Works (57)

Updated: March 6th, 2026 09:25

2026 article

BPS2026 - Integrating spectroscopic single-molecule localization microscopy with DNA-PAINT for simultaneous multiplexing super-resolution microscopy

Shahid, M. A., Patel, K., & Zhang, Y. (2026, February 1). Biophysical Journal, Vol. 2.

By: M. Shahid n, K. Patel n & Y. Zhang n

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Near-Field Optical Microscopy; Digital Holography and Microscopy
Sources: NC State University Libraries, NC State University Libraries
Added: March 3, 2026

2025 article

Framework for Accurate Single-Molecule Spectroscopic Imaging Analyses Using Monte Carlo Simulation and Deep Learning

Mao, H., Liu, Y., KanchanadeviVenkataraman, O., Shahid, M. A., Laplante, C., Xu, D., … Zhang, Y. (2025, July 4). Analytical Chemistry, Vol. 7.

By: H. Mao n, Y. Liu n, O. KanchanadeviVenkataraman n, M. Shahid n, C. Laplante n, D. Xu n, K. Song*, Y. Zhang n

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Photoacoustic and Ultrasonic Imaging; Optical Imaging and Spectroscopy Techniques
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 4, 2025

2025 article

Functional super-resolution microscopy of fibers and polymers: convergence of artificial and biological systems at the nanoscale

Rao, S.-J., Gong, X., Shahid, M. A., Liu, Y., Mao, H., & Zhang, Y. (2025, December 17). Nanoscale Horizons.

By: S. Rao n, X. Gong n, M. Shahid n, Y. Liu n, H. Mao n & Y. Zhang n

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Luminescence and Fluorescent Materials; Near-Field Optical Microscopy
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: January 9, 2026

2025 article

Mineral Deposition from Liquid Precursors Triggered by Complementary Polyelectrolytes

Patoary, M. K., Pierce, E. H., Siu, E., Gallagher, B., Shahid, M. A., Zhang, Y., & Schroeder, T. B. H. (2025, December 10).

By: M. Patoary n, E. Pierce n, E. Siu n, B. Gallagher n, M. Shahid n, Y. Zhang n, T. Schroeder n

topics (OpenAlex): Polymer Surface Interaction Studies; Calcium Carbonate Crystallization and Inhibition; Hydrogels: synthesis, properties, applications
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: December 12, 2025

2025 article

Photoactivation of BODIPY Fluorescence with Green Light

Tomassini, A., Liu, Y., Zheng, Y., Shahid, M. A., Singh, A., Singh, A. K., … Raymo, F. M. (2025, June 6). The Journal of Organic Chemistry, Vol. 6.

By: A. Tomassini*, Y. Liu n, Y. Zheng*, M. Shahid n, A. Singh*, A. Singh*, W. Piedra*, X. Gong n ...

topics (OpenAlex): Luminescence and Fluorescent Materials; Advanced Fluorescence Microscopy Techniques; Photoreceptor and optogenetics research
Sources: Web Of Science, NC State University Libraries
Added: June 16, 2025

2025 article

Photoswitchable Fluorescent Hydrazone for Super-Resolution Cell Membrane Imaging

Qi, Q., Liu, Y., Puranik, V., Patra, S., Svindrych, Z., Gong, X., … Aprahamian, I. (2025, May 2). Journal of the American Chemical Society, Vol. 5.

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Photochromic and Fluorescence Chemistry; Photodynamic Therapy Research Studies
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 2, 2025

2025 article

Solvatochromic BODIPYs with Polarity-Independent Absorption for Functional Super-resolution Imaging of Live Cell Membranes

Liu, Y., Gong, X., Yoder, B., Gluck, J. M., Vinueza, N. R., Liu, X., & Zhang, Y. (2025, November 18). Chemical & Biomedical Imaging.

By: Y. Liu n, X. Gong n, B. Yoder n, J. Gluck n, N. Vinueza n, X. Liu n, Y. Zhang n

topics (OpenAlex): Luminescence and Fluorescent Materials; Advanced Fluorescence Microscopy Techniques; Random lasers and scattering media
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: November 19, 2025

2024 article

Multiscale imaging of corneal endothelium damage and Rho-kinase inhibitor application in mouse models of acute ocular hypertension

Cai, Z., Zhang, Y., Fang, R. S., Brenner, B., Kweon, J., Sun, C., … Zhang, H. F. (2024, January 17). Biomedical Optics Express, Vol. 15.

topics (OpenAlex): Glaucoma and retinal disorders; Corneal surgery and disorders; Retinal Diseases and Treatments
Sources: Web Of Science, NC State University Libraries
Added: April 22, 2024

2024 article

Quantifying nanoscopic alterations associated with mitochondrial dysfunction using three-dimensional single-molecule localization microscopy

Brenner, B., Xu, F., Zhang, Y., Kweon, J., Fang, R., Sheibani, N., … Zhang, H. F. (2024, February 6). Biomedical Optics Express, Vol. 15, pp. 1571–1584.

By: B. Brenner*, F. Xu*, Y. Zhang n, J. Kweon*, R. Fang*, N. Sheibani, S. Zhang*, C. Sun, H. Zhang*

topics (OpenAlex): Mitochondrial Function and Pathology; Advanced Fluorescence Microscopy Techniques; ATP Synthase and ATPases Research
Sources: Web Of Science, NC State University Libraries
Added: May 7, 2024

2023 article

Integrating Machine Learning and Color Chemistry: Developing a High-School Curriculum toward Real-World Problem-Solving

Jiang, S., McClure, J., Mao, H., Chen, J., Liu, Y., & Zhang, Y. (2023, December 7). Journal of Chemical Education, Vol. 12.

