@article{brown_zou_shirvanyants_zhang_samanta_mantravadi_dokholyan_deiters_2015, title={Light-cleavable rapamycin dimer as an optical trigger for protein dimerization}, volume={51}, ISSN={["1364-548X"]}, DOI={10.1039/c4cc09442e}, abstractNote={Rapamycin-induced protein heterodimerization of FKBP12 and FRB is one of the most commonly employed switches to conditionally control biological processes. We developed an optically activated rapamycin dimer that does not induce FKBP12-FRB dimerization until exposed to light, and applied it to control kinase, protease, and recombinase function.}, number={26}, journal={CHEMICAL COMMUNICATIONS}, author={Brown, Kalyn A. and Zou, Yan and Shirvanyants, David and Zhang, Jie and Samanta, Subhas and Mantravadi, Pavan K. and Dokholyan, Nikolay V. and Deiters, Alexander}, year={2015}, pages={5702–5705} }
 @article{zou_lin_maggard_deiters_2011, title={Efficacy of C-N Coupling Reactions with a New Multinuclear Copper Complex Catalyst and Its Dissociation into Mononuclear Species}, volume={2011}, ISSN={["1099-0690"]}, DOI={10.1002/ejoc.201100399}, abstractNote={A new tetranuclear copper(I)–pyridazine (pda)/rhenate hybrid has been synthesized under hydrothermal conditions and structurally characterized by X-ray crystallography. The activity of this catalyst, as well as its dissociation into mononuclear species, was investigated in homogeneous C–N arylation reactions. A variety of N-arylamides and -azoles were synthesized in good to excellent yields, revealing the effect of polynuclear versus mononuclear Cu complexation in this type of coupling reaction.}, number={22}, journal={EUROPEAN JOURNAL OF ORGANIC CHEMISTRY}, author={Zou, Yan and Lin, Haisheng and Maggard, Paul A. and Deiters, Alexander}, year={2011}, month={Aug}, pages={4154–4159} }
 @article{karginov_zou_shirvanyants_kota_dokholyan_young_hahn_deiters_2011, title={Light Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP}, volume={133}, ISSN={["0002-7863"]}, DOI={10.1021/ja109630v}, abstractNote={We developed a new system for light-induced protein dimerization in living cells using a photocaged analogue of rapamycin together with an engineered rapamycin binding domain. Using focal adhesion kinase as a target, we demonstrated successful light-mediated regulation of protein interaction and localization in living cells. Modification of this approach enabled light-triggered activation of a protein kinase and initiation of kinase-induced phenotypic changes in vivo.}, number={3}, journal={JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}, author={Karginov, Andrei V. and Zou, Yan and Shirvanyants, David and Kota, Pradeep and Dokholyan, Nikolay V. and Young, Douglas D. and Hahn, Klaus M. and Deiters, Alexander}, year={2011}, month={Jan}, pages={420–423} }
 @article{gardner_zou_mara_cropp_deiters_2011, title={Photochemical control of bacterial signal processing using a light-activated erythromycin}, volume={7}, ISSN={["1742-206X"]}, DOI={10.1039/c1mb05166k}, abstractNote={Bacterial cells control resistance to the macrolide antibiotic erythromycin using the MphR(A) repressor protein. Erythromycin binds to MphR(A), causing release of the PmphR promoter, activating expression of the 2'-phosphotransferase Mph(A). We engineered the MphR(A)/promoter system to, in conjunction with a light-activatable derivative of erythromycin, enable photochemical activation of gene expression in E. coli. We applied this photochemical gene switch to the construction of a light-triggered logic gate, a light-controlled band-pass filter, as well as spatial and temporal control of gene expression.}, number={9}, journal={MOLECULAR BIOSYSTEMS}, author={Gardner, Laura and Zou, Yan and Mara, Alexandria and Cropp, T. Ashton and Deiters, Alexander}, year={2011}, pages={2554–2557} }
 @article{zou_liu_deiters_2011, title={Synthesis of the Pyridine Core of Cyclothiazomycin}, volume={13}, ISSN={["1523-7052"]}, DOI={10.1021/ol201682k}, abstractNote={A highly convergent synthesis of the pyridine core of the thiopeptide antibiotic cyclothiazomycin has been developed based on a [2+2+2] cyclotrimerization key step. The regioselective assembly of the heterocyclic center of this important class of antibiotics takes advantage of a temporary silicon tether and the ruthenium-catalyzed cyclotrimerization reaction of a diyne and an electron-poor thiazole nitrile.}, number={16}, journal={ORGANIC LETTERS}, author={Zou, Yan and Liu, Qingyang and Deiters, Alexander}, year={2011}, month={Aug}, pages={4352–4355} }
 @article{zou_deiters_2010, title={Total Synthesis of Cryptoacetalide}, volume={75}, ISSN={["1520-6904"]}, DOI={10.1021/jo100867v}, abstractNote={We are reporting the first total synthesis of the tetracyclic terpene natural product cryptoacetalide. Key steps of the synthesis are a microwave-mediated [2+2+2] cyclo-trimerization reaction to construct the central benzene ring, and a light-mediated radical cyclization to assemble the spiro-ketal moiety.}, number={15}, journal={JOURNAL OF ORGANIC CHEMISTRY}, author={Zou, Yan and Deiters, Alexander}, year={2010}, month={Aug}, pages={5355–5358} }
 @article{zou_young_cruz-montanez_deiters_2008, title={Synthesis of Anthracene and Azaanthracene Fluorophores via [2+2+2] Cyclotrimerization Reactions}, volume={10}, ISSN={["1523-7052"]}, DOI={10.1021/ol8019549}, abstractNote={A highly convergent [2+2+2] cyclotrimerization approach to anthracenes and 2-azaanthracenes has been developed. It allows for the facile introduction of the anthracene moiety on alkyne and nitrile bearing molecules and the rapid construction of compound arrays. This is showcased in the assembly of a collection of fluorophores and their photochemical evaluation.}, number={20}, journal={ORGANIC LETTERS}, author={Zou, Yan and Young, Douglas D. and Cruz-Montanez, Alejandra and Deiters, Alexander}, year={2008}, month={Oct}, pages={4661–4664} }