@article{yao_li_zhu_li_tasoudis_liu_mei_popowski_caranasos_wang_et al._2024, title={An infusible biologically active adhesive for chemotherapy-related heart failure in elderly rats}, volume={40}, ISSN={["2452-199X"]}, url={http://dx.doi.org/10.1016/j.bioactmat.2024.06.020}, DOI={10.1016/j.bioactmat.2024.06.020}, abstractNote={Chemotherapy-induced cardiotoxicity with subsequent heart failure (HF) is a major cause of morbidity and mortality in cancer survivors worldwide. Chemotherapy-induced HF is exceptionally challenging as it generally manifests in patients who are typically not eligible for left ventricular device implantation or heart transplantation. To explore alternative treatment strategies for cancer survivors suffering from chemotherapy-induced HF, we developed a minimally invasive infusible cardiac stromal cell secretomes adhesive (MISA) that could be delivered locally through an endoscope-guided intrapericardial injection. To mimic the typical clinical presentation of chemotherapy-induced HF in elder patients, we established an aged rat model in which restrictive cardiomyopathy with sequential HF was induced}, journal={BIOACTIVE MATERIALS}, author={Yao, Jialu and Li, Junlang and Zhu, Dashuai and Li, Yuan and Tasoudis, Panagiotis and Liu, Shuo and Mei, Xuan and Popowski, Kristen and Caranasos, Thomas G. and Wang, Haipeng and et al.}, year={2024}, month={Oct}, pages={571–581} }
 @article{li_sun_zhu_mei_lyu_huang_li_liu_wang_hu_et al._2024, title={Inhalable Stem Cell Exosomes Promote Heart Repair After Myocardial Infarction}, volume={150}, ISSN={["1524-4539"]}, url={https://doi.org/10.1161/CIRCULATIONAHA.123.065005}, DOI={10.1161/CIRCULATIONAHA.123.065005}, abstractNote={Exosome therapy shows potential for cardiac repair after injury. However, intrinsic challenges such as short half-life and lack of clear targets hinder the clinical feasibility. Here, we report a noninvasive and repeatable method for exosome delivery through inhalation after myocardial infarction (MI), which we called stem cell-derived exosome nebulization therapy (SCENT).}, number={9}, journal={CIRCULATION}, author={Li, Junlang and Sun, Shenghuan and Zhu, Dashuai and Mei, Xuan and Lyu, Yongbo and Huang, Ke and Li, Yuan and Liu, Shuo and Wang, Zhenzhen and Hu, Shiqi and et al.}, year={2024}, month={Aug}, pages={710–723} }
 @article{kwon_wu_li_yuan_lopez_huang_bai_2024, title={On-demand drug delivery bioelectronics through a water-processable low dimensional highly conductive MXene layer}, volume={6}, ISSN={["1473-0189"]}, url={http://dx.doi.org/10.1039/d4lc00234b}, DOI={10.1039/d4lc00234b}, abstractNote={On-demand drug delivery holds great promise to optimize pharmaceutical efficacy while minimizing the side effects. However, existing on-demand drug delivery systems often require complicated manufacturing processes that preclude their wide implementation of a broad range of drugs. In this work, we demonstrate the introduction of MXene-coated microneedles (MNs) into bioelectronics for digitally controllable gate-valve drug delivery. MXenes, featuring high electronic conductivity, excellent biocompatibility, and solution processibility, enable low-cost scalability for printable bioelectronics. In an electrolytic state (}, journal={LAB ON A CHIP}, author={Kwon, Hyeok-jin and Wu, Yizhang and Li, Yuan and Yuan, Gongkai and Lopez, Rene and Huang, Ke and Bai, Wubin}, year={2024}, month={Jun} }
 @article{wu_liu_li_wei_xing_wang_zhu_guo_zhang_yuan_et al._2024, title={Symmetry engineering in 2D bioelectronics facilitating augmented biosensing interfaces}, volume={121}, ISSN={["1091-6490"]}, DOI={10.1073/pnas.2412684121}, abstractNote={Symmetry lies at the heart of two-dimensional (2D) bioelectronics, determining material properties at the fundamental level. Breaking the symmetry allows emergent functionalities and effects. However, symmetry modulation in 2D bioelectronics and the resultant applications have been largely overlooked. Here, we devise an oxidized architectural MXene, referred to as oxidized MXene (OXene), that couples orbit symmetric breaking with inverse symmetric breaking to entitle the optimized interfacial impedance and Schottky-induced piezoelectric effects. The resulting OXene validates applications ranging from microelectrode arrays, gait analysis, active transistor matrix, and wireless signaling transmission, which enables high-fidelity signal transmission and reconfigurable logic gates. Furthermore, OXene interfaces were investigated in both rodent and porcine myocardium, featuring high-quality and spatiotemporally resolved physiological recordings, while accurate differentiated predictions, enabled via various machine learning pipelines.}, number={48}, journal={PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA}, author={Wu, Yizhang and Liu, Yihan and Li, Yuan and Wei, Ziquan and Xing, Sicheng and Wang, Yunlang and Zhu, Dashuai and Guo, Ziheng and Zhang, Anran and Yuan, Gongkai and et al.}, year={2024}, month={Nov} }
