. Yu n, Q. Chen n, J. Wang n, Y. Zhang n ...

co-author countries: United States of America 🇺🇸
author keywords: liquid metal; melanin nanoparticles; nanomedicine; shape-controlled synthesis; photothermal therapy
Source: Web Of Science
Added: June 17, 2019

2018 journal article

Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy

ACS NANO, 12(6), 5995–6005.

By: W. Chen*, Y. Wang*, M. Qin*, X. Zhang n, Z. Zhang*, X. Sun*, Z. Gu n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: salmonella; polydopamine; hypoxia targeting; photothermal therapy; malignant melanoma
MeSH headings : Animals; Antineoplastic Agents / adverse effects; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Cell Survival / drug effects; Hypoxia / metabolism; Indoles / adverse effects; Indoles / metabolism; Indoles / pharmacology; Lasers; Melanoma, Experimental / metabolism; Melanoma, Experimental / pathology; Melanoma, Experimental / therapy; Mice; Phototherapy; Polymers / adverse effects; Polymers / metabolism; Polymers / pharmacology; Salmonella / growth & development; Salmonella / metabolism; Tissue Distribution; Tumor Cells, Cultured
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Bioresponsive Microneedles with a Sheath Structure for H2O2 and pH Cascade-Triggered Insulin Delivery

SMALL, 14(14).

co-author countries: United States of America 🇺🇸
author keywords: diabetes; drug delivery; insulin; microneedles; stimuli-responsive
MeSH headings : Animals; Drug Delivery Systems / methods; Humans; Hydrogen Peroxide / chemistry; Hydrogen-Ion Concentration; Insulin / administration & dosage; Insulin / chemistry; Mice; Oxidation-Reduction
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

NATURE BIOMEDICAL ENGINEERING, 2(11), 831–840.

By: Q. Hu n, W. Sun*, J. Wang n, H. Ruan n, X. Zhang*, Y. Ye n, S. Shen*, C. Wang n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Animals; Antibodies / chemistry; Antibodies / immunology; Blood Platelets / chemistry; Blood Platelets / cytology; Blood Platelets / metabolism; Cell Line, Tumor; Chemokines / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / chemistry; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / metabolism; Leukemia / therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Receptor / deficiency; Programmed Cell Death 1 Receptor / genetics; Programmed Cell Death 1 Receptor / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology; T-Lymphocytes / metabolism
Source: Web Of Science
Added: November 26, 2018

2018 journal article

Engineering PD-1-Presenting Platelets for Cancer Immunotherapy

NANO LETTERS, 18(9), 5716–5725.

By: X. Zhang n, J. Wang n, Z. Chen n, Q. Hu n, C. Wang n, J. Yan n, G. Dotti*, P. Huang*, Z. Gu n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Drug delivery; platelet; immune checkpoint blockade; immunotherapy; nanomedicine
Source: Web Of Science
Added: October 16, 2018

2018 journal article

In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

SCIENCE TRANSLATIONAL MEDICINE, 10(429).

By: C. Wang n, J. Wang n, X. Zhang n, S. Yu n, D. Wen n, Q. Hu n, Y. Ye n, H. Bomba n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Animals; Cell Line, Tumor; Combined Modality Therapy; Deoxycytidine / analogs & derivatives; Deoxycytidine / therapeutic use; Female; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Immunotherapy / methods; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor / metabolism; Gemcitabine
Source: Web Of Science
Added: August 6, 2018

2018 journal article

PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy

ADVANCED MATERIALS, 30(22).

By: X. Zhang n, C. Wang n, J. Wang n, Q. Hu n, B. Langworthy*, Y. Ye n, W. Sun n, J. Lin* ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: cancer immunotherapy; cell therapy; drug delivery; immune checkpoint blockade; nanomedicine
MeSH headings : Humans; Immunotherapy; Lymphocytes, Tumor-Infiltrating; Neoplasms / therapy; Programmed Cell Death 1 Receptor; T-Lymphocytes; Tumor Microenvironment
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Phosphorylcholine-based stealthy nanocapsules decorating TPGS for combatting multi-drug-resistant cancer

ACS Biomaterials-Science & Engineering, 4(5), 1679–1686.

