Works (103)

Updated: March 2nd, 2024 02:42

2023 review

AI in healthcare: navigating opportunities and challenges in digital communication

[Review of ]. FRONTIERS IN DIGITAL HEALTH, 5.

By: G. Sun n & Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: remote; AI solutions; telemedicine; transformative healthcare; chatbot; Trust-AI
Sources: Web Of Science, ORCID
Added: January 16, 2024

2023 journal article

Association of Pseudomonas aeruginosa infection stage with lung function trajectory in children with cystic fibrosis

JOURNAL OF CYSTIC FIBROSIS, 22(5), 857–863.

By: M. Rosenfeld*, A. Faino, P. Qu, F. Onchiri, E. Blue*, J. Collaco*, W. Gordon*, R. Szczesniak* ...

co-author countries: United States of America 🇺🇸
author keywords: Cystic fibrosis; Pseudomonas aeruginosa; Lung function
Sources: Web Of Science, ORCID
Added: January 16, 2024

2023 journal article

Genetic Modifiers of Cystic Fibrosis Lung Disease Severity

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 207(10), 1324–1333.

By: Y. Zhou*, P. Gallins*, R. Pace*, H. Dang*, M. Aksit, E. Blue*, K. Buckingham*, J. Collaco ...

co-author countries: Canada 🇨🇦 Germany 🇩🇪 France 🇫🇷 Japan 🇯🇵 United States of America 🇺🇸
author keywords: cystic fibrosis; whole-genome sequencing; lung disease severity; GWAS/TWAS; pathway analyses
MeSH headings : Humans; Cystic Fibrosis / genetics; Genome-Wide Association Study / methods; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Patient Acuity; Lung; Microtubule-Associated Proteins / genetics
Sources: ORCID, Web Of Science
Added: May 16, 2023

2023 journal article

Integrative Chemical-Biological Grouping of Complex High Production Volume Substances from Lower Olefin Manufacturing Streams

TOXICS, 11(7).

By: A. Cordova*, W. Klaren*, L. Ford*, F. Grimm*, E. Baker*, Y. Zhou n, F. Wright n, I. Rusyn*

co-author countries: United States of America 🇺🇸
author keywords: UVCB; petroleum; regulatory risk assessment; read-across; ion mobility spectrometry
Sources: ORCID, Web Of Science
Added: July 6, 2023

2023 journal article

Leveraging Scheme for Cross-Study Microbiome Machine Learning Prediction and Feature Evaluations

BIOENGINEERING-BASEL, 10(2).

By: K. Song n & Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: feature selection; machine learning; microbiome; random forest; support vector machine; logistic regression
Sources: ORCID, Web Of Science
Added: February 10, 2023

2023 article

Simultaneous modeling of multivariate heterogeneous responses and heteroskedasticity via a two-stage composite likelihood

Ting, B. W. W., Wright, F. A., & Zhou, Y.-H. (2023, May 22). BIOMETRICAL JOURNAL.

By: B. Ting n, F. Wright n & Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: heterogeneity; heteroskedasticity; multivariate statistics; precision medicine; prediction
Sources: ORCID, Web Of Science
Added: May 23, 2023

2022 journal article

A Double Penalty Model for Ensemble Learning

MATHEMATICS, 10(23).

By: W. Wang* & Y. Zhou n

co-author countries: China 🇨🇳 Hong Kong 🇭🇰 United States of America 🇺🇸
author keywords: double penalty model; interpretability; partially linear model; separability
Sources: ORCID, Web Of Science
Added: December 1, 2022

2022 journal article

A Machine Learning Pipeline for Mortality Prediction in the ICU

International Journal of Digital Health, 2(1).

By: Y. Sun n & Y. Zhou n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: May 13, 2022

2022 journal article

A Population-Based Human In Vitro Approach to Quantify Inter-Individual Variability in Responses to Chemical Mixtures

TOXICS, 10(8).

By: L. Ford*, S. Jang*, Z. Chen*, Y. Zhou n, P. Gallins n, F. Wright n, W. Chiu*, I. Rusyn*

co-author countries: United States of America 🇺🇸
author keywords: population-wide; inter-individual variability; toxicodynamics; chemical mixtures; defined mixtures; human health risk assessment; uncertainty factors; genome-wide association study
Sources: ORCID, Web Of Science
Added: August 2, 2022

2022 journal article

A resource for integrated genomic analysis of the human liver

SCIENTIFIC REPORTS, 12(1).

co-author countries: United States of America 🇺🇸
MeSH headings : Bayes Theorem; Genome-Wide Association Study / methods; Genomics; Humans; Liver; Polymorphism, Single Nucleotide; Quantitative Trait Loci
Sources: ORCID, Web Of Science
Added: September 8, 2022

2022 journal article

Accounting for population structure in genetic studies of cystic fibrosis

HUMAN GENETICS AND GENOMICS ADVANCES, 3(3).

By: H. Kingston*, A. Stilp*, W. Gordon*, J. Broome*, S. Gogarten*, H. Ling*, J. Barnard*, S. Dugan-Perez* ...

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: June 27, 2022

2022 journal article

C3NA: correlation and consensus-based cross-taxonomy network analysis for compositional microbial data

BMC BIOINFORMATICS, 23(1).

