Works (195)

Updated: August 28th, 2023 21:15

2022 journal article

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

NATIONAL SCIENCE REVIEW, 9(3).

By: H. Li*, Z. Wang*, E. Archibong*, Q. Wu*, G. Chen*, Q. Hu n, T. Ci*, Z. Chen* ...

author keywords: drug delivery; CAR T therapy; microneedle patch; solid tumor treatment; cell delivery
TL;DR: A porous microneedle patch is implemented that accommodates CAR T cells and allows in situ penetration-mediated seeding ofCAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 28, 2022

2021 article

Bioorthogonal catalytic patch

Chen, Z., Li, H., Bian, Y., Wang, Z., Chen, G., Zhang, X., … Gu, Z. (2021, May 10). NATURE NANOTECHNOLOGY.

By: Z. Chen*, H. Li*, Y. Bian*, Z. Wang*, G. Chen*, X. Zhang*, Y. Miao*, D. Wen* ...

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Catalysis; Drug Delivery Systems; Hep G2 Cells; Humans; Melanoma, Experimental; Metal Nanoparticles / chemistry; Metal Nanoparticles / therapeutic use; Mice; Palladium / chemistry; Palladium / pharmacokinetics; Palladium / pharmacology; Prodrugs / chemistry; Prodrugs / pharmacokinetics; Prodrugs / pharmacology; Titanium / chemistry; Titanium / pharmacokinetics; Titanium / pharmacology
TL;DR: The authors fill the needles of a microneedle array patch with palladium nanoparticles deposited on titanium nanosheets and show that the device, applied locally on the skin of mouse models bearing melanoma, promotes intratumoural conversion of systemically injected caged doxorubicin into the active drug, reducing its toxicity and side effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 10, 2021

2021 article

Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets

Hu, Q., Li, H., Archibong, E., Chen, Q., Ruan, H., Ahn, S., … Gu, Z. (2021, April 26). NATURE BIOMEDICAL ENGINEERING.

By: Q. Hu n, H. Li*, E. Archibong n, Q. Chen n, H. Ruan*, S. Ahn*, E. Dukhovlinova*, Y. Kang* ...

MeSH headings : Animals; Antibodies, Monoclonal, Humanized; Blood Platelets; Cell-Derived Microparticles; Hydrogels; Immunotherapy, Adoptive; Mice; Neoplasm Recurrence, Local / prevention & control; T-Lymphocytes; Tumor Microenvironment
TL;DR: A hydrogel implanted into the cavity of a resected tumour and releasing CAR-T cells and platelets conjugated with a checkpoint inhibitor inhibits local tumour recurrence and the growth of distant tumours in mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 10, 2021

2021 journal article

Integrated microneedle-smartphone nucleic acid amplification platform for in-field diagnosis of plant diseases

BIOSENSORS & BIOELECTRONICS, 187.

author keywords: Plant disease diagnostics; Nucleic acid extraction; Microneedle; Isothermal amplification; Smartphone
MeSH headings : Biosensing Techniques; Molecular Diagnostic Techniques; Nucleic Acid Amplification Techniques; Plant Diseases; Smartphone
TL;DR: It is found that the MN patch containing as few as a single needle tip successfully extracted enough RNA for RT-PCR or RT-LAMP analysis, and MN-extracted RNA samples remained stable on MN surfaces for up to three days. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: June 14, 2021

2020 journal article

CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation

SCIENCE ADVANCES, 6(21).