By: G. Liu, H. Tsai, X. Zeng, W. Cheng, L. Jiang, H. Chen, X. Zhang, J. Zhang, L. Mei

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

The mechanism of lauric acid-modified protein nanocapsules escape from intercellular trafficking vesicles and its implication for drug delivery

Drug Delivery, 25(1), 985–994.

By: L. Jiang, X. Liang, G. Liu, Y. Zhou, X. Ye, X. Chen, Q. Miao, L. Gao, X. Zhang, L. Mei

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

A melanin-mediated cancer immunotherapy patch

SCIENCE IMMUNOLOGY, 2(17).

By: Y. Ye n, C. Wang n, X. Zhang n, Q. Hu n, Y. Zhang n, Q. Liu n, D. Wen n, J. Milligan n ...

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cancer Vaccines / immunology; Cancer Vaccines / metabolism; Cell Line, Tumor; Dendritic Cells / immunology; Dendritic Cells / metabolism; Female; Immunotherapy / instrumentation; Immunotherapy / methods; Infrared Rays; Kaplan-Meier Estimate; Melanins / immunology; Melanins / metabolism; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Needles; Neoplasms, Experimental / immunology; Neoplasms, Experimental / pathology; Neoplasms, Experimental / therapy; Transdermal Patch; Tumor Burden / immunology
Source: Web Of Science
Added: August 6, 2018

2017 journal article

A pH-sensitive methenamine mandelate-loaded nanoparticle induces DNA damage and apoptosis of cancer cells

Acta Biomaterialia, 62, 246–256.

By: L. Zhang, W. Hao, L. Xu, Y. Gao, X. Wang, D. Zhu, Z. Chen, X. Zhang, H. Chen, L. Mei

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Investigation and intervention of autophagy to guide cancer treatment with nanogels

NANOSCALE, 9(1), 150–163.

By: X. Zhang n, X. Liang*, J. Gu*, D. Chang*, J. Zhang*, Z. Chen n, Y. Ye n, C. Wang n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Animals; Autophagy; Chloroquine / administration & dosage; Doxorubicin / administration & dosage; Drug Delivery Systems; Endocytosis; Endosomes; Exocytosis; Female; Gels; Humans; MCF-7 Cells; Mice; Mice, SCID; Nanoparticles; Neoplasms, Experimental / drug therapy; Rhodamines; Xenograft Model Antitumor Assays; rab GTP-Binding Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Synthetic beta cells for fusion-mediated dynamic insulin secretion

Nature Chemical Biology, 14(1), 86–93.

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Artificial Cells; Biomimetic Materials / chemistry; Blood Glucose / analysis; Cell Engineering / methods; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Hydrogen-Ion Concentration; Insulin / blood; Insulin / metabolism; Insulin Secretion; Insulin-Secreting Cells / metabolism; Male; Membrane Fusion; Mice, Inbred C57BL
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Systematic investigation on the intracellular trafficking network of polymeric nanoparticles

Nanoscale, 9(9), 3269–3282.

By: J. Zhang, D. Chang, Y. Yang, X. Zhang, W. Tao, L. Jiang, X. Liang, H. Tsai, L. Huang, L. Mei

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Iron oxide nanoparticles induce autophagosome accumulation through multiple mechanisms: Lysosome impairment, mitochondrial damage, and ER stress

Molecular Pharmaceutics, 13(7), 2578–2587.

By: X. Zhang, H. Zhang, X. Liang, J. Zhang, W. Tao, X. Zhu, D. Chang, X. Zeng, L. Mei

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

intracellular trafficking network of protein nanocapsules: endocytosis, exocytosis and autophagy

Theranostics, 6(12), 2099–2113.

By: J. Zhang, X. Zhang, G. Liu, D. Chang, X. Liang, X. Zhu, W. Tao, L. Mei

Source: NC State University Libraries
Added: August 6, 2018

journal article

Core-Shell Microneedle Gel for Self-Regulated Insulin Delivery

Wang, J. Q., Ye, Y. Q., Yu, J. C., Kahkoska, A. R., Zhang, X. D., Wang, C., … Gu, Z. ACS Nano, 12(3), 2466–2473.

By: J. Wang, Y. Ye, J. Yu, A. Kahkoska, X. Zhang, C. Wang, W. Sun, R. Corder ...

Source: NC State University Libraries
Added: August 6, 2018

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