By: K. Song n & Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: Co-occurrence network analysis; Microbiome; R package; Consensus clustering; Module preservation analysis
MeSH headings : Phylogeny; Consensus
Sources: Web Of Science, ORCID
Added: November 21, 2022

2022 journal article

Comparing encounter-based and annualized chronic pseudomonas infection definitions in cystic fibrosis

JOURNAL OF CYSTIC FIBROSIS, 21(1), 40–44.

By: M. Rosenfeld*, A. Faino, F. Onchiri, M. Aksit*, S. Blackman*, E. Blue*, J. Collaco*, W. Gordon* ...

co-author countries: United States of America 🇺🇸
author keywords: cystic fibrosis; Pseudomonas aeruginosa; chronic infection; definitions
MeSH headings : Child; Child, Preschool; Chronic Disease; Cohort Studies; Cystic Fibrosis / microbiology; Humans; Infant; Pseudomonas Infections / diagnosis; Pseudomonas aeruginosa; Registries; Terminology as Topic; Time Factors
Sources: Web Of Science, ORCID
Added: March 28, 2022

2022 journal article

Complete CFTR gene sequencing in 5,058 individuals with cystic fibrosis informs variant-specific treatment

JOURNAL OF CYSTIC FIBROSIS, 21(1), 463–470.

By: K. Raraigh*, M. Aksit*, K. Hetrick*, R. Pace*, H. Ling*, W. O'Neal*, E. Blue*, Y. Zhou n ...

co-author countries: United States of America 🇺🇸
author keywords: Whole genome sequencing; CFTR; Modulator therapy; Variant identification; Variant annotation
MeSH headings : Alleles; Cohort Studies; Cystic Fibrosis / diagnosis; Cystic Fibrosis / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Genotype; Humans; Mutation
Sources: Web Of Science, ORCID
Added: July 5, 2022

2022 article

Fast Multivariate Probit Estimation via a Two-Stage Composite Likelihood

Ting, B., Wright, F., & Zhou, Y.-H. (2022, February 15). STATISTICS IN BIOSCIENCES, Vol. 2.

By: B. Ting n, F. Wright n & Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: Composite; Likelihood; Multivariate; Probit; Two-stage; Two-step
Sources: ORCID, Web Of Science
Added: February 15, 2022

2022 journal article

Improve the Colorectal Cancer Diagnosis Using Gut Microbiome Data

FRONTIERS IN MOLECULAR BIOSCIENCES, 9.

By: Y. Zhou n & G. Sun

co-author countries: United States of America 🇺🇸
author keywords: machine learning; prediction; feature engineering; colorectal cancer; mediation analysis; 16S rRNA
Sources: Web Of Science, ORCID
Added: September 6, 2022

2022 journal article

Leveraging TOPMed imputation server and constructing a cohort-specific imputation reference panel to enhance genotype imputation among cystic fibrosis patients

HUMAN GENETICS AND GENOMICS ADVANCES, 3(2).

By: Q. Sun*, W. Liu*, J. Rosen*, L. Huang*, R. Pace*, H. Dang*, P. Gallins n, E. Blue* ...

co-author countries: Canada 🇨🇦 France 🇫🇷 United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: May 10, 2022

2022 journal article

MagicalRsq: Machine-learning-based genotype imputation quality calibration

AMERICAN JOURNAL OF HUMAN GENETICS, 109(11), 1986–1997.

By: Q. Sun*, Y. Yang*, J. Rosen*, M. Jiang*, J. Chen*, W. Liu*, J. Wen*, L. Raffield* ...

co-author countries: Italy 🇮🇹 United States of America 🇺🇸
MeSH headings : Humans; Genome-Wide Association Study / methods; Polymorphism, Single Nucleotide / genetics; Calibration; Genotype; Machine Learning
Sources: Web Of Science, ORCID
Added: January 17, 2023

2022 journal article

Pleiotropic modifiers of age-related diabetes and neonatal intestinal obstruction in cystic fibrosis

AMERICAN JOURNAL OF HUMAN GENETICS, 109(10), 1894–1908.

By: M. Aksit*, H. Ling*, R. Pace*, K. Raraigh*, F. Onchiri, A. Faino, K. Pagel*, E. Pugh* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Cystic Fibrosis / complications; Cystic Fibrosis / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Diabetes Mellitus / genetics; Genome-Wide Association Study; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction / complications; Intestinal Obstruction / genetics
Sources: Web Of Science, ORCID
Added: November 21, 2022

2021 journal article

Eigenvector-based sparse canonical correlation analysis: Fast computation for estimation of multiple canonical vectors

JOURNAL OF MULTIVARIATE ANALYSIS, 185.

By: W. Wang* & Y. Zhou n

co-author countries: China 🇨🇳 Hong Kong 🇭🇰 United States of America 🇺🇸
author keywords: GTEx; High-dimensional data analysis; Multivariate regression; Sparse canonical correlation analysis
Sources: ORCID, Web Of Science
Added: June 19, 2021

2021 journal article

ImputEHR: A Visualization Tool of Imputation for the Prediction of Biomedical Data

FRONTIERS IN GENETICS, 12.

