Works (195)

Updated: August 28th, 2023 21:15

2022 journal article

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

NATIONAL SCIENCE REVIEW, 9(3).

By: H. Li*, Z. Wang*, E. Archibong*, Q. Wu*, G. Chen*, Q. Hu n, T. Ci*, Z. Chen* ...

author keywords: drug delivery; CAR T therapy; microneedle patch; solid tumor treatment; cell delivery
Source: Web Of Science
Added: March 28, 2022

2021 article

Bioorthogonal catalytic patch

Chen, Z., Li, H., Bian, Y., Wang, Z., Chen, G., Zhang, X., … Gu, Z. (2021, May 10). NATURE NANOTECHNOLOGY.

By: Z. Chen*, H. Li*, Y. Bian*, Z. Wang*, G. Chen n, X. Zhang n, Y. Miao*, D. Wen n ...

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Catalysis; Drug Delivery Systems; Hep G2 Cells; Humans; Melanoma, Experimental; Metal Nanoparticles / chemistry; Metal Nanoparticles / therapeutic use; Mice; Palladium / chemistry; Palladium / pharmacokinetics; Palladium / pharmacology; Prodrugs / chemistry; Prodrugs / pharmacokinetics; Prodrugs / pharmacology; Titanium / chemistry; Titanium / pharmacokinetics; Titanium / pharmacology
Source: Web Of Science
Added: June 10, 2021

2021 article

Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets

Hu, Q., Li, H., Archibong, E., Chen, Q., Ruan, H., Ahn, S., … Gu, Z. (2021, April 26). NATURE BIOMEDICAL ENGINEERING.

By: Q. Hu n, H. Li*, E. Archibong n, Q. Chen n, H. Ruan*, S. Ahn*, E. Dukhovlinova*, Y. Kang* ...

MeSH headings : Animals; Antibodies, Monoclonal, Humanized; Blood Platelets; Cell-Derived Microparticles; Hydrogels; Immunotherapy, Adoptive; Mice; Neoplasm Recurrence, Local / prevention & control; T-Lymphocytes; Tumor Microenvironment
Source: Web Of Science
Added: June 10, 2021

2021 journal article

Integrated microneedle-smartphone nucleic acid amplification platform for in-field diagnosis of plant diseases

BIOSENSORS & BIOELECTRONICS, 187.

By: R. Paul n, E. Ostermann n, Y. Chen n, A. Saville n, Y. Yang*, Z. Gu*, A. Whitfield n, J. Ristaino n, Q. Wei n

author keywords: Plant disease diagnostics; Nucleic acid extraction; Microneedle; Isothermal amplification; Smartphone
MeSH headings : Biosensing Techniques; Molecular Diagnostic Techniques; Nucleic Acid Amplification Techniques; Plant Diseases; Smartphone
Sources: Web Of Science, ORCID
Added: June 14, 2021

2020 journal article

CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation

SCIENCE ADVANCES, 6(21).

MeSH headings : CRISPR-Cas Systems; Cholesterol; DNA / genetics; DNA / metabolism; Gene Editing; Polymers / metabolism; Proprotein Convertase 9 / genetics; Proprotein Convertase 9 / metabolism; RNA / genetics; Ribonucleoproteins / genetics
Source: Web Of Science
Added: June 22, 2020

2020 journal article

Engineered PD-L1-Expressing Platelets Reverse New-Onset Type 1 Diabetes

ADVANCED MATERIALS, 32(26).

author keywords: drug delivery; immune tolerance; platelets; programmed death-ligand 1 (PD-L1); type 1 diabetes (T1D)
MeSH headings : Animals; B7-H1 Antigen / genetics; B7-H1 Antigen / metabolism; Blood Glucose / analysis; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Diabetes Mellitus, Type 1 / pathology; Diabetes Mellitus, Type 1 / therapy; Diabetes Mellitus, Type 1 / veterinary; Genetic Engineering; Immune Tolerance; Insulin / blood; Insulin-Secreting Cells / cytology; Insulin-Secreting Cells / immunology; Insulin-Secreting Cells / metabolism; Megakaryocyte Progenitor Cells / cytology; Megakaryocyte Progenitor Cells / metabolism; Megakaryocyte Progenitor Cells / transplantation; Mice; Mice, Inbred NOD; T-Lymphocytes, Regulatory / cytology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism
Source: Web Of Science
Added: June 8, 2020

2020 journal article

Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs

NATURE BIOMEDICAL ENGINEERING, 4(5), 499–506.

MeSH headings : Animals; Blood Glucose / metabolism; Diabetes Mellitus, Experimental / blood; Disease Models, Animal; Drug Delivery Systems; Humans; Insulin / pharmacology; Insulin Secretion / drug effects; Male; Mice, Inbred C57BL; Needles; Swine; Swine, Miniature; Transdermal Patch
Source: Web Of Science
Added: February 17, 2020

2020 review

Non-transdermal microneedles for advanced drug delivery

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 165-166, 41–59.

author keywords: Microneedle; Implant; Drug delivery; Non-transdermal; Biocompatibility; Biodegradability
MeSH headings : Administration, Topical; Biological Transport; Drug Delivery Systems / methods; Equipment Design; Humans; Microinjections / instrumentation; Microinjections / methods; Microtechnology / methods; Polymers; Prostheses and Implants
Source: Web Of Science
Added: January 11, 2021

2020 journal article

Targeted Delivery of Notch Inhibitor Attenuates Obesity-Induced Glucose Intolerance and Liver Fibrosis

ACS NANO, 14(6), 6878–6886.

By: L. Richter, Q. Wan, D. Wen n, Y. Zhang n, J. Yu, J. Kang, C. Zhu*, E. McKinnon* ...

author keywords: drug delivery; nanomedicine; Notch inhibitor; nonalcoholic steatohepatitis; obesity; liver fibrosis
MeSH headings : Animals; Diabetes Mellitus, Type 2 / pathology; Disease Models, Animal; Glucose Intolerance / drug therapy; Glucose Intolerance / pathology; Liver / pathology; Liver Cirrhosis / drug therapy; Liver Cirrhosis / pathology; Mice; Obesity / drug therapy
Source: Web Of Science
Added: July 20, 2020

2019 journal article

A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade

ADVANCED MATERIALS, 31(17).

author keywords: bioresponsive materials; drug delivery; epigenetic modulation; immune checkpoint blockade; immunotherapy
MeSH headings : Animals; Antibodies, Monoclonal / pharmacology; Antibodies, Monoclonal, Humanized; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / pharmacology; Calcium Carbonate / chemistry; Cell Line, Tumor; Cytidine / analogs & derivatives; Cytidine / pharmacology; Drug Delivery Systems / methods; Drug Liberation; Drug Therapy, Combination / methods; Humans; Hydrogen-Ion Concentration; Immunosuppressive Agents / chemistry; Immunosuppressive Agents / pharmacology; Immunotherapy / methods; Melanoma / drug therapy; Nanoparticles / chemistry; Programmed Cell Death 1 Receptor / metabolism; Reactive Oxygen Species / metabolism; Tumor Microenvironment / drug effects
Source: Web Of Science
Added: May 13, 2019

2019 journal article

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

ACS NANO, 13(4), 4354–4360.

By: G. Yang n, Q. Chen n, D. Wen n, Z. Chen n, J. Wang n, G. Chen n, Z. Wang*, X. Zhang n ...

author keywords: drug delivery; microneedle; exosome; keratin; hair regrowth; transdermal drug delivery
MeSH headings : Animals; Cell Line; Delayed-Action Preparations / chemistry; Drug Delivery Systems / instrumentation; Equipment Design; Hair / chemistry; Hair / drug effects; Hair / growth & development; Hair Follicle / drug effects; Hair Follicle / growth & development; Humans; Injections, Subcutaneous; Keratins / chemistry; Mice, Inbred C57BL; Transdermal Patch
Source: Web Of Science
Added: June 4, 2019

2019 journal article

A forskolin-conjugated insulin analog targeting endogenous glucose-transporter for glucose-responsive insulin delivery

BIOMATERIALS SCIENCE, 7(11), 4508–4513.

By: J. Wang*, Z. Wang*, J. Yu n, Y. Zhang n, Y. Zeng* & Z. Gu*

MeSH headings : Animals; Colforsin / administration & dosage; Colforsin / pharmacology; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Type 1 / drug therapy; Diabetes Mellitus, Type 1 / metabolism; Drug Delivery Systems; Glucose / metabolism; Glucose Tolerance Test; Glucose Transport Proteins, Facilitative / antagonists & inhibitors; Glucose Transport Proteins, Facilitative / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / pharmacology; Injections, Subcutaneous; Insulin / administration & dosage; Insulin / metabolism; Insulin / pharmacology; Mice
Source: Web Of Science
Added: December 16, 2019

2019 journal article

Adipocytes as Anticancer Drug Delivery Depot

MATTER, 1(5), 1203–1214.

By: D. Wen n, J. Wang n, G. Van Den Driessche n, Q. Chen n, Y. Zhang n, G. Chen n, H. Li*, J. Soto* ...

Source: Web Of Science
Added: April 6, 2020

2019 journal article

Advances in drug delivery for post-surgical cancer treatment

Biomaterials, 219, 119182.

By: L. Bu*, J. Yan, Z. Wang*, H. Ruan*, Q. Chen*, V. Gunadhi*, R. Bell*, Z. Gu*

author keywords: Drug delivery; Surgery; Local delivery; Cancer treatment; Immunotherapy
MeSH headings : Drug Delivery Systems / trends; Humans; Hydrogels / chemistry; Immunotherapy; Nanotechnology; Neoplasms / drug therapy; Neoplasms / surgery
Source: Crossref
Added: January 19, 2020

2019 review

Advances in transdermal insulin delivery

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 139, 51–70.

author keywords: Drug delivery; Transdermal delivery; Insulin; Diabetes; Iontophoresis; Electroporation; Ultrasound; Jet injection; Microneedle
MeSH headings : Administration, Cutaneous; Animals; Electroporation; Humans; Hypoglycemic Agents / administration & dosage; Insulin / administration & dosage; Iontophoresis; Microinjections; Needles; Ultrasonic Waves
Source: Web Of Science
Added: September 9, 2019

2019 journal article

Bioresponsive Protein Complex of aPD1 and aCD47 Antibodies for Enhanced Immunotherapy

NANO LETTERS, 19(8), 4879–4889.

author keywords: Drug delivery; immunotherapy; immune checkpoint blockade; bioresponsive; nanomedicine
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Antibodies, Monoclonal / therapeutic use; Antineoplastic Agents, Immunological / immunology; Antineoplastic Agents, Immunological / therapeutic use; CD47 Antigen / immunology; Female; Immunotherapy; Melanoma / immunology; Melanoma / therapy; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor / immunology; Reactive Oxygen Species / immunology; Tumor Microenvironment / drug effects
Source: Web Of Science
Added: September 3, 2019

2019 journal article

Cancer Stem Cell-Platelet Hybrid Membrane-Coated Magnetic Nanoparticles for Enhanced Photothermal Therapy of Head and Neck Squamous Cell Carcinoma

Advanced Functional Materials, 29(10), 1807733.

author keywords: cancer stem cell; hybrid mimic membrane; magnetic resonance imaging; photothermal therapy; platelet
Source: Crossref
Added: January 19, 2020

2019 journal article

Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs

SCIENCE ADVANCES, 5(7).

By: J. Wang n, J. Yu n, Y. Zhang n, X. Zhang*, A. Kahkoska*, G. Chen*, Z. Wang*, W. Sun* ...