By: S. Jiang n, J. McClure n, H. Mao n, J. Chen n, Y. Liu n & Y. Zhang n

author keywords: Machine Learning; High School; Analytical Chemistry; pH Test; Colorimetric Analysis; Interdisciplinarity
topics (OpenAlex): Various Chemistry Research Topics; Genetics, Bioinformatics, and Biomedical Research; Machine Learning in Materials Science
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
4. Quality Education (Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 1, 2024

2023 article

Investigating Uncertainties in Single-Molecule Localization Microscopy Using Experimentally Informed Monte Carlo Simulation

Yeo, W.-H., Zhang, Y., Neely, A. E., Bao, X., Sun, C., & Zhang, H. F. (2023, July 18). Nano Letters, Vol. 7.

By: W. Yeo*, Y. Zhang n, A. Neely*, X. Bao*, C. Sun* & H. Zhang*

author keywords: Single-molecule localization microscopy; Monte Carlosimulation; nuclear pore complex; image processing
topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Advanced Electron Microscopy Techniques and Applications; Single-cell and spatial transcriptomics
TL;DR: A Monte Carlo (MC) simulation based on experimental imaging parameters and geometric information is developed to generate synthetic SMLM images and illustrated using the MC model to generate cellular substructures with different angles of labeling to inform the structural understanding of the images obtained. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 7, 2023

2023 article

Nucleoporin downregulation modulates progenitor differentiation independent of nuclear pore numbers

Neely, A. E., Zhang, Y., Blumensaadt, L. A., Mao, H., Brenner, B., Sun, C., … Bao, X. (2023, October 18). Communications Biology, Vol. 6.

By: A. Neely*, Y. Zhang n, L. Blumensaadt*, H. Mao n, B. Brenner*, C. Sun*, H. Zhang*, X. Bao*

MeSH headings : Humans; Nuclear Pore Complex Proteins / genetics; Nuclear Pore Complex Proteins / metabolism; Nuclear Pore / genetics; Nuclear Pore / metabolism; NF-kappa B / metabolism; Down-Regulation; Active Transport, Cell Nucleus
topics (OpenAlex): Nuclear Structure and Function; RNA Research and Splicing; Genomics and Chromatin Dynamics
TL;DR: It is identified that NUP93 knockdown induces differentiation genes related to both mechanical and immune barrier functions, including the activation of known NF-κB target genes, including the activation of known NF-κB target genes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 18, 2023

2023 article

Photoactivatable BODIPYs for Live-Cell PALM

Zhang, Y., Zheng, Y., Tomassini, A., Singh, A. K., & Raymo, F. M. (2023, March 7). Molecules, Vol. 28.

author keywords: borondipyrromethenes (BODIPYs); fluorescence imaging; photoactivatable fluorophores (PAFs); photoactivated localization microscopy (PALM); single-molecule localization microscopy (SMLM)
MeSH headings : Microscopy, Fluorescence / methods; Boron Compounds / chemistry; Fluorescent Dyes / chemistry
topics (OpenAlex): Luminescence and Fluorescent Materials; Molecular Sensors and Ion Detection; Advanced biosensing and bioanalysis techniques
TL;DR: This work has shown that photoactivatable BODIPYs have already allowed the sub-diffraction imaging of diverse cellular substructures in live cells using PALM and can evolve into invaluable analytical probes for bioimaging applications. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 17, 2023

2023 article

Photoactivatable Fluorophores for Bioimaging Applications

Zhang, Y., Zheng, Y., Tomassini, A., Singh, A. K., & Raymo, F. M. (2023, February 27). ACS Applied Optical Materials, Vol. 1, pp. 640–651.

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Photochromic and Fluorescence Chemistry; Click Chemistry and Applications
Source: ORCID
Added: February 1, 2024

2023 article

Photoactivatable fluorophores for bioimaging applications

Zhang, Y., Zheng, Y., Tomassini, A., Hayter, C. E., & Raymo, F. M. (2023, March 18). COLLOIDAL NANOPARTICLES FOR BIOMEDICAL APPLICATIONS XVIII, Vol. 12395.

By: Y. Zhang n, Y. Zheng*, A. Tomassini*, C. Hayter* & F. Raymo*

author keywords: BODIPYs; fluorescence imaging; PALM; photoactivatable fluorophores; photocages; SMLM; singlemolecule; tracking; super-resolution imaging
topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Click Chemistry and Applications; Advanced Biosensing Techniques and Applications
TL;DR: A new family of synthetic photoactivatable fluorophores specifically designed for single-molecule localization microscopy, which combine a borondipyrromethene (BODIPY) fluorophore and an ortho-nitrobenzyl (ONB) photocage in a single molecular skeleton. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2023 article

Spectral precision improvement with demagnifying spectral images in spectroscopic nanoscopy

Song, K.-H., & Zhang, Y. (2023, November 17). Journal of the Optical Society of America A, Vol. 41, pp. 39–44.