By: Y. Zhou n & E. Saghapour n

co-author countries: United States of America 🇺🇸
author keywords: electronic health records; imputation; gradient boosting; prediction; decision trees
Sources: Web Of Science, ORCID
Added: August 2, 2021

2021 journal article

Potential Human Health Hazard of Post-Hurricane Harvey Sediments in Galveston Bay and Houston Ship Channel: A Case Study of Using In Vitro Bioactivity Data to Inform Risk Management Decisions

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(24).

co-author countries: United States of America 🇺🇸
author keywords: new approach methods (NAMs); environmental mixtures; disaster research
MeSH headings : Bays; Cyclonic Storms; Disasters; Environmental Monitoring; Geologic Sediments; Humans; Polycyclic Aromatic Hydrocarbons / analysis; Risk Management; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
Sources: ORCID, Web Of Science
Added: December 20, 2021

2021 journal article

Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-Derived cardiomyocytes

FOOD AND CHEMICAL TOXICOLOGY, 149.

By: Y. Luo*, Z. Chen*, A. Blanchette*, Y. Zhou n, F. Wright n, E. Baker n, W. Chiu*, I. Rusyn*

co-author countries: United States of America 🇺🇸
author keywords: Cardiovascular; Heart rate; QT interval; Theophylline; Adenine; Azelate
MeSH headings : Calcium / metabolism; Cell Differentiation; Cell Survival / drug effects; Drug-Related Side Effects and Adverse Reactions; Energy Drinks / analysis; Heart Diseases / chemically induced; Humans; Induced Pluripotent Stem Cells / drug effects; Myocytes, Cardiac / drug effects; Risk Assessment
Sources: Web Of Science, ORCID
Added: February 4, 2021

2021 personal communication

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning

Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y.-H., Wright, F. A., … Reif, D. M. (2021, January).

co-author countries: United States of America 🇺🇸
MeSH headings : COVID-19 / epidemiology; Data Visualization; Health Status Indicators; Humans; Machine Learning; Models, Statistical; Vulnerable Populations
Sources: Web Of Science, ORCID
Added: March 22, 2021

2020 journal article

A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes

CLINICAL PHARMACOLOGY & THERAPEUTICS, 107(6), 1383–1393.

By: A. Etheridge*, P. Gallins n, D. Jima n, K. Broadaway*, M. Ratain*, E. Schuetz*, E. Schadt*, A. Schroder* ...

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents / adverse effects; Antineoplastic Agents / pharmacology; Child; Child, Preschool; Female; Gene Expression Regulation / genetics; Genetic Variation; Genome-Wide Association Study; Genotype; Humans; Hypolipidemic Agents / pharmacology; Infant; Liver / metabolism; Male; Middle Aged; Phenotype; Proprotein Convertase 9 / genetics; Quantitative Trait Loci / genetics; Receptors, G-Protein-Coupled / genetics; Sex Factors; Young Adult
Sources: Web Of Science, ORCID
Added: February 10, 2020

2020 journal article

Exploring the Limits of Combined Image/'omics Analysis for Non-cancer Histological Phenotypes

FRONTIERS IN GENETICS, 11.

By: P. Gallins n, E. Saghapour n & Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: imaging; genomics; pathology; prediction; integration; histology; machine learning; embedding
Sources: Web Of Science, ORCID
Added: November 24, 2020

2020 journal article

Systematic Comparisons for Composition Profiles, Taxonomic Levels, and Machine Learning Methods for Microbiome-Based Disease Prediction

FRONTIERS IN MOLECULAR BIOSCIENCES, 7.

By: K. Song n, F. Wright n & Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: phenotype prediction; machine learning method; k-mers; operational taxonomic unit (OTU); amplicon sequence variant (ASV); phylogenetic analysis
Sources: Web Of Science, ORCID
Added: January 19, 2021

2019 review

A Review and Tutorial of Machine Learning Methods for Microbiome Host Trait Prediction

[Review of ]. FRONTIERS IN GENETICS, 10.

By: Y. Zhou n & P. Gallins n

co-author countries: United States of America 🇺🇸
author keywords: disease; phenotype; modeling; machine learning; prediction
Sources: Web Of Science, ORCID
Added: July 15, 2019

2019 journal article

A note on cyclic shift permutation testing for large eigenvalues

Stat, 8(1).

By: Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: eigendecomposition; Marcenko-Pastur; Tracy-Widom
Source: ORCID
Added: December 18, 2019

2019 article

Marker-Trait Complete Analysis

Zhou, Y.-H., Gallins, P., & Wright, F. (2019, November 9). (Vol. 11). Vol. 11.

By: Y. Zhou*, P. Gallins* & F. Wright n

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
Source: ORCID
Added: November 10, 2019

2019 journal article

Set‐based differential covariance testing for genomics

Stat, 8(1).

By: Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: asymptotics; covariance testing; permutation
Source: ORCID
Added: October 7, 2019

2018 journal article

A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure

Cell Reports, 23(2), 327–336.

By: T. Frayling, R. Beaumont, S. Jones, H. Yaghootkar, M. Tuke, K. Ruth, F. Casanova, B. West ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure

Cell Reports, 23(2), 327–336.

By: T. Frayling, R. Beaumont, S. Jones, H. Yaghootkar, M. Tuke, K. Ruth, F. Casanova, B. West ...

Source: ORCID
Added: October 7, 2019

2018 journal article

A survey of high dimension low sample size asymptotics

AUSTRALIAN & NEW ZEALAND JOURNAL OF STATISTICS, 60(1), 4–19.

