Yong-Jun Goh
Works (34)
Updated: July 20th, 2023 21:17
2022 journal article
Genomic and epigenetic landscapes drive CRISPR-based genome editing in Bifidobacterium
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(30).
author keywords: CRISPR-Cas; bifidobacterium; genomics; epigenomics; probiotics
MeSH headings : Bifidobacterium / genetics; CRISPR-Cas Systems; Gene Editing / methods; Genome, Bacterial / genetics; Genomics; Humans; Probiotics
doi.org (publisher)
Sources: Web Of Science, ORCID
Added: July 21, 2022
2021 journal article
In Vivo Transcriptome of Lactobacillus acidophilus and Colonization Impact on Murine Host Intestinal Gene Expression
MBIO, 12(1).
Ed(s): G. Huffnagle
author keywords: Lactobacillus; acidophilus; gut adaptation; in vivo gene expression; mouse colonization; probiotic
MeSH headings : Animals; Bacterial Adhesion; Bacterial Proteins / genetics; Gene Expression Profiling; Host Microbial Interactions / genetics; Immunity; Intestines / microbiology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / physiology; Mice; Probiotics / administration & dosage; Sequence Analysis, RNA; Signal Transduction; Transcriptome
Sources: Web Of Science, ORCID
Added: January 26, 2021
2021 journal article
Portable CRISPR-Cas9(N) System for Flexible Genome Engineering in Lactobacillus acidophilus, Lactobacillus gasseri, and Lactobacillus paracasei
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 87(6).
Ed(s): E. Dudley
author keywords: Lactobacillus acidophilus; CRISPR; Cas9; nickase; genome editing; probiotic; lactic acid bacteria; Lactobacillus
MeSH headings : CRISPR-Associated Protein 9; CRISPR-Cas Systems; Deoxyribonuclease I; Gene Editing / methods; Genome, Bacterial; Lactobacillus acidophilus / genetics; Lactobacillus gasseri / genetics; Lacticaseibacillus paracasei / genetics
Sources: Web Of Science, ORCID
Added: February 26, 2021
2020 journal article
An 1,4-alpha-Glucosyltransferase Defines a New Maltodextrin Catabolism Scheme in Lactobacillus acidophilus
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 86(15).
author keywords: carbohydrate metabolism; Lactobacillus; disproportionating enzyme; gut microbiota; maltooligosaccharides; microbiota; oligosaccharide 1,4-alpha-glucanotransferase; prebiotic; probiotic; starch
MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Glycogen Debranching Enzyme System / chemistry; Glycogen Debranching Enzyme System / genetics; Glycogen Debranching Enzyme System / metabolism; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Polysaccharides / metabolism
Source: Web Of Science
Added: August 24, 2020
2020 journal article
Comparative Analysis of Lactobacillus gasseri and Lactobacillus crispatus Isolated From Human Urogenital and Gastrointestinal Tracts
FRONTIERS IN MICROBIOLOGY, 10.
author keywords: probiotics; niche-specific adaptation; Lactobacillus; women's health; in vitro vaginal fluid model
Sources: Web Of Science, ORCID
Added: February 17, 2020
2020 journal article
Deletion of S-Layer Associated Ig-Like Domain Protein Disrupts the Lactobacillus acidophilus Cell Surface
FRONTIERS IN MICROBIOLOGY, 11.
author keywords: Lactobacillus; probiotic; S-layer; cell surface; S-layer associated protein; Ig-like domain
Sources: Web Of Science, ORCID
Added: April 27, 2020
2019 review
Characterization and Repurposing of Type I and Type II CRISPR-Cas Systems in Bacteria
[Review of ]. JOURNAL OF MOLECULAR BIOLOGY, 431(1), 21–33.
author keywords: CRISPR-Cas systems; CRISPR characterization; endogenous systems; genome editing
Sources: Web Of Science, ORCID
Added: February 11, 2019
2019 review
Harnessing CRISPR-Cas systems for precision engineering of designer probiotic lactobacilli
[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 56, 163–171.
