Works (74)

2020 article

A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes

CLINICAL PHARMACOLOGY & THERAPEUTICS.

By: A. Etheridge, P. Gallins, D. Jima, K. Broadaway, M. Ratain, E. Schuetz, E. Schadt, A. Schroder ...

Sources: Web Of Science, ORCID
Added: February 10, 2020

2019 review

A Review and Tutorial of Machine Learning Methods for Microbiome Host Trait Prediction

[Review of ]. FRONTIERS IN GENETICS, 10.

By: Y. Zhou & P. Gallins

Sources: Web Of Science, ORCID
Added: July 15, 2019

2019 journal article

A note on cyclic shift permutation testing for large eigenvalues

Stat, 8(1).

By: Y. Zhou

Source: ORCID
Added: December 18, 2019

2019 article

Marker-Trait Complete Analysis

Zhou, Y.-H., Gallins, P., & Wright, F. (2019, November 9). (Vol. 11). Vol. 11.

By: Y. Zhou, P. Gallins & F. Wright

Source: ORCID
Added: November 10, 2019

2019 journal article

Set‐based differential covariance testing for genomics

Stat, 8(1).

By: Y. Zhou

Source: ORCID
Added: October 7, 2019

2018 journal article

A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure

Cell Reports, 23(2), 327–336.

By: T. Frayling, R. Beaumont, S. Jones, H. Yaghootkar, M. Tuke, K. Ruth, F. Casanova, B. West ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure

Cell Reports, 23(2), 327–336.

By: T. Frayling, R. Beaumont, S. Jones, H. Yaghootkar, M. Tuke, K. Ruth, F. Casanova, B. West, J. Locke, S. Sharp

Source: ORCID
Added: October 7, 2019

2018 journal article

A survey of high dimension low sample size asymptotics

Australian & New Zealand Journal of Statistics, 60(1), 4–19.

By: M. Aoshima, D. Shen, H. Shen, K. Yata, Y. Zhou & J. Marron

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

A zero-inflated beta-binomial model for microbiome data analysis

Stat, 7(1), e185.

By: T. Hu, P. Gallins & Y. Zhou

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

Airway mucosal host defense is key to genomic regulation of cystic fibrosis lung disease severity

American Journal of Respiratory and Critical Care Medicine, 197(1), 79–93.

By: D. Polineni, H. Dang, P. Gallins, L. Jones, R. Pace, J. Stonebraker, L. Commander, J. Krenicky ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Airway mucosal host defense is key to genomic regulation of cystic fibrosis lung disease severity

American Journal of Respiratory and Critical Care Medicine, 197(1), 79–93.

By: D. Polineni, H. Dang, P. Gallins, L. Jones, R. Pace, J. Stonebraker, L. Commander, J. Krenicky, Y. Zhou, H. Corvol

Source: ORCID
Added: October 7, 2019

2018 journal article

Computation of ancestry scores with mixed families and unrelated individuals

Biometrics, 74(1), 155–164.

By: Y. Zhou, J. Marron & F. Wright

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

Eigenvalue significance testing for genetic association

Biometrics, 74(2), 439–447.

By: Y. Zhou, J. Marron & F. Wright

Source: ORCID
Added: October 7, 2019

2018 journal article

Estimation of cis-eQTL effect sizes using a log of linear model

Biometrics, 74(2), 616–625.

By: J. Palowitch, A. Shabalin, Y. Zhou, A. Nobel & F. Wright

Sources: NC State University Libraries, ORCID
Added: October 16, 2018

2017 journal article

A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics

Frontiers in Genetics, 8, 168.

By: J. House, F. Grimm, D. Jima, Y. Zhou, I. Rusyn & F. Wright

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

A Two-Stage Hidden Markov Model Design for Biomarker Detection, with Application to Microbiome Research

Statistics in Biosciences, 10(1), 41–58.