By: M. Aoshima*, D. Shen*, H. Shen*, K. Yata*, Y. Zhou n & J. Marron*

co-author countries: Hong Kong 🇭🇰 Japan 🇯🇵 United States of America 🇺🇸
author keywords: canonical correlations; classification; geometric representation; hypothesis testing; principal component analysis
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

A zero-inflated beta-binomial model for microbiome data analysis

STAT, 7(1).

By: T. Hu n, P. Gallins n & Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: count data; penalized generalized linear model; zero-inflated beta-binomial modelling
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Airway mucosal host defense is key to genomic regulation of cystic fibrosis lung disease severity

American Journal of Respiratory and Critical Care Medicine, 197(1), 79–93.

By: D. Polineni, H. Dang, P. Gallins, L. Jones, R. Pace, J. Stonebraker, L. Commander, J. Krenicky ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Airway mucosal host defense is key to genomic regulation of cystic fibrosis lung disease severity

American Journal of Respiratory and Critical Care Medicine, 197(1), 79–93.

By: D. Polineni, H. Dang, P. Gallins, L. Jones, R. Pace, J. Stonebraker, L. Commander, J. Krenicky ...

Source: ORCID
Added: October 7, 2019

2018 journal article

Computation of ancestry scores with mixed families and unrelated individuals

BIOMETRICS, 74(1), 155–164.

By: Y. Zhou n, J. Marron* & F. Wright n

co-author countries: United States of America 🇺🇸
author keywords: Genetic association; Population stratification; Principal components
MeSH headings : Cystic Fibrosis / genetics; Family; Genome; Genotype; Humans; Models, Genetic; Pedigree; Principal Component Analysis
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Eigenvalue Significance Testing for Genetic Association

Biometrics.

By: Y. Zhou n, J. Marron & F. Wright n

co-author countries: United States of America 🇺🇸
author keywords: Eigenvalue testing; Population stratification
MeSH headings : Computer Simulation; Cystic Fibrosis / genetics; Data Interpretation, Statistical; Genetic Association Studies / methods; Genomics / methods; Genotype; Humans; Models, Genetic; Models, Statistical
Source: ORCID
Added: October 7, 2019

2018 journal article

Estimation of cis-eQTL effect sizes using a log of linear model

BIOMETRICS, 74(2), 616–625.

By: J. Palowitch*, A. Shabalin*, Y. Zhou n, A. Nobel* & F. Wright n

co-author countries: United States of America 🇺🇸
author keywords: eQTL analyses; EQTL effect size; Multiple testing; Nonlinear regression
MeSH headings : Algorithms; Alleles; Gene Expression; Humans; Linear Models; Quantitative Trait Loci; Statistics as Topic
Sources: Web Of Science, ORCID
Added: October 16, 2018

2017 journal article

A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics

Frontiers in Genetics, 8, 168.

By: J. House, F. Grimm, D. Jima, Y. Zhou, I. Rusyn & F. Wright

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

A Two-Stage Hidden Markov Model Design for Biomarker Detection, with Application to Microbiome Research

Statistics in Biosciences, 10(1), 41–58.

By: Y. Zhou n, P. Brooks* & X. Wang

co-author countries: United States of America 🇺🇸
author keywords: Biomarker; False discovery rates; Hidden Markov model; Metagenomics; Metatranscriptomics; PCR
Sources: Crossref, ORCID
Added: January 25, 2020

2017 journal article

A procedure to detect general association based on concentration of ranks

Stat, 6(1), 88–101.

By: P. Rudra, Y. Zhou & F. Wright

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Changes in vaginal community state types reflect major shifts in the microbiome

Microbial Ecology in Health and Disease, 28(1), 1303265.

By: J. Brooks*, G. Buck*, G. Chen*, L. Diao*, D. Edwards*, J. Fettweis*, S. Huzurbazar*, A. Rakitin ...

co-author countries: Israel 🇮🇱 United States of America 🇺🇸
Source: Crossref
Added: February 5, 2020

2017 journal article

Changes in vaginal community state types reflect major shifts in the microbiome

Microbial Ecology in Health and Disease, 28(1), 1303265.

By: J. Brooks, G. Buck, G. Chen, L. Diao, D. Edwards, J. Fettweis, S. Huzurbazar, A. Rakitin ...

Source: ORCID
Added: October 7, 2019

2017 journal article

Dynamic landscape and regulation of RNA editing in mammals

Nature, 550(7675), 249–254.

By: M. Tan*, Q. Li*, R. Shanmugam*, R. Piskol*, J. Kohler*, A. Young*, K. Liu*, R. Zhang* ...

co-author countries: Australia 🇦🇺 Czechia 🇨🇿 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Italy 🇮🇹 Singapore 🇸🇬 United States of America 🇺🇸
MeSH headings : Adenosine Deaminase / genetics; Adenosine Deaminase / metabolism; Animals; Female; Genotype; HEK293 Cells; Humans; Male; Mice; Muscles / metabolism; Nuclear Proteins / metabolism; Organ Specificity / genetics; Primates / genetics; Proteolysis; RNA Editing / genetics; RNA-Binding Proteins / genetics; RNA-Binding Proteins / metabolism; Spatio-Temporal Analysis; Species Specificity; Transcriptome / genetics
Sources: Crossref, ORCID
Added: January 25, 2020

2017 journal article

Editor's Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse

TOXICOLOGICAL SCIENCES, 160(1), 95–110.

