Yue Lu

Works (14)

Updated: July 5th, 2023 15:42

2019 review

Cysteine-rich Proteins for Drug Delivery and Diagnosis

[Review of ]. CURRENT MEDICINAL CHEMISTRY, 26(8), 1377–1388.

By: G. Yang *, Y. Lu n, H. Bomba n & Z. Gu n

author keywords: Cysteine-rich protein; drug delivery; cancer diagnostics; protein-based nanoparticle; hydrogel; biomedical material
MeSH headings : Animals; Biocompatible Materials / chemistry; Cysteine / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / methods; Gold / chemistry; Humans; Hydrogels / chemistry; Nanocomposites / chemistry; Nanoparticles / chemistry; Nanotechnology / methods; Neoplasms / diagnosis; Neoplasms / drug therapy; Proteins / chemistry
TL;DR: This review surveys cysteine-rich protein-based biomedical materials, including protein-metal nanohybrids, gold nanoparticle-protein agglomerates, protein- based nanoparticles, and hydrogels, with an emphasis on their preparation methods, especially those based on the cysteined residue-related reactions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 17, 2019

2017 review

Bioresponsive materials

[Review of ]. NATURE REVIEWS MATERIALS, 2(1).

By: Y. Lu n, A. Aimetti, R. Langer * & Z. Gu*

TL;DR: This Review highlights recent advances in the design of smart materials capable of responding to the physiological environment, to biomarkers and to biological particulates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Enhanced Endosomal Escape by Light-Fueled Liquid-Metal Transformer

NANO LETTERS, 17(4), 2138–2145.

By: Y. Lu n, Y. Lin n, Z. Chen n, Q. Hu n, Y. Liu  n, S. Yu  n, W. Gao n, M. Dickey n , Z. Gu n

author keywords: Drug delivery; liquid metal; stimuli-responsive; morphological transformation; endosomal escape
TL;DR: A light-fueled liquid-metal transformer for effective endosomal escape-facilitated cargo delivery via a chemical-mechanical process and equipped with graphene quantum dots provides a new strategy for facilitating effective endOSomal escape to achieve spatiotemporally controlled drug delivery with enhanced efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery

ACS NANO, 11(1), 613–620.

By: X. Hu n, J. Yu n, C. Qian n, Y. Lu n, A. Kahkoska *, Z. Xie *, X. Jing *, J. Buse *, Z. Gu n

author keywords: drug delivery; vesicles; polymersome; glucose-responsive; insulin; diabetes
MeSH headings : Animals; Diabetes Mellitus, Experimental / chemically induced; Diabetes Mellitus, Experimental / drug therapy; Drug Carriers / chemical synthesis; Drug Carriers / chemistry; Drug Delivery Systems / methods; Glucose / analysis; Glucose / metabolism; Glucose Oxidase / metabolism; Hydrogen Peroxide / chemistry; Hypoglycemia / drug therapy; Insulin / administration & dosage; Insulin / chemistry; Insulin / pharmacology; Kinetics; Male; Mice; Mice, Inbred C57BL; Polymers / chemical synthesis; Polymers / chemistry; Streptozocin; Transdermal Patch
TL;DR: In vivo testing indicates that a single patch can regulate glucose levels effectively with reduced risk of hypoglycemia and its kinetics can be modulated by adjusting the concentration of GOx loaded into the microneedles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 article

KIDNEY PHYSIOLOGYA size bandpass filter

Lu, Y., & Gu, Z. (2017, November). NATURE NANOTECHNOLOGY, Vol. 12, pp. 1023–1025.

By: Y. Lu n & Z. Gu n

MeSH headings : Animals; Glomerular Filtration Rate; Humans; Kidney Glomerulus / metabolism; Nanoparticles; Particle Size
TL;DR: The next-generation precision medications and diagnostic tools developed in this study will help improve the quality of life for patients and improve the efficiency of existing treatments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging

THERANOSTICS, 6(7), 1053–1064.