MeSH headings : Animals; Blood Glucose / drug effects; Diabetes Mellitus, Experimental / drug therapy; Drug Carriers / chemical synthesis; Drug Carriers / chemistry; Drug Delivery Systems; Insulin / administration & dosage; Mice; Molecular Structure; Polymers / chemical synthesis; Polymers / chemistry; Swine
Source: Web Of Science
Added: August 19, 2019

2019 review

Cysteine-rich Proteins for Drug Delivery and Diagnosis

[Review of ]. CURRENT MEDICINAL CHEMISTRY, 26(8), 1377–1388.

By: G. Yang*, Y. Lu n, H. Bomba n & Z. Gu n

author keywords: Cysteine-rich protein; drug delivery; cancer diagnostics; protein-based nanoparticle; hydrogel; biomedical material
MeSH headings : Animals; Biocompatible Materials / chemistry; Cysteine / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / methods; Gold / chemistry; Humans; Hydrogels / chemistry; Nanocomposites / chemistry; Nanoparticles / chemistry; Nanotechnology / methods; Neoplasms / diagnosis; Neoplasms / drug therapy; Proteins / chemistry
Source: Web Of Science
Added: June 17, 2019

2019 journal article

Drug Delivery: A Dual‐Bioresponsive Drug‐Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade (Adv. Mater. 17/2019)

Advanced Materials, 31(17), 1970120.

Source: Crossref
Added: January 19, 2020

2019 journal article

Engineering Protein Delivery Depots for Cancer Immunotherapy

Bioconjugate Chemistry, 30(3), 515–524.

By: D. Wen*, G. Chen*, Q. Chen*, P. Li*, H. Cheng* & Z. Gu*

MeSH headings : Animals; Antibodies / administration & dosage; Antibodies / therapeutic use; Antigens / administration & dosage; Antigens / therapeutic use; Cancer Vaccines / administration & dosage; Cancer Vaccines / therapeutic use; Cytokines / administration & dosage; Cytokines / therapeutic use; Humans; Immunotherapy / methods; Neoplasms / therapy; Proteins / administration & dosage; Proteins / therapeutic use
Source: Crossref
Added: January 19, 2020

2019 journal article

Enhanced local cancer therapy using a CA4P and CDDP co-loaded polypeptide gel depot

BIOMATERIALS SCIENCE, 7(3), 860–866.

MeSH headings : Animals; Cell Line, Tumor; Cell Survival / drug effects; Cisplatin / chemistry; Cisplatin / metabolism; Cisplatin / therapeutic use; Cisplatin / toxicity; Colonic Neoplasms / drug therapy; Colonic Neoplasms / pathology; Drug Liberation; Female; Humans; Hydrogels / chemical synthesis; Hydrogels / chemistry; Mice, Inbred BALB C; Peptides / chemistry; Polymers / chemical synthesis; Polymers / chemistry; Stilbenes / chemistry; Stilbenes / metabolism; Stilbenes / therapeutic use; Stilbenes / toxicity; Transplantation, Heterologous; Tumor Microenvironment / drug effects
Source: Web Of Science
Added: April 22, 2019

2019 journal article

Extraction of Plant DNA by Microneedle Patch for Rapid Detection of Plant Diseases

ACS Nano, 13(6), 6540–6549.

By: R. Paul*, A. Saville*, J. Hansel*, Y. Ye n, C. Ball, A. Williams, X. Chang*, G. Chen n ...

author keywords: plant disease; DNA extraction; microneedle patch; Phytophthora infestans; nucleic acid amplification; point-of-care diagnostics
MeSH headings : DNA Barcoding, Taxonomic / instrumentation; DNA Barcoding, Taxonomic / methods; DNA, Fungal / chemistry; DNA, Fungal / genetics; Solanum lycopersicum / microbiology; Metagenomics / instrumentation; Metagenomics / methods; Needles; Phytophthora / genetics; Phytophthora / pathogenicity; Plant Diseases / microbiology; Plant Leaves / chemistry; Plant Leaves / microbiology
Sources: Web Of Science, ORCID, Crossref
Added: July 15, 2019

2019 journal article

Glucose transporter inhibitor-conjugated insulin mitigates hypoglycemia

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(22), 10744–10748.

By: J. Wang*, J. Yu n, Y. Zhang n, A. Kahkoska*, Z. Wang*, J. Fang*, J. Whitelegge*, S. Li*, J. Buse*, Z. Gu*

author keywords: drug delivery; diabetes; glucose-responsive; insulin; insulin analog
MeSH headings : Animals; Blood Glucose / analysis; Blood Glucose / drug effects; Diabetes Mellitus, Experimental; Drug Delivery Systems / methods; Glucose Transport Proteins, Facilitative / antagonists & inhibitors; Hyperglycemia / drug therapy; Hypoglycemia / prevention & control; Hypoglycemic Agents / chemistry; Hypoglycemic Agents / pharmacology; Insulin / analogs & derivatives; Insulin / chemistry; Insulin / pharmacology; Mice
Source: Web Of Science
Added: June 17, 2019

2019 journal article

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

NATURE NANOTECHNOLOGY, 14(1), 89-+.

By: Q. Chen n, C. Wang n, X. Zhang*, G. Chen*, Q. Hu n, H. Li*, J. Wang n, D. Wen* ...

MeSH headings : Animals; Biocompatible Materials / chemistry; Calcium Carbonate / chemistry; Female; Fibrin / chemistry; Gels / chemistry; Humans; Immunity; Immunotherapy / methods; Luminescent Measurements; Melanoma, Experimental / pathology; Mice, Inbred C57BL; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasm Recurrence, Local / pathology; Neoplasms / pathology; Neoplasms / surgery; Phagocytosis
Source: Web Of Science
Added: January 21, 2019

2019 journal article

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

ADVANCED MATERIALS, 31(23).

By: Q. Chen n, Q. Hu n, E. Dukhovlinova*, G. Chen*, S. Ahn*, C. Wang n, E. Ogunnaike n, F. Ligler n, G. Dotti*, Z. Gu n

author keywords: CAR T cells; cell therapy; drug delivery; immunotherapy; photothermal therapy
MeSH headings : Animals; Antigens / metabolism; Cell Line, Tumor; Chondroitin Sulfate Proteoglycans / metabolism; Combined Modality Therapy; Female; Heterografts; Humans; Hyperthermia, Induced; Immunotherapy, Adoptive / methods; Indocyanine Green / chemistry; Melanoma / pathology; Melanoma / therapy; Membrane Proteins / metabolism; Mice, SCID; Nanoparticles / chemistry; Photosensitizing Agents / chemistry; Phototherapy / methods; Polylactic Acid-Polyglycolic Acid Copolymer / chemistry; Proteoglycans / metabolism; Skin Neoplasms / pathology; Skin Neoplasms / therapy; T-Lymphocytes / metabolism; T-Lymphocytes / transplantation; Tumor Microenvironment
Source: Web Of Science
Added: July 22, 2019

2019 journal article

Platelet for drug delivery

Current Opinion in Biotechnology, 58, 81–91.

MeSH headings : Blood Platelets; Drug Delivery Systems; Hemostasis; Humans; Inflammation; Neoplasms
Source: Crossref
Added: January 19, 2020

2019 journal article

Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy

NANO RESEARCH, 12(6), 1313–1320.

By: J. Yan n, X. Zhang n, Y. Liu n, Y. Ye n, J. Yu n, Q. Chen n, J. Wang n, Y. Zhang n ...

author keywords: liquid metal; melanin nanoparticles; nanomedicine; shape-controlled synthesis; photothermal therapy
Source: Web Of Science
Added: June 17, 2019

2019 article

Topical and Transdermal Nanomedicines for Cancer Therapy

NANOTHERANOSTICS FOR CANCER APPLICATIONS, Vol. 5, pp. 231–251.

By: Y. Ye n, J. Wang n, W. Sun n, H. Bomba n & Z. Gu n

Source: Web Of Science
Added: October 26, 2020

2019 journal article

Topography‐Induced Cell Self‐Organization from Simple to Complex Aggregates

Small, 15(15), 1900030.

By: J. Luo*, J. Meng*, Z. Gu*, L. Wang*, F. Zhang* & S. Wang*

author keywords: cellular aggregate; intermolecular interaction; self-organization; topographic interaction
MeSH headings : Cell Aggregation / drug effects; Cell Line; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cell Shape / drug effects; Cell Survival / drug effects; Cells / drug effects; Cells / metabolism; Humans; Hydrogels / pharmacology; Microscopy, Fluorescence
Source: Crossref
Added: January 19, 2020

2018 journal article

Advances in bioresponsive closed-loop drug delivery systems

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 544(2), 350–357.

author keywords: Closed-loop; Drug delivery; Bioresponsive; Glucose-responsive; Enzyme-responsive
MeSH headings : Anticoagulants / administration & dosage; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Drug Delivery Systems / methods; Feedback, Physiological / drug effects; Homeostasis / drug effects; Humans; Hypoglycemic Agents / administration & dosage; Thrombosis / blood; Thrombosis / drug therapy
Source: Web Of Science
Added: August 6, 2018

2018 review

Advances in glycosylation-mediated cancer-targeted drug delivery

[Review of ]. DRUG DISCOVERY TODAY, 23(5), 1126–1138.

By: L. Cai n, Z. Gu*, J. Zhong*, D. Wen n, G. Chen n, L. He, J. Wu*, Z. Gu n

MeSH headings : Animals; Drug Delivery Systems; Glycosylation; Humans; Neoplasms / drug therapy
Source: Web Of Science
Added: August 6, 2018

2018 review

Advances in liquid metals for biomedical applications

[Review of ]. CHEMICAL SOCIETY REVIEWS, 47(8), 2518–2533.

By: J. Yan*, Y. Lu*, G. Chen*, M. Yang & Z. Gu*

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Biocompatible Materials / chemistry; Biocompatible Materials / toxicity; Biosensing Techniques / methods; Drug Carriers / chemistry; Drug Carriers / toxicity; Gallium / chemistry; Humans; Metals / chemistry; Microfluidics / instrumentation; Microfluidics / methods; Nanostructures / chemistry; Neoplasms / diagnosis; Neoplasms / drug therapy; Photosensitizing Agents / chemistry; Photosensitizing Agents / therapeutic use
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Advances in transformable drug delivery systems

BIOMATERIALS, 178, 546–558.

By: Q. Hu n, Q. Chen n & Z. Gu n

author keywords: Drug delivery; Stimuli-responsive; Cancer therapy; Transformable formulation
MeSH headings : Animals; Drug Delivery Systems / methods; Extracellular Space / chemistry; Humans; Intracellular Space / chemistry; Microbubbles; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasms / diagnosis; Neoplasms / pathology
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy

ACS NANO, 12(6), 5995–6005.