MeSH headings : CRISPR-Cas Systems / genetics; Drug Delivery Systems; Gene Editing; Genetic Engineering / methods; Lactobacillus / genetics; Probiotics / metabolism
Sources: Web Of Science, ORCID
Added: June 17, 2019
2019 journal article
Outcomes and characterization of chromosomal self-targeting by native CRISPR-Cas systems in Streptococcus thermophilus
FEMS MICROBIOLOGY LETTERS, 366(9).
author keywords: CRISPR; lactic acid bacteria; Cas9; Streptococcus; genome editing
MeSH headings : Bacteriophages / genetics; CRISPR-Cas Systems; Chromosomes, Bacterial / genetics; Gene Editing; Genome, Bacterial; Homologous Recombination; Plasmids / genetics; Streptococcus thermophilus / genetics; Streptococcus thermophilus / virology
Sources: Web Of Science, ORCID
Added: September 3, 2019
2018 journal article
Deletion-based escape of CRISPR-Cas9 targeting in Lactobacillus gasseri
MICROBIOLOGY-SGM, 164(9), 1098–1111.
author keywords: Lactobacillus; CRISPR; Cas; Cas9; interference; spacer
MeSH headings : CRISPR-Associated Protein 9 / metabolism; Clustered Regularly Interspaced Short Palindromic Repeats; Interspersed Repetitive Sequences; Lactobacillus gasseri / genetics; Mutation; Plasmids; Recombination, Genetic; Sequence Deletion; Transformation, Bacterial
Sources: Web Of Science, ORCID
Added: December 31, 2018
2017 journal article
An Extracellular Cell-Attached Pullulanase Confers Branched alpha-Glucan Utilization in Human Gut Lactobacillus acidophilus
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 83(12).
author keywords: glycoside hydrolase family 13; human gut microbiota; starch; starch binding modules
MeSH headings : Amylopectin / chemistry; Amylopectin / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Enzyme Stability; Gastrointestinal Tract / microbiology; Glucans / chemistry; Glucans / metabolism; Glycoside Hydrolases / chemistry; Glycoside Hydrolases / genetics; Glycoside Hydrolases / metabolism; Humans; Hydrolysis; Kinetics; Lactobacillus acidophilus / enzymology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Substrate Specificity
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Deletion of Lipoteichoic Acid Synthase Impacts Expression of Genes Encoding Cell Surface Proteins in Lactobacillus acidophilus
Frontiers in Microbiology, 8.
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Investigating the Effect of Growth Phase on the Surface-Layer Associated Proteome of Lactobacillus acidophilus Using Quantitative Proteomics
FRONTIERS IN MICROBIOLOGY, 8.
author keywords: Lactobacillus; probiotic; cell surface; S-layer; quantitative proteomics
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Lactobacillus acidophilus Metabolizes Dietary Plant Glucosides and Externalizes Their Bioactive Phytochemicals
MBIO, 8(6).
Ed(s): E. Martens & M. McFall-Ngai
author keywords: Lactobacillus; beta-glucoside; bioavailability; gut microbiota; phytochemical; polydatin; polyphenols; resveratrol; xenobiotic metabolism
MeSH headings : Biological Availability; Dietary Carbohydrates / metabolism; Gastrointestinal Microbiome / physiology; Glucosides / metabolism; Glucosides / pharmacology; Humans; Hydrolysis; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / metabolism; Phytochemicals / metabolism; Polyphenols / metabolism; Resveratrol; Stilbenes / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
The S-layer Associated Serine Protease Homolog PrtX Impacts Cell Surface-Mediated Microbe-Host Interactions of Lactobacillus acidophilus NCFM
FRONTIERS IN MICROBIOLOGY, 8.
author keywords: serine protease; S-layer; S-layer associated proteins; Lactobacillus; probiotic; intestinal barrier integrity; mucin; fibronectin
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose - an emerging prebiotic
PROTEOMICS, 16(9), 1361–1375.
author keywords: Adhesion; HT-29 cells; Moonlighting proteins; Probiotics; Raffinose; Surface and whole cell proteomes
Source: Web Of Science
Added: August 6, 2018
2016 review
Prebiotics: why definitions matter
[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 37, 1–7.