By: Y. Zhou, P. Brooks & X. Wang

Sources: Crossref, ORCID
Added: January 25, 2020

2017 journal article

A procedure to detect general association based on concentration of ranks

Stat, 6(1), 88–101.

By: P. Rudra, Y. Zhou & F. Wright

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Changes in vaginal community state types reflect major shifts in the microbiome

Microbial Ecology in Health and Disease, 28(1), 1303265.

By: J. Brooks, G. Buck, G. Chen, L. Diao, D. Edwards, J. Fettweis, S. Huzurbazar, A. Rakitin, G. Satten, E. Smirnova

Source: ORCID
Added: October 7, 2019

2017 journal article

Changes in vaginal community state types reflect major shifts in the microbiome

Microbial Ecology in Health and Disease, 28(1), 1303265.

By: J. Brooks, G. Buck, G. Chen, L. Diao, D. Edwards, J. Fettweis, S. Huzurbazar, A. Rakitin ...

Source: Crossref
Added: February 5, 2020

2017 journal article

Dynamic landscape and regulation of RNA editing in mammals

Nature, 550(7675), 249–254.

By: M. Tan, Q. Li, R. Shanmugam, R. Piskol, J. Kohler, A. Young, K. Liu, R. Zhang ...

Sources: Crossref, ORCID
Added: January 25, 2020

2017 journal article

Editor’s Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse

Toxicological Sciences, 160(1), 95–110.

By: Y. Zhou, J. Cichocki, V. Soldatow, E. Scholl, P. Gallins, D. Jima, H. Yoo, W. Chiu, F. Wright, I. Rusyn

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

The impact of rare variation on gene expression across tissues

Nature, 550(7675), 239–243.

By: X. Li, Y. Kim, E. Tsang, J. Davis, F. Damani, C. Chiang, G. Hess, Z. Zappala ...

Sources: Crossref, ORCID
Added: January 25, 2020

2016 journal article

Estimation of interpretable eQTL effect sizes using a log of linear model

ArXiv Preprint ArXiv:1605.08799.

By: J. Palowitch, A. Shabalin, Y. Zhou, A. Nobel & F. Wright

Source: ORCID
Added: October 7, 2019

2016 journal article

Genomic characterization of metformin hepatic response

PLoS Genetics, 12(11), e1006449.

By: M. Luizon, W. Eckalbar, Y. Wang, S. Jones, R. Smith, M. Laurance, L. Lin, P. Gallins, A. Etheridge, F. Wright

Source: ORCID
Added: October 7, 2019

2016 journal article

Homologous recombination and translesion DNA synthesis play critical roles on tolerating DNA damage caused by trace levels of hexavalent chromium

PLoS One, 11(12).

By: X. Tian, K. Patel, J. Ridpath, Y. Chen, Y. Zhou, D. Neo, J. Clement, M. Takata ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Homologous recombination and translesion DNA synthesis play critical roles on tolerating DNA damage caused by trace levels of hexavalent chromium

PloS One, 11(12), e0167503.

By: X. Tian, K. Patel, J. Ridpath, Y. Chen, Y. Zhou, D. Neo, J. Clement, M. Takata, S. Takeda, J. Sale

Source: ORCID
Added: October 7, 2019

2016 journal article

Pathway analysis for RNA-Seq data using a score-based approach

Biometrics, 72(1), 165–174.

By: Y. Zhou

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2016 conference paper

Poster: risk-based attack surface approximation

Symposium and Bootcamp on the Science of Security, 121–123.

By: C. Theisen & L. Williams

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

The projack: a resampling approach to correct for ranking bias in high-throughput studies

Biostatistics (Oxford, England), 17(1), 54–64.

By: Y. Zhou & F. Wright

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Visualization of robust L1PCA

Stat, 5(1), 173–184.

By: Y. Zhou & J. Marron

Sources: ORCID, Crossref
Added: October 7, 2019

2015 journal article

Effect of predicted protein-truncating genetic variants on the human transcriptome

Science, 348(6235), 666–669.