 @article{kasper_cydis_afridi_smadi_li_charlier_barnes_hohn_cline_carver_et al._2023, title={Development of a bioactive tunable hyaluronic-protein bioconjugate hydrogel for tissue regenerative applications}, url={http://dx.doi.org/10.1039/d2tb02766f}, DOI={10.1039/d2tb02766f}, abstractNote={Hyaluronic acid-based hydrogels conjugated with a fibrinogen linker were found to contribute to faster scaffold degradationviaactive enzymatic breakdown, paving the pathway for use in a variety of multi-purpose tissue engineering applications.}, journal={Journal of Materials Chemistry B}, publisher={Royal Society of Chemistry (RSC)}, author={Kasper, Mary and Cydis, Madison and Afridi, Abdullah and Smadi, Bassam M and Li, Yuan and Charlier, Alban and Barnes, Brooke E. and Hohn, Julia and Cline, Michael and Carver, Wayne and et al.}, year={2023}, month={Jul} }
 @article{hlavac_bousalis_pallack_li_manousiouthakis_ahmad_schmidt_2023, title={Injectable Neural Hydrogel as in vivo Therapeutic Delivery Vehicle}, volume={1}, url={http://dx.doi.org/10.1007/s40883-022-00292-9}, DOI={10.1007/s40883-022-00292-9}, journal={Regenerative Engineering and Translational Medicine}, publisher={Springer Science and Business Media LLC}, author={Hlavac, Nora and Bousalis, Deanna and Pallack, Emily and Li, Yuan and Manousiouthakis, Eleana and Ahmad, Raffae N. and Schmidt, Christine E.}, year={2023}, month={Jan} }
 @article{kasper_ellenbogen_li_schmidt_2023, title={Temporal characterization of hyaluronidases after peripheral nerve injury}, url={http://dx.doi.org/10.1371/journal.pone.0289956}, DOI={10.1371/journal.pone.0289956}, abstractNote={Hyaluronic acid (HA) is ubiquitously found in biological tissues and mediates wound healing mechanisms after injury by promoting cell migration and proliferation. With the development of tissue-engineered neural therapeutics, including off-the-shelf grafts for peripheral nerve repair, HA is an attractive material for clinical use because of its various biological roles. HA-based biomaterials have been carefully engineered to elicit specificin vivohost responses, however an important design feature that should be considered in these scaffolds is endogenous degradation. Hyaluronidases (HYALs) are the complementary enzymes that are responsible for HA turnover. Although HYAL expression has been widely characterized in various tissues, including the central nervous system, and for different pathologies, there remains a lack of knowledge of HYAL mediated turnover in peripheral nerve tissue. In this work, gene expression of two hyaluronidases, HYAL1 and HYAL2, and HA-binding receptor, CD44, were studied in two injury models: rat sciatic nerve crush and critical gap transection. HYAL2 and CD44 were shown to be upregulated 3 days after crush injury, whereas HYAL1 was upregulated at 3 weeks, which collectively demonstrate temporal patterning of HA breakdown. Additionally, differences were observed between HYAL and HA expression at 3 weeks when compared for both nerve injury models. The activity of HYAL in peripheral nerve tissue was determined to be approximately 0.11 μmol/min, which could be used to further model HA-based biomaterial breakdown for peripheral nerve applications. Overall, this work provides a landscape of HA turnover in peripheral nerve that can be used for future neural applications.}, journal={PLOS ONE}, author={Kasper, Mary and Ellenbogen, Bret and Li, Yuan and Schmidt, Christine E.}, year={2023}, month={Aug} }
 @article{hlavac_bousalis_ahmad_pallack_vela_li_mobini_patrick_schmidt_2021, title={Effects of Varied Stimulation Parameters on Adipose-Derived Stem Cell Response to Low-Level Electrical Fields}, url={http://dx.doi.org/10.1007/s10439-021-02875-z}, DOI={10.1007/s10439-021-02875-z}, journal={Annals of Biomedical Engineering}, author={Hlavac, Nora and Bousalis, Deanna and Ahmad, Raffae N. and Pallack, Emily and Vela, Angelique and Li, Yuan and Mobini, Sahba and Patrick, Erin and Schmidt, Christine}, year={2021}, month={Dec} }