Zhen Gu

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

NATIONAL SCIENCE REVIEW, 9(3).

Bioorthogonal catalytic patch

Chen, Z., Li, H., Bian, Y., Wang, Z., Chen, G., Zhang, X., … Gu, Z. (2021, May 10). NATURE NANOTECHNOLOGY.

Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets

Hu, Q., Li, H., Archibong, E., Chen, Q., Ruan, H., Ahn, S., … Gu, Z. (2021, April 26). NATURE BIOMEDICAL ENGINEERING.

Integrated microneedle-smartphone nucleic acid amplification platform for in-field diagnosis of plant diseases

BIOSENSORS & BIOELECTRONICS, 187.

CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation

SCIENCE ADVANCES, 6(21).

Engineered PD-L1-Expressing Platelets Reverse New-Onset Type 1 Diabetes

ADVANCED MATERIALS, 32(26).

Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs

NATURE BIOMEDICAL ENGINEERING, 4(5), 499–506.

Non-transdermal microneedles for advanced drug delivery

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 165-166, 41–59.

Targeted Delivery of Notch Inhibitor Attenuates Obesity-Induced Glucose Intolerance and Liver Fibrosis

ACS NANO, 14(6), 6878–6886.

A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade

ADVANCED MATERIALS, 31(17).

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

ACS NANO, 13(4), 4354–4360.

A forskolin-conjugated insulin analog targeting endogenous glucose-transporter for glucose-responsive insulin delivery

BIOMATERIALS SCIENCE, 7(11), 4508–4513.

Adipocytes as Anticancer Drug Delivery Depot

MATTER, 1(5), 1203–1214.

Advances in drug delivery for post-surgical cancer treatment

Biomaterials, 219, 119182.

Advances in transdermal insulin delivery

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 139, 51–70.

Bioresponsive Protein Complex of aPD1 and aCD47 Antibodies for Enhanced Immunotherapy

NANO LETTERS, 19(8), 4879–4889.

Cancer Stem Cell-Platelet Hybrid Membrane-Coated Magnetic Nanoparticles for Enhanced Photothermal Therapy of Head and Neck Squamous Cell Carcinoma

Advanced Functional Materials, 29(10), 1807733.

Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs

SCIENCE ADVANCES, 5(7).

Cysteine-rich Proteins for Drug Delivery and Diagnosis

[Review of ]. CURRENT MEDICINAL CHEMISTRY, 26(8), 1377–1388.

Drug Delivery: A Dual‐Bioresponsive Drug‐Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade (Adv. Mater. 17/2019)

Advanced Materials, 31(17), 1970120.

Engineering Protein Delivery Depots for Cancer Immunotherapy

Bioconjugate Chemistry, 30(3), 515–524.

Enhanced local cancer therapy using a CA4P and CDDP co-loaded polypeptide gel depot

BIOMATERIALS SCIENCE, 7(3), 860–866.

Extraction of Plant DNA by Microneedle Patch for Rapid Detection of Plant Diseases

ACS Nano, 13(6), 6540–6549.

Glucose transporter inhibitor-conjugated insulin mitigates hypoglycemia

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(22), 10744–10748.

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

NATURE NANOTECHNOLOGY, 14(1), 89-+.

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

ADVANCED MATERIALS, 31(23).

Platelet for drug delivery

Current Opinion in Biotechnology, 58, 81–91.

Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy

NANO RESEARCH, 12(6), 1313–1320.

Topical and Transdermal Nanomedicines for Cancer Therapy

NANOTHERANOSTICS FOR CANCER APPLICATIONS, Vol. 5, pp. 231–251.

Topography‐Induced Cell Self‐Organization from Simple to Complex Aggregates

Small, 15(15), 1900030.

Advances in bioresponsive closed-loop drug delivery systems

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 544(2), 350–357.

Advances in glycosylation-mediated cancer-targeted drug delivery

[Review of ]. DRUG DISCOVERY TODAY, 23(5), 1126–1138.

Advances in liquid metals for biomedical applications

[Review of ]. CHEMICAL SOCIETY REVIEWS, 47(8), 2518–2533.

Advances in transformable drug delivery systems

BIOMATERIALS, 178, 546–558.

Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy

ACS NANO, 12(6), 5995–6005.

Biodegradable Gelatin Methacryloyl Microneedles for Transdermal Drug Delivery

Advanced Healthcare Materials, 8(3), 1801054.

Bioresponsive Microneedles with a Sheath Structure for H2O2 and pH Cascade-Triggered Insulin Delivery

SMALL, 14(14).

Blood sampling using microneedles as a minimally invasive platform for biomedical diagnostics

[Review of ]. APPLIED MATERIALS TODAY, 13, 144–157.