MeSH headings : CRISPR-Cas Systems; Cholesterol; DNA / genetics; DNA / metabolism; Gene Editing; Polymers / metabolism; Proprotein Convertase 9 / genetics; Proprotein Convertase 9 / metabolism; RNA / genetics; Ribonucleoproteins / genetics
TL;DR: A DNA nanoclew (NC)-based carrier for delivery of Cas12a/CRISPR RNA (crRNA) ribonucleoprotein (R NP) toward regulating serum cholesterol levels and significantly reducing the expression of PCSK9 and gaining the therapeutic benefit of cholesterol control. (via Semantic Scholar)
Source: Web Of Science
Added: June 22, 2020

2020 journal article

Engineered PD-L1-Expressing Platelets Reverse New-Onset Type 1 Diabetes

ADVANCED MATERIALS, 32(26).

author keywords: drug delivery; immune tolerance; platelets; programmed death-ligand 1 (PD-L1); type 1 diabetes (T1D)
MeSH headings : Animals; B7-H1 Antigen / genetics; B7-H1 Antigen / metabolism; Blood Glucose / analysis; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Diabetes Mellitus, Type 1 / pathology; Diabetes Mellitus, Type 1 / therapy; Diabetes Mellitus, Type 1 / veterinary; Genetic Engineering; Immune Tolerance; Insulin / blood; Insulin-Secreting Cells / cytology; Insulin-Secreting Cells / immunology; Insulin-Secreting Cells / metabolism; Megakaryocyte Progenitor Cells / cytology; Megakaryocyte Progenitor Cells / metabolism; Megakaryocyte Progenitor Cells / transplantation; Mice; Mice, Inbred NOD; T-Lymphocytes, Regulatory / cytology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism
TL;DR: It is demonstrated that the rescue of β‐cells by PD‐L1 platelets can effectively maintain normoglycemia and reverse diabetes in newly hyperglycemic NOD mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 8, 2020

2020 journal article

Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs

NATURE BIOMEDICAL ENGINEERING, 4(5), 499–506.

MeSH headings : Animals; Blood Glucose / metabolism; Diabetes Mellitus, Experimental / blood; Disease Models, Animal; Drug Delivery Systems; Humans; Insulin / pharmacology; Insulin Secretion / drug effects; Male; Mice, Inbred C57BL; Needles; Swine; Swine, Miniature; Transdermal Patch
TL;DR: It is shown that a single removable transdermal patch, bearing microneedles loaded with insulin and a non-degradable glucose-responsive polymeric matrix, and fabricated via in situ photopolymerization, regulated blood glucose in insulin-deficient diabetic mice and minipigs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 17, 2020

2020 review

Non-transdermal microneedles for advanced drug delivery

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 165-166, 41–59.

By: K. Lee*, M. Goudie*, P. Tebon*, W. Sun*, Z. Luo*, J. Lee*, S. Zhang*, K. Fetah* ...

author keywords: Microneedle; Implant; Drug delivery; Non-transdermal; Biocompatibility; Biodegradability
MeSH headings : Administration, Topical; Biological Transport; Drug Delivery Systems / methods; Equipment Design; Humans; Microinjections / instrumentation; Microinjections / methods; Microtechnology / methods; Polymers; Prostheses and Implants
TL;DR: The design and creation of modern MNs that aim to surpass the biological barriers of non-transdermal drug delivery in ocular, vascular, oral, and mucosal tissue are discussed. (via Semantic Scholar)
Source: Web Of Science
Added: January 11, 2021

2020 journal article

Targeted Delivery of Notch Inhibitor Attenuates Obesity-Induced Glucose Intolerance and Liver Fibrosis

ACS NANO, 14(6), 6878–6886.

By: L. Richter*, Q. Wan*, D. Wen n, Y. Zhang n, J. Yu*, J. Kang*, C. Zhu*, E. McKinnon* ...

author keywords: drug delivery; nanomedicine; Notch inhibitor; nonalcoholic steatohepatitis; obesity; liver fibrosis
MeSH headings : Animals; Diabetes Mellitus, Type 2 / pathology; Disease Models, Animal; Glucose Intolerance / drug therapy; Glucose Intolerance / pathology; Liver / pathology; Liver Cirrhosis / drug therapy; Liver Cirrhosis / pathology; Mice; Obesity / drug therapy
TL;DR: A nanoparticle-mediated delivery system to target γ-secretase inhibitor to liver (GSI NPs) reduces hepatic glucose production in diet-induced obese mice and reduced hepatic fibrosis and inflammation in mice fed a NASH-provoking diet, without apparent gastrointestinal toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 20, 2020