By: Y. Zhou n, J. Cichocki*, V. Soldatow*, E. Scholl n, P. Gallins n, D. Jima n, H. Yoo*, W. Chiu*, F. Wright n, I. Rusyn*

co-author countries: United States of America 🇺🇸
author keywords: volatile organic compounds; agents; toxicogenomics; methods; dose-response; risk assessment; kidney; systems toxicology; liver; systems toxicology
MeSH headings : Animals; Dose-Response Relationship, Drug; Environmental Pollutants / toxicity; Gene Expression Profiling / methods; Gene Expression Regulation; Gene Regulatory Networks; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Male; Mice; Risk Assessment; Sequence Analysis, RNA; Tetrachloroethylene / toxicity; Transcriptome; Trichloroethylene / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Genetic effects on gene expression across human tissues

Nature, 550(7675), 204–213.

By: F. Aguet, A. Brown*, S. Castel, J. Davis, Y. He*, B. Jo, P. Mohammadi, Y. Park ...

co-author countries: United States of America 🇺🇸
MeSH headings : Alleles; Chromosomes, Human / genetics; Disease / genetics; Female; Gene Expression Profiling; Gene Expression Regulation / genetics; Genetic Variation; Genome, Human / genetics; Genotype; Humans; Male; Organ Specificity / genetics; Quantitative Trait Loci / genetics
Sources: Crossref, ORCID
Added: December 19, 2020

2017 journal article

The impact of rare variation on gene expression across tissues

Nature, 550(7675), 239–243.

By: X. Li*, Y. Kim*, E. Tsang*, J. Davis*, F. Damani*, C. Chiang*, G. Hess*, Z. Zappala* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Bayes Theorem; Female; Gene Expression Profiling; Genetic Variation / genetics; Genome, Human / genetics; Genomics; Genotype; Humans; Male; Models, Genetic; Organ Specificity / genetics; Sequence Analysis, RNA
Sources: Crossref, ORCID
Added: January 25, 2020

2016 journal article

Estimation of interpretable eQTL effect sizes using a log of linear model

ArXiv Preprint ArXiv:1605.08799.

By: J. Palowitch, A. Shabalin, Y. Zhou, A. Nobel & F. Wright

Source: ORCID
Added: October 7, 2019

2016 journal article

Genomic characterization of metformin hepatic response

PLoS Genetics, 12(11), e1006449.

By: M. Luizon, W. Eckalbar, Y. Wang, S. Jones, R. Smith, M. Laurance, L. Lin, P. Gallins ...

Source: ORCID
Added: October 7, 2019

2016 journal article

Homologous recombination and translesion DNA synthesis play critical roles on tolerating DNA damage caused by trace levels of hexavalent chromium

PLoS One, 11(12).

By: X. Tian, K. Patel, J. Ridpath, Y. Chen, Y. Zhou, D. Neo, J. Clement, M. Takata ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Homologous recombination and translesion DNA synthesis play critical roles on tolerating DNA damage caused by trace levels of hexavalent chromium

PloS One, 11(12), e0167503.

By: X. Tian, K. Patel, J. Ridpath, Y. Chen, Y. Zhou, D. Neo, J. Clement, M. Takata ...

Source: ORCID
Added: October 7, 2019

2016 journal article

Pathway Analysis for RNA-Seq Data Using a Score-Based Approach

BIOMETRICS, 72(1), 165–174.

By: Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: Linear model; Pathway analysis; RNA-seq; Statistical genetics
MeSH headings : Algorithms; Animals; Data Interpretation, Statistical; Data Mining / methods; Databases, Nucleic Acid; Female; High-Throughput Nucleotide Sequencing / methods; Male; Protein Interaction Mapping / methods; Rats; Sequence Analysis, RNA / methods; Sex Factors; Signal Transduction / genetics; Species Specificity; Transcription Factors / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 conference paper

Poster: risk-based attack surface approximation

Symposium and Bootcamp on the Science of Security, 121–123.

By: C. Theisen & L. Williams

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

The projack: a resampling approach to correct for ranking bias in high-throughput studies

Biostatistics (Oxford, England), 17(1), 54–64.

By: Y. Zhou & F. Wright

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Visualization of robust L1PCA

Stat, 5(1), 173–184.

By: Y. Zhou n & J. Marron*

co-author countries: United States of America 🇺🇸
author keywords: L1-norm; outlier; PCA; robustness
Sources: Crossref, ORCID
Added: October 7, 2019

2015 journal article

Effect of predicted protein-truncating genetic variants on the human transcriptome

Science, 348(6235), 666–669.

By: M. Rivas, M. Pirinen, D. Conrad, M. Lek, E. Tsang, K. Karczewski, J. Maller, K. Kukurba ...

Source: ORCID
Added: October 7, 2019

2015 journal article

Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

Human Molecular Genetics, 24(15), 4464–4479.

By: E. Demerath, W. Guan, M. Grove, S. Aslibekyan, M. Mendelson, Y. Zhou, A. Hedman, J. Sandling ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

Human Molecular Genetics, 24(15), 4464–4479.