By: W. Chen*, Y. Wang*, M. Qin*, X. Zhang n, Z. Zhang*, X. Sun*, Z. Gu n

author keywords: salmonella; polydopamine; hypoxia targeting; photothermal therapy; malignant melanoma
MeSH headings : Animals; Antineoplastic Agents / adverse effects; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Cell Survival / drug effects; Hypoxia / metabolism; Indoles / adverse effects; Indoles / metabolism; Indoles / pharmacology; Lasers; Melanoma, Experimental / metabolism; Melanoma, Experimental / pathology; Melanoma, Experimental / therapy; Mice; Phototherapy; Polymers / adverse effects; Polymers / metabolism; Polymers / pharmacology; Salmonella / growth & development; Salmonella / metabolism; Tissue Distribution; Tumor Cells, Cultured
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Biodegradable Gelatin Methacryloyl Microneedles for Transdermal Drug Delivery

Advanced Healthcare Materials, 8(3), 1801054.

author keywords: gelatin methacryloyl; microneedle; sustained release; transdermal drug delivery
MeSH headings : Administration, Cutaneous; Animals; Biocompatible Materials / chemistry; Biocompatible Materials / pharmacology; Doxorubicin / chemistry; Doxorubicin / pharmacology; Gelatin / chemistry; Gelatin / pharmacology; Hydrogels / chemistry; Hydrogels / pharmacology; Melanoma, Experimental / drug therapy; Melanoma, Experimental / metabolism; Melanoma, Experimental / pathology; Mice; Needles; Skin Neoplasms / drug therapy; Skin Neoplasms / metabolism; Skin Neoplasms / pathology
Source: Crossref
Added: January 19, 2020

2018 journal article

Bioresponsive Microneedles with a Sheath Structure for H2O2 and pH Cascade-Triggered Insulin Delivery

SMALL, 14(14).

author keywords: diabetes; drug delivery; insulin; microneedles; stimuli-responsive
MeSH headings : Animals; Drug Delivery Systems / methods; Humans; Hydrogen Peroxide / chemistry; Hydrogen-Ion Concentration; Insulin / administration & dosage; Insulin / chemistry; Mice; Oxidation-Reduction
Source: Web Of Science
Added: August 6, 2018

2018 review

Blood sampling using microneedles as a minimally invasive platform for biomedical diagnostics

[Review of ]. APPLIED MATERIALS TODAY, 13, 144–157.

author keywords: Blood sampling; Microneedle; Minimally invasive; Hemotological analysis; Point-of-care test
Source: Web Of Science
Added: December 31, 2018

2018 journal article

Cancer Immunotherapy: PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy (Adv. Mater. 22/2018)

Advanced Materials, 30(22), 1870152.

By: X. Zhang n, C. Wang n, J. Wang n, Q. Hu n, B. Langworthy*, Y. Ye n, W. Sun n, J. Lin* ...

Source: Crossref
Added: December 19, 2020

2018 journal article

Cardiac cell-integrated microneedle patch for treating myocardial infarction

SCIENCE ADVANCES, 4(11).

By: J. Tang n, J. Wang n, K. Huang n, Y. Ye n, T. Su n, L. Qiao n, M. Hensley n, T. Caranasos* ...

MeSH headings : Animals; Cells, Cultured; Microtechnology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Needles; Rats; Rats, Inbred WKY; Regeneration; Stromal Cells / cytology; Stromal Cells / transplantation; Swine; Tissue Engineering / instrumentation
Sources: Web Of Science, ORCID
Added: December 31, 2018

2018 journal article

Cationic lipid-assisted nanoparticles for delivery of mRNA cancer vaccine

Biomaterials Science, 6(11), 3009–3018.

MeSH headings : Animals; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / immunology; Cancer Vaccines / chemistry; Cancer Vaccines / genetics; Cancer Vaccines / immunology; Cell Line; Dendritic Cells / cytology; Dendritic Cells / immunology; Drug Carriers / chemistry; Lipids / chemistry; Lymphoma / pathology; Lymphoma / prevention & control; Mice; Mice, Inbred C57BL; Nanoparticles / chemistry; RNA, Messenger / chemistry; RNA, Messenger / genetics; RNA, Messenger / immunology
Source: Crossref
Added: January 19, 2020

2018 review

Cellular Bioparticulates with Therapeutics for Cancer Immunotherapy

[Review of ]. BIOCONJUGATE CHEMISTRY, 29(3), 702–708.

By: C. Wang n, D. Wen n & Z. Gu n

MeSH headings : Animals; Antigen-Presenting Cells / cytology; Antigen-Presenting Cells / immunology; Blood Platelets / cytology; Blood Platelets / immunology; Cell Engineering / methods; Drug Delivery Systems / methods; Erythrocytes / cytology; Erythrocytes / immunology; Humans; Immunologic Factors / administration & dosage; Immunologic Factors / immunology; Immunologic Factors / therapeutic use; Immunotherapy / methods; Microbiota; Neoplasms / immunology; Neoplasms / microbiology; Neoplasms / therapy; T-Lymphocytes / cytology; T-Lymphocytes / immunology
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

NATURE BIOMEDICAL ENGINEERING, 2(11), 831–840.

By: Q. Hu n, W. Sun*, J. Wang n, H. Ruan n, X. Zhang*, Y. Ye n, S. Shen*, C. Wang n ...

MeSH headings : Animals; Antibodies / chemistry; Antibodies / immunology; Blood Platelets / chemistry; Blood Platelets / cytology; Blood Platelets / metabolism; Cell Line, Tumor; Chemokines / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / chemistry; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / metabolism; Leukemia / therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Receptor / deficiency; Programmed Cell Death 1 Receptor / genetics; Programmed Cell Death 1 Receptor / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology; T-Lymphocytes / metabolism
Source: Web Of Science
Added: November 26, 2018

2018 journal article

Core–Shell Microneedle Gel for Self-Regulated Insulin Delivery

ACS Nano, 12(3), 2466–2473.

By: J. Wang n, Y. Ye n, J. Yu n, A. Kahkoska*, X. Zhang n, C. Wang n, W. Sun n, R. Corder n ...

MeSH headings : Animals; Blood Glucose / analysis; Blood Glucose / metabolism; Delayed-Action Preparations / metabolism; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Diabetes Mellitus, Type 1 / metabolism; Drug Delivery Systems / instrumentation; Enzymes, Immobilized / metabolism; Equipment Design; Humans; Hydrogels / metabolism; Hydrogen Peroxide / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / therapeutic use; Insulin / administration & dosage; Insulin / therapeutic use; Male; Mice; Mice, Inbred C57BL; Needles; Transdermal Patch
Source: Crossref
Added: January 19, 2020

2018 journal article

Delivery Strategies for Immune Checkpoint Blockade

ADVANCED HEALTHCARE MATERIALS, 7(20).

By: Q. Chen n, C. Wang n, G. Chen n, Q. Hu n & Z. Gu n

author keywords: biomaterials; cancer therapy; drug delivery; immune checkpoint blockade; immunotherapy
MeSH headings : Autoimmune Diseases / immunology; Autoimmune Diseases / therapy; Humans; Immunotherapy / methods; Neoplasms / immunology; Neoplasms / therapy
Source: Web Of Science
Added: November 19, 2018

2018 journal article

Drug-Bearing Supramolecular MMP Inhibitor Nanofibers for Inhibition of Metastasis and Growth of Liver Cancer

Advanced Science, 5(8), 1700867.

By: Y. Ji*, Y. Xiao*, L. Xu*, J. He*, C. Qian*, W. Li*, L. Wu*, R. Chen* ...

author keywords: doxorubicin; liver cancer; metastasis; matrix metalloproteinase (MMP) inhibitor; peptide drug conjugates
Source: Crossref
Added: December 19, 2020

2018 journal article

Engineering PD-1-Presenting Platelets for Cancer Immunotherapy

NANO LETTERS, 18(9), 5716–5725.

By: X. Zhang n, J. Wang n, Z. Chen n, Q. Hu n, C. Wang n, J. Yan n, G. Dotti*, P. Huang*, Z. Gu n

author keywords: Drug delivery; platelet; immune checkpoint blockade; immunotherapy; nanomedicine
Source: Web Of Science
Added: October 16, 2018

2018 article

Glucose-responsive insulin by molecular and physical design (vol 9, pg 937, 2017)

Bakh, N. A., Cortinas, A. B., Weiss, M. A., Langer, R. S., Anderson, D. G., Gu, Z., … Strano, M. S. (2018, January). NATURE CHEMISTRY, Vol. 10, pp. 109–109.

By: N. Bakh, A. Cortinas, M. Weiss, R. Langer, D. Anderson, Z. Gu*, S. Dutta, M. Strano

Source: Web Of Science
Added: August 6, 2018

2018 journal article

Glucose-responsive oral insulin delivery for postprandial glycemic regulation

Nano Research, 12(7), 1539–1545.

author keywords: diabetes; drug delivery; glucose-responsive; insulin; nanomedicine
Source: Crossref
Added: January 19, 2020

2018 journal article

Hierarchical Nanoassemblies-Assisted Combinational Delivery of Cytotoxic Protein and Antibiotic for Cancer Treatment

NANO LETTERS, 18(4), 2294–2303.

By: M. Liu, S. Shen*, D. Wen n, M. Li*, T. Li*, X. Chen*, Z. Gu n, R. Mo*

author keywords: Drug delivery; protein therapy; radical polymerization; cancer stem-like cells; combination cancer therapy
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Breast Neoplasms / drug therapy; Breast Neoplasms / pathology; Cell Line, Tumor; Cell Survival / drug effects; Delayed-Action Preparations / chemistry; Doxycycline / administration & dosage; Doxycycline / pharmacokinetics; Doxycycline / pharmacology; Doxycycline / therapeutic use; Drug Delivery Systems; Female; Humans; Mice; Nanostructures / chemistry; Neoplastic Stem Cells / drug effects; Ribonuclease, Pancreatic / administration & dosage; Ribonuclease, Pancreatic / pharmacokinetics; Ribonuclease, Pancreatic / pharmacology; Ribonuclease, Pancreatic / therapeutic use
Source: Web Of Science
Added: August 6, 2018

2018 journal article

In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

SCIENCE TRANSLATIONAL MEDICINE, 10(429).

By: C. Wang n, J. Wang n, X. Zhang n, S. Yu n, D. Wen n, Q. Hu n, Y. Ye n, H. Bomba n ...

MeSH headings : Animals; Cell Line, Tumor; Combined Modality Therapy; Deoxycytidine / analogs & derivatives; Deoxycytidine / therapeutic use; Female; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Immunotherapy / methods; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor / metabolism; Gemcitabine
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade

Advanced Materials, 30(28), 1801527.

By: S. Yu n, C. Wang n, J. Yu n, J. Wang n, Y. Lu n, Y. Zhang n, X. Zhang n, Q. Hu n ...

author keywords: checkpoint blockade; drug delivery; hydrogel; immunotherapy; stimuli responsive
MeSH headings : Gels; Humans; Immunotherapy; Melanoma; Tumor Microenvironment
Source: Crossref
Added: December 19, 2020

2018 journal article

Leverage physiology for precision medications

Nanomedicine: Nanotechnology, Biology and Medicine, 14(5), 1883–1884.

By: Z. Gu n

Source: Crossref
Added: January 19, 2020

2018 review

Leveraging Engineering of Cells for Drug Delivery

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 51(3), 668–677.

By: Z. Chen n, Q. Hu n & Z. Gu n

MeSH headings : Animals; Cell Engineering; Drug Delivery Systems; Humans
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Local generation of hydrogen for enhanced photothermal therapy

Nature Communications, 9(1).

