@article{kasper_cydis_afridi_smadi_li_charlier_barnes_hohn_cline_carver_et al._2023, title={Development of a bioactive tunable hyaluronic-protein bioconjugate hydrogel for tissue regenerative applications}, url={http://dx.doi.org/10.1039/d2tb02766f}, DOI={10.1039/d2tb02766f}, abstractNote={Hyaluronic acid-based hydrogels conjugated with a fibrinogen linker were found to contribute to faster scaffold degradationviaactive enzymatic breakdown, paving the pathway for use in a variety of multi-purpose tissue engineering applications.}, journal={Journal of Materials Chemistry B}, publisher={Royal Society of Chemistry (RSC)}, author={Kasper, Mary and Cydis, Madison and Afridi, Abdullah and Smadi, Bassam M and Li, Yuan and Charlier, Alban and Barnes, Brooke E. and Hohn, Julia and Cline, Michael and Carver, Wayne and et al.}, year={2023}, month={Jul} }
 @article{hlavac_bousalis_pallack_li_manousiouthakis_ahmad_schmidt_2023, title={Injectable Neural Hydrogel as in vivo Therapeutic Delivery Vehicle}, volume={1}, url={http://dx.doi.org/10.1007/s40883-022-00292-9}, DOI={10.1007/s40883-022-00292-9}, journal={Regenerative Engineering and Translational Medicine}, publisher={Springer Science and Business Media LLC}, author={Hlavac, Nora and Bousalis, Deanna and Pallack, Emily and Li, Yuan and Manousiouthakis, Eleana and Ahmad, Raffae N. and Schmidt, Christine E.}, year={2023}, month={Jan} }
 @article{kasper_ellenbogen_li_schmidt_2023, title={Temporal characterization of hyaluronidases after peripheral nerve injury}, url={http://dx.doi.org/10.1371/journal.pone.0289956}, DOI={10.1371/journal.pone.0289956}, abstractNote={Hyaluronic acid (HA) is ubiquitously found in biological tissues and mediates wound healing mechanisms after injury by promoting cell migration and proliferation. With the development of tissue-engineered neural therapeutics, including off-the-shelf grafts for peripheral nerve repair, HA is an attractive material for clinical use because of its various biological roles. HA-based biomaterials have been carefully engineered to elicit specificin vivohost responses, however an important design feature that should be considered in these scaffolds is endogenous degradation. Hyaluronidases (HYALs) are the complementary enzymes that are responsible for HA turnover. Although HYAL expression has been widely characterized in various tissues, including the central nervous system, and for different pathologies, there remains a lack of knowledge of HYAL mediated turnover in peripheral nerve tissue. In this work, gene expression of two hyaluronidases, HYAL1 and HYAL2, and HA-binding receptor, CD44, were studied in two injury models: rat sciatic nerve crush and critical gap transection. HYAL2 and CD44 were shown to be upregulated 3 days after crush injury, whereas HYAL1 was upregulated at 3 weeks, which collectively demonstrate temporal patterning of HA breakdown. Additionally, differences were observed between HYAL and HA expression at 3 weeks when compared for both nerve injury models. The activity of HYAL in peripheral nerve tissue was determined to be approximately 0.11 μmol/min, which could be used to further model HA-based biomaterial breakdown for peripheral nerve applications. Overall, this work provides a landscape of HA turnover in peripheral nerve that can be used for future neural applications.}, journal={PLOS ONE}, author={Kasper, Mary and Ellenbogen, Bret and Li, Yuan and Schmidt, Christine E.}, year={2023}, month={Aug} }
 @article{hlavac_bousalis_ahmad_pallack_vela_li_mobini_patrick_schmidt_2021, title={Effects of Varied Stimulation Parameters on Adipose-Derived Stem Cell Response to Low-Level Electrical Fields}, url={http://dx.doi.org/10.1007/s10439-021-02875-z}, DOI={10.1007/s10439-021-02875-z}, journal={Annals of Biomedical Engineering}, author={Hlavac, Nora and Bousalis, Deanna and Ahmad, Raffae N. and Pallack, Emily and Vela, Angelique and Li, Yuan and Mobini, Sahba and Patrick, Erin and Schmidt, Christine}, year={2021}, month={Dec} }