Cancer Immunotherapy: PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy (Adv. Mater. 22/2018)

Advanced Materials, 30(22), 1870152.

Cardiac cell-integrated microneedle patch for treating myocardial infarction

SCIENCE ADVANCES, 4(11).

Cationic lipid-assisted nanoparticles for delivery of mRNA cancer vaccine

Biomaterials Science, 6(11), 3009–3018.

Cellular Bioparticulates with Therapeutics for Cancer Immunotherapy

[Review of ]. BIOCONJUGATE CHEMISTRY, 29(3), 702–708.

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

NATURE BIOMEDICAL ENGINEERING, 2(11), 831–840.

Core–Shell Microneedle Gel for Self-Regulated Insulin Delivery

ACS Nano, 12(3), 2466–2473.

Delivery Strategies for Immune Checkpoint Blockade

ADVANCED HEALTHCARE MATERIALS, 7(20).

Drug-Bearing Supramolecular MMP Inhibitor Nanofibers for Inhibition of Metastasis and Growth of Liver Cancer

Advanced Science, 5(8), 1700867.

Engineering PD-1-Presenting Platelets for Cancer Immunotherapy

NANO LETTERS, 18(9), 5716–5725.

Glucose-responsive insulin by molecular and physical design (vol 9, pg 937, 2017)

Bakh, N. A., Cortinas, A. B., Weiss, M. A., Langer, R. S., Anderson, D. G., Gu, Z., … Strano, M. S. (2018, January). NATURE CHEMISTRY, Vol. 10, pp. 109–109.

Glucose-responsive oral insulin delivery for postprandial glycemic regulation

Nano Research, 12(7), 1539–1545.

Hierarchical Nanoassemblies-Assisted Combinational Delivery of Cytotoxic Protein and Antibiotic for Cancer Treatment

NANO LETTERS, 18(4), 2294–2303.

In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

SCIENCE TRANSLATIONAL MEDICINE, 10(429).

Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade

Advanced Materials, 30(28), 1801527.

Leverage physiology for precision medications

Nanomedicine: Nanotechnology, Biology and Medicine, 14(5), 1883–1884.

Leveraging Engineering of Cells for Drug Delivery

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 51(3), 668–677.

Local generation of hydrogen for enhanced photothermal therapy

Nature Communications, 9(1).

Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles

ACS NANO, 12(2), 994–1005.

Nanomedicine for obesity treatment

Science China Life Sciences, 61(4), 373–379.

PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy

ADVANCED MATERIALS, 30(22).

PDT-Driven Highly Efficient Intracellular Delivery and Controlled Release of CO in Combination with Sufficient Singlet Oxygen Production for Synergistic Anticancer Therapy

Advanced Functional Materials, 28(41), 1804324.

Polymeric microneedles for transdermal protein delivery

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 127, 106–118.

ROS-Responsive Microneedle Patch for Acne Vulgaris Treatment

Advanced Therapeutics, 1(3), 1800035.

ROS-Responsive Microneedle Patch for Acne Vulgaris Treatment (Adv. Therap. 3/2018)

Advanced Therapeutics, 1(3), 1870006.

Strategies of Combination Drug Delivery for Immune Checkpoint Blockades

Advanced Healthcare Materials, 1801099.

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

NATURE BIOMEDICAL ENGINEERING, 2(1), 17–26.

Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

Nature Communications, 9(1).

The potential of a microneedle patch for reducing obesity

EXPERT OPINION ON DRUG DELIVERY, Vol. 15, pp. 431–433.

Towards Enhancing Skin Drug Delivery

Gu, Z., & Chen, X. (2018, March 1). ADVANCED DRUG DELIVERY REVIEWS, Vol. 127, pp. 1–2.

A melanin-mediated cancer immunotherapy patch

SCIENCE IMMUNOLOGY, 2(17).

Anaerobe-Inspired Anticancer Nanovesicles

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(10), 2588–2593.

Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs

[Review of ]. THERANOSTICS, 7(14), 3504–3516.

Bioresponsive materials

[Review of ]. NATURE REVIEWS MATERIALS, 2(1).

Bioresponsive transcutaneous patches

[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 48, 28–32.

Conjugated polymer nanomaterials for theranostics

[Review of ]. ACTA PHARMACOLOGICA SINICA, 38(6), 764–781.

Engineering platelet-mimicking drug delivery vehicles

[Review of ]. FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING, 11(4), 624–632.

Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species

NANO LETTERS, 17(2), 928–937.

Enhanced Endosomal Escape by Light-Fueled Liquid-Metal Transformer

NANO LETTERS, 17(4), 2138–2145.

Glucose-responsive insulin by molecular and physical design

NATURE CHEMISTRY, 9(10), 937–943.