By: P. Zhao*, Z. Jin*, Q. Chen n, T. Yang*, D. Chen*, J. Meng*, X. Lu*, Z. Gu n, Q. He*

MeSH headings : Catalysis; Hydrogen / chemistry; Nanoparticles / chemistry; Nanostructures / chemistry; Photoacoustic Techniques; Phototherapy / methods; Spectroscopy, Near-Infrared
Source: Crossref
Added: January 19, 2020

2018 journal article

Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles

ACS NANO, 12(2), 994–1005.

author keywords: CRISPR/Cas9; specific gene editing; nanomedicine; specific promoter; type 2 diabetes
MeSH headings : Animals; CRISPR-Cas Systems / genetics; Cations / chemistry; Cells, Cultured; Diabetes Mellitus, Experimental / chemically induced; Diabetes Mellitus, Experimental / genetics; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Type 2 / chemically induced; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / metabolism; Diet, High-Fat; Gene Editing; HEK293 Cells; Humans; Lipids / chemistry; Macrophages / chemistry; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Nanoparticles / chemistry; Netrin-1 / genetics; Netrin-1 / metabolism; Polymers / chemistry; RAW 264.7 Cells
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Nanomedicine for obesity treatment

Science China Life Sciences, 61(4), 373–379.

author keywords: drug delivery; nanomedicine; obesity; browning; fat absorption; energy expenditure
MeSH headings : Anti-Obesity Agents / pharmacology; Anti-Obesity Agents / therapeutic use; Drug Delivery Systems / trends; Energy Metabolism / drug effects; Humans; Models, Biological; Nanomedicine; Obesity / drug therapy; Obesity / metabolism
Source: Crossref
Added: January 19, 2020

2018 journal article

PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy

ADVANCED MATERIALS, 30(22).

By: X. Zhang n, C. Wang n, J. Wang n, Q. Hu n, B. Langworthy*, Y. Ye n, W. Sun n, J. Lin* ...

author keywords: cancer immunotherapy; cell therapy; drug delivery; immune checkpoint blockade; nanomedicine
MeSH headings : Humans; Immunotherapy; Lymphocytes, Tumor-Infiltrating; Neoplasms / therapy; Programmed Cell Death 1 Receptor; T-Lymphocytes; Tumor Microenvironment
Source: Web Of Science
Added: August 6, 2018

2018 journal article

PDT-Driven Highly Efficient Intracellular Delivery and Controlled Release of CO in Combination with Sufficient Singlet Oxygen Production for Synergistic Anticancer Therapy

Advanced Functional Materials, 28(41), 1804324.

author keywords: carbon monoxide; combination therapy; nanogels; peptide dendrimers; photodynamic therapy
Source: Crossref
Added: January 19, 2020

2018 review

Polymeric microneedles for transdermal protein delivery

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 127, 106–118.

By: Y. Ye, J. Yu, D. Wen*, A. Kahkoska* & Z. Gu n

author keywords: Drug delivery; Transdermal; Microneedle; Protein delivery; Vaccine
MeSH headings : Administration, Cutaneous; Drug Delivery Systems; Humans; Microinjections; Needles; Polymers / chemistry; Proteins / administration & dosage; Proteins / metabolism; Proteins / pharmacokinetics; Skin / metabolism
Source: Web Of Science
Added: August 6, 2018

2018 journal article

ROS-Responsive Microneedle Patch for Acne Vulgaris Treatment

Advanced Therapeutics, 1(3), 1800035.

author keywords: acne vulgaris; drug delivery; microneedle patch; stimuli responsive
Source: Crossref
Added: December 19, 2020

2018 journal article

ROS-Responsive Microneedle Patch for Acne Vulgaris Treatment (Adv. Therap. 3/2018)

Advanced Therapeutics, 1(3), 1870006.

By: Y. Zhang, P. Feng, J. Yu, J. Yang, J. Zhao, J. Wang, Q. Shen, Z. Gu*

Source: Crossref
Added: December 19, 2020

2018 journal article

Strategies of Combination Drug Delivery for Immune Checkpoint Blockades

Advanced Healthcare Materials, 1801099.

author keywords: cancer immunity circles; cancer immunotherapy; combination delivery; drug delivery; immune checkpoint blockades
MeSH headings : Animals; Antigens, Neoplasm / immunology; Antigens, Neoplasm / therapeutic use; Drug Delivery Systems; Humans; Immunotherapy; Lymphocyte Activation / drug effects; Neoplasms / immunology; Neoplasms / pathology; Neoplasms / therapy; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Cytotoxic / pathology
Source: Crossref
Added: January 19, 2020

2018 journal article

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

NATURE BIOMEDICAL ENGINEERING, 2(1), 17–26.

By: J. Tang n, T. Su n, K. Huang, P. Dinh n, Z. Wang*, A. Vandergriff n, M. Hensley n, J. Cores n ...

Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

Nature Communications, 9(1).

By: C. Xu*, Z. Lu*, Y. Luo*, Y. Liu*, Z. Cao*, S. Shen*, H. Li*, J. Liu* ...

MeSH headings : Amino Acid Sequence; Animals; Apoptosis Regulatory Proteins / metabolism; CRISPR-Cas Systems; Calcium-Binding Proteins / metabolism; Caspase Activation and Recruitment Domain; Female; Gene Editing; Genetic Therapy; Inflammasomes / genetics; Inflammation / therapy; Male; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Peritonitis / immunology; Protein Conformation
Source: Crossref
Added: January 19, 2020

2018 article

The potential of a microneedle patch for reducing obesity

EXPERT OPINION ON DRUG DELIVERY, Vol. 15, pp. 431–433.

By: Y. Zhang n, J. Yu n, D. Wen n, G. Chen n & Z. Gu n

author keywords: Obesity; browning; microneedle; intradermal delivery
Source: Web Of Science
Added: August 6, 2018

2018 article

Towards Enhancing Skin Drug Delivery

Gu, Z., & Chen, X. (2018, March 1). ADVANCED DRUG DELIVERY REVIEWS, Vol. 127, pp. 1–2.

By: Z. Gu* & X. Chen*

MeSH headings : Administration, Cutaneous; Animals; Drug Delivery Systems; Humans; Skin / metabolism
Source: Web Of Science
Added: August 6, 2018

2017 journal article

A melanin-mediated cancer immunotherapy patch

SCIENCE IMMUNOLOGY, 2(17).

By: Y. Ye n, C. Wang n, X. Zhang n, Q. Hu n, Y. Zhang n, Q. Liu n, D. Wen n, J. Milligan n ...

MeSH headings : Animals; Cancer Vaccines / immunology; Cancer Vaccines / metabolism; Cell Line, Tumor; Dendritic Cells / immunology; Dendritic Cells / metabolism; Female; Immunotherapy / instrumentation; Immunotherapy / methods; Infrared Rays; Kaplan-Meier Estimate; Melanins / immunology; Melanins / metabolism; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Needles; Neoplasms, Experimental / immunology; Neoplasms, Experimental / pathology; Neoplasms, Experimental / therapy; Transdermal Patch; Tumor Burden / immunology
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Anaerobe-Inspired Anticancer Nanovesicles

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(10), 2588–2593.

By: C. Qian n, P. Feng*, J. Yu n, Y. Chen*, Q. Hu n, W. Sun n, X. Xiao*, X. Hu n ...

author keywords: drug delivery; nanomedicines; photodynamic therapy
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Cell Death / drug effects; Cell Proliferation / drug effects; Clostridium / chemistry; Clostridium / metabolism; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Hypoxia / metabolism; Imidazoles / chemistry; Imidazoles / pharmacology; Nanoparticles / chemistry; Prodrugs / chemistry; Prodrugs / pharmacology; Salmonella / chemistry; Salmonella / metabolism; Tirapazamine / chemistry; Tirapazamine / pharmacology
Source: Web Of Science
Added: August 6, 2018

2017 review

Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs

[Review of ]. THERANOSTICS, 7(14), 3504–3516.

By: C. Wang*, W. Sun*, Y. Ye*, H. Bomba & Z. Gu*

author keywords: artificial immune cells; lymphoid organs
MeSH headings : Animals; Antigen-Presenting Cells / immunology; Artificial Cells / chemistry; Artificial Cells / immunology; Biomimetic Materials / chemistry; Humans; Lymphoid Tissue / cytology; Lymphoid Tissue / immunology
Source: Web Of Science
Added: August 6, 2018

2017 review

Bioresponsive materials

[Review of ]. NATURE REVIEWS MATERIALS, 2(1).

By: Y. Lu n, A. Aimetti*, R. Langer* & Z. Gu n

Source: Web Of Science
Added: August 6, 2018

2017 review

Bioresponsive transcutaneous patches

[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 48, 28–32.

By: J. Yu*, Y. Zhang*, A. Kahkoska* & Z. Gu*

MeSH headings : Administration, Cutaneous; Animals; Drug Delivery Systems / methods; Drug Monitoring / methods; Humans; Needles; Skin; Transdermal Patch
Source: Web Of Science
Added: August 6, 2018

2017 review

Conjugated polymer nanomaterials for theranostics

[Review of ]. ACTA PHARMACOLOGICA SINICA, 38(6), 764–781.

author keywords: conjugated polymer; theranostics; biomedical imaging; photodynamic therapy; photothermal therapy; stimuli; responsive drug delivery
MeSH headings : Drug Delivery Systems; Nanostructures / chemistry; Photochemotherapy; Polymers / chemistry; Theranostic Nanomedicine
Source: Web Of Science
Added: August 6, 2018

2017 review

Engineering platelet-mimicking drug delivery vehicles

[Review of ]. FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING, 11(4), 624–632.

By: Q. Hu n, H. Bomba n & Z. Gu n

author keywords: drug delivery; platelets; nanomedicine; bio-inspired; biomimetic
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species

NANO LETTERS, 17(2), 928–937.

By: P. Ma*, H. Xiao*, C. Yu*, J. Liu*, Z. Cheng*, H. Song*, X. Zhang*, C. Li* ...

author keywords: Drug delivery; cisplatin; iron oxide; Fenton's reaction; reactive oxygen species
MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Cell Line, Tumor; Cell Survival; Cisplatin / chemistry; Cisplatin / pharmacology; Cisplatin / therapeutic use; Drug Carriers; Drug Liberation; Electromagnetic Fields; Ferric Compounds / chemistry; Humans; Liver Neoplasms / diagnostic imaging; Liver Neoplasms / drug therapy; Metal Nanoparticles / chemistry; Mice, Inbred BALB C; Oxidation-Reduction; Particle Size; Reactive Oxygen Species / metabolism; Surface Properties; Tissue Distribution
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Enhanced Endosomal Escape by Light-Fueled Liquid-Metal Transformer

NANO LETTERS, 17(4), 2138–2145.

By: Y. Lu n, Y. Lin n, Z. Chen n, Q. Hu n, Y. Liu n, S. Yu n, W. Gao n, M. Dickey n, Z. Gu n

author keywords: Drug delivery; liquid metal; stimuli-responsive; morphological transformation; endosomal escape
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Glucose-responsive insulin by molecular and physical design

NATURE CHEMISTRY, 9(10), 937–943.

By: N. Bakh*, A. Cortinas*, M. Weiss*, R. Langer*, D. Anderson*, Z. Gu n, S. Dutta*, M. Strano*

MeSH headings : Diabetes Mellitus / drug therapy; Diabetes Mellitus / metabolism; Glucose / metabolism; Humans; Insulin / metabolism; Insulin / therapeutic use; Models, Biological
Source: Web Of Science
Added: August 6, 2018

2017 journal article

H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery

ACS NANO, 11(1), 613–620.