MeSH headings : Animals; Community Participation; Food Industry; Gastrointestinal Microbiome; Humans; Prebiotics
Source: Web Of Science
Added: August 6, 2018
2015 article
Genetic Mechanisms of Prebiotic Oligosaccharide Metabolism in Probiotic Microbes
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 6, Vol. 6, pp. 137–156.
author keywords: Lactobacillus; Bifidobacterium; fructooligosaccharide; galactooligosaccharide; prebiotic; probiotic
MeSH headings : Bifidobacterium / metabolism; Lactobacillus / metabolism; Oligosaccharides / metabolism; Prebiotics; Probiotics
Source: Web Of Science
Added: August 6, 2018
2015 journal article
SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis
EMBO JOURNAL, 34(7), 881–895.
author keywords: colitis; immune regulation; Lactobacillus acidophilus; SIGNR3; surface layer protein A
MeSH headings : Animals; Antigens, CD / genetics; Antigens, CD / immunology; Bacterial Proteins / genetics; Bacterial Proteins / immunology; Inflammatory Bowel Diseases / genetics; Inflammatory Bowel Diseases / immunology; Inflammatory Bowel Diseases / microbiology; Inflammatory Bowel Diseases / pathology; Intestinal Mucosa / immunology; Intestinal Mucosa / pathology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / immunology; Lectins, C-Type / genetics; Lectins, C-Type / immunology; Lipopolysaccharides / genetics; Lipopolysaccharides / immunology; Mice; Mice, Knockout; Protein Binding / genetics; Protein Binding / immunology; Teichoic Acids / genetics; Teichoic Acids / immunology
Source: Web Of Science
Added: August 6, 2018
2015 article
Sortase-deficient lactobacilli: effect on immunomodulation and gut retention
Call, E. K., Goh, Y. J., Selle, K., Klaenhammer, T. R., & O'Flaherty, S. (2015, February). MICROBIOLOGY-SGM, Vol. 161, pp. 311–321.
MeSH headings : Aminoacyltransferases / genetics; Aminoacyltransferases / immunology; Aminoacyltransferases / metabolism; Animals; Bacterial Adhesion; Bacterial Proteins / genetics; Bacterial Proteins / immunology; Bacterial Proteins / metabolism; Caco-2 Cells; Cysteine Endopeptidases / genetics; Cysteine Endopeptidases / immunology; Cysteine Endopeptidases / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Gastrointestinal Tract / immunology; Gastrointestinal Tract / microbiology; Humans; Immunomodulation; Lactobacillus / enzymology; Lactobacillus / genetics; Lactobacillus / growth & development; Lactobacillus / physiology; Lactobacillus acidophilus / enzymology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / physiology; Mice; Swine; Tumor Necrosis Factor-alpha / immunology
Source: Web Of Science
Added: August 6, 2018
2014 review
Insights into glycogen metabolism in Lactobacillus acidophilus: impact on carbohydrate metabolism, stress tolerance and gut retention
[Review of ]. MICROBIAL CELL FACTORIES, 13.
author keywords: Lactobacilli; Glycogen; Probiotic; Raffinose; Gastrointestinal retention
MeSH headings : Adaptation, Physiological / drug effects; Animals; Carbohydrate Metabolism / drug effects; Carbon / pharmacology; Colony Count, Microbial; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / microbiology; Glycogen / biosynthesis; Glycogen / metabolism; Humans; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / metabolism; Metabolic Networks and Pathways / drug effects; Metabolic Networks and Pathways / genetics; Mice; Models, Biological; Mutation / genetics; Operon / genetics; Prokaryotic Cells / drug effects; Prokaryotic Cells / metabolism; Raffinose / pharmacology; Species Specificity; Stress, Physiological / drug effects; Trehalose / pharmacology
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Recent insight in alpha-glucan metabolism in probiotic bacteria
BIOLOGIA, 69(6), 713–721.