By: C. Qian n, Y. Chen, S. Zhu *, J. Yu n, L. Zhang *, P. Feng*, X. Tang *, Q. Hu n ...

author keywords: drug delivery; nanomedicine; stimuli-responsive; ATP-responsive; theranostics; conjugated polymers
MeSH headings : Adenosine Triphosphate / metabolism; Antineoplastic Agents / administration & dosage; Boronic Acids / metabolism; Doxorubicin / administration & dosage; Drug Carriers / administration & dosage; Hep G2 Cells; Humans; Liver Neoplasms / diagnostic imaging; Liver Neoplasms / drug therapy; Nanoparticles / administration & dosage; Optical Imaging / methods; Theranostic Nanomedicine / methods
TL;DR: In vivo studies validate that this adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drugs and real-time imaging exhibits promising capability for inhibition of tumor growth. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

NANO LETTERS, 16(2), 1118–1126.

By: Q. Hu n, W. Sun n, Y. Lu n, H. Bomba n, Y. Ye n, T. Jiang *, A. Isaacson*, Z. Gu n

author keywords: Drug delivery; stimuli-responsive; tumor microenvironment; apoptosis; antiangiogenesis
MeSH headings : Angiogenesis Inhibitors / administration & dosage; Angiogenesis Inhibitors / chemistry; Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Apoptosis / drug effects; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Cell Line, Tumor; Cell Membrane Permeability / drug effects; Drug Delivery Systems; Endosomes / drug effects; Gene Transfer Techniques; Humans; Hyaluronoglucosaminidase / biosynthesis; Hyaluronoglucosaminidase / chemistry; Mice; Snake Venoms / administration & dosage; Snake Venoms / chemistry; TNF-Related Apoptosis-Inducing Ligand / administration & dosage; Tumor Microenvironment / drug effects; Xenograft Model Antitumor Assays
TL;DR: Equipped with an acid-degradable modality, the resulting CS-NG can substantially release combinational anticancer drugs-tumor necrosis factor-related apoptosis inducing ligand and antiangiogenic cilengitide toward the membrane of cancer cells and endothelial cells at the acidic tumor microenvironment, respectively. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment

NANOSCALE, 7(28), 12096–12103.

By: D. Pacardo n, B. Neupane n, S. Rikard  n, Y. Lu n, R. Mo n, S. Mishra n, J. Tracy n , G. Wang n, F. Ligler n, Z. Gu n

Contributors: D. Pacardo n, B. Neupane n, S. Rikard  n, Y. Lu n, R. Mo n, S. Mishra n, J. Tracy n , G. Wang n, F. Ligler n, Z. Gu n

MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Drug Screening Assays, Antitumor; Gold / chemistry; Gold / pharmacology; HeLa Cells; Humans; Infrared Rays; Nanotubes / chemistry; Neoplasms / drug therapy; Photochemotherapy
TL;DR: This multifunctional AuNR-based system represents a novel theranostic strategy for spatiotemporal delivery of anticancer therapeutics and demonstrates enhanced anticancer efficacy through the synergistic combination of promoted drug release upon ultraviolet (UV) light irradiation and photothermal therapy upon infrared (IR) irradiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Hybrid Fe3O4-Poly(acrylic acid) Nanogels for Theranostic Cancer Treatment

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 11(5), 771–779.

