Works (34)

2022 journal article

Genomic and epigenetic landscapes drive CRISPR-based genome editing in Bifidobacterium

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(30).

By: M. Pan n, W. Morovic*, C. Hidalgo-Cantabrana n, A. Roberts, K. Walden*, Y. Goh, R. Barrangou

author keywords: CRISPR-Cas; bifidobacterium; genomics; epigenomics; probiotics
Sources: Web Of Science, ORCID
Added: July 21, 2022

2021 journal article

In Vivo Transcriptome of Lactobacillus acidophilus and Colonization Impact on Murine Host Intestinal Gene Expression

MBIO, 12(1).

By: Y. Goh, R. Barrangou & T. Klaenhammer

Ed(s): G. Huffnagle

author keywords: Lactobacillus; acidophilus; gut adaptation; in vivo gene expression; mouse colonization; probiotic
Sources: Web Of Science, ORCID
Added: January 26, 2021

2021 journal article

Portable CRISPR-Cas9(N) System for Flexible Genome Engineering in Lactobacillus acidophilus, Lactobacillus gasseri, and Lactobacillus paracasei

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 87(6).

By: Y. Goh & R. Barrangou

Ed(s): E. Dudley

author keywords: Lactobacillus acidophilus; CRISPR; Cas9; nickase; genome editing; probiotic; lactic acid bacteria; Lactobacillus
Sources: Web Of Science, ORCID
Added: February 26, 2021

2020 journal article

An 1,4-alpha-Glucosyltransferase Defines a New Maltodextrin Catabolism Scheme in Lactobacillus acidophilus

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 86(15).

author keywords: carbohydrate metabolism; Lactobacillus; disproportionating enzyme; gut microbiota; maltooligosaccharides; microbiota; oligosaccharide 1,4-alpha-glucanotransferase; prebiotic; probiotic; starch
Source: Web Of Science
Added: August 24, 2020

2020 journal article

Comparative Analysis of Lactobacillus gasseri and Lactobacillus crispatus Isolated From Human Urogenital and Gastrointestinal Tracts

FRONTIERS IN MICROBIOLOGY, 10.

author keywords: probiotics; niche-specific adaptation; Lactobacillus; women's health; in vitro vaginal fluid model
Sources: Web Of Science, ORCID
Added: February 17, 2020

2020 journal article

Deletion of S-Layer Associated Ig-Like Domain Protein Disrupts the Lactobacillus acidophilus Cell Surface

FRONTIERS IN MICROBIOLOGY, 11.

author keywords: Lactobacillus; probiotic; S-layer; cell surface; S-layer associated protein; Ig-like domain
Sources: Web Of Science, ORCID
Added: April 27, 2020

2019 review

Characterization and Repurposing of Type I and Type II CRISPR-Cas Systems in Bacteria

[Review of ]. JOURNAL OF MOLECULAR BIOLOGY, 431(1), 21–33.

author keywords: CRISPR-Cas systems; CRISPR characterization; endogenous systems; genome editing
Sources: Web Of Science, ORCID
Added: February 11, 2019

2019 review

Harnessing CRISPR-Cas systems for precision engineering of designer probiotic lactobacilli

[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 56, 163–171.

By: Y. Goh & R. Barrangou

Sources: Web Of Science, ORCID
Added: June 17, 2019

2019 journal article

Outcomes and characterization of chromosomal self-targeting by native CRISPR-Cas systems in Streptococcus thermophilus

FEMS MICROBIOLOGY LETTERS, 366(9).

By: C. Canez n, K. Selle, Y. Goh & R. Barrangou

author keywords: CRISPR; lactic acid bacteria; Cas9; Streptococcus; genome editing
Sources: Web Of Science, ORCID
Added: September 3, 2019

2018 journal article

Deletion-based escape of CRISPR-Cas9 targeting in Lactobacillus gasseri

MICROBIOLOGY-SGM, 164(9), 1098–1111.