author keywords: prebiotic; oligosaccharide uptake; ATP-binding cassette transport system; phosphotransferase system; transcriptional analysis; isomalto-oligosaccharide; malto-oligosaccharide
Source: Web Of Science
Added: August 6, 2018
2013 journal article
A functional glycogen biosynthesis pathway in Lactobacillus acidophilus: expression and analysis of the glg operon
MOLECULAR MICROBIOLOGY, 89(6), 1187–1200.
MeSH headings : 1,4-alpha-Glucan Branching Enzyme / genetics; 1,4-alpha-Glucan Branching Enzyme / metabolism; Bile / metabolism; Biosynthetic Pathways / genetics; Carbon / metabolism; Energy Metabolism; Gene Deletion; Gene Expression Regulation, Bacterial; Glucose / metabolism; Glycogen / biosynthesis; Glycogen Phosphorylase / genetics; Glycogen Phosphorylase / metabolism; Glycogen Synthase / genetics; Glycogen Synthase / metabolism; Humans; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / metabolism; Operon; Raffinose / metabolism; Trehalose / metabolism
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Identification of extracellular surface-layer associated proteins in Lactobacillus acidophilus NCFM
MICROBIOLOGY-SGM, 159, 2269–2282.
MeSH headings : Animals; Cells, Cultured; Chromatography, Liquid; Dendritic Cells / drug effects; Lactobacillus acidophilus / chemistry; Lactobacillus acidophilus / immunology; Mass Spectrometry; Membrane Glycoproteins / analysis; Membrane Glycoproteins / immunology; Mice; Tumor Necrosis Factor-alpha / metabolism
Source: Web Of Science
Added: August 6, 2018
2013 review
Recent insight into oligosaccharide uptake and metabolism in probiotic bacteria
[Review of ]. BIOCATALYSIS AND BIOTRANSFORMATION, 31(4), 226–235.
author keywords: Prebiotic; oligosaccharide uptake; ATP-binding cassette transport system; phosphotransferase system; transcriptional analysis
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Transcriptional analysis of oligosaccharide utilization by Bifidobacterium lactis Bl-04
BMC GENOMICS, 14(1).
author keywords: Bifidobacterium lactis; Transcriptomics; ABC transporter; GPH transporter; Prebiotics; Glycoside hydrolase
MeSH headings : Bifidobacterium / drug effects; Bifidobacterium / genetics; Cell Membrane / drug effects; Cell Membrane / metabolism; Data Mining; Gene Expression Profiling; Genetic Variation / genetics; Genomics; Multigene Family / genetics; Oligosaccharides / pharmacology; Prebiotics; Transcription, Genetic / drug effects; Up-Regulation / drug effects
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Transcriptional Analysis of Prebiotic Uptake and Catabolism by Lactobacillus acidophilus NCFM
PLOS ONE, 7(9).
Ed(s): C. Gibas
MeSH headings : ATP-Binding Cassette Transporters / metabolism; Cellobiose / pharmacology; Gene Expression Regulation, Bacterial / drug effects; Glucans / pharmacology; Isomaltose / analogs & derivatives; Isomaltose / pharmacology; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / enzymology; Lactobacillus acidophilus / metabolism; Oligosaccharides / pharmacology; Phosphoenolpyruvate Sugar Phosphotransferase System / metabolism; Prebiotics; Raffinose / pharmacology; Sugar Alcohols / pharmacology
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 article
Specialized adaptation of a lactic acid bacterium to the milk environment: the comparative genomics of Streptococcus thermophilus LMD-9
Goh, Y. J., Goin, C., O'Flaherty, S., Altermann, E., & Hutkins, R. (2011, August 30). MICROBIAL CELL FACTORIES, Vol. 10.
