Yev Brudno

VanBlunk, M., Srikanth, V., Pandit, S. S., Kuznetsov, A. V., & Brudno, Y. (2023, January 26). Absorption rate governs cell transduction in dry macroporous scaffolds. BIOMATERIALS SCIENCE, Vol. 1. https://doi.org/10.1039/d2bm01753a

Moody, C. T., Durham, P. G., Dayton, P. A., & Brudno, Y. (2023). Loading Intracranial Drug-Eluting Reservoirs Across the Blood-Brain Barrier With Focused Ultrasound. ULTRASOUND IN MEDICINE AND BIOLOGY, 49(7), 1679–1685. https://doi.org/10.1016/j.ultrasmedbio.2023.03.012

Agarwalla, P., Ogunnaike, E. A., Ahn, S., Froehlich, K. A., Jansson, A., Ligler, F. S., … Brudno, Y. (2022, March 24). Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells. NATURE BIOTECHNOLOGY, Vol. 3. https://doi.org/10.1038/s41587-022-01245-x

VanBlunk, M., Agarwalla, P., Pandit, S., & Brudno, Y. (2022). Fabrication and Use of Dry Macroporous Alginate Scaffolds for Viral Transduction of T Cells. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 9(187). https://doi.org/10.3791/64036

Moody, C. T., Brown, A. E., Massaro, N. P., Patel, A. S., Agarwalla, P. A., Simpson, A. M., … Brudno, Y. (2022). Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture. ACTA BIOMATERIALIA, 138, 208–217. https://doi.org/10.1016/j.actbio.2021.10.046

Pandit, S., Palvai, S., Massaro, N. P., Pierce, J. G., & Brudno, Y. (2022). Tissue-reactive drugs enable materials-free local depots. JOURNAL OF CONTROLLED RELEASE, 343, 142–151. https://doi.org/10.1016/j.jconrel.2022.01.023

Palvai, S., Moody, C. T., Pandit, S., & Brudno, Y. (2021). On-Demand Drug Release from Click-Refillable Drug Depots. MOLECULAR PHARMACEUTICS, 18(10), 3920–3925. https://doi.org/10.1021/acs.molpharmaceut.1c00535

Moody, C. T., Palvai, S., & Brudno, Y. (2020). Click cross-linking improves retention and targeting of refillable alginate depots. Acta Biomaterialia, 112, 112–121. https://doi.org/10.1016/j.actbio.2020.05.033

Wang, H., Sobral, M. C., Snyder, T., Brudno, Y., Gorantla, V. S., & Mooney, D. J. (2020). Clickable, acid labile immunosuppressive prodrugs for in vivo targeting. Biomaterials Science, 8(1), 266–277. https://doi.org/10.1039/C9BM01487J

Palvai, S., Bhangu, J., Akgun, B., Moody, C. T., Hall, D. G., & Brudno, Y. (2020). In Vivo Targeting Using Arylboronate/Nopoldiol Click Conjugation. BIOCONJUGATE CHEMISTRY, 31(10), 2288–2292. https://doi.org/10.1021/acs.bioconjchem.0c00453

McNamara, S. L., Brudno, Y., Miller, A. B., Ham, H. O., Aizenberg, M., Chaikof, E. L., & Mooney, D. J. (2020). Regenerating Antithrombotic Surfaces through Nucleic Acid Displacement. ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(4), 2159–2166. https://doi.org/10.1021/acsbiomaterials.0c00038

Agarwalla, P., Ogunnaike, E. A., Ahn, S., Ligler, F. S., Dotti, G., & Brudno, Y. (2020). Scaffold-Mediated Static Transduction of T Cells for CAR-T Cell Therapy. ADVANCED HEALTHCARE MATERIALS, 9(14). https://doi.org/10.1002/adhm.202000275

Su, T., Huang, K., Ma, H., Liang, H., Dinh, P.-U., Chen, J., … Cheng, K. (2019). Biomimetics: Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury (Adv. Funct. Mater. 4/2019). Advanced Functional Materials, 29(4), 1970019. https://doi.org/10.1002/ADFM.201970019

Adams, M. R., Moody, C. T., Sollinger, J. L., & Brudno, Y. (2019). Extracellular-Matrix-Anchored Click Motifs for Specific Tissue Targeting. Molecular Pharmaceutics, 17(2), 392–403. https://doi.org/10.1021/acs.molpharmaceut.9b00589

Su, T., Huang, K., Ma, H., Liang, H., Dinh, P.-U., Chen, J., … Cheng, K. (2019). Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury. ADVANCED FUNCTIONAL MATERIALS, 29(4). https://doi.org/10.1002/adfm.201803567