By: E. Stout n, R. Sanozky-Dawes, Y. Goh, A. Crawley, T. Klaenhammer & R. Barrangou

author keywords: Lactobacillus; CRISPR; Cas; Cas9; interference; spacer
Sources: Web Of Science, ORCID
Added: December 31, 2018

2017 journal article

An Extracellular Cell-Attached Pullulanase Confers Branched alpha-Glucan Utilization in Human Gut Lactobacillus acidophilus

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 83(12).

author keywords: glycoside hydrolase family 13; human gut microbiota; starch; starch binding modules
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Deletion of Lipoteichoic Acid Synthase Impacts Expression of Genes Encoding Cell Surface Proteins in Lactobacillus acidophilus

Frontiers in Microbiology, 8.

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Investigating the Effect of Growth Phase on the Surface-Layer Associated Proteome of Lactobacillus acidophilus Using Quantitative Proteomics

FRONTIERS IN MICROBIOLOGY, 8.

By: C. Klotz, S. O'Flaherty, Y. Goh & R. Barrangou

author keywords: Lactobacillus; probiotic; cell surface; S-layer; quantitative proteomics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Lactobacillus acidophilus Metabolizes Dietary Plant Glucosides and Externalizes Their Bioactive Phytochemicals

MBIO, 8(6).

By: M. Theilmann*, Y. Goh, K. Nielsen*, T. Klaenhammer, R. Barrangou & M. Abou Hachem*

Ed(s): E. Martens & M. McFall-Ngai

author keywords: Lactobacillus; beta-glucoside; bioavailability; gut microbiota; phytochemical; polydatin; polyphenols; resveratrol; xenobiotic metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

The S-layer Associated Serine Protease Homolog PrtX Impacts Cell Surface-Mediated Microbe-Host Interactions of Lactobacillus acidophilus NCFM

FRONTIERS IN MICROBIOLOGY, 8.

author keywords: serine protease; S-layer; S-layer associated proteins; Lactobacillus; probiotic; intestinal barrier integrity; mucin; fibronectin
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose - an emerging prebiotic

PROTEOMICS, 16(9), 1361–1375.

By: H. Celebioglu*, M. Ejby*, A. Majumder*, C. Kobler*, Y. Goh, K. Thorsen*, B. Schmidt*, S. O'Flaherty ...

author keywords: Adhesion; HT-29 cells; Moonlighting proteins; Probiotics; Raffinose; Surface and whole cell proteomes
Source: Web Of Science
Added: August 6, 2018

2016 review

Prebiotics: why definitions matter

[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 37, 1–7.

By: R. Hutkins*, J. Krumbeck*, L. Bindels*, P. Cani*, G. Fahey*, Y. Goh, B. Hamaker*, E. Martens* ...

Source: Web Of Science
Added: August 6, 2018

2015 article

Genetic Mechanisms of Prebiotic Oligosaccharide Metabolism in Probiotic Microbes

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 6, Vol. 6, pp. 137–156.

By: Y. Goh & T. Klaenhammer

author keywords: Lactobacillus; Bifidobacterium; fructooligosaccharide; galactooligosaccharide; prebiotic; probiotic
Source: Web Of Science
Added: August 6, 2018

2015 journal article

SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis

EMBO JOURNAL, 34(7), 881–895.

By: Y. Lightfoot*, K. Selle, T. Yang*, Y. Goh, B. Sahay*, M. Zadeh*, J. Owen*, N. Colliou* ...

author keywords: colitis; immune regulation; Lactobacillus acidophilus; SIGNR3; surface layer protein A
Source: Web Of Science
Added: August 6, 2018

2015 article

Sortase-deficient lactobacilli: effect on immunomodulation and gut retention

Call, E. K., Goh, Y. J., Selle, K., Klaenhammer, T. R., & O'Flaherty, S. (2015, February). MICROBIOLOGY-SGM, Vol. 161, pp. 311–321.

By: E. Call n, Y. Goh, K. Selle, T. Klaenhammer & S. O'Flaherty

Source: Web Of Science
Added: August 6, 2018

2014 review

Insights into glycogen metabolism in Lactobacillus acidophilus: impact on carbohydrate metabolism, stress tolerance and gut retention

[Review of ]. MICROBIAL CELL FACTORIES, 13.