2019 journal article

A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade

ADVANCED MATERIALS, 31(17).

author keywords: bioresponsive materials; drug delivery; epigenetic modulation; immune checkpoint blockade; immunotherapy
MeSH headings : Animals; Antibodies, Monoclonal / pharmacology; Antibodies, Monoclonal, Humanized; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / pharmacology; Calcium Carbonate / chemistry; Cell Line, Tumor; Cytidine / analogs & derivatives; Cytidine / pharmacology; Drug Delivery Systems / methods; Drug Liberation; Drug Therapy, Combination / methods; Humans; Hydrogen-Ion Concentration; Immunosuppressive Agents / chemistry; Immunosuppressive Agents / pharmacology; Immunotherapy / methods; Melanoma / drug therapy; Nanoparticles / chemistry; Programmed Cell Death 1 Receptor / metabolism; Reactive Oxygen Species / metabolism; Tumor Microenvironment / drug effects
TL;DR: It is demonstrated that this combination therapy increases the immunogenicity of cancer cells, and also plays roles in reversing immunosuppressive TME, which contributes to inhibiting the tumor growth and prolonging the survival time of B16F10‐melanoma‐bearing mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: May 13, 2019

2019 journal article

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

ACS NANO, 13(4), 4354–4360.

By: G. Yang n, Q. Chen n, D. Wen n, Z. Chen n, J. Wang n, G. Chen n, Z. Wang*, X. Zhang n ...

author keywords: drug delivery; microneedle; exosome; keratin; hair regrowth; transdermal drug delivery
MeSH headings : Animals; Cell Line; Delayed-Action Preparations / chemistry; Drug Delivery Systems / instrumentation; Equipment Design; Hair / chemistry; Hair / drug effects; Hair / growth & development; Hair Follicle / drug effects; Hair Follicle / growth & development; Humans; Injections, Subcutaneous; Keratins / chemistry; Mice, Inbred C57BL; Transdermal Patch
TL;DR: It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 4, 2019

2019 journal article

A forskolin-conjugated insulin analog targeting endogenous glucose-transporter for glucose-responsive insulin delivery

BIOMATERIALS SCIENCE, 7(11), 4508–4513.

By: J. Wang*, Z. Wang*, J. Yu n, Y. Zhang n, Y. Zeng* & Z. Gu*

MeSH headings : Animals; Colforsin / administration & dosage; Colforsin / pharmacology; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Type 1 / drug therapy; Diabetes Mellitus, Type 1 / metabolism; Drug Delivery Systems; Glucose / metabolism; Glucose Tolerance Test; Glucose Transport Proteins, Facilitative / antagonists & inhibitors; Glucose Transport Proteins, Facilitative / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / pharmacology; Injections, Subcutaneous; Insulin / administration & dosage; Insulin / metabolism; Insulin / pharmacology; Mice
TL;DR: A new insulin analog is prepared by modifying insulin with forskolin (designated as insulin-F), a glucose-transporter (Glut) inhibitor that binds to endogenous Gluts and rapidly restores BGLs to the normal range. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 16, 2019

2019 journal article

Adipocytes as Anticancer Drug Delivery Depot

MATTER, 1(5), 1203–1214.

By: D. Wen n, J. Wang n, G. Van Den Driessche n, Q. Chen n, Y. Zhang n, G. Chen n, H. Li*, J. Soto* ...

TL;DR: The lipid metabolism is exploited to engineer adipocytes that serve as a depot to deliver cancer therapeutics at the tumor site, promoting antitumor efficacy and downregulation of PD-L1 expression is observed in tumor cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 6, 2020

2019 journal article

Advances in drug delivery for post-surgical cancer treatment

Biomaterials, 219, 119182.