By: E. Demerath, W. Guan, M. Grove, S. Aslibekyan, M. Mendelson, Y. Zhou, Å. Hedman, J. Sandling ...

Source: ORCID
Added: October 7, 2019

2015 journal article

Gene Expression in Transformed Lymphocytes Reveals Variation in Endomembrane and HLA Pathways Modifying Cystic Fibrosis Pulmonary Phenotypes

The American Journal of Human Genetics, 96(2), 318–328.

By: W. O’Neal*, P. Gallins*, R. Pace*, H. Dang*, W. Wolf*, L. Jones*, X. Guo*, Y. Zhou n ...

co-author countries: Canada 🇨🇦 China 🇨🇳 United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Cystic Fibrosis / genetics; Cystic Fibrosis / pathology; Endoplasmic Reticulum Stress / genetics; Gene Expression Profiling; Genes, MHC Class I / genetics; Genetic Variation; Humans; Linear Models; Phenotype; Receptors, Lysophosphatidic Acid / genetics; Sequence Deletion / genetics
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

Gene expression in transformed lymphocytes reveals variation in endomembrane and HLA pathways modifying cystic fibrosis pulmonary phenotypes

The American Journal of Human Genetics, 96(2), 318–328.

By: W. O’Neal, P. Gallins, R. Pace, H. Dang, W. Wolf, L. Jones, X. Guo, Y. Zhou ...

Source: ORCID
Added: October 7, 2019

2015 journal article

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

Nature Communications, 6(1).

By: H. Corvol*, S. Blackman*, P. Boëlle*, P. Gallins*, R. Pace*, J. Stonebraker*, F. Accurso*, A. Clement* ...

co-author countries: Canada 🇨🇦 France 🇫🇷 United States of America 🇺🇸
MeSH headings : Adolescent; Adult; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral / genetics; Child; Cystic Fibrosis / genetics; Cystic Fibrosis / metabolism; Cystic Fibrosis / pathology; Female; Genome-Wide Association Study; Humans; Lung / metabolism; Lung / pathology; Male; Middle Aged; Mucin-4 / genetics; Mucins / genetics; Severity of Illness Index; Transcription Factors / genetics; Young Adult
Source: Crossref
Added: February 5, 2020

2015 journal article

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

Nature Communications, 6.

By: H. Corvol, S. Blackman, P. Boelle, P. Gallins, R. Pace, J. Stonebraker, F. Accurso, A. Clement ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

Nature Communications, 6, 8382.

By: H. Corvol, S. Blackman, P. Boëlle, P. Gallins, R. Pace, J. Stonebraker, F. Accurso, A. Clement ...

Source: ORCID
Added: October 7, 2019

2015 journal article

High dimension low sample size asymptotics of robust PCA

ELECTRONIC JOURNAL OF STATISTICS, 9(1), 204–218.

By: Y. Zhou* & J. Marron

author keywords: Outlier; robustness; spherical PCA; spike model
Source: Web Of Science
Added: August 6, 2018

2015 journal article

High dimension low sample size asymptotics of robust PCA

Electronic Journal of Statistics, 9(1), 204–218.

By: Y. Zhou, J. Marron & others

Source: ORCID
Added: October 7, 2019

2015 journal article

Hypothesis testing at the extremes: fast and robust association for high-throughput data

BIOSTATISTICS, 16(3), 611–625.

By: Y. Zhou n & F. Wright n

co-author countries: United States of America 🇺🇸
author keywords: Density approximation; Exact testing; Permutation
MeSH headings : Biostatistics; Breast Neoplasms / genetics; Computer Simulation; Cystic Fibrosis / genetics; Databases, Nucleic Acid / statistics & numerical data; Female; High-Throughput Nucleotide Sequencing / statistics & numerical data; High-Throughput Screening Assays / statistics & numerical data; Humans; Likelihood Functions; Linear Models; Polymorphism, Single Nucleotide; Sample Size; Software
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer

Chemical Research in Toxicology, 28(6), 1144–1155.

By: J. Rager*, S. Tilley*, S. Tulenko*, L. Smeester*, P. Ray*, A. Yosim*, J. Currier*, M. Ishida* ...

co-author countries: Mexico 🇲🇽 United States of America 🇺🇸
MeSH headings : Adult; Aged; Arsenic / metabolism; Arsenic / toxicity; Cell Transformation, Neoplastic / chemically induced; DNA Methylation / drug effects; DNA Methylation / genetics; Female; Humans; Middle Aged; Urinary Bladder Neoplasms / chemically induced; Urinary Bladder Neoplasms / genetics; Urinary Bladder Neoplasms / pathology; Urothelium / cytology; Urothelium / drug effects; Young Adult
Source: Crossref
Added: February 5, 2020

2015 journal article

Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer

Chemical Research in Toxicology, 28(6), 1144–1155.

By: J. Rager, S. Tilley, S. Tulenko, L. Smeester, P. Ray, A. Yosim, J. Currier, M. Ishida ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer

Chemical Research in Toxicology, 28(6), 1144–1155.

Yi-Hui Zhou

Source: ORCID
Added: October 7, 2019

2015 journal article

Metabolomic evaluation of neutrophilic airway inflammation in cystic fibrosis

Chest, 148(2), 507–515.