By: K. Song* & Y. Zhang n

topics (OpenAlex): Spectroscopy Techniques in Biomedical and Chemical Research; Advanced Fluorescence Microscopy Techniques; Optical Coherence Tomography Applications
Sources: Web Of Science, NC State University Libraries
Added: May 7, 2024

2023 article

Switchable and Functional Fluorophores for Multidimensional Single-Molecule Localization Microscopy

Liu, Y., Shahid, M. A., Mao, H., Chen, J., Waddington, M., Song, K.-H., & Zhang, Y. (2023, June 28). Chemical & Biomedical Imaging.

By: Y. Liu n, M. Shahid n, H. Mao n, J. Chen n, M. Waddington n, K. Song*, Y. Zhang n

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Advanced Electron Microscopy Techniques and Applications; Advanced Biosensing Techniques and Applications
Source: ORCID
Added: February 1, 2024

2023 article

Techniques for navigating postsurgical adhesions: Insights into mechanisms and future directions

Chen, J., Tang, X., Wang, Z., Perez, A., Yao, B., Huang, K., … King, M. W. (2023, June 26). Bioengineering & Translational Medicine, Vol. 6.

By: J. Chen n, X. Tang n, Z. Wang n, A. Perez*, B. Yao*, K. Huang n, Y. Zhang n, M. King n

author keywords: abdominal adhesion; adhesion prevention; anti-adhesion strategy; anti-inflammatory; fibrinolytic agent; physical barrier; postsurgical adhesion
topics (OpenAlex): Intestinal and Peritoneal Adhesions; Hernia repair and management; Thyroid and Parathyroid Surgery
TL;DR: Anti‐adhesion agents represent a promising approach for reducing the burden of adhesion‐related complications in surgical patients and further research is needed to optimize their use and develop new therapies for this challenging clinical problem. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023

2022 article

Experimental Parameters-Based Monte-Carlo Simulation of Single-Molecule Localization Microscopy of Nuclear Pore Complex to Evaluate Clustering Algorithms

Yeo, W.-H., Zhang, Y., Neely, A. E., Bao, X., Sun, C., & Zhang, H. F. (2022, September 22).

By: W. Yeo*, Y. Zhang n, A. Neely*, X. Bao*, C. Sun* & H. Zhang*

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Nuclear Structure and Function; Advanced Electron Microscopy Techniques and Applications
TL;DR: A Monte-Carlo simulation was developed to generate synthetic SMLM images of NPC and the simulated NPC images were used as the ground truth to evaluate the performance of six clustering algorithms and identified HDBSCAN as the optimal clustering algorithm for NPC counting and sizing. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2022 article

Minimizing Molecular Misidentification in Imaging Low-Abundance Protein Interactions Using Spectroscopic Single-Molecule Localization Microscopy

Zhang, Y., Wang, G., Huang, P., Sun, E., Kweon, J., Li, Q., … Zhang, H. F. (2022, September 27). Analytical Chemistry.

MeSH headings : Biological Phenomena; Fluorescent Dyes / chemistry; Microscopy, Fluorescence / methods; Single Molecule Imaging / methods; Staurosporine / pharmacology
topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Advanced Electron Microscopy Techniques and Applications; Cell Image Analysis Techniques
TL;DR: A deep learning-based imaging analysis method for spectroscopic single-molecule localization microscopy to minimize molecular misidentification in three-color super-resolution imaging is developed. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2021 article

Investigating Single-Molecule Fluorescence Spectral Heterogeneity of Rhodamines Using High-Throughput Single-Molecule Spectroscopy

Zhang, Y., Zhang, Y., Song, K.-H., Lin, W., Sun, C., Schatz, G. C., & Zhang, H. F. (2021, April 16). The Journal of Physical Chemistry Letters, Vol. 12, pp. 3914–3921.

MeSH headings : Fluorescence; Fluorescent Dyes / chemistry; Molecular Conformation; Rhodamines / chemistry; Rotation; Single Molecule Imaging / methods
topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Advanced Biosensing Techniques and Applications; Optical Imaging and Spectroscopy Techniques
TL;DR: It is found that the rotational flexibility of N,N-dialkylated groups contributed to the smFSH, and the system's noise uncertainty, single-molecule spectral diffusion, and environmental polarity were ruled out. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2020 article

Accelerating multicolor spectroscopic single-molecule localization microscopy using deep learning

Gaire, S. K., Zhang, Y., Li, H., Yu, R., Zhang, H. F., & Ying, L. (2020, April 14). Biomedical Optics Express.

By: S. Gaire*, Y. Zhang*, H. Li*, R. Yu*, H. Zhang* & L. Ying*

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Cell Image Analysis Techniques; Photoacoustic and Ultrasonic Imaging
TL;DR: This method uses deep convolution neural networks to reconstruct high-density multicolor super-resolution images from low-density, contaminated multicolors rendered using sSMLM datasets with much fewer frames, without compromising spatial resolution. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2020 article

Compact, “Clickable” Quantum Dots Photoligated with Multifunctional Zwitterionic Polymers for Immunofluorescence and In Vivo Imaging

Wang, W., Niekerk, E. A., Zhang, Y., Du, L., Ji, X., Wang, S., … Mattoussi, H. (2020, April 25). Bioconjugate Chemistry, Vol. 31, pp. 1497–1509.