By: X. Hu n, J. Yu n, C. Qian n, Y. Lu n, A. Kahkoska*, Z. Xie*, X. Jing*, J. Buse*, Z. Gu n

author keywords: drug delivery; vesicles; polymersome; glucose-responsive; insulin; diabetes
MeSH headings : Animals; Diabetes Mellitus, Experimental / chemically induced; Diabetes Mellitus, Experimental / drug therapy; Drug Carriers / chemical synthesis; Drug Carriers / chemistry; Drug Delivery Systems / methods; Glucose / analysis; Glucose / metabolism; Glucose Oxidase / metabolism; Hydrogen Peroxide / chemistry; Hypoglycemia / drug therapy; Insulin / administration & dosage; Insulin / chemistry; Insulin / pharmacology; Kinetics; Male; Mice; Mice, Inbred C57BL; Polymers / chemical synthesis; Polymers / chemistry; Streptozocin; Transdermal Patch
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery

NANO LETTERS, 17(2), 733–739.

author keywords: Drug delivery; diabetes; insulin; glucose-responsive; hypoxia-sensitive; H2O2-sensitive
MeSH headings : Animals; Blood Glucose / metabolism; Cell Hypoxia; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Type 1 / drug therapy; Diabetes Mellitus, Type 1 / metabolism; Drug Carriers / chemistry; Drug Liberation; Glucose / metabolism; Glucose Oxidase / metabolism; HeLa Cells; Humans; Hydrogen Peroxide / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / chemistry; Insulin / administration & dosage; Insulin / chemistry; Male; Mice, Inbred C57BL; Nitroimidazoles / chemistry; Oxidation-Reduction; Peptides / chemistry; Polyethylene Glycols / chemistry
Source: Web Of Science
Added: August 6, 2018

2017 journal article

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

Nature Biomedical Engineering, 1(2).

By: C. Wang n, W. Sun n, Y. Ye n, Q. Hu n, H. Bomba n & Z. Gu n

Source: Crossref
Added: December 19, 2020

2017 journal article

Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody

Advanced Materials, 29(15).

By: C. Wang, W. Sun, G. Wright, A. Wang & Z. Gu*

Source: Crossref
Added: December 19, 2020

2017 journal article

Injectable Thermosensitive Polypeptide-Based CDDP-Complexed Hydrogel for Improving Localized Antitumor Efficacy

Biomacromolecules, 18(12), 4341–4348.

By: S. Yu n, D. Zhang*, C. He*, W. Sun n, R. Cao*, S. Cui*, M. Deng*, Z. Gu n, X. Chen*

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Biocompatible Materials / chemistry; Biodegradable Plastics / chemistry; Cell Line, Tumor; Cisplatin / chemistry; Cisplatin / pharmacology; Drug Carriers / chemistry; Female; Glutamic Acid / chemistry; HeLa Cells; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Injections / methods; MCF-7 Cells; Mice; Mice, Inbred BALB C; Peptides / chemistry; Polyethylene Glycols / chemistry; Rats; Rats, Sprague-Dawley
Source: Crossref
Added: December 19, 2020

2017 journal article

Inside Cover: Anaerobe-Inspired Anticancer Nanovesicles (Angew. Chem. Int. Ed. 10/2017)

Angewandte Chemie International Edition, 56(10), 2516–2516.

By: C. Qian n, P. Feng*, J. Yu n, Y. Chen*, Q. Hu n, W. Sun n, X. Xiao*, X. Hu n ...

Source: Crossref
Added: December 19, 2020

2017 journal article

Insulin-Responsive Glucagon Delivery for Prevention of Hypoglycemia

Small, 13(19), 1603028.

MeSH headings : Animals; Blood Glucose / metabolism; Glucagon / metabolism; Humans; Hypoglycemia / metabolism; Insulin / therapeutic use; Mice
Source: Crossref
Added: December 19, 2020

2017 journal article

Insulin-responsive glucagon delivery for prevention of hypoglycemia

Small (Weinheim An Der Bergstrasse, Germany), 13(19).

By: J. Yu n, Y. Zhang n, W. Sun n, A. Kahkoska*, J. Wang n, J. Buse*, Z. Gu n

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Investigation and intervention of autophagy to guide cancer treatment with nanogels

NANOSCALE, 9(1), 150–163.

By: X. Zhang n, X. Liang*, J. Gu*, D. Chang*, J. Zhang*, Z. Chen n, Y. Ye n, C. Wang n ...

MeSH headings : Animals; Autophagy; Chloroquine / administration & dosage; Doxorubicin / administration & dosage; Drug Delivery Systems; Endocytosis; Endosomes; Exocytosis; Female; Gels; Humans; MCF-7 Cells; Mice; Mice, SCID; Nanoparticles; Neoplasms, Experimental / drug therapy; Rhodamines; Xenograft Model Antitumor Assays; rab GTP-Binding Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2017 article

KIDNEY PHYSIOLOGYA size bandpass filter

Lu, Y., & Gu, Z. (2017, November). NATURE NANOTECHNOLOGY, Vol. 12, pp. 1023–1025.

By: Y. Lu* & Z. Gu*

MeSH headings : Animals; Glomerular Filtration Rate; Humans; Kidney Glomerulus / metabolism; Nanoparticles; Particle Size
Source: Web Of Science
Added: August 6, 2018

2017 journal article

KO of 5-InsP(7) kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(45), 11968–11973.

By: C. Gu*, H. Nguyen*, D. Ganini*, Z. Chen n, H. Jessen*, Z. Gu n, H. Wang*, S. Shears*

author keywords: bioenergetics; signaling; inositol pyrophosphates
MeSH headings : Adenosine Triphosphate / metabolism; CRISPR-Cas Systems; Cell Line, Tumor; Colonic Neoplasms / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / biosynthesis; G1 Phase Cell Cycle Checkpoints / genetics; Gene Knockout Techniques; Glycolysis / genetics; Glycolysis / physiology; HCT116 Cells; HEK293 Cells; Humans; Inositol Phosphates / metabolism; Mitochondria / metabolism; Phosphotransferases (Phosphate Group Acceptor) / genetics; Phosphotransferases (Phosphate Group Acceptor) / metabolism; Signal Transduction; Tumor Suppressor Protein p53 / biosynthesis
Source: Web Of Science
Added: August 6, 2018

2017 review

LEVERAGING PHYSIOLOGY FOR PRECISION DRUG DELIVERY

[Review of ]. PHYSIOLOGICAL REVIEWS, 97(1), 189–225.

By: W. Sun n, Q. Hu n, W. Ji n, G. Wright n & Z. Gu n

Source: Web Of Science
Added: August 6, 2018

2017 journal article

Leveraging H2O2Levels for Biomedical Applications

Advanced Biosystems, 1(9), 1700084.

By: J. Wang n, Y. Zhang n, E. Archibong n, F. Ligler n & Z. Gu n

author keywords: diagnosis; drug delivery; H2O2-responsive; oxidation-responsive; polymers
Source: Crossref
Added: November 30, 2020

2017 journal article

Local delivery of checkpoints antibodies

HUMAN VACCINES & IMMUNOTHERAPEUTICS, 13(1), 245–248.

By: C. Wang n, Y. Ye* & Z. Gu*

author keywords: biomaterials; cancer immunotherapy; drug delivery; immune checkpoint inhibitors; microneedle
MeSH headings : Antibodies / administration & dosage; Biomedical Research / trends; Humans; Immunologic Factors / administration & dosage; Immunotherapy / methods; Molecular Targeted Therapy / methods; Neoplasms / immunology; Neoplasms / therapy
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment

ACS NANO, 11(9), 9223–9230.

By: Y. Zhang n, Q. Liu*, J. Yu n, S. Yu n, J. Wang n, L. Qiang*, Z. Gu n

author keywords: drug delivery; microneedle patch; obesity; browning agent; adipose tissue
MeSH headings : Adipocytes, White / drug effects; Adipose Tissue, White / drug effects; Animals; Anti-Obesity Agents / administration & dosage; Anti-Obesity Agents / therapeutic use; Drug Delivery Systems / instrumentation; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / therapeutic use; Male; Mice, Inbred C57BL; Obesity / drug therapy; Rosiglitazone / administration & dosage; Rosiglitazone / therapeutic use; Transdermal Patch
Source: Web Of Science
Added: August 6, 2018

2017 review

Photoacoustic Drug Delivery

[Review of ]. SENSORS, 17(6).

By: Y. Zhang n, J. Yu n, A. Kahkoska* & Z. Gu n

author keywords: photoacoustic imaging; drug delivery; chemotherapy; photothermal therapy
MeSH headings : Drug Delivery Systems; Humans; Optical Imaging; Photoacoustic Techniques; Spectrum Analysis; Theranostic Nanomedicine
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Red Blood Cells for Drug Delivery

Small Methods, 1(12), 1700270.

author keywords: interface engineering; layer-by-layer assembly; multilayer thin films; optoelectronic devices
Source: Crossref
Added: December 19, 2020

2017 journal article

Red Blood Cells for Glucose-Responsive Insulin Delivery

ADVANCED MATERIALS, 29(18).

MeSH headings : Erythrocytes; Glucose; Insulin
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy

ADVANCED MATERIALS, 29(13).

By: Q. Hu n, W. Sun n, C. Qian n, H. Bomba n, H. Xin n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Biomimetic Materials / chemistry; Blood Vessels / drug effects; Blood Vessels / metabolism; Cell Line, Tumor; Cell Survival / drug effects; Cells, Cultured; Dextrans / chemistry; Drug Delivery Systems; Human Umbilical Vein Endothelial Cells / drug effects; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Mice, Nude; Microtubules / enzymology; Microtubules / metabolism; Nanostructures / chemistry; Neoplasm Transplantation; Neoplasms / blood supply; Neoplasms / drug therapy; Neoplasms / metabolism; Oligopeptides / chemistry; Paclitaxel / administration & dosage; Paclitaxel / pharmacokinetics; Tumor Necrosis Factor-alpha / chemistry; Tumor Necrosis Factor-alpha / pharmacokinetics
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Smart materials and systems as artificial pancreas for diabetes treatment

Smart Materials for Tissue Engineering: Applications, 25, 358–381.

By: Y. Zhang, M. Wang, J. Yu & Z. Gu

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Stimuli-Responsive Polymersomes for Biomedical Applications

BIOMACROMOLECULES, 18(3), 649–673.

MeSH headings : Biomimetic Materials / chemistry; Diagnostic Imaging; Drug Carriers / chemistry; Drug Delivery Systems; Hydrogen-Ion Concentration; Membranes, Artificial; Nanoparticles / chemistry; Polymers / chemistry; Reactive Oxygen Species / metabolism
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Synthetic beta cells for fusion-mediated dynamic insulin secretion

Nature Chemical Biology, 14(1), 86–93.

MeSH headings : Animals; Artificial Cells; Biomimetic Materials / chemistry; Blood Glucose / analysis; Cell Engineering / methods; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Hydrogen-Ion Concentration; Insulin / blood; Insulin / metabolism; Insulin Secretion; Insulin-Secreting Cells / metabolism; Male; Membrane Fusion; Mice, Inbred C57BL
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

ADVANCED MATERIALS, 29(29).

By: C. Wang n, Y. Ye n, Q. Hu n, A. Bellotti n & Z. Gu n

author keywords: biomaterials; cancer immunotherapy; cell therapy; drug delivery
MeSH headings : Animals; Antigen-Presenting Cells / cytology; Antigen-Presenting Cells / metabolism; Antigens / genetics; Antigens / immunology; Antigens / metabolism; Biocompatible Materials / chemistry; Cell- and Tissue-Based Therapy; Humans; Immunologic Factors / metabolism; Immunologic Factors / therapeutic use; Immunotherapy; Nanostructures / chemistry; Neoplasms / therapy
Source: Web Of Science
Added: August 6, 2018

2017 review

Tailoring non-viral delivery vehicles for transporting genome-editing tools

[Review of ]. Science China-Materials, 60(6), 511–515.