Yi-Hui Zhou

Source: ORCID
Added: October 7, 2019

2015 journal article

PathwaySeq: Pathway analysis for RNA-Seq data using a score-based approach

Dim (Data. Test), 1(1000), 448.

By: Y. Zhou

Source: ORCID
Added: October 7, 2019

2015 journal article

Population-Based in Vitro Hazard and Concentration-Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study

ENVIRONMENTAL HEALTH PERSPECTIVES, 123(5), 458–466.

By: N. Abdo*, M. Xia*, C. Brown*, O. Kosyk*, R. Huang*, S. Sakamuru*, Y. Zhou n, J. Jack* ...

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
MeSH headings : Cell Line, Tumor; Genome-Wide Association Study / methods; Genotype; Humans; Risk Assessment; Toxicity Tests / methods
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Population-based in vitro hazard and concentration--response assessment of chemicals: the 1000 genomes high-throughput screening study

Environmental Health Perspectives, 123(5), 458.

By: N. Abdo, M. Xia, C. Brown, O. Kosyk, R. Huang, S. Sakamuru, Y. Zhou, J. Jack ...

Source: ORCID
Added: October 7, 2019

2015 journal article

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

Science, 348(6235), 648–660.

By: K. Ardlie, D. DeLuca, A. Segre, T. Sullivan, T. Young, E. Gelfand, C. Trowbridge, J. Maller ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

The projack: a resampling approach to correct for ranking bias in high-throughput studies

Biostatistics, 17(1), 54–64.

By: Y. Zhou & F. Wright

Source: ORCID
Added: October 7, 2019

2014 journal article

Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs

Epigenetics, 9(2), 212–221.

By: A. Sanders, L. Smeester, D. Rojas, T. DeBussycher, M. Wu, F. Wright, Y. Zhou, J. Laine ...

Source: ORCID
Added: October 7, 2019

2014 journal article

Heritability and genomics of gene expression in peripheral blood

Nature Genetics, 46(5), 430–437.

By: F. Wright n, P. Sullivan*, A. Brooks*, F. Zou*, W. Sun*, K. Xia*, V. Madar*, R. Jansen* ...

co-author countries: Netherlands 🇳🇱 United States of America 🇺🇸
MeSH headings : Blood / metabolism; Gene Expression Profiling; Gene Expression Regulation / genetics; Genotype; Humans; Inheritance Patterns / genetics; Likelihood Functions; Netherlands; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci / genetics
Source: Crossref
Added: February 5, 2020

2014 journal article

Heritability and genomics of gene expression in peripheral blood

Nature Genetics, 46(5), 430–437.

By: F. Wright, P. Sullivan, A. Brooks, F. Zou, W. Sun, K. Xia, V. Madar, R. Jansen ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Heritability and genomics of gene expression in peripheral blood

Nature Genetics, 46(5), 430.

By: F. Wright, P. Sullivan, A. Brooks, F. Zou, W. Sun, K. Xia, V. Madar, R. Jansen ...

Source: ORCID
Added: October 7, 2019

2014 journal article

Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

ENVIRONMENTAL HEALTH PERSPECTIVES, 122(5), 456–463.

By: W. Chiu*, J. Campbell*, H. Clewell*, Y. Zhou n, F. Wright n, K. Guyton*, I. Rusyn*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Bayes Theorem; Dichloroacetic Acid / metabolism; Humans; Male; Mice; Trichloroethylene / metabolism; Trichloroethylene / pharmacokinetics
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse

Environmental Health Perspectives, 122(5), 456.

Yi-Hui Zhou

Source: ORCID
Added: October 7, 2019

2014 journal article

RNA-Seq pathway analysis

By: Y. Zhou & H. Dang

Source: ORCID
Added: October 7, 2019

2013 journal article

Empirical pathway analysis, without permutation

Biostatistics, (doi:10.1093/biostatistics/kxt004), 1–13.

By: Y. Zhou, W. Barry & F. Wright

Source: ORCID
Added: October 7, 2019

2013 chapter

Metabolomic Evaluation Of Cystic Fibrosis Airways Disease

In A26. PEDIATRIC CYSTIC FIBROSIS (pp. A1165–A1165). American Thoracic Society.

By: C. Esther, Y. Zhou, F. Wright & R. Boucher

Source: ORCID
Added: October 7, 2019

2013 journal article

Single Nucleotide Polymorphism (SNP) Detection and Genotype Calling from Massively Parallel Sequencing (MPS) Data

Statistics in Biosciences, 5(1), 3–25.

By: Y. Li*, W. Chen*, E. Liu* & Y. Zhou*

co-author countries: United States of America 🇺🇸
author keywords: Massively parallel sequencing; Next-generationsequencing; SNP detection; Genotype calling; Linkage disequilibrium (LD)
Source: Crossref
Added: December 21, 2020

2013 journal article

Skill-assessments of statistical and Ensemble Kalman Filter data assimilative analyses using surface and deep observations in the Gulf of Mexico

Frontiers of Earth Science, 7(3), 271–281.

By: Z. Sun*, L. Oey* & Y. Zhou*

co-author countries: United States of America 🇺🇸
author keywords: data assimilation; deep observation; Gulf of Mexico
Sources: Crossref, ORCID
Added: October 7, 2019

2013 journal article

Space-time clustering and the permutation moments of quadratic forms

Stat, 2(1), 292–302.