By: Y. Goh & T. Klaenhammer

author keywords: Lactobacilli; Glycogen; Probiotic; Raffinose; Gastrointestinal retention
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Recent insight in alpha-glucan metabolism in probiotic bacteria

BIOLOGIA, 69(6), 713–721.

author keywords: prebiotic; oligosaccharide uptake; ATP-binding cassette transport system; phosphotransferase system; transcriptional analysis; isomalto-oligosaccharide; malto-oligosaccharide
Source: Web Of Science
Added: August 6, 2018

2013 journal article

A functional glycogen biosynthesis pathway in Lactobacillus acidophilus: expression and analysis of the glg operon

MOLECULAR MICROBIOLOGY, 89(6), 1187–1200.

By: Y. Goh & T. Klaenhammer

Source: Web Of Science
Added: August 6, 2018

2013 journal article

Identification of extracellular surface-layer associated proteins in Lactobacillus acidophilus NCFM

MICROBIOLOGY-SGM, 159, 2269–2282.

Source: Web Of Science
Added: August 6, 2018

2013 review

Recent insight into oligosaccharide uptake and metabolism in probiotic bacteria

[Review of ]. BIOCATALYSIS AND BIOTRANSFORMATION, 31(4), 226–235.

By: M. Abou Hachem*, J. Andersen*, R. Barrangou, M. Moller*, F. Fredslund*, A. Majumder*, M. Ejby*, S. Lahtinen* ...

author keywords: Prebiotic; oligosaccharide uptake; ATP-binding cassette transport system; phosphotransferase system; transcriptional analysis
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Transcriptional analysis of oligosaccharide utilization by Bifidobacterium lactis Bl-04

BMC GENOMICS, 14(1).

author keywords: Bifidobacterium lactis; Transcriptomics; ABC transporter; GPH transporter; Prebiotics; Glycoside hydrolase
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Transcriptional Analysis of Prebiotic Uptake and Catabolism by Lactobacillus acidophilus NCFM

PLOS ONE, 7(9).

Ed(s): C. Gibas

Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 article

Specialized adaptation of a lactic acid bacterium to the milk environment: the comparative genomics of Streptococcus thermophilus LMD-9

Goh, Y. J., Goin, C., O'Flaherty, S., Altermann, E., & Hutkins, R. (2011, August 30). MICROBIAL CELL FACTORIES, Vol. 10.

By: Y. Goh, C. Goin*, S. O'Flaherty, E. Altermann* & R. Hutkins*

Source: Web Of Science
Added: August 6, 2018

2011 journal article

Transcriptional and functional analysis of galactooligosaccharide uptake by lacS in Lactobacillus acidophilus

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(43), 17785–17790.

author keywords: lactose permease; catabolite repression element
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Functional Roles of Aggregation-Promoting-Like Factor in Stress Tolerance and Adherence of Lactobacillus acidophilus NCFM

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76(15), 5005–5012.

By: Y. Goh & T. Klaenhammer

Source: Web Of Science
Added: August 6, 2018

2009 journal article

Development and Application of a upp-Based Counterselective Gene Replacement System for the Study of the S-Layer Protein SlpX of Lactobacillus acidophilus NCFM

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 75(10), 3093–3105.

Source: Web Of Science
Added: August 6, 2018

2009 review

Genomic features of Lactobacillus species

[Review of ]. Frontiers in Bioscience, 14, 1362–1386.

By: Y. Goh & T. Klaenhammer

Source: NC State University Libraries
Added: August 6, 2018

2008 article

Analysis of the genome sequence of Lactobacillus gasseri ATCC 33323 reveals the molecular basis of an autochthonous intestinal organism

Azcarate-Peril, M. A., Altermann, E., Goh, Y. J., Tallon, R., Sanozky-Dawes, R. B., Pfeiler, E. A., … Klaenhammer, T. R. (2008, August). APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol. 74, pp. 4610–4625.

By: M. Azcarate-Peril n, E. Altermann, Y. Goh, R. Tallon n, R. Sanozky-Dawes n, E. Pfeiler, S. O'Flaherty, B. Buck n ...

Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 article

Functional genomics of probiotic Lactobacilli

Klaenhammer, T. R., Altermann, E., Pfeiler, E., Buck, B. L., Goh, Y.-J., O'Flaherty, S., … Duong, T. (2008, September). JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol. 42, pp. S160–S162.

author keywords: Lactobacillus acidophilus; Lactobacillus johnsonii; Lactobacillus plantarum; Lactobacillus gasseri; genomics; probiotic cultures; lactic acid bacteria
Sources: Web Of Science, ORCID
Added: August 6, 2018