By: W. Sun n & Z. Gu n

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Thrombin-responsive transcutaneous patch for auto-anticoagulant regulation

Advanced Materials, 29(4).

By: Y. Zhang n, J. Yu n, J. Wang n, N. Hanne n, Z. Cui n, C. Qian n, C. Wang n, H. Xin n ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules

Nano Research, 10(4), 1393–1402.

By: J. Di n, J. Yu n, Q. Wang*, S. Yao n, D. Suo n, Y. Ye n, M. Pless n, Y. Zhu n, Y. Jing n, Z. Gu n

author keywords: controlled drug delivery; focused ultrasound; diabetes; nanocapsule; microgel
Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 article

ATP-Responsive Drug Delivery Systems

Sun, W., & Gu, Z. (2016, March 3). EXPERT OPINION ON DRUG DELIVERY, Vol. 13, pp. 311–314.

By: W. Sun n & Z. Gu*

MeSH headings : Adenosine Triphosphate / metabolism; Drug Carriers / chemistry; Drug Delivery Systems; Humans
Source: Web Of Science
Added: August 6, 2018

2016 journal article

ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging

THERANOSTICS, 6(7), 1053–1064.

By: C. Qian*, Y. Chen*, S. Zhu*, J. Yu*, L. Zhang*, P. Feng*, X. Tang*, Q. Hu* ...

author keywords: drug delivery; nanomedicine; stimuli-responsive; ATP-responsive; theranostics; conjugated polymers
MeSH headings : Adenosine Triphosphate / metabolism; Antineoplastic Agents / administration & dosage; Boronic Acids / metabolism; Doxorubicin / administration & dosage; Drug Carriers / administration & dosage; Hep G2 Cells; Humans; Liver Neoplasms / diagnostic imaging; Liver Neoplasms / drug therapy; Nanoparticles / administration & dosage; Optical Imaging / methods; Theranostic Nanomedicine / methods
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Anticancer Therapy: Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy (Adv. Mater. 17/2016)

Advanced Materials, 28(17), 3226–3226.

Source: Crossref
Added: April 3, 2022

2016 conference paper

Cell membrane-mediated anticancer drug delivery

Nanotechnology: delivering on the promise, vol 2, 1224, 197–211.

By: Q. Hu & Z. Gu

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Drug Delivery: Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery (Adv. Mater. 16/2016)

Advanced Materials, 28(16), 3223–3223.

By: Y. Ye n, J. Yu n, C. Wang n, N. Nguyen n, G. Walker n, J. Buse*, Z. Gu n

Source: Crossref
Added: December 17, 2020

2016 journal article

Dual targeted nanocarrier for brain ischemic stroke treatment

JOURNAL OF CONTROLLED RELEASE, 233, 64–71.

By: Y. Zhao*, Y. Jiang*, W. Lv*, Z. Wang*, L. Lv*, B. Wang*, X. Liu*, Y. Liu* ...

author keywords: Stroke; Stroke homing peptide; Dual-targeting liposomes; ZL006; Neuroprotection
Source: Web Of Science
Added: August 6, 2018

2016 article

Elastic drug delivery: could treatments be triggered by patient movement?

NANOMEDICINE, Vol. 11, pp. 323–325.

By: Y. Zhang n, J. Yu n, Y. Zhu n & Z. Gu n

author keywords: drug delivery; mechanical-responsive; nanoparticle; wearable devices
MeSH headings : Drug Delivery Systems; Elasticity; Humans; Movement; Patients
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus

ADVANCED MATERIALS, 28(43), 9573-+.

By: Q. Hu n, C. Qian n, W. Sun n, J. Wang n, Z. Chen n, H. Bomba n, H. Xin n, Q. Shen*, Z. Gu n

MeSH headings : Animals; Biomimetic Materials / chemistry; Biomimetic Materials / pharmacokinetics; Biomimetics; Blood Platelets / cytology; Bone and Bones / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Cellular Microenvironment; Disease Models, Animal; Drug Carriers / chemistry; Drug Carriers / pharmacokinetics; Humans; Mice; Multiple Myeloma / complications; Multiple Myeloma / drug therapy; Multiple Myeloma / metabolism; Multiple Myeloma / pathology; Nanoparticles / chemistry; Thrombosis / complications; Thrombosis / drug therapy
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Enhanced Antiglioblastoma Efficacy of Neovasculature and Glioma Cells Dual Targeted Nanoparticles

MOLECULAR PHARMACEUTICS, 13(10), 3506–3517.

By: L. Lv*, Y. Jiang*, X. Liu*, B. Wang*, W. Lv*, Y. Zhao*, H. Shi*, Q. Hu n ...

author keywords: glioma; antineovasculature; dual-targeted nanoparticle; drug delivery; paclitaxel
MeSH headings : Animals; Antineoplastic Agents, Phytogenic / chemistry; Antineoplastic Agents, Phytogenic / therapeutic use; Cell Line, Tumor; Drug Delivery Systems; Glioblastoma / drug therapy; Glioma / drug therapy; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles / chemistry; Paclitaxel / chemistry; Paclitaxel / therapeutic use; Polyesters / chemistry; Polyethylene Glycols / chemistry; Rats
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

NANO LETTERS, 16(4), 2334–2340.

By: C. Wang n, Y. Ye n, G. Hochu n, H. Sadeghifar n & Z. Gu n

author keywords: Anti-PD-1; cancer immunotherapy; microneedle patch; melanoma; drug delivery
MeSH headings : Animals; Antibodies, Neoplasm / immunology; Antibodies, Neoplasm / pharmacology; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Immunotherapy / instrumentation; Immunotherapy / methods; Mice; Needles; Programmed Cell Death 1 Receptor / immunology; Skin Neoplasms / immunology; Skin Neoplasms / pathology; Skin Neoplasms / therapy
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Hypoxia-Sensitive Materials for Biomedical Applications

ANNALS OF BIOMEDICAL ENGINEERING, 44(6), 1931–1945.

By: J. Yu n, Y. Zhang n, X. Hu*, G. Wright n & Z. Gu*

author keywords: Hypoxia-responsive; Drug delivery; Bioimaging; Hypoxia inducible factor-1; Bioreductive molecule
MeSH headings : Animals; Cell Hypoxia; Humans; Hypoxia-Inducible Factor 1 / metabolism; Tissue Scaffolds / chemistry
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody

ADVANCED MATERIALS, 28(40), 8912–8920.

By: C. Wang n, W. Sun n, G. Wright n, A. Wang n & Z. Gu n

MeSH headings : Adjuvants, Immunologic; Animals; Antibodies; CpG Islands; Immunotherapy; Inflammation; Mice; Neoplasms / therapy; Programmed Cell Death 1 Receptor / immunology
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Internalized compartments encapsulated nanogels for targeted drug delivery

NANOSCALE, 8(17), 9178–9184.

By: J. Yu n, Y. Zhang n, W. Sun n, C. Wang n, D. Ranson n, Y. Ye n, Y. Weng*, Z. Gu n

MeSH headings : Doxorubicin / administration & dosage; Drug Delivery Systems; Ferrous Compounds; Hyaluronic Acid; Nanoparticles; Silicon Dioxide
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Introduction to special issue on “Responsive Materials and Systems: Toward Smart and Precision Medications”

Introduction to special issue on “Responsive Materials and Systems: Toward Smart and Precision Medications.” Bioengineering & Translational Medicine, 1(3), 235–236.

By: Z. Gu n

Source: Crossref
Added: August 16, 2021

2016 journal article

Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy

ADVANCED MATERIALS, 28(17), 3313–3320.

By: C. Qian n, J. Yu n, Y. Chen*, Q. Hu n, X. Xiao*, W. Sun n, C. Wang n, P. Feng*, Q. Shen*, Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Cell Hypoxia; Cell Survival / drug effects; Doxorubicin / chemistry; Doxorubicin / pharmacology; Doxorubicin / therapeutic use; Drug Carriers / chemistry; HeLa Cells; Humans; Hydrogen-Ion Concentration; Light; Mice; Mice, Nude; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles / chemistry; Neoplasms / diagnostic imaging; Neoplasms / drug therapy; Neoplasms / pathology; Optical Imaging; Polyvinyl Alcohol / chemistry; Singlet Oxygen / chemistry; Singlet Oxygen / metabolism; Transplantation, Heterologous
Source: Web Of Science
Added: August 6, 2018

2016 review

Mechanical Force-Triggered Drug Delivery

[Review of ]. CHEMICAL REVIEWS, 116(19), 12536–12563.

By: Y. Zhang n, J. Yu n, H. Bomba n, Y. Zhu n & Z. Gu n

MeSH headings : Animals; Drug Carriers / chemistry; Drug Carriers / pharmacology; Drug Delivery Systems / methods; Liposomes / chemistry; Liposomes / pharmacology; Magnetic Phenomena; Mechanical Phenomena; Microbubbles; Nanoparticles / chemistry; Ultrasonic Waves
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery

Advanced Materials, 28(16), 3115–3121.

MeSH headings : Animals; Blood Glucose / analysis; Blood Glucose / metabolism; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Experimental / pathology; Insulin / metabolism; Insulin Secretion; Islets of Langerhans / metabolism; Mice; Needles; Time Factors
Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 journal article

Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration

ACS NANO, 10(1), 1292–1299.

By: D. Shi*, X. Xu*, Y. Ye n, K. Song*, Y. Cheng, J. Di n, Q. Hu n, J. Li ...

author keywords: drug delivery; tissue engineering; hydrogel; regenerative medicine; nanoparticles
Source: Web Of Science
Added: August 6, 2018

2016 review

Recent advances of cocktail chemotherapy by combination drug delivery systems

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 98, 19–34.

By: Q. Hu*, W. Sun*, C. Wang* & Z. Gu n

author keywords: Chemotherapy; Combination; Cancer; Nanocarriers; Drug delivery
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Drug Delivery Systems; Humans; Nanoparticles / administration & dosage; Nanoparticles / therapeutic use; Neoplasms / drug therapy
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Stimuli-responsive delivery of therapeutics for diabetes treatment

Bioengineering & Translational Medicine, 1(3), 323–337.

Source: Crossref
Added: August 16, 2021

2016 journal article

Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors

ACS NANO, 10(9), 8956–8963.

By: Y. Ye n, J. Wang n, Q. Hu n, G. Hochu n, H. Xin n, C. Wang n, Z. Gu n

author keywords: drug delivery; immunotherapy; anti-PD1; IDO; microneedle
MeSH headings : Animals; Cell Cycle Checkpoints / drug effects; Drug Delivery Systems; Immunosuppression Therapy; Immunotherapy / methods; Indoleamine-Pyrrole 2,3,-Dioxygenase / therapeutic use; Melanoma / therapy; Programmed Cell Death 1 Receptor / therapeutic use; Skin Neoplasms / therapy; Tumor Microenvironment
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Thrombin-Responsive Transcutaneous Patch for Auto-Anticoagulant Regulation

Advanced Materials, 29(4), 1604043.

By: Y. Zhang n, J. Yu n, J. Wang n, N. Hanne n, Z. Cui n, C. Qian n, C. Wang n, H. Xin n ...

MeSH headings : Anticoagulants; Blood Coagulation; Heparin; Skin; Thrombin / administration & dosage
Sources: Crossref, ORCID
Added: January 19, 2020

2016 journal article

Transformable DNA nanocarriers for plasma membrane targeted delivery of cytokine

BIOMATERIALS, 96, 1–10.