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: exact testing; resampling; statistical computing
Sources: Crossref, ORCID
Added: October 7, 2019

2013 journal article

Stochastic comparisons in a price-quantity setting firm with uncertain demand and emergency procurement

Journal of Systems Science and Systems Engineering, 22(4), 401–420.

By: M. Xu*, X. Xu* & Y. Zhou*

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Price-dependent newsvendor; stochastic comparison; demand uncertainty; pricing; emergency supply option
Source: Crossref
Added: February 5, 2020

2013 journal article

Stochastic comparisons in a price-quantity setting firm with uncertain demand and emergency procurement

Journal of Systems Science and Systems Engineering, 22(4), 401–420.

By: M. Xu, X. Xu & Y. Zhou

Source: ORCID
Added: October 7, 2019

2012 journal article

Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model

Toxicological Sciences.

By: E. Lock, N. Abdo, R. Huang, M. Xia, O. Kosyk, S. O’Shea, Y. Zhou, A. Sedykh ...

Source: ORCID
Added: October 7, 2019

2012 journal article

Simple and accurate trend tests using a permutation approximation

By: Y. Zhou & F. Wright

Source: ORCID
Added: October 7, 2019

2012 journal article

Single Nucleotide Polymorphism (SNP) Detection and Genotype Calling from Massively Parallel Sequencing (MPS) Data

Statistics in Biosciences, 1–23.

By: Y. Li, W. Chen, E. Liu & Y. Zhou

Source: ORCID
Added: October 7, 2019

2012 journal article

Supplementary material for: Empirical Pathway Analysis, Without Permutation

By: Y. Zhou, W. Barry, F. Wright & C. Hill

Source: ORCID
Added: October 7, 2019

2011 journal article

A powerful and flexible approach to the analysis of RNA sequence count data

Bioinformatics, 27(19), 2672–2678.

By: Y. Zhou, K. Xia & F. Wright

Source: ORCID
Added: October 7, 2019

2011 journal article

seeQTL: a searchable database for human eQTLs

Bioinformatics, 28(3), 451–452.

By: K. Xia, A. Shabalin, S. Huang, V. Madar, Y. Zhou, W. Wang, F. Zou, W. Sun, P. Sullivan, F. Wright

Source: ORCID
Added: October 7, 2019

2009 journal article

On the finiteness of the cone spectrum of certain linear transformations on Euclidean Jordan algebras

Linear Algebra and Its Applications, 431(5-7), 772–782.

By: Y. Zhou* & M. Gowda*

co-author countries: United States of America 🇺🇸
author keywords: Euclidean Jordan algebra; Symmetric cone; Cone spectrum; Z-transformation; Quadratic representation
Sources: Crossref, ORCID
Added: October 7, 2019

journal article

Medical Center, New York, NY 10032, USA. 18Wellcome Trust Centre for Human Genetics Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, UK. 19Department of Computer Science, Stanford University, Stanford, CA 94305, USA. 20Department of Computer Science, Johns

Yi-Hui Zhou

Source: ORCID
Added: October 7, 2019

journal article

Significant Chlorinated Paraffin Concentrations Together with Traditional and Emerging Pollutants in Wildlife from a Yangtze River Delta Area Site

Yin, G., Zhou, Y., Asplund, L., Athanassiadis, I., Wideqvist, U., Qiu, Y., … Bergman, Å.

By: G. Yin, Y. Zhou, L. Asplund, I. Athanassiadis, U. Wideqvist, Y. Qiu, Z. Zhu, J. Zhao, Å. Bergman

Source: ORCID
Added: October 7, 2019

journal article

Supplemental Material Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

Yi-Hui Zhou

Source: ORCID
Added: October 7, 2019

journal article

Supplementary Appendix to: Hypothesis testing at the extremes: fast and robust association for high-throughput data

Zhou, Y.-H., & Wright, F. A.

By: Y. Zhou & F. Wright

Source: ORCID
Added: October 7, 2019

journal article

on July 8, 2015

DeLuca, D. S., Segrè, A. V., Sullivan, T. J., Young, T. R., Gelfand, E. T., Trowbridge, C. A., … others.

By: D. DeLuca, A. Segrè, T. Sullivan, T. Young, E. Gelfand, C. Trowbridge, J. Maller, T. Tukiainen ...

Source: ORCID
Added: October 7, 2019

Employment

Updated: January 21st, 2023 09:08

2018 - present

North Carolina State University Raleigh, North Carolina, US
Associate Professor Biological Sciences

2018 - present

NC State University Bioinformatics Research Center Raleigh, NC, US
Associate Director

Education

Updated: August 31st, 2018 19:20

2007 - 2011

University of North Carolina at Chapel Hill Chapel Hill, NC, US
PhD Biostatitsics

Funding History

Funding history based on the linked ORCID record. Updated: January 3rd, 2024 13:54

grant September 1, 2022 - August 31, 2025
A tiered hybrid experimental-computational strategy for rapid risk assessment of complex environmental mixtures using novel analytical and toxicological methods
Environmental Protection Agency
grant June 16, 2015 - April 30, 2018
Permutation Approximations for Next Generation Association
National Human Genome Research Institute
grant June 1, 2015 - May 31, 2019
A Pipeline for in vitro-to-in vivo Extrapolation, Population Modeling,& Prioritization
Environmental Protection Agency

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