@article{shi_pierce_2015, title={Synthesis of the 5,6-Dihydroxymorpholin-3-one Fragment of Monanchocidin A}, volume={17}, ISSN={["1523-7052"]}, DOI={10.1021/acs.orglett.5b00069}, abstractNote={Monanchocidin A is a recently isolated pentacyclic guanidinium alkaloid that contains an unusual highly oxidized morpholinone fragment. Herein we report a rapid synthesis of this heterocyclic scaffold and confirm its structure. The key reaction involves an acid promoted hemiketalization/hemiaminalization of an α-hydroxyamide and α-ketoaldehyde that proceeds with exclusive regioselectivity and high diastereoselectivity to form the natural scaffold in moderate to high yield.}, number={4}, journal={ORGANIC LETTERS}, author={Shi, Yunlong and Pierce, Joshua G.}, year={2015}, month={Feb}, pages={968–971} }