By: L. Bu*, J. Yan, Z. Wang*, H. Ruan*, Q. Chen*, V. Gunadhi*, R. Bell*, Z. Gu*

author keywords: Drug delivery; Surgery; Local delivery; Cancer treatment; Immunotherapy
MeSH headings : Drug Delivery Systems / trends; Humans; Hydrogels / chemistry; Immunotherapy; Nanotechnology; Neoplasms / drug therapy; Neoplasms / surgery
TL;DR: A review of the rapidly evolving fields of drug delivery systems (DDSs) for the release of chemotherapy and immunotherapy agents, utilizing a variety of formulations and devices, such as implantable wafers, injectable/sprayable hydrogels, micro/nanoparticles, and cellular particles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: January 19, 2020

2019 review

Advances in transdermal insulin delivery

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 139, 51–70.

author keywords: Drug delivery; Transdermal delivery; Insulin; Diabetes; Iontophoresis; Electroporation; Ultrasound; Jet injection; Microneedle
MeSH headings : Administration, Cutaneous; Animals; Electroporation; Humans; Hypoglycemic Agents / administration & dosage; Insulin / administration & dosage; Iontophoresis; Microinjections; Needles; Ultrasonic Waves
TL;DR: Different transdermal insulin delivery techniques and their respective advantages and limitations are focused on, including chemical enhancers-promoted, electrically enhanced, mechanical force-triggered, and microneedle-assisted methods. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 9, 2019

2019 journal article

Bioresponsive Protein Complex of aPD1 and aCD47 Antibodies for Enhanced Immunotherapy

NANO LETTERS, 19(8), 4879–4889.

author keywords: Drug delivery; immunotherapy; immune checkpoint blockade; bioresponsive; nanomedicine
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Antibodies, Monoclonal / therapeutic use; Antineoplastic Agents, Immunological / immunology; Antineoplastic Agents, Immunological / therapeutic use; CD47 Antigen / immunology; Female; Immunotherapy; Melanoma / immunology; Melanoma / therapy; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor / immunology; Reactive Oxygen Species / immunology; Tumor Microenvironment / drug effects
TL;DR: A bioresponsive ICB treatment is developed based on the reactive oxygen species (ROS)-sensitive protein complex for controlled sequential release of anti- "don't eat me" signal antibody and antiprogrammed cell death protein 1 (aPD1), by leveraging the abundant ROS in the tumor microenvironment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 3, 2019

2019 journal article

Cancer Stem Cell-Platelet Hybrid Membrane-Coated Magnetic Nanoparticles for Enhanced Photothermal Therapy of Head and Neck Squamous Cell Carcinoma

Advanced Functional Materials, 29(10), 1807733.

author keywords: cancer stem cell; hybrid mimic membrane; magnetic resonance imaging; photothermal therapy; platelet
TL;DR: A platelet–cancer stem cell (CSC) hybrid membrane‐coated iron oxide magnetic nanoparticle (MN) {CSC‐P]MN is presented for the first time for the enhanced photothermal therapy of head and neck squamous cell carcinoma (HNSCC). (via Semantic Scholar)
Source: Crossref
Added: January 19, 2020

2019 journal article

Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs

SCIENCE ADVANCES, 5(7).

By: J. Wang n, J. Yu n, Y. Zhang n, X. Zhang*, A. Kahkoska*, G. Chen*, Z. Wang*, W. Sun* ...

MeSH headings : Animals; Blood Glucose / drug effects; Diabetes Mellitus, Experimental / drug therapy; Drug Carriers / chemical synthesis; Drug Carriers / chemistry; Drug Delivery Systems; Insulin / administration & dosage; Mice; Molecular Structure; Polymers / chemical synthesis; Polymers / chemistry; Swine
TL;DR: A new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insulin driven by electrostatic interaction achieves high insulin loading efficiency and loading capacity and promotes release under hyperglycemic conditions. (via Semantic Scholar)
Source: Web Of Science
Added: August 19, 2019

2019 review

Cysteine-rich Proteins for Drug Delivery and Diagnosis

[Review of ]. CURRENT MEDICINAL CHEMISTRY, 26(8), 1377–1388.

