Works (6)

Updated: July 5th, 2023 15:41

2018 journal article

Evaluation of point-of-care thoracic ultrasound and NT-proBNP for the diagnosis of congestive heart failure in cats with respiratory distress

JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(5), 1530–1540.

By: J. Ward*, G. Lisciandro, W. Ware*, A. Viall*, B. Aona n, K. Kurtz n, Y. Reina-Doreste n, T. DeFrancesco n

author keywords: B-lines; biomarker; cardiac; feline; lung; point-of-care; respiratory
MeSH headings : Animals; Biomarkers / blood; Cat Diseases / blood; Cat Diseases / diagnosis; Cats; Echocardiography / veterinary; False Negative Reactions; False Positive Reactions; Female; Heart Failure / blood; Heart Failure / diagnosis; Heart Failure / veterinary; Male; Natriuretic Peptide, Brain / blood; Peptide Fragments / blood; Point-of-Care Systems; Retrospective Studies
TL;DR: Lung ultrasound and blood NT‐proBNP were significant predictors of CHF in a multivariate model and point‐of‐care diagnostic techniques of LUS, FCU, and NT‐ proBNP are useful to diagnoseCHF in cats with respiratory distress. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 5, 2018

2017 journal article

Angiotensin-converting enzyme activity and inhibition in dogs with cardiac disease and an angiotensin-converting enzyme polymorphism

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 18(4).

By: K. Meurs n, J. Stern n, C. Atkins n, D. Adin n, B. Aona n, J. Condit n, T. DeFrancesco n, Y. Reina-Doreste n ...

author keywords: Polymorphism; canine; angiotensin-converting enzyme; enalapril
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Breeding; Dogs; Genotype; Heart Diseases / drug therapy; Heart Diseases / enzymology; Heart Diseases / genetics; Peptidyl-Dipeptidase A / genetics; Polymorphism, Genetic
TL;DR: It is possible that the genetic status and ACE activity of dogs may impact the response of dogs with this variant to an ACE inhibitor, and an ACE polymorphism is associated with lower levels of ACE activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Impact of the canine double-deletion beta 1 adrenoreceptor polymorphisms on protein structure and heart rate response to atenolol, a beta 1-selective beta-blocker

PHARMACOGENETICS AND GENOMICS, 25(9), 427–431.

By: K. Meurs n, J. Stern*, Y. Reina-Doreste*, B. Maran, L. Chdid*, S. Lahmers*, B. Keene*, K. Mealey

author keywords: beta-adrenergic receptor; atenolol; beta-blocker; canine; polymorphism
MeSH headings : Adrenergic beta-1 Receptor Antagonists / administration & dosage; Adrenergic beta-1 Receptor Antagonists / pharmacology; Animals; Atenolol / administration & dosage; Atenolol / pharmacology; Dogs; Electrocardiography / veterinary; Heart Rate / drug effects; Models, Molecular; Protein Structure, Secondary; Receptors, Adrenergic, beta-1 / chemistry; Receptors, Adrenergic, beta-1 / genetics; Sequence Deletion
TL;DR: The heart rates of the dogs with deletions were lower than those of the control dogs (the average heart rates were significantly lower), and individual genome-based treatment recommendations could impact the management of dogs with heart disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 article

Polymorphisms in the canine and feline renin-angiotensin-aldosterone system genes

Meurs, K. M., Chdid, L., Reina-Doreste, Y., & Stern, J. A. (2015, April). ANIMAL GENETICS, Vol. 46, pp. 226–226.

By: K. Meurs n, L. Chdid n, Y. Reina-Doreste n & J. Stern n

MeSH headings : Animals; Cats; Dogs; Polymorphism, Genetic; Renin-Angiotensin System / genetics; Sequence Analysis, DNA
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Sudden Death Associated with QT Interval Prolongation and KCNQ1 Gene Mutation in a Family of English Springer Spaniels

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(2), 561–568.

By: W. Ware*, Y. Reina-Doreste n, J. Stern n & K. Meurs n

author keywords: Long QT Syndrome
MeSH headings : Animals; Arrhythmias, Cardiac / genetics; Arrhythmias, Cardiac / veterinary; Case-Control Studies; Death, Sudden / veterinary; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Female; Genetic Predisposition to Disease; KCNQ1 Potassium Channel / genetics; KCNQ1 Potassium Channel / metabolism; Long QT Syndrome / complications; Long QT Syndrome / genetics; Male; Mutation; Pedigree
TL;DR: This family represents the first documentation in dogs of spontaneous familial QT prolongation, which was associated with a KCNQ1 gene mutation and sudden death, and their phenotypic manifestations of QT interval prolongation and abnormal ECG restitution suggested increased risk for sudden arrhythmic death. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 245(5), 534–539.

By: Y. Reina-Doreste n, J. Stern*, B. Keene*, S. Tou*, C. Atkins*, T. DeFrancesco*, M. Ames*, T. Hodge*, K. Meurs*

MeSH headings : Animals; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / mortality; Cardiomyopathy, Hypertrophic / veterinary; Cardiotonic Agents / therapeutic use; Case-Control Studies; Cat Diseases / drug therapy; Cat Diseases / mortality; Cats; Female; Heart Failure / drug therapy; Heart Failure / mortality; Heart Failure / veterinary; Male; Pyridazines / therapeutic use; Retrospective Studies
TL;DR: The addition of pimobendan to traditional treatment for CHF may provide a substantial clinical benefit in survival time for HCM-affected cats with CHF and possibly HOCM- affected cats withCHF. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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