By: M. Rivas, M. Pirinen, D. Conrad, M. Lek, E. Tsang, K. Karczewski, J. Maller, K. Kukurba, D. DeLuca, M. Fromer

Source: ORCID
Added: October 7, 2019

2015 journal article

Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

Human Molecular Genetics, 24(15), 4464–4479.

By: E. Demerath, W. Guan, M. Grove, S. Aslibekyan, M. Mendelson, Y. Zhou, A. Hedman, J. Sandling ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

Human Molecular Genetics, 24(15), 4464–4479.

By: E. Demerath, W. Guan, M. Grove, S. Aslibekyan, M. Mendelson, Y. Zhou, Å. Hedman, J. Sandling, L. Li, M. Irvin

Source: ORCID
Added: October 7, 2019

2015 journal article

Gene Expression in Transformed Lymphocytes Reveals Variation in Endomembrane and HLA Pathways Modifying Cystic Fibrosis Pulmonary Phenotypes

The American Journal of Human Genetics, 96(2), 318–328.

By: W. O’Neal, P. Gallins, R. Pace, H. Dang, W. Wolf, L. Jones, X. Guo, Y. Zhou ...

Sources: NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Gene expression in transformed lymphocytes reveals variation in endomembrane and HLA pathways modifying cystic fibrosis pulmonary phenotypes

The American Journal of Human Genetics, 96(2), 318–328.

By: W. O’Neal, P. Gallins, R. Pace, H. Dang, W. Wolf, L. Jones, X. Guo, Y. Zhou, V. Madar, J. Huang

Source: ORCID
Added: October 7, 2019

2015 journal article

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

Nature Communications, 6.

By: H. Corvol, S. Blackman, P. Boelle, P. Gallins, R. Pace, J. Stonebraker, F. Accurso, A. Clement ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

Nature Communications, 6, 8382.

By: H. Corvol, S. Blackman, P. Boëlle, P. Gallins, R. Pace, J. Stonebraker, F. Accurso, A. Clement, J. Collaco, H. Dang

Source: ORCID
Added: October 7, 2019

2015 journal article

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

Nature Communications, 6(1).

By: H. Corvol, S. Blackman, P. Boëlle, P. Gallins, R. Pace, J. Stonebraker, F. Accurso, A. Clement ...

Source: Crossref
Added: February 5, 2020

2015 journal article

High dimension low sample size asymptotics of robust PCA

Electronic Journal of Statistics, 9(1), 204–218.

By: Y. Zhou & J. Marron

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Hypothesis testing at the extremes: fast and robust association for high-throughput data

Biostatistics, 16(3), 611–625.

By: Y. Zhou & F. Wright

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer

Chemical Research in Toxicology, 28(6), 1144–1155.

By: J. Rager, S. Tilley, S. Tulenko, L. Smeester, P. Ray, A. Yosim, J. Currier, M. Ishida ...

Source: Crossref
Added: February 5, 2020

2015 journal article

Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer

Chemical Research in Toxicology, 28(6), 1144–1155.

By: J. Rager, S. Tilley, S. Tulenko, L. Smeester, P. Ray, A. Yosim, J. Currier, M. Ishida ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer

Chemical Research in Toxicology, 28(6), 1144–1155.

Source: ORCID
Added: October 7, 2019

2015 journal article

Metabolomic evaluation of neutrophilic airway inflammation in cystic fibrosis

Chest, 148(2), 507–515.

Source: ORCID
Added: October 7, 2019

2015 journal article

PathwaySeq: Pathway analysis for RNA-Seq data using a score-based approach

Dim (Data. Test), 1(1000), 448.

By: Y. Zhou

Source: ORCID
Added: October 7, 2019

2015 journal article

Population-based in vitro hazard and concentration--response assessment of chemicals: the 1000 genomes high-throughput screening study

Environmental Health Perspectives, 123(5), 458.