By: G. Yang*, Y. Lu n, H. Bomba n & Z. Gu n

author keywords: Cysteine-rich protein; drug delivery; cancer diagnostics; protein-based nanoparticle; hydrogel; biomedical material
MeSH headings : Animals; Biocompatible Materials / chemistry; Cysteine / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / methods; Gold / chemistry; Humans; Hydrogels / chemistry; Nanocomposites / chemistry; Nanoparticles / chemistry; Nanotechnology / methods; Neoplasms / diagnosis; Neoplasms / drug therapy; Proteins / chemistry
TL;DR: This review surveys cysteine-rich protein-based biomedical materials, including protein-metal nanohybrids, gold nanoparticle-protein agglomerates, protein- based nanoparticles, and hydrogels, with an emphasis on their preparation methods, especially those based on the cysteined residue-related reactions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 17, 2019

2019 journal article

Drug Delivery: A Dual‐Bioresponsive Drug‐Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade (Adv. Mater. 17/2019)

Advanced Materials, 31(17), 1970120.

Source: Crossref
Added: January 19, 2020

2019 journal article

Engineering Protein Delivery Depots for Cancer Immunotherapy

Bioconjugate Chemistry, 30(3), 515–524.

MeSH headings : Animals; Antibodies / administration & dosage; Antibodies / therapeutic use; Antigens / administration & dosage; Antigens / therapeutic use; Cancer Vaccines / administration & dosage; Cancer Vaccines / therapeutic use; Cytokines / administration & dosage; Cytokines / therapeutic use; Humans; Immunotherapy / methods; Neoplasms / therapy; Proteins / administration & dosage; Proteins / therapeutic use
TL;DR: This Topical Review highlights the recent studies on depot-mediated delivery of protein/peptide therapeutics for cancer immunotherapy and discusses the opportunities and challenges in this field. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: January 19, 2020

2019 journal article

Enhanced local cancer therapy using a CA4P and CDDP co-loaded polypeptide gel depot

BIOMATERIALS SCIENCE, 7(3), 860–866.

MeSH headings : Animals; Cell Line, Tumor; Cell Survival / drug effects; Cisplatin / chemistry; Cisplatin / metabolism; Cisplatin / therapeutic use; Cisplatin / toxicity; Colonic Neoplasms / drug therapy; Colonic Neoplasms / pathology; Drug Liberation; Female; Humans; Hydrogels / chemical synthesis; Hydrogels / chemistry; Mice, Inbred BALB C; Peptides / chemistry; Polymers / chemical synthesis; Polymers / chemistry; Stilbenes / chemistry; Stilbenes / metabolism; Stilbenes / therapeutic use; Stilbenes / toxicity; Transplantation, Heterologous; Tumor Microenvironment / drug effects
TL;DR: The results indicated that this material possessed concentration-dependent thermogelling properties and tunable in vivo biodegradability and showed the highest antitumor efficacy compared with the other experimental groups after peritumoral injection toward C26 tumor bearing mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 22, 2019

2019 journal article

Extraction of Plant DNA by Microneedle Patch for Rapid Detection of Plant Diseases

ACS Nano, 13(6), 6540–6549.

By: R. Paul n, A. Saville n, J. Hansel n, Y. Ye n, C. Ball n, A. Williams n, X. Chang*, G. Chen n ...

author keywords: plant disease; DNA extraction; microneedle patch; Phytophthora infestans; nucleic acid amplification; point-of-care diagnostics
MeSH headings : DNA Barcoding, Taxonomic / instrumentation; DNA Barcoding, Taxonomic / methods; DNA, Fungal / chemistry; DNA, Fungal / genetics; Solanum lycopersicum / microbiology; Metagenomics / instrumentation; Metagenomics / methods; Needles; Phytophthora / genetics; Phytophthora / pathogenicity; Plant Diseases / microbiology; Plant Leaves / chemistry; Plant Leaves / microbiology
TL;DR: A simple, cell-lysis-free, and purification-free DNA extraction method that could be a transformative approach to facilitate rapid sample preparation for molecular diagnosis of various plant diseases directly in the field is developed. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: July 15, 2019