By: W. Sun n, W. Ji n, Q. Hu n, J. Yu n, C. Wang n, C. Qian n, G. Hochu n, Z. Gu n

author keywords: Cancer; Protein delivery; DNA structures; Cytokine; Nanomedicine
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

NANO LETTERS, 16(2), 1118–1126.

By: Q. Hu n, W. Sun n, Y. Lu n, H. Bomba n, Y. Ye n, T. Jiang*, A. Isaacson*, Z. Gu n

author keywords: Drug delivery; stimuli-responsive; tumor microenvironment; apoptosis; antiangiogenesis
MeSH headings : Angiogenesis Inhibitors / administration & dosage; Angiogenesis Inhibitors / chemistry; Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Apoptosis / drug effects; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Cell Line, Tumor; Cell Membrane Permeability / drug effects; Drug Delivery Systems; Endosomes / drug effects; Gene Transfer Techniques; Humans; Hyaluronoglucosaminidase / biosynthesis; Hyaluronoglucosaminidase / chemistry; Mice; Snake Venoms / administration & dosage; Snake Venoms / chemistry; TNF-Related Apoptosis-Inducing Ligand / administration & dosage; Tumor Microenvironment / drug effects; Xenograft Model Antitumor Assays
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Tumor microenvironment and intracellular signal-activated nanomaterials for anticancer drug delivery

MATERIALS TODAY, 19(5), 274–283.

By: R. Mo* & Z. Gu n

Source: Web Of Science
Added: August 6, 2018

2016 journal article

Versatile Protein Nanogels Prepared by In Situ Polymerization

MACROMOLECULAR CHEMISTRY AND PHYSICS, 217(3), 333–343.

By: Y. Ye n, J. Yu n & Z. Gu n

author keywords: drug delivery; in situ polymerization; nanogels; protein; stimuli-responsive
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment

NANOSCALE, 7(28), 12096–12103.

MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Drug Screening Assays, Antitumor; Gold / chemistry; Gold / pharmacology; HeLa Cells; Humans; Infrared Rays; Nanotubes / chemistry; Neoplasms / drug therapy; Photochemotherapy
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

A temperature microsensor for measuring laser-induced heating in gold nanorods

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407(3), 719–725.

By: D. Pacardo n, B. Neupane n, G. Wang n, Z. Gu n, G. Walker n & F. Ligler n

author keywords: Microsensor; Gold nanorods; Temperature; Nanoparticles; Microfluidics
MeSH headings : Chemistry Techniques, Analytical / instrumentation; Chemistry Techniques, Analytical / methods; Equipment Design; Gold; Heating; Hot Temperature; Lasers; Microtechnology; Nanotubes / analysis
Source: Web Of Science
Added: August 6, 2018

2015 journal article

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

BIOMATERIALS, 50, 67–74.

By: R. Mo n, T. Jiang n, W. Sun n & Z. Gu n

author keywords: ATP responsive; Graphene oxide; DNA; Drug delivery; Nanomedicine
MeSH headings : Adenosine Triphosphate / pharmacology; Antineoplastic Agents / pharmacology; Cell Death / drug effects; DNA, Single-Stranded / chemistry; Doxorubicin / pharmacology; Drug Delivery Systems; Endocytosis / drug effects; Graphite / chemistry; HeLa Cells; Humans; Intracellular Space / metabolism; Nanoparticles / chemistry; Particle Size; Spectrometry, Fluorescence
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Accelerating the Translation of Nanomaterials in Biomedicine

ACS NANO, 9(7), 6644–6654.

By: S. Mitragotri*, D. Anderson*, X. Chen*, E. Chow*, D. Ho*, A. Kabanov*, J. Karp*, K. Kataoka ...

MeSH headings : Nanomedicine / methods; Nanomedicine / trends; Translational Research, Biomedical
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Anticancer Platelet-Mimicking Nanovehicles

ADVANCED MATERIALS, 27(44), 7043-+.

By: Q. Hu n, W. Sun n, C. Qian n, C. Wang n, H. Bomba n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Blood Platelets / cytology; Cell Line, Tumor; Cell Membrane / chemistry; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Humans; Intracellular Space / metabolism; Mice; Nanomedicine / methods; Nanostructures / chemistry; TNF-Related Apoptosis-Inducing Ligand / chemistry; TNF-Related Apoptosis-Inducing Ligand / metabolism
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Characterization of a novel N-acetylneuraminic acid lyase favoring N-acetylneuraminic acid synthesis

SCIENTIFIC REPORTS, 5.

By: W. Ji*, W. Sun n, J. Feng*, T. Song*, D. Zhang*, P. Ouyang*, Z. Gu n, J. Xie*

MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Biocatalysis; Cloning, Molecular; Corynebacterium glutamicum / chemistry; Corynebacterium glutamicum / classification; Corynebacterium glutamicum / enzymology; Escherichia coli / enzymology; Escherichia coli / genetics; Gene Expression; Hexosamines / metabolism; Hydro-Lyases / chemistry; Hydro-Lyases / classification; Hydro-Lyases / genetics; Hydro-Lyases / metabolism; Kinetics; Molecular Sequence Data; N-Acetylneuraminic Acid / biosynthesis; Oxo-Acid-Lyases / chemistry; Oxo-Acid-Lyases / genetics; Oxo-Acid-Lyases / metabolism; Phylogeny; Pyruvic Acid / metabolism; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sequence Alignment; Substrate Specificity
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Confinement-induced nanocrystal alignment of conjugated polymer by the soft-stamped nanoimprint lithography

CHINESE PHYSICS B, 24(10).

author keywords: conjugated polymer; soft lithography; nanocrystalline material; x-ray technique
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Cover Picture: Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing (Angew. Chem. Int. Ed. 41/2015)

Angewandte Chemie International Edition, 54(41), 11877–11877.

By: W. Sun, W. Ji, J. Hall, Q. Hu, C. Wang, C. Beisel*, Z. Gu*

Source: Crossref
Added: February 24, 2020

2015 journal article

Drug Delivery: Furin-Mediated Sequential Delivery of Anticancer Cytokine and Small-Molecule Drug Shuttled by Graphene (Adv. Mater. 6/2015)

Advanced Materials, 27(6), 958–958.

By: T. Jiang n, W. Sun*, Q. Zhu*, N. Burns n, S. Khan n, R. Mo n, Z. Gu*

Sources: Crossref, ORCID
Added: March 26, 2021

2015 review

Engineering DNA scaffolds for delivery of anticancer therapeutics

[Review of ]. BIOMATERIALS SCIENCE, 3(7), 1018–1024.

By: W. Sun n & Z. Gu n

MeSH headings : DNA / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / methods; Engineering; Humans; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Nanostructures / chemistry; Nanostructures / therapeutic use; Nanotechnology / methods; Neoplasms / chemistry; Neoplasms / drug therapy; Nucleic Acids / chemistry
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Engineering Synthetic Insulin-Secreting Cells Using Hyaluronic Acid Microgels Integrated with Glucose-Responsive Nanoparticles

CELLULAR AND MOLECULAR BIOENGINEERING, 8(3), 445–454.

By: J. Di n, J. Yu n, Y. Ye n, D. Ranson n, A. Jindal n & Z. Gu n

author keywords: Insulin delivery; Diabetes; Glucose responsive; Bio-inspired; Hyaluronic acid; Dextran
Source: Web Of Science
Added: August 6, 2018

2015 review

Glucose-responsive synthetic closed-loop insulin delivery systems

[Review of ]. Progress in Chemistry, 27(1), 11–26.

By: Y. Zhang, J. Yu, Q. Shen & Z. Gu

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Hybrid Fe3O4-Poly(acrylic acid) Nanogels for Theranostic Cancer Treatment

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 11(5), 771–779.

By: Y. Chen, J. Nan, Y. Lu*, C. Wang, F. Chu & Z. Gu*

author keywords: Hybrid Magnetic Nanogels; In Situ Co-Precipitation; MRI Imaging; High Drug Loading Capacity; Tumor Target
MeSH headings : Acrylic Resins / chemistry; Acrylic Resins / therapeutic use; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Drug Delivery Systems; Ferric Compounds / chemistry; Ferric Compounds / therapeutic use; Humans; Magnetic Resonance Imaging; Materials Testing; Mice; Mice, Inbred ICR; Nanogels; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Neoplasms / drug therapy; Neoplasms / metabolism; Neoplasms / pathology; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Polyethylene Glycols / therapeutic use; Polyethyleneimine / chemical synthesis; Polyethyleneimine / chemistry; Polyethyleneimine / therapeutic use; Tumor Cells, Cultured
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(27), 8260–8265.

By: J. Yu n, Y. Zhang n, Y. Ye n, R. DiSanto n, W. Sun n, D. Ranson n, F. Ligler n, J. Buse*, Z. Gu n

author keywords: diabetes; drug delivery; glucose-responsive; hypoxia-sensitive; microneedle
MeSH headings : Animals; Blood Glucose / analysis; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Glucose / metabolism; Glucose Oxidase / metabolism; Humans; Hyaluronic Acid / chemistry; Hyaluronic Acid / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / chemistry; Hypoxia / metabolism; Insulin / administration & dosage; Insulin / chemistry; Insulin / metabolism; Male; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Molecular Structure; Oxidation-Reduction; Reproducibility of Results
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Nanomedicine: Anticancer Platelet-Mimicking Nanovehicles (Adv. Mater. 44/2015)

Advanced Materials, 27(44), 7014–7014.

By: Q. Hu n, W. Sun n, C. Qian n, C. Wang n, H. Bomba n & Z. Gu n

Source: Crossref
Added: April 3, 2022

2015 journal article

Polypyrrole-Based Implantable Electroactive Pump for Controlled Drug Microinjection

ACS APPLIED MATERIALS & INTERFACES, 7(27), 14563–14568.

By: B. Yan, B. Li, F. Kunecke, Z. Gu n & L. Guo

author keywords: polypyrrole; electroactuator; implantable; controlled drug delivery; diabetes
MeSH headings : Electric Conductivity; Electrodes; Equipment Design; Equipment Failure Analysis; Infusion Pumps, Implantable; Micro-Electrical-Mechanical Systems / instrumentation; Microfluidics / instrumentation; Microinjections / instrumentation; Polymers / chemistry; Pyrroles / chemistry
Source: Web Of Science
Added: August 6, 2018

2015 review

Programmable nanomedicine: synergistic and sequential drug delivery systems

[Review of ]. NANOSCALE, 7(8), 3381–3391.

By: D. Pacardo n, F. Ligler n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; DNA / chemistry; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Resistance, Neoplasm; Humans; Microscopy, Electron, Transmission; Nanomedicine / methods; Nanoparticles / chemistry; Neoplasms / drug therapy; Neoplasms / pathology
Source: Web Of Science
Added: August 6, 2018

2015 review

Recent advances in nanotechnology for diabetes treatment

[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 7(4), 548–564.

By: R. DiSanto n, V. Subramanian n & Z. Gu*

MeSH headings : Diabetes Mellitus / therapy; Electrochemical Techniques; Glucose / analysis; Humans; Insulin / administration & dosage; Insulin Infusion Systems; Nanotechnology / trends
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

Angewandte Chemie International Edition, 54(41), 12029–12033.