MeSH headings : Animals; Cattle; Computational Biology; Dairy Products / microbiology; Genomics; Humans; Lactic Acid / metabolism; Milk / microbiology; Streptococcus thermophilus / genetics; Streptococcus thermophilus / metabolism
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Transcriptional and functional analysis of galactooligosaccharide uptake by lacS in Lactobacillus acidophilus
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(43), 17785–17790.
author keywords: lactose permease; catabolite repression element
MeSH headings : DNA, Complementary / genetics; Gene Expression Regulation, Bacterial / physiology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Membrane Transport Proteins / metabolism; Microarray Analysis; Oligonucleotide Array Sequence Analysis; Oligosaccharides / pharmacokinetics; Prebiotics; Reverse Transcriptase Polymerase Chain Reaction; beta-Galactosidase / genetics; beta-Galactosidase / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Functional Roles of Aggregation-Promoting-Like Factor in Stress Tolerance and Adherence of Lactobacillus acidophilus NCFM
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76(15), 5005–5012.
MeSH headings : Adhesins, Bacterial / chemistry; Adhesins, Bacterial / genetics; Adhesins, Bacterial / metabolism; Anti-Bacterial Agents / toxicity; Bacterial Adhesion; Bile; Detergents / toxicity; Epithelial Cells / microbiology; Fibronectins / metabolism; Gastric Juice; Gene Deletion; Gene Expression Profiling; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / physiology; Microbial Viability / drug effects; Molecular Weight; Mucins / metabolism; Phylogeny; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Sodium Dodecyl Sulfate / toxicity
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Development and Application of a upp-Based Counterselective Gene Replacement System for the Study of the S-Layer Protein SlpX of Lactobacillus acidophilus NCFM
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 75(10), 3093–3105.
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Drug Resistance, Bacterial; Fluorouracil / pharmacology; Gene Deletion; Genetic Complementation Test; Lactobacillus acidophilus / genetics; Membrane Glycoproteins / genetics; Molecular Sequence Data; Mutagenesis, Insertional / methods; Pentosyltransferases / genetics; Pentosyltransferases / metabolism; Plasmids; Recombination, Genetic; Selection, Genetic
Source: Web Of Science
Added: August 6, 2018
2009 review
Genomic features of Lactobacillus species
[Review of ]. Frontiers in Bioscience, 14, 1362–1386.
Source: NC State University Libraries
Added: August 6, 2018
2008 article
Analysis of the genome sequence of Lactobacillus gasseri ATCC 33323 reveals the molecular basis of an autochthonous intestinal organism
Azcarate-Peril, M. A., Altermann, E., Goh, Y. J., Tallon, R., Sanozky-Dawes, R. B., Pfeiler, E. A., … Klaenhammer, T. R. (2008, August). APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol. 74, pp. 4610–4625.
MeSH headings : Adult; Bacterial Adhesion / genetics; Bacterial Adhesion / physiology; Bacterial Proteins / genetics; Child; DNA Primers; Gastrointestinal Tract / microbiology; Genes, Bacterial; Genome, Bacterial; Humans; Infant, Newborn; Intestines / microbiology; Lactobacillus / genetics; Lactobacillus / isolation & purification; Lactobacillus / pathogenicity; Open Reading Frames
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 article
Functional genomics of probiotic Lactobacilli
Klaenhammer, T. R., Altermann, E., Pfeiler, E., Buck, B. L., Goh, Y.-J., O'Flaherty, S., … Duong, T. (2008, September). JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol. 42, pp. S160–S162.
author keywords: Lactobacillus acidophilus; Lactobacillus johnsonii; Lactobacillus plantarum; Lactobacillus gasseri; genomics; probiotic cultures; lactic acid bacteria
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Evolution, Molecular; Genome, Bacterial; Genomics; Humans; Lactobacillus / classification; Lactobacillus / genetics; Lactobacillus / metabolism; Lactobacillus / physiology; Probiotics / metabolism; Species Specificity
Sources: Web Of Science, ORCID
Added: August 6, 2018