2019 journal article

Glucose transporter inhibitor-conjugated insulin mitigates hypoglycemia

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(22), 10744–10748.

author keywords: drug delivery; diabetes; glucose-responsive; insulin; insulin analog
MeSH headings : Animals; Blood Glucose / analysis; Blood Glucose / drug effects; Diabetes Mellitus, Experimental; Drug Delivery Systems / methods; Glucose Transport Proteins, Facilitative / antagonists & inhibitors; Hyperglycemia / drug therapy; Hypoglycemia / prevention & control; Hypoglycemic Agents / chemistry; Hypoglycemic Agents / pharmacology; Insulin / analogs & derivatives; Insulin / chemistry; Insulin / pharmacology; Mice
TL;DR: An insulin-facilitated glucose transporter (Glut) inhibitor conjugate is reported, in which the insulin molecule is rendered glucose-responsive via conjugation to an inhibitor of Glut to regulate blood glucose levels within a normal range while mitigating the risk of hypoglycemia in a type 1 diabetic mouse model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 17, 2019

2019 journal article

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

NATURE NANOTECHNOLOGY, 14(1), 89-+.

By: Q. Chen n, C. Wang n, X. Zhang*, G. Chen*, Q. Hu n, H. Li*, J. Wang n, D. Wen* ...

MeSH headings : Animals; Biocompatible Materials / chemistry; Calcium Carbonate / chemistry; Female; Fibrin / chemistry; Gels / chemistry; Humans; Immunity; Immunotherapy / methods; Luminescent Measurements; Melanoma, Experimental / pathology; Mice, Inbred C57BL; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasm Recurrence, Local / pathology; Neoplasms / pathology; Neoplasms / surgery; Phagocytosis
TL;DR: The findings indicate that the immunotherapeutic fibrin gel ‘awakens’ the host innate and adaptive immune systems to inhibit both local tumour recurrence post surgery and potential metastatic spread. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 21, 2019

2019 journal article

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

ADVANCED MATERIALS, 31(23).

By: Q. Chen n, Q. Hu n, E. Dukhovlinova*, G. Chen*, S. Ahn*, C. Wang n, E. Ogunnaike n, F. Ligler n, G. Dotti*, Z. Gu n

author keywords: CAR T cells; cell therapy; drug delivery; immunotherapy; photothermal therapy
MeSH headings : Animals; Antigens / metabolism; Cell Line, Tumor; Chondroitin Sulfate Proteoglycans / metabolism; Combined Modality Therapy; Female; Heterografts; Humans; Hyperthermia, Induced; Immunotherapy, Adoptive / methods; Indocyanine Green / chemistry; Melanoma / pathology; Melanoma / therapy; Membrane Proteins / metabolism; Mice, SCID; Nanoparticles / chemistry; Photosensitizing Agents / chemistry; Phototherapy / methods; Polylactic Acid-Polyglycolic Acid Copolymer / chemistry; Proteoglycans / metabolism; Skin Neoplasms / pathology; Skin Neoplasms / therapy; T-Lymphocytes / metabolism; T-Lymphocytes / transplantation; Tumor Microenvironment
TL;DR: It is found that the chondroitin sulfate proteoglycan‐4 (CSPG4)‐specific CAR T cells infused in Nod scid gamma mice engrafted with the human melanoma WM115 cell line have superior antitumor activity after photothermal ablation of the tumor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 22, 2019

2019 journal article

Platelet for drug delivery

Current Opinion in Biotechnology, 58, 81–91.

MeSH headings : Blood Platelets; Drug Delivery Systems; Hemostasis; Humans; Inflammation; Neoplasms
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: January 19, 2020

2019 journal article

Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy

NANO RESEARCH, 12(6), 1313–1320.