Brudno, Y., Pezone, M. J., Snyder, T. K., Uzun, O., Moody, C. T., Aizenberg, M., & Mooney, D. J. (2018). Replenishable drug depot to combat post-resection cancer recurrence. BIOMATERIALS, 178, 373–382. https://doi.org/10.1016/j.biomaterials.2018.05.005

De Leon Peralta, E. J., Brudno, Y., Kwee, B., & Mooney, D. (2016). Improving wound healing through the use of tetrazine-modified alginate. The FASEB Journal, 30(Supplement 1), 1177.10–1177.10. https://doi.org/10.1096/fasebj.30.1_supplement.1177.10

Brudno, Y., Desai, R. M., Kwee, B. J., Joshi, N. S., Aizenberg, M., & Mooney, D. J. (2015). In Vivo Targeting through Click Chemistry. ChemMedChem, 10(4), 617–620. https://doi.org/10.1002/CMDC.201402527

Brudno, Y., & Mooney, D. J. (2015). On-demand drug delivery from local depots. Journal of Controlled Release, 219, 8–17. https://doi.org/10.1016/J.JCONREL.2015.09.011

Maione, A. G., Brudno, Y., Stojadinovic, O., Park, L. K., Smith, A., Tellechea, A., … Garlick, J. A. (2015). Three-Dimensional Human Tissue Models That Incorporate Diabetic Foot Ulcer-Derived Fibroblasts Mimic <i>In Vivo</i> Features of Chronic Wounds. Tissue Engineering Part C: Methods, 21(5), 499–508. https://doi.org/10.1089/ten.tec.2014.0414

Roche, E. T., Hastings, C. L., Lewin, S. A., Shvartsman, D. E., Brudno, Y., Vasilyev, N. V., … Biomaterials. (2014). Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart. Biomaterials, 35(25), 6850–6858. https://doi.org/10.1016/J.BIOMATERIALS.2014.04.114

Brudno, Y., Aizenberg, M., & Mooney, D. (2014). Pro-angiogenic factors enhance pericyte function during angiogenesis. Presented at the 2014 40th Annual Northeast Bioengineering Conference (NEBEC). https://doi.org/10.1109/nebec.2014.6972741

Brudno, Y., Silva, E. A., Kearney, C. J., Lewin, S. A., Miller, A., Martinick, K. D., … Mooney, D. J. (2014). Refilling drug delivery depots through the blood. Proceedings of the National Academy of Sciences, 111(35), 12722–12727. https://doi.org/10.1073/PNAS.1413027111

Shvartsman, D., Storrie-White, H., Lee, K., Kearney, C., Brudno, Y., Ho, N., … Mooney, D. J. (2014). Sustained Delivery of VEGF Maintains Innervation and Promotes Reperfusion in Ischemic Skeletal Muscles Via NGF/GDNF Signaling. Molecular Therapy, 22(7), 1243–1253. https://doi.org/10.1038/MT.2014.76

Brudno, Y., Ennett-Shepard, A. B., Chen, R. R., Aizenberg, M., Mooney, D. J., & Biomaterials. (2013). Enhancing microvascular formation and vessel maturation through temporal control over multiple pro-angiogenic and pro-maturation factors. Biomaterials, 34(36), 9201–9209. https://doi.org/10.1016/J.BIOMATERIALS.2013.08.007

Shamis, Y., Silva, E. A., Hewitt, K. J., Brudno, Y., Levenberg, S., Mooney, D. J., & Garlick, J. A. (2013). Fibroblasts Derived from Human Pluripotent Stem Cells Activate Angiogenic Responses In Vitro and In Vivo. PLoS ONE, 8(12), e83755. https://doi.org/10.1371/journal.pone.0083755

Pastor, W. A., Pape, U. J., Huang, Y., Henderson, H. R., Lister, R., Ko, M., … Rao, A. (2011). Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature, 473(7347), 394–397. https://doi.org/10.1038/nature10102

Brudno, Y., Birnbaum, M. E., Kleiner, R. E., & Liu, D. R. (2010). An in vitro translation, selection and amplification system for peptide nucleic acids. Nature Chemical Biology, 6(2), 148–155. https://doi.org/10.1038/nchembio.280

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., … Rao, A. (2009). Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1. Science, 324(5929), 930–935. https://doi.org/10.1126/science.1170116

Brudno, Y., & Liu, D. R. (2009). Recent Progress Toward the Templated Synthesis and Directed Evolution of Sequence-Defined Synthetic Polymers. Chemistry & Biology, 16(3), 265–276. https://doi.org/10.1016/j.chembiol.2009.02.004

Kleiner, R. E., Brudno, Y., Birnbaum, M. E., & Liu, D. R. (2008). DNA-Templated Polymerization of Side-Chain-Functionalized Peptide Nucleic Acid Aldehydes. Journal of the American Chemical Society, 130(14), 4646–4659. https://doi.org/10.1021/ja0753997