By: W. Sun n, W. Ji n, J. Hall n, Q. Hu n, C. Wang n, C. Beisel n, Z. Gu n

author keywords: CRISPR-Cas9; DNA; drug delivery; genome editing; nanoparticles
MeSH headings : Animals; CRISPR-Associated Proteins / administration & dosage; CRISPR-Associated Proteins / chemistry; CRISPR-Associated Proteins / genetics; CRISPR-Cas Systems; Cell Line; Clustered Regularly Interspaced Short Palindromic Repeats; DNA / administration & dosage; DNA / chemistry; DNA / genetics; Green Fluorescent Proteins / genetics; Humans; Mice, Nude; Nanoparticles / chemistry; Neoplasms / genetics; Neoplasms / therapy; RNA, Guide, Kinetoplastida / administration & dosage; RNA, Guide, Kinetoplastida / chemistry; RNA, Guide, Kinetoplastida / genetics; Streptococcus pyogenes / chemistry; Streptococcus pyogenes / genetics
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 article

Spatiotemporal drug delivery using laser-generated-focused ultrasound system

Di, J., Kim, J., Hu, Q., Jiang, X., & Gu, Z. (2015, December 28). JOURNAL OF CONTROLLED RELEASE, Vol. 220, pp. 592–599.

By: J. Di n, J. Kim n, Q. Hu n, X. Jiang n & Z. Gu n

author keywords: Drug delivery; Photoacoustic; Nanoparticles; Microgels; Stimuli responsive
MeSH headings : Alginates / chemistry; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / chemistry; Cell Proliferation / drug effects; Cell Survival / drug effects; Chemistry, Pharmaceutical; Ciprofloxacin / administration & dosage; Ciprofloxacin / chemistry; Delayed-Action Preparations; Dimethylpolysiloxanes / chemistry; Disk Diffusion Antimicrobial Tests; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers; Equipment Design; Escherichia coli / drug effects; Escherichia coli / growth & development; Gels; Glucuronic Acid / chemistry; HeLa Cells; Hexuronic Acids / chemistry; Humans; Kinetics; Lactic Acid / chemistry; Lasers; Nanoparticles; Photoacoustic Techniques; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Soot / chemistry; Spheroids, Cellular; Technology, Pharmaceutical / instrumentation; Technology, Pharmaceutical / methods; Transducers; Ultrasonic Waves; Ultrasonics / instrumentation; Ultrasonics / methods
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots

ACS NANO, 9(9), 9407–9415.

By: J. Di n, S. Yao n, Y. Ye n, Z. Cui n, J. Yu n, T. Ghosh n, Y. Zhu n, Z. Gu n

author keywords: drug delivery; wearable devices; stimuli-responsive; nanoparticles; microdepots
MeSH headings : Animals; Drug Delivery Systems; Drug Liberation; Elastomers / chemistry; Elastomers / pharmacology; Mice; Nanoparticles / chemistry; Polymers / chemistry; Polymers / pharmacology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Transformable liquid-metal nanomedicine

NATURE COMMUNICATIONS, 6(1).

By: Y. Lu n, Q. Hu n, Y. Lin n, D. Pacardo n, C. Wang n, W. Sun n, F. Ligler n, M. Dickey n, Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Female; Gallium / chemistry; Humans; Indium / chemistry; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Nanomedicine / instrumentation; Nanomedicine / methods; Neoplasms / drug therapy
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

ATP-triggered anticancer drug delivery

NATURE COMMUNICATIONS, 5.

By: R. Mo n, T. Jiang n, R. DiSanto n, W. Tai n & Z. Gu n

MeSH headings : Adenosine Triphosphate / chemistry; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Apoptosis; Cell Line; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Drug Carriers / chemistry; Female; Humans; MCF-7 Cells; Mice; Mice, Nude; Nanoparticles / chemistry; Polymers / chemistry; Xenograft Model Antitumor Assays
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Advances in Anticancer Protein Delivery using Micro-/Nanoparticles

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 31(12), 1204–1222.

By: W. Sun n, Y. Lu n & Z. Gu n

Source: Web Of Science
Added: August 6, 2018

2014 journal article

Bio-lnspired Synthetic Nanovesicles for Glucose-Responsive Release of Insulin

BIOMACROMOLECULES, 15(10), 3495–3502.

MeSH headings : Animals; Blood Glucose / drug effects; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Experimental / metabolism; Drug Delivery Systems / methods; Gluconates / chemistry; Glucose / administration & dosage; Glucose / chemistry; Glucose Oxidase / metabolism; Hydrogen-Ion Concentration; Insulin / administration & dosage; Insulin / chemistry; Male; Mice; Mice, Inbred C57BL; Polymers / administration & dosage; Polymers / chemistry
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Clickable Protein Nanocapsules for Targeted Delivery of Recombinant p53 Protein

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(43), 15319–15325.

By: M. Zhao*, Y. Liu*, R. Hsieh*, N. Wang*, W. Tai n, K. Joo*, P. Wang*, Z. Gu n, Y. Tang*

MeSH headings : Amino Acid Sequence; Azides / chemistry; Cell Survival / drug effects; Click Chemistry; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Carriers / toxicity; Drug Liberation; Gonadotropin-Releasing Hormone / chemistry; HeLa Cells; Humans; Ligands; Nanocapsules / chemistry; Nanocapsules / toxicity; Peptide Fragments / chemistry; Peptide Fragments / metabolism; Polyethylene Glycols / chemistry; Recombinant Proteins / chemistry; Single-Chain Antibodies / chemistry; Single-Chain Antibodies / metabolism; Surface Properties; Tumor Suppressor Protein p53 / chemistry
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(42), 14722–14725.

By: W. Sun n, T. Jiang n, Y. Lu n, M. Reiff n, R. Mo n & Z. Gu n

MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; DNA / chemistry; DNA / metabolism; Deoxyribonucleases / metabolism; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Liberation; Humans; MCF-7 Cells; Models, Molecular; Molecular Conformation; Nanoparticles / chemistry
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Drug Delivery: Gel-Liposome-Mediated Co-Delivery of Anticancer Membrane-Associated Proteins and Small-Molecule Drugs for Enhanced Therapeutic Efficacy (Adv. Funct. Mater. 16/2014)

Advanced Functional Materials, 24(16), 2258–2258.

Source: Crossref
Added: April 3, 2022

2014 journal article

Drug Delivery: Ultrasound-Triggered Regulation of Blood Glucose Levels Using Injectable Nano-Network (Adv. Healthcare Mater. 6/2014)

Advanced Healthcare Materials, 3(6), 789–789.

By: J. Di n, J. Price n, X. Gu*, X. Jiang n, Y. Jing n & Z. Gu*

Source: Crossref
Added: August 28, 2020

2014 review

Emerging micro-and nanotechnology based synthetic approaches for insulin delivery

[Review of ]. CHEMICAL SOCIETY REVIEWS, 43(10), 3595–3629.

By: R. Mo*, T. Jiang*, J. Di*, W. Tai* & Z. Gu*

MeSH headings : Diabetes Mellitus / drug therapy; Drug Delivery Systems; Equipment Design; Humans; Insulin / administration & dosage; Insulin / therapeutic use; Insulin Infusion Systems; Nanotechnology / instrumentation
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Enhanced Anticancer Efficacy by ATP-Mediated Liposomal Drug Delivery

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53(23), 5815–5820.

By: R. Mo n, T. Jiang n & Z. Gu n

author keywords: ATP; drug delivery; liposomes; nanomedicine; stimuli-responsive materials
MeSH headings : Adenosine Triphosphate / metabolism; Animals; Drug Delivery Systems / methods; Humans; Liposomes / metabolism; MCF-7 Cells; Mice; Nanomedicine / methods
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Enzyme-responsive nanomaterials for controlled drug delivery

NANOSCALE, 6(21), 12273–12286.

By: Q. Hu n, P. Katti* & Z. Gu n

MeSH headings : Animals; Apoptosis; Biotechnology; Drug Delivery Systems; Enzymes / chemistry; Humans; Inorganic Chemicals / chemistry; Liposomes / chemistry; Metal Nanoparticles / chemistry; Mice; Nanostructures / chemistry; Nanotechnology; Oxidoreductases / chemistry; Peptide Hydrolases / chemistry; Phospholipases / chemistry
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Folding graft copolymer with pendant drug segments for co-delivery of anticancer drugs

BIOMATERIALS, 35(25), 7194–7203.

By: W. Tai n, R. Mo n, Y. Lu n, T. Jiang n & Z. Gu n

author keywords: Graft copolymer; Micelle; Combination therapy; Bio-inspired; Ring open polymerization; Nanomedicine
MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Camptothecin / chemistry; Camptothecin / pharmacology; Cell Line, Tumor; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Endocytosis / drug effects; Female; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Mice, Nude; Micelles; Nanostructures / chemistry; Polyethylene Glycols / chemistry; Polymers / chemistry; Xenograft Model Antitumor Assays
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Furin-Mediated Sequential Delivery of Anticancer Cytokine and Small-Molecule Drug Shuttled by Graphene

Advanced Materials, 27(6), 1021–1028.

By: T. Jiang n, W. Sun n, Q. Zhu*, N. Burns n, S. Khan n, R. Mo n, Z. Gu n

MeSH headings : Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Apoptosis / drug effects; Cell Line, Tumor; Cytokines / administration & dosage; Cytokines / chemistry; Diffusion; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Furin / metabolism; Graphite / chemistry; Humans; Nanocapsules / administration & dosage; Nanocapsules / chemistry; Nanocapsules / ultrastructure; Neoplasms, Experimental / drug therapy; Neoplasms, Experimental / pathology; Oxides / chemistry; Particle Size; Peptides / pharmacokinetics; Polyethylene Glycols / chemistry; TNF-Related Apoptosis-Inducing Ligand / administration & dosage; TNF-Related Apoptosis-Inducing Ligand / chemistry; Treatment Outcome
Source: Crossref
Added: March 27, 2021

2014 journal article

Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo

Advanced Healthcare Materials, 3(9), 1392–1397.

By: Y. Dong*, A. Eltoukhy*, C. Alabi*, O. Khan*, O. Veiseh*, J. Dorkin*, S. Sirirungruang*, H. Yin* ...

MeSH headings : Animals; Gene Expression; Gene Silencing; HeLa Cells; Humans; Lipids / chemistry; Lipids / pharmacokinetics; Mice; Mice, Inbred C57BL; Nanostructures / chemistry; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; Transfection / methods; Triazines / chemistry
Source: Crossref
Added: April 3, 2022

2014 journal article

Molecule Drugs for Enhanced Therapeutic Efficacy

ADVANCED FUNCTIONAL MATERIALS, 24(16), 2295–2304.

author keywords: drug delivery; combination cancer therapy; site-specific delivery; nanomedicine; apoptosis
Source: Web Of Science
Added: August 6, 2018

2014 article

Recent progress in multidrug delivery to cancer cells by liposomes

Mo, R., Jiang, T., & Gu, Z. (2014, June). NANOMEDICINE, Vol. 9, pp. 1117–1120.

By: R. Mo n, T. Jiang n & Z. Gu n

author keywords: chemotherapy; co-delivery; combination cancer therapy; drug delivery; gene therapy; liposome; protein therapy
MeSH headings : Antineoplastic Agents / administration & dosage; Drug Delivery Systems; Genetic Therapy; Humans; Liposomes / chemistry; Neoplasms / drug therapy; Neoplasms / therapy
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Self-folded redox/acid dual-responsive nanocarriers for anticancer drug delivery

CHEMICAL COMMUNICATIONS, 50(95), 15105–15108.

By: Y. Lu n,