By: J. Yan n, X. Zhang n, Y. Liu n, Y. Ye n, J. Yu n, Q. Chen n, J. Wang n, Y. Zhang n ...

author keywords: liquid metal; melanin nanoparticles; nanomedicine; shape-controlled synthesis; photothermal therapy
TL;DR: Interestingly, shape-controlled synthesis of LM nanodroplets can be achieved by the incorporation of MNPs, and among these shapes, EGaIn nanorice has the best photothermal conversion efficiency, which could be leveraged for photothermal therapy. (via Semantic Scholar)
Source: Web Of Science
Added: June 17, 2019

2019 article

Topical and Transdermal Nanomedicines for Cancer Therapy

NANOTHERANOSTICS FOR CANCER APPLICATIONS, Vol. 5, pp. 231–251.

By: Y. Ye n, J. Wang n, W. Sun n, H. Bomba n & Z. Gu*

TL;DR: This chapter summarizes the principles and the recent innovations in the field of transdermal nanomedicine together with opportunities and challenges in clinical translation. (via Semantic Scholar)
Source: Web Of Science
Added: October 26, 2020

2019 journal article

Topography‐Induced Cell Self‐Organization from Simple to Complex Aggregates

Small, 15(15), 1900030.

author keywords: cellular aggregate; intermolecular interaction; self-organization; topographic interaction
MeSH headings : Cell Aggregation / drug effects; Cell Line; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cell Shape / drug effects; Cell Survival / drug effects; Cells / drug effects; Cells / metabolism; Humans; Hydrogels / pharmacology; Microscopy, Fluorescence
TL;DR: It is reported that self-organization of cells from simple to complex aggregates can be induced by multiscale topography through confined templates at the macroscale and cell interactions at the nanoscale. (via Semantic Scholar)
Source: Crossref
Added: January 19, 2020

2018 journal article

Advances in bioresponsive closed-loop drug delivery systems

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 544(2), 350–357.

author keywords: Closed-loop; Drug delivery; Bioresponsive; Glucose-responsive; Enzyme-responsive
MeSH headings : Anticoagulants / administration & dosage; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Drug Delivery Systems / methods; Feedback, Physiological / drug effects; Homeostasis / drug effects; Humans; Hypoglycemic Agents / administration & dosage; Thrombosis / blood; Thrombosis / drug therapy
TL;DR: The recent advances in bioresponsive closed‐loop drug delivery systems, including glucose‐responsive, enzyme‐activated, and other biosignal‐mediated delivery systems are surveyed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 review

Advances in glycosylation-mediated cancer-targeted drug delivery

[Review of ]. DRUG DISCOVERY TODAY, 23(5), 1126–1138.

MeSH headings : Animals; Drug Delivery Systems; Glycosylation; Humans; Neoplasms / drug therapy
TL;DR: This review surveys a variety of glycosylation-mediated cancer-targeted drug nanocarriers as well as their applications for cancer therapy and discusses their challenges, opportunities, and future perspectives. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 review

Advances in liquid metals for biomedical applications

[Review of ]. CHEMICAL SOCIETY REVIEWS, 47(8), 2518–2533.

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Biocompatible Materials / chemistry; Biocompatible Materials / toxicity; Biosensing Techniques / methods; Drug Carriers / chemistry; Drug Carriers / toxicity; Gallium / chemistry; Humans; Metals / chemistry; Microfluidics / instrumentation; Microfluidics / methods; Nanostructures / chemistry; Neoplasms / diagnosis; Neoplasms / drug therapy; Photosensitizing Agents / chemistry; Photosensitizing Agents / therapeutic use
TL;DR: This tutorial review introduces the common performances of liquid metals, highlights their featured properties, as well as summarizes various state-of-the-art bio-applications involving carriers for drug delivery, molecular imaging, cancer therapy and biomedical devices. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Advances in transformable drug delivery systems

BIOMATERIALS, 178, 546–558.

By: Q. Hu n, Q. Chen n & Z. Gu n

author