By: N. Abdo, M. Xia, C. Brown, O. Kosyk, R. Huang, S. Sakamuru, Y. Zhou, J. Jack, P. Gallins, K. Xia

Source: ORCID
Added: October 7, 2019

2015 journal article

Population-based in vitro hazard and concentration-response assessment of chemicals: The 1000 genomes high-throughput screening study

Environmental Health Perspectives, 123(5), 458–466.

By: N. Abdo, M. Xia, C. Brown, O. Kosyk, R. Huang, S. Sakamuru, Y. Zhou, J. Jack ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

Science, 348(6235), 648–660.

By: K. Ardlie, D. DeLuca, A. Segre, T. Sullivan, T. Young, E. Gelfand, C. Trowbridge, J. Maller ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

The projack: a resampling approach to correct for ranking bias in high-throughput studies

Biostatistics, 17(1), 54–64.

By: Y. Zhou & F. Wright

Source: ORCID
Added: October 7, 2019

2014 journal article

Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs

Epigenetics, 9(2), 212–221.

By: A. Sanders, L. Smeester, D. Rojas, T. DeBussycher, M. Wu, F. Wright, Y. Zhou, J. Laine, J. Rager, G. Swamy

Source: ORCID
Added: October 7, 2019

2014 journal article

Heritability and genomics of gene expression in peripheral blood

Nature Genetics, 46(5), 430–437.

By: F. Wright, P. Sullivan, A. Brooks, F. Zou, W. Sun, K. Xia, V. Madar, R. Jansen ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Heritability and genomics of gene expression in peripheral blood

Nature Genetics, 46(5), 430.

By: F. Wright, P. Sullivan, A. Brooks, F. Zou, W. Sun, K. Xia, V. Madar, R. Jansen, W. Chung, Y. Zhou

Source: ORCID
Added: October 7, 2019

2014 journal article

Heritability and genomics of gene expression in peripheral blood

Nature Genetics, 46(5), 430–437.

By: F. Wright, P. Sullivan, A. Brooks, F. Zou, W. Sun, K. Xia, V. Madar, R. Jansen ...

Source: Crossref
Added: February 5, 2020

2014 journal article

Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse

Environmental Health Perspectives, 122(5), 456–463.

By: W. Chiu, J. Campbell, H. Clewell, Y. Zhou, F. Wright, K. Guyton, I. Rusyn

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse

Environmental Health Perspectives, 122(5), 456.

Source: ORCID
Added: October 7, 2019

2014 journal article

RNA-Seq pathway analysis

By: Y. Zhou & H. Dang

Source: ORCID
Added: October 7, 2019

2013 journal article

Empirical pathway analysis, without permutation

Biostatistics, (doi:10.1093/biostatistics/kxt004), 1–13.

By: Y. Zhou, W. Barry & F. Wright

Source: ORCID
Added: October 7, 2019

2013 chapter

Metabolomic Evaluation Of Cystic Fibrosis Airways Disease

In A26. PEDIATRIC CYSTIC FIBROSIS (pp. A1165–A1165). American Thoracic Society.

By: C. Esther, Y. Zhou, F. Wright & R. Boucher

Source: ORCID
Added: October 7, 2019

2013 journal article

Skill-assessments of statistical and Ensemble Kalman Filter data assimilative analyses using surface and deep observations in the Gulf of Mexico

Frontiers of Earth Science, 7(3), 271–281.

By: Z. Sun, L. Oey & Y. Zhou

Sources: ORCID, Crossref
Added: October 7, 2019

2013 journal article

Space-time clustering and the permutation moments of quadratic forms

Stat, 2(1), 292–302.

By: Y. Zhou, G. Mayhew, Z. Sun, X. Xu, F. Zou & F. Wright

Sources: ORCID, Crossref
Added: October 7, 2019

2013 journal article

Stochastic comparisons in a price-quantity setting firm with uncertain demand and emergency procurement

Journal of Systems Science and Systems Engineering, 22(4), 401–420.