H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery

ACS NANO, 11(1), 613–620.

Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery

NANO LETTERS, 17(2), 733–739.

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

Nature Biomedical Engineering, 1(2).

Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody

Advanced Materials, 29(15).

Injectable Thermosensitive Polypeptide-Based CDDP-Complexed Hydrogel for Improving Localized Antitumor Efficacy

Biomacromolecules, 18(12), 4341–4348.

Inside Cover: Anaerobe-Inspired Anticancer Nanovesicles (Angew. Chem. Int. Ed. 10/2017)

Angewandte Chemie International Edition, 56(10), 2516–2516.

Insulin-Responsive Glucagon Delivery for Prevention of Hypoglycemia

Small, 13(19), 1603028.

Insulin-responsive glucagon delivery for prevention of hypoglycemia

Small (Weinheim An Der Bergstrasse, Germany), 13(19).

Investigation and intervention of autophagy to guide cancer treatment with nanogels

NANOSCALE, 9(1), 150–163.

KIDNEY PHYSIOLOGYA size bandpass filter

Lu, Y., & Gu, Z. (2017, November). NATURE NANOTECHNOLOGY, Vol. 12, pp. 1023–1025.

KO of 5-InsP(7) kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(45), 11968–11973.

LEVERAGING PHYSIOLOGY FOR PRECISION DRUG DELIVERY

[Review of ]. PHYSIOLOGICAL REVIEWS, 97(1), 189–225.

Leveraging H2O2Levels for Biomedical Applications

Advanced Biosystems, 1(9), 1700084.

Local delivery of checkpoints antibodies

HUMAN VACCINES & IMMUNOTHERAPEUTICS, 13(1), 245–248.

Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment

ACS NANO, 11(9), 9223–9230.

Photoacoustic Drug Delivery

[Review of ]. SENSORS, 17(6).

Red Blood Cells for Drug Delivery

Small Methods, 1(12), 1700270.

Red Blood Cells for Glucose-Responsive Insulin Delivery

ADVANCED MATERIALS, 29(18).

Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy

ADVANCED MATERIALS, 29(13).

Smart materials and systems as artificial pancreas for diabetes treatment

Smart Materials for Tissue Engineering: Applications, 25, 358–381.

Stimuli-Responsive Polymersomes for Biomedical Applications

BIOMACROMOLECULES, 18(3), 649–673.

Synthetic beta cells for fusion-mediated dynamic insulin secretion

Nature Chemical Biology, 14(1), 86–93.

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

ADVANCED MATERIALS, 29(29).

Tailoring non-viral delivery vehicles for transporting genome-editing tools

[Review of ]. Science China-Materials, 60(6), 511–515.

Thrombin-responsive transcutaneous patch for auto-anticoagulant regulation

Advanced Materials, 29(4).

Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules

Nano Research, 10(4), 1393–1402.

ATP-Responsive Drug Delivery Systems

Sun, W., & Gu, Z. (2016, March 3). EXPERT OPINION ON DRUG DELIVERY, Vol. 13, pp. 311–314.

ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging

THERANOSTICS, 6(7), 1053–1064.

Anticancer Therapy: Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy (Adv. Mater. 17/2016)

Advanced Materials, 28(17), 3226–3226.

Cell membrane-mediated anticancer drug delivery

Nanotechnology: delivering on the promise, vol 2, 1224, 197–211.

Drug Delivery: Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery (Adv. Mater. 16/2016)

Advanced Materials, 28(16), 3223–3223.

Dual targeted nanocarrier for brain ischemic stroke treatment

JOURNAL OF CONTROLLED RELEASE, 233, 64–71.

Elastic drug delivery: could treatments be triggered by patient movement?

NANOMEDICINE, Vol. 11, pp. 323–325.

Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus

ADVANCED MATERIALS, 28(43), 9573-+.

Enhanced Antiglioblastoma Efficacy of Neovasculature and Glioma Cells Dual Targeted Nanoparticles

MOLECULAR PHARMACEUTICS, 13(10), 3506–3517.

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

NANO LETTERS, 16(4), 2334–2340.

Hypoxia-Sensitive Materials for Biomedical Applications

ANNALS OF BIOMEDICAL ENGINEERING, 44(6), 1931–1945.

Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody

ADVANCED MATERIALS, 28(40), 8912–8920.

Internalized compartments encapsulated nanogels for targeted drug delivery

NANOSCALE, 8(17), 9178–9184.

Introduction to special issue on “Responsive Materials and Systems: Toward Smart and Precision Medications”

Introduction to special issue on “Responsive Materials and Systems: Toward Smart and Precision Medications.” Bioengineering & Translational Medicine, 1(3), 235–236.

Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy

ADVANCED MATERIALS, 28(17), 3313–3320.