MeSH headings : Animals; Azides / chemistry; Cell Line; Click Chemistry; Drosophila melanogaster / embryology; Fluorescent Antibody Technique; Fluorescent Dyes / chemistry; Imidazoles / chemistry; Ligands; Neurons / cytology; Optical Imaging / methods; Particle Size; Polymers / chemistry; Quantum Dots / chemistry; Signal Transduction; Sulfhydryl Compounds / chemistry
topics (OpenAlex): Quantum Dots Synthesis And Properties; Advanced biosensing and bioanalysis techniques; Advanced Biosensing Techniques and Applications
TL;DR: The preparation of highly fluorescent quantum dots, surface-engineered with multifunctional polymer ligands that are compact, readily compatible with strain-promoted click conjugation, and the use of these nanocrystals in immunofluorescence and in-vivo imaging are detailed. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2020 article

Live-Cell Imaging at the Nanoscale with Bioconjugatable and Photoactivatable Fluorophores

Zhang, Y., & Raymo, F. M. (2020, March 9). Bioconjugate Chemistry, Vol. 31, pp. 1052–1062.

By: Y. Zhang* & F. Raymo*

MeSH headings : Cell Line; Cell Survival; Fluorescent Dyes / chemistry; Fluorescent Dyes / metabolism; Humans; Intracellular Space / metabolism; Light; Molecular Imaging / methods; Nanotechnology / methods
topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Click Chemistry and Applications; Nanoplatforms for cancer theranostics
TL;DR: Significant synthetic efforts in conjunction with spectroscopic analyses are still very much needed to advance this promising research area further and turn photoactivatable fluorophores into the imaging probes of choice for the investigation of live cells. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2020 article

Photoactivatable fluorophores for single-molecule localization microscopy of live cells

Zhang, Y., & Raymo, F. M. (2020, April 23). Methods and Applications in Fluorescence.

By: Y. Zhang* & F. Raymo*

MeSH headings : Humans; Microscopy, Fluorescence / methods; Single Molecule Imaging / methods
topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Photochromic and Fluorescence Chemistry; bioluminescence and chemiluminescence research
Source: ORCID
Added: March 13, 2023

2020 article

Super-Resolution Imaging of Self-Assembled Nanocarriers Using Quantitative Spectroscopic Analysis for Cluster Extraction

Davis, J. L., Zhang, Y., Yi, S., Du, F., Song, K.-H., Scott, E. A., … Zhang, H. F. (2020, February 18). Langmuir, Vol. 36, pp. 2291–2299.

MeSH headings : Cluster Analysis; Fluorescent Dyes / chemistry; Liposomes / chemistry; Nanoparticles / chemistry; Oxazines / chemistry; Polymers / chemistry; Single Molecule Imaging / methods; Single Molecule Imaging / statistics & numerical data
topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Spectroscopy Techniques in Biomedical and Chemical Research; Photodynamic Therapy Research Studies
TL;DR: The feasibility of using spectroscopic point accumulation for imaging in nanoscale topography to visualize self-assembled polymersomes (PS) with molecular specificity was shown and the unique spectral signatures of Nile Red molecules bound to the PS were analyzed to reject artifacts from non-specific NR bindings. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2019 article

High-Throughput Single-Molecule Spectroscopy Resolves the Conformational Isomers of BODIPY Chromophores

Sansalone, L., Zhang, Y., Mazza, M. M. A., Davis, J. L., Song, K.-H., Captain, B., … Raymo, F. M. (2019, October 17). The Journal of Physical Chemistry Letters, Vol. 10, pp. 6807–6812.

topics (OpenAlex): Luminescence and Fluorescent Materials; Advanced Fluorescence Microscopy Techniques; Nanoplatforms for cancer theranostics
TL;DR: Statistical analysis of multiple single-molecule emission spectra can discriminate stereoisomers that would otherwise be impossible to distinguish by ensemble measurements alone. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: ORCID
Added: March 13, 2023

2019 article

Machine-learning based spectral classification for spectroscopic single-molecule localization microscopy

Zhang, Z., Zhang, Y., Ying, L., Sun, C., & Zhang, H. F. (2019, November 27). Optics Letters.

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Cell Image Analysis Techniques; Optical Imaging and Spectroscopy Techniques
TL;DR: This work developed a machine learning (ML)-based method to analyze the full spectral profiles of each molecular emission and reduce the misclassification rate, and showed that the ML method achieved 10-fold reduction in mis classification and two-fold improvement in spectral data utilization comparing with the existing spectral centroid method. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2019 article

Multicolor super-resolution imaging using spectroscopic single-molecule localization microscopy with optimal spectral dispersion

Zhang, Y., Song, K.-H., Dong, B., Davis, J. L., Shao, G., Sun, C., & Zhang, H. F. (2019, March 14). Applied Optics.

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Near-Field Optical Microscopy; Advanced Optical Sensing Technologies
TL;DR: Transmission diffraction grating-based spectroscopic single-molecule localization microscopy (sSMLM) was developed to collect the spatial and spectral information of single-Molecule blinking events concurrently and the spectral heterogeneities of multiple far-red emitting dyes were characterized. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2019 article

Three-dimensional biplane spectroscopic single-molecule localization microscopy

Song, K.-H., Zhang, Y., Wang, G., Sun, C., & Zhang, H. F. (2019, May 21). Optica.

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Advanced Electron Microscopy Techniques and Applications; Near-Field Optical Microscopy
Source: ORCID
Added: March 13, 2023

2019 article

Three-dimensional biplane spectroscopic single-molecule localization microscopy: erratum

Song, K.-H., Zhang, Y., Wang, G., Sun, C., & Zhang, H. F. (2019, October 14). Optica.