By: M. Xu, X. Xu & Y. Zhou

Source: ORCID
Added: October 7, 2019

2013 journal article

Stochastic comparisons in a price-quantity setting firm with uncertain demand and emergency procurement

Journal of Systems Science and Systems Engineering, 22(4), 401–420.

By: M. Xu, X. Xu & Y. Zhou

Source: Crossref
Added: February 5, 2020

2012 journal article

Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model

Toxicological Sciences.

By: E. Lock, N. Abdo, R. Huang, M. Xia, O. Kosyk, S. O’Shea, Y. Zhou, A. Sedykh, A. Tropsha, C. Austin

Source: ORCID
Added: October 7, 2019

2012 journal article

Simple and accurate trend tests using a permutation approximation

By: Y. Zhou & F. Wright

Source: ORCID
Added: October 7, 2019

2012 journal article

Single Nucleotide Polymorphism (SNP) Detection and Genotype Calling from Massively Parallel Sequencing (MPS) Data

Statistics in Biosciences, 1–23.

By: Y. Li, W. Chen, E. Liu & Y. Zhou

Source: ORCID
Added: October 7, 2019

2012 journal article

Supplementary material for: Empirical Pathway Analysis, Without Permutation

By: Y. Zhou, W. Barry, F. Wright & C. Hill

Source: ORCID
Added: October 7, 2019

2011 journal article

A powerful and flexible approach to the analysis of RNA sequence count data

Bioinformatics, 27(19), 2672–2678.

By: Y. Zhou, K. Xia & F. Wright

Source: ORCID
Added: October 7, 2019

2011 journal article

seeQTL: a searchable database for human eQTLs

Bioinformatics, 28(3), 451–452.

By: K. Xia, A. Shabalin, S. Huang, V. Madar, Y. Zhou, W. Wang, F. Zou, W. Sun, P. Sullivan, F. Wright

Source: ORCID
Added: October 7, 2019

2009 journal article

On the finiteness of the cone spectrum of certain linear transformations on Euclidean Jordan algebras

Linear Algebra and Its Applications, 431(5-7), 772–782.

By: Y. Zhou & M. Gowda

Source: ORCID
Added: October 7, 2019

journal article

Medical Center, New York, NY 10032, USA. 18Wellcome Trust Centre for Human Genetics Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, UK. 19Department of Computer Science, Stanford University, Stanford, CA 94305, USA. 20Department of Computer Science, Johns

Source: ORCID
Added: October 7, 2019

journal article

Significant Chlorinated Paraffin Concentrations Together with Traditional and Emerging Pollutants in Wildlife from a Yangtze River Delta Area Site

Yin, G., Zhou, Y., Asplund, L., Athanassiadis, I., Wideqvist, U., Qiu, Y., … Bergman, Å.

By: G. Yin, Y. Zhou, L. Asplund, I. Athanassiadis, U. Wideqvist, Y. Qiu, Z. Zhu, J. Zhao, Å. Bergman

Source: ORCID
Added: October 7, 2019

journal article

Supplemental Material Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

Source: ORCID
Added: October 7, 2019

journal article

Supplementary Appendix to: Hypothesis testing at the extremes: fast and robust association for high-throughput data

Zhou, Y.-H., & Wright, F. A.

By: Y. Zhou & F. Wright

Source: ORCID
Added: October 7, 2019

journal article

on July 8, 2015

DeLuca, D. S., Segrè, A. V., Sullivan, T. J., Young, T. R., Gelfand, E. T., Trowbridge, C. A., … Ward, L. D.

By: D. DeLuca, A. Segrè, T. Sullivan, T. Young, E. Gelfand, C. Trowbridge, J. Maller, T. Tukiainen, M. Lek, L. Ward

Source: ORCID
Added: October 7, 2019

Employment

2018 - present

North Carolina State University Raleigh, North Carolina, US
Associate Professor Biological Sciences

Education

2007 - 2011

University of North Carolina at Chapel Hill Chapel Hill, NC, US
PhD Biostatitsics