By: Y. Chen, J. Nan, Y. Lu*, C. Wang, F. Chu & Z. Gu*

author keywords: Hybrid Magnetic Nanogels; In Situ Co-Precipitation; MRI Imaging; High Drug Loading Capacity; Tumor Target
MeSH headings : Acrylic Resins / chemistry; Acrylic Resins / therapeutic use; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Drug Delivery Systems; Ferric Compounds / chemistry; Ferric Compounds / therapeutic use; Humans; Magnetic Resonance Imaging; Materials Testing; Mice; Mice, Inbred ICR; Nanogels; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Neoplasms / drug therapy; Neoplasms / metabolism; Neoplasms / pathology; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Polyethylene Glycols / therapeutic use; Polyethyleneimine / chemical synthesis; Polyethyleneimine / chemistry; Polyethyleneimine / therapeutic use; Tumor Cells, Cultured
TL;DR: Cytotoxicity assays and cellular imaging demonstrated that the hybrid Fe3O4-PAA nanogels were highly biocompatible and efficiently internalized in human neuroblastoma SH-SY5Y cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Transformable liquid-metal nanomedicine

NATURE COMMUNICATIONS, 6(1).

By: Y. Lu n, Q. Hu n, Y. Lin n, D. Pacardo n, C. Wang n, W. Sun n, F. Ligler n, M. Dickey n , Z. Gu*

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Female; Gallium / chemistry; Humans; Indium / chemistry; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Nanomedicine / instrumentation; Nanomedicine / methods; Neoplasms / drug therapy
TL;DR: A transformable liquid-metal nanomedicine, based on a core–shell nanosphere composed of a liquid-phase eutectic gallium-indium core and a thiolated polymeric shell, providing a new strategy for engineering theranostic agents with low toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Advances in Anticancer Protein Delivery using Micro-/Nanoparticles

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 31(12), 1204–1222.

By: W. Sun n, Y. Lu n & Z. Gu n

TL;DR: Recent advances in delivering anticancer proteins directly to tumor tissue for inducing apoptosis/necrosis or indirectly to antigen presenting cells for provoking immune responses are surveyed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(42), 14722–14725.

By: W. Sun n, T. Jiang n, Y. Lu n, M. Reiff n, R. Mo n & Z. Gu n

MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; DNA / chemistry; DNA / metabolism; Deoxyribonucleases / metabolism; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Liberation; Humans; MCF-7 Cells; Models, Molecular; Molecular Conformation; Nanoparticles / chemistry
TL;DR: In an acidic environment, the activity of DNase I was activated through the acid-triggered shedding of the polymeric shell of the NCa, resulting in the cocoon-like self-degradation of the NCl and promoting the release of DOX for enhanced therapeutic efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Folding graft copolymer with pendant drug segments for co-delivery of anticancer drugs

BIOMATERIALS, 35(25), 7194–7203.

By: W. Tai  n, R. Mo  n, Y. Lu n, T. Jiang n & Z. Gu n

author keywords: Graft copolymer; Micelle; Combination therapy; Bio-inspired; Ring open polymerization; Nanomedicine
MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Camptothecin / chemistry; Camptothecin / pharmacology; Cell Line, Tumor; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Endocytosis / drug effects; Female; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Mice, Nude; Micelles; Nanostructures / chemistry; Polyethylene Glycols / chemistry; Polymers / chemistry; Xenograft Model Antitumor Assays
TL;DR: In vivo study validated that the nanocarriers exhibited strong accumulation in tumor sites and showed a prominent anticancer activity against the lung cancer xenograft mice model compared with free drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Self-folded redox/acid dual-responsive nanocarriers for anticancer drug delivery

CHEMICAL COMMUNICATIONS, 50(95), 15105–15108.

By: Y. Lu n, R. Mo n, W. Tai n, W. Sun n, D. Pacardo n, C. Qian  n, Q. Shen *, F. Ligler n, Z. Gu n

MeSH headings : Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Cell Survival / drug effects; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers / administration & dosage; Drug Carriers / chemistry; Folic Acid / administration & dosage; Folic Acid / chemistry; Glutathione / chemistry; HeLa Cells; Humans; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Oxidation-Reduction; Peptides / chemistry; Polyethylene Glycols / chemistry
TL;DR: Self-folded redox/acid dual-responsive nanocarriers developed for physiologically triggered delivery of anticancer drugs suggest their potential as a promising formulation for tumor-targeted chemotherapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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