By: K. Song, Y. Zhang*, G. Wang*, C. Sun & H. Zhang

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Advanced Electron Microscopy Techniques and Applications; Near-Field Optical Microscopy
Source: ORCID
Added: March 13, 2023

2018 article

A Photoactivatable Far-Red/Near-Infrared BODIPY To Monitor Cellular Dynamics in Vivo

Sansalone, L., Tang, S., Garcia-Amorós, J., Zhang, Y., Nonell, S., Baker, J. D., … Raymo, F. M. (2018, June 4). ACS Sensors, Vol. 3, pp. 1347–1353.

MeSH headings : Animals; Boron Compounds / chemistry; Drosophila melanogaster / embryology; Fluorescent Dyes / chemistry; Infrared Rays; Models, Molecular; Optical Imaging / methods; Oxazines / chemistry; Photolysis; Pyrroles / chemistry
topics (OpenAlex): Luminescence and Fluorescent Materials; Photochromic and Fluorescence Chemistry; Photoreceptor and optogenetics research
TL;DR: The structural design and operating principles for the photoactivation of far-red/near-infrared fluorescence can evolve into invaluable probes to monitor cellular dynamics in vivo to enable tracking of individual cells within the embryos in real time. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2018 article

Far-Red Photoactivatable BODIPYs for the Super-Resolution Imaging of Live Cells

Zhang, Y., Song, K.-H., Tang, S., Ravelo, L., Cusido, J., Sun, C., … Raymo, F. M. (2018, September 24). Journal of the American Chemical Society, Vol. 140, pp. 12741–12745.

By: Y. Zhang*, K. Song*, S. Tang*, L. Ravelo*, J. Cusido*, C. Sun*, H. Zhang*, F. Raymo*

MeSH headings : Animals; Boron Compounds / analysis; COS Cells; Chlorocebus aethiops; Fluorescence; Fluorescent Dyes / analysis; Lysosomes / chemistry; Lysosomes / ultrastructure; Microscopy, Fluorescence / methods; Optical Imaging / methods; Photochemical Processes; Single Molecule Imaging / methods
topics (OpenAlex): Luminescence and Fluorescent Materials; Advanced Fluorescence Microscopy Techniques; Photoreceptor and optogenetics research
TL;DR: The combination of photochemical, photophysical and structural properties designed into the fluorophores enable the visualization of live cells with a spatial resolution that is inaccessible to conventional fluorescence imaging. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2018 article

Fluorescence activation with switchable oxazines

Zhang, Y., Tang, S., Thapaliya, E. R., Sansalone, L., & Raymo, F. M. (2018, January 1). Chemical Communications.

topics (OpenAlex): Photochromic and Fluorescence Chemistry; Photoreceptor and optogenetics research; Luminescence and Fluorescent Materials
TL;DR: These mechanisms for fluorescence activation enable the acquisition of images with subdiffraction resolution, the selective signaling of cancer cells and the monitoring of translocating species in real time, and can evolve into invaluable probes for the implementation of bioimaging strategies that would be impossible to perform with conventional fluorophores. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: March 13, 2023

2018 article

Photochemical Barcodes

Tang, S., Zhang, Y., Dhakal, P., Ravelo, L., Anderson, C. L., Collins, K. M., & Raymo, F. M. (2018, March 21). Journal of the American Chemical Society, Vol. 140, pp. 4485–4488.

By: S. Tang*, Y. Zhang*, P. Dhakal*, L. Ravelo*, C. Anderson*, K. Collins*, F. Raymo*

MeSH headings : Boron Compounds / chemistry; DNA Barcoding, Taxonomic; Light; Oxyquinoline / chemistry
topics (OpenAlex): Luminescence and Fluorescent Materials; Molecular Sensors and Ion Detection; Polydiacetylene-based materials and applications
TL;DR: The authors' photochemical strategy for the generation of fluorescence barcodes can produce multiple and distinguishable labels in the same biological sample to enable the spatiotemporal tracking of, otherwise indistinguishable, targets. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2017 article

A photoactivatable light tracer

Liu, X., Zhang, Y., Baker, J. D., & Raymo, F. M. (2017, January 1). Journal of Materials Chemistry C.

By: X. Liu*, Y. Zhang*, J. Baker* & F. Raymo*

topics (OpenAlex): Photoreceptor and optogenetics research; Advanced Fluorescence Microscopy Techniques; Photonic and Optical Devices
TL;DR: The results suggest that photoactivatable fluorophores can be optimal chemical probes to trace propagating light in microoptics and provide definitive experimental evidence of the light-guiding and light-enhancing capabilities of these particular pyramidal PDMS objects. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2017 article

Bioimaging with Macromolecular Probes Incorporating Multiple BODIPY Fluorophores

Thapaliya, E. R., Zhang, Y., Dhakal, P., Brown, A. S., Wilson, J. N., Collins, K. M., & Raymo, F. M. (2017, April 21). Bioconjugate Chemistry, Vol. 28, pp. 1519–1528.

MeSH headings : Animals; Boron Compounds / chemistry; Caenorhabditis elegans / cytology; Caenorhabditis elegans / metabolism; Diagnostic Imaging / methods; Fluorescent Dyes / chemistry; HeLa Cells; Humans; Macromolecular Substances / chemistry; Nanoparticles / chemistry; Polymers / chemistry
topics (OpenAlex): Luminescence and Fluorescent Materials; Nanoplatforms for cancer theranostics; Advanced Fluorescence Microscopy Techniques
TL;DR: The results demonstrate that this particular structural design for the incorporation of multiple chromophores within the same covalent construct is a viable one to preserve the photophysical properties of the emissive species and enable the assembly of bioimaging probes with enhanced brightness. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2017 article

Detection of nitroaromatic explosives by a 3D hyperbranched σ–π conjugated polymer based on a POSS scaffold

Ma, X., Tao, F., Zhang, Y., Li, T., Raymo, F. M., & Cui, Y. (2017, January 1). Journal of Materials Chemistry A.

topics (OpenAlex): Luminescence and Fluorescent Materials; Dendrimers and Hyperbranched Polymers; Organic Light-Emitting Diodes Research
Source: ORCID
Added: March 13, 2023

2017 article

Facile fabrication of AIE/AIEE-active fluorescent nanoparticles based on barbituric for cell imaging applications

Li, K., Zhang, Y., Qiao, B., Tao, F., Li, T., Ding, Y., … Cui, Y. (2017, January 1). RSC Advances, Vol. 7, pp. 30229–30241.

topics (OpenAlex): Luminescence and Fluorescent Materials; Molecular Sensors and Ion Detection; Organic Light-Emitting Diodes Research
Source: ORCID
Added: March 13, 2023

2017 article

Fluorescence patterning with mild illumination in polymer films of photocleavable oxazines

Thapaliya, E. R., Zhang, Y., & Raymo, F. M. (2017, January 1). Journal of Materials Chemistry C, Vol. 5, pp. 1179–1183.

By: E. Thapaliya*, Y. Zhang* & F. Raymo*

topics (OpenAlex): Photochromic and Fluorescence Chemistry; Luminescence and Fluorescent Materials; Advanced Polymer Synthesis and Characterization
Source: ORCID
Added: March 13, 2023

2017 article

Highlighting cancer cells with macromolecular probes

Tang, S., Zhang, Y., Thapaliya, E. R., Brown, A. S., Wilson, J. N., & Raymo, F. M. (2017, February 22). (M. Osiński, W. J. Parak, & X.-J. Liang, Eds.). Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE.

By: S. Tang*, Y. Zhang*, E. Thapaliya*, A. Brown*, J. Wilson* & F. Raymo*

Ed(s): M. Osiński, W. Parak & X. Liang*

topics (OpenAlex): Luminescence and Fluorescent Materials; Nanoplatforms for cancer theranostics; Click Chemistry and Applications
TL;DR: A viable structural design is identified based on the integration of activatable fluorophores and targeting ligands within the same macromolecular construct that translates into a 170-fold enhancement in brightness, relative to equivalent but isolated chromophoric components, and a 3-fold increase in contrast. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2017 article

Probing the intracellular fate of supramolecular nanocarriers and their cargo with FRET schemes

Thapaliya, E. R., Fowley, C., Callan, B., Tang, S., Zhang, Y., Callan, J. F., & Raymo, F. M. (2017, February 22). (M. Osiński, W. J. Parak, & X.-J. Liang, Eds.). Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE.

Ed(s): M. Osiński, W. Parak & X. Liang*

topics (OpenAlex): Supramolecular Self-Assembly in Materials; Supramolecular Chemistry and Complexes; Advanced Polymer Synthesis and Characterization
TL;DR: This protocol is particularly valuable to monitor the transport properties of supramolecular nanocarriers inside living cells and can eventually contribute to the fundamental understating of the ability of these promising vehicles to deliver contrast agents and/ or drugs intracellularly in view of possible diagnostics and/or therapeutic applications. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: March 13, 2023

2017 article

Supramolecular delivery of photoactivatable fluorophores in developing embryos

Zhang, Y., Tang, S., Sansalone, L., Thapaliya, E. R., Baker, J. D., & Raymo, F. M. (2017, February 22). (M. Osiński, W. J. Parak, & X.-J. Liang, Eds.). Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE.

Ed(s): M. Osiński, W. Parak & X. Liang*

topics (OpenAlex): Supramolecular Self-Assembly in Materials; Luminescence and Fluorescent Materials; Photochromic and Fluorescence Chemistry
TL;DR: The supramolecular delivery of photoactivatable fluorophores in Drosophila melanogaster embryos allows the real-time tracking of translocating molecules and translates into a noninvasive method to monitor dynamics in vivo and can evolve into a general chemical tool to track motion in biological specimens. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2016 article

A Photoswitchable Fluorophore for the Real‐Time Monitoring of Dynamic Events in Living Organisms

Zhang, Y., Tang, S., Sansalone, L., Baker, J. D., & Raymo, F. M. (2016, August 30). Chemistry - A European Journal, Vol. 22, pp. 15027–15034.

MeSH headings : Animals; Drosophila melanogaster; Fluorescent Dyes / chemistry; Photochemical Processes
topics (OpenAlex): Photochromic and Fluorescence Chemistry; Photoreceptor and optogenetics research; Luminescence and Fluorescent Materials
TL;DR: The synthesis of a photoactivatable fluorophore with optimal photochemical and photophysical properties for the real-time tracking of motion in vivo can evolve into a general chemical tool to monitor dynamic processes in living biological specimens. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2016 article

A pH‐Gated Photocage

Zhang, Y., Captain, B., & Raymo, F. M. (2016, May 31). Advanced Optical Materials, Vol. 5.

By: Y. Zhang*, B. Captain* & F. Raymo*

topics (OpenAlex): Photochromic and Fluorescence Chemistry; Luminescence and Fluorescent Materials; Molecular Sensors and Ion Detection
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: March 13, 2023

2016 article

Highlighting Cancer Cells with Halochromic Switches

Tang, S., Zhang, Y., Thapaliya, E. R., Brown, A. S., Wilson, J. N., & Raymo, F. M. (2016, December 21). ACS Sensors, Vol. 2, pp. 92–101.

By: S. Tang*, Y. Zhang*, E. Thapaliya*, A. Brown*, J. Wilson* & F. Raymo*

topics (OpenAlex): Nanoplatforms for cancer theranostics; Photochromic and Fluorescence Chemistry; Click Chemistry and Applications
TL;DR: The structural design for the covalent integration of activatable signaling units and targeting ligands within the same nanostructured assembly together with the photophysical properties engineered into the emissive components offer the opportunity to highlight cancer cells selectively with high brightness and optimal contrast. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: ORCID
Added: March 13, 2023

2016 article

Semiconductor Quantum Dots with Photoresponsive Ligands

Sansalone, L., Tang, S., Zhang, Y., Thapaliya, E. R., Raymo, F. M., & Garcia-Amorós, J. (2016, October 28). Topics in Current Chemistry Collections, pp. 31–60.

topics (OpenAlex): Quantum Dots Synthesis And Properties
Source: ORCID
Added: March 13, 2023

2016 article

Supramolecular delivery of fluorescent probes in developing embryos

Zhang, Y., Thapaliya, E. R., Tang, S., Baker, J. D., & Raymo, F. M. (2016, January 1). RSC Advances, Vol. 6, pp. 72756–72760.

topics (OpenAlex): Supramolecular Self-Assembly in Materials; Polymer Surface Interaction Studies; Advanced Polymer Synthesis and Characterization
TL;DR: Self-assembling nanocarriers of amphiphilic polymers encapsulate hydrophobic fluorophores in their hydrophilic interior and, upon injection in Drosophila melanogaster embryos, release their cargo into the cellular blastoderm. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2016 article

Supramolecular nanocarriers with photoresponsive cargo

Zhang, Y., Tang, S., Thapaliya, E. R., & Raymo, F. M. (2016, March 8). (W. J. Parak, M. Osinski, & X.-J. Liang, Eds.). Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE.

Ed(s): W. Parak, M. Osinski & X. Liang*

topics (OpenAlex): Photochromic and Fluorescence Chemistry; Luminescence and Fluorescent Materials; Supramolecular Chemistry and Complexes
TL;DR: Operating principles to solubilize and operate photoswitchable fluorophores in aqueous environments with the aid of supramolecular nanocarriers can lead to valuable protocols to image specimens with subdiffraction resolution and to monitor dynamic events noninvasively. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2016 article

Synthesis in living cells with the assistance of supramolecular nanocarriers

Ragab, S. S., Thapaliya, E. R., Zhang, Y., Tang, S., McMahan, J. B., Syed, S., … Raymo, F. M. (2016, January 1). RSC Advances, Vol. 6, pp. 32441–32445.

topics (OpenAlex): Supramolecular Self-Assembly in Materials; Supramolecular Chemistry and Complexes; Advanced Polymer Synthesis and Characterization
TL;DR: The results demonstrate that supramolecular delivery can be exploited to perform chemical reactions inside target cells and can lead to valuable strategies for the intracellular synthesis of drugs. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2015 article

A fluorescent and halochromic indolizine switch

Zhang, Y., Garcia-Amorós, J., Captain, B., & Raymo, F. M. (2015, November 9). Journal of Materials Chemistry C, Vol. 4, pp. 2744–2747.

topics (OpenAlex): Photochromic and Fluorescence Chemistry; Luminescence and Fluorescent Materials; Porphyrin and Phthalocyanine Chemistry
Source: ORCID
Added: March 13, 2023

2015 article

Energy-Transfer Schemes To Probe Fluorescent Nanocarriers and Their Emissive Cargo

Thapaliya, E. R., Fowley, C., Callan, B., Tang, S., Zhang, Y., Callan, J. F., & Raymo, F. M. (2015, August 14). Langmuir, Vol. 31, pp. 9557–9565.

MeSH headings : Drug Carriers / chemistry; Energy Transfer; Fluorescence; HeLa Cells; Humans; Molecular Structure; Nanoparticles / chemistry
topics (OpenAlex): Supramolecular Self-Assembly in Materials; Supramolecular Chemistry and Complexes; Hydrogels: synthesis, properties, applications
TL;DR: Operating principles and choice of supramolecular synthons are particularly valuable to monitor self-assembling nanocarriers and their cargo inside living cells and can facilitate the elucidation of the behavior of these promising delivery vehicles in a diversity of biological specimens. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: March 13, 2023

2015 article

Optical writing and reading with a photoactivatable carbazole

Garcia-Amorós, J., Swaminathan, S., Zhang, Y., Nonell, S., & Raymo, F. M. (2015, January 1). Physical Chemistry Chemical Physics, Vol. 17, pp. 11140–11143.

By: J. Garcia-Amorós*, S. Swaminathan*, Y. Zhang*, S. Nonell* & F. Raymo*

topics (OpenAlex): Photochromic and Fluorescence Chemistry; Photoreceptor and optogenetics research; Polydiacetylene-based materials and applications
TL;DR: The plasmonic effects responsible for such enhancements, together with the photochemical and photophysical properties engineered into this particular photoactivatable fluorophore, permit the optical writing and reading of microscaled patterns at low illumination intensities. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Source: ORCID
Added: March 13, 2023

2015 article

Photoactivatable BODIPYs Designed To Monitor the Dynamics of Supramolecular Nanocarriers

Zhang, Y., Swaminathan, S., Tang, S., Garcia-Amorós, J., Boulina, M., Captain, B., … Raymo, F. M. (2015, March 20). Journal of the American Chemical Society, Vol. 137, pp. 4709–4719.

By: Y. Zhang*, S. Swaminathan*, S. Tang*, J. Garcia-Amorós*, M. Boulina*, B. Captain*, J. Baker*, F. Raymo*

MeSH headings : Animals; Boron Compounds / chemistry; Drosophila melanogaster / embryology; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Design; Fluorescent Dyes / chemistry; Indoles / chemistry; Nanoparticles / chemistry; Optical Imaging; Oxazines / chemistry; Photochemical Processes
topics (OpenAlex): Luminescence and Fluorescent Materials; Photochromic and Fluorescence Chemistry; Supramolecular Self-Assembly in Materials
TL;DR: This work designed molecular guests with photoactivatable fluorescence for supramolecular hosts and demonstrated that the activation of the fluorescent cargo, under optical control, permits the tracking of the nanocarrier translocation across hydrogel matrices with the sequential acquisition of fluorescence images. (via Semantic Scholar)
Source: ORCID
Added: March 13, 2023

2015 article

Self-Assembling Nanoparticles of Amphiphilic Polymers for In Vitro and In Vivo FRET Imaging

Garcia-Amorós, J., Tang, S., Zhang, Y., Thapaliya, E. R., & Raymo, F. M. (2015, November 20). Topics in Current Chemistry, pp. 29–59.

By: J. Garcia-Amorós*, S. Tang*, Y. Zhang*, E. Thapaliya* & F. Raymo*

MeSH headings : Fluorescence Resonance Energy Transfer; Humans; In Vitro Techniques; Nanoparticles / chemistry; Polymers / chemistry
topics (OpenAlex): Supramolecular Self-Assembly in Materials; Supramolecular Chemistry and Complexes; Luminescence and Fluorescent Materials
TL;DR: Self-assembling nanoparticles of amphiphilic polymers are viable delivery vehicles for transporting hydrophobic molecules across hydrophilic media and energy-transfer schemes are becoming invaluable protocols to elucidate the transport properties of these fascinating supramolecular constructs in a diversity of biological preparations. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: March 13, 2023

2013 article

Two-Photon Absorption Properties of <i>s</i>-Triazine Derivatives With Near Octupolar Symmetry

Cui, Y. Z., Zhang, Y., Zhou, L. L., & Yu, F. (2013, January 25). Advanced Materials Research, Vol. 652-654, pp. 542–545.

By: Y. Cui*, Y. Zhang*, L. Zhou* & F. Yu*

topics (OpenAlex): Nonlinear Optical Materials Studies; Photochromic and Fluorescence Chemistry; Luminescence and Fluorescent Materials
Source: ORCID
Added: March 13, 2023

2011 article

Optical Properties of Chromophores with Different Six-Membered N-Heterocyclic Aromatic Ring

Peng, H. T., Cui, Y. Z., Zhang, T., Zhang, Y., & Guan, H. X. (2011, May 1). Advanced Materials Research, Vol. 236-238, pp. 1598–1602.

By: H. Peng*, Y. Cui*, T. Zhang*, Y. Zhang* & H. Guan*

topics (OpenAlex): Photochromic and Fluorescence Chemistry; Nonlinear Optical Materials Studies; Luminescence and Fluorescent Materials
Source: ORCID
Added: March 13, 2023

Employment

Updated: March 13th, 2023 20:44

2022 - present

North Carolina State University Raleigh, North Carolina, US
Assistant Professor Textile Engineering, Chemistry

2019 - 2022

Northwestern University Evanston, IL, US
Research Assistant Professor Biomedical Engineering

2017 - 2019

Northwestern University Evanston, IL, US
Postdoc Biomedical Engineering

2012 - 2017

University of Miami Coral Gables, FL, US
Graduate assistant Department of Chemistry

Education

Updated: May 16th, 2020 21:16

2017 - 2019

Northwestern University Evanston, IL, US
Postdoc Biomedical Engineering

2012 - 2017

University of Miami Coral Gables, FL, US
Doctorate Chemistry

2008 - 2012

Qilu University of Technology Jinan, Shandong, CN
Bachelor of Science Chemistry

Funding History

Funding history based on the linked ORCID record. Updated: March 13th, 2023 20:46

grant May 1, 2022 - February 28, 2026
Photoactivatable Fluorophores for High-Throughput Multiplexed Tracking of Single-Molecules in Live Cells
National Institute of General Medical Sciences
grant July 1, 2021 - June 30, 2023
Bright and switchable fluorophores for highly multiplexed super-resolution microscopy towards molecular interaction imaging
National Institute of General Medical Sciences
award May 1 - August 1, 2016
Photoresponsive Nanocarriers For Lipophilic Anticancer Drug Delivery With Orthogonal Control
University of Miami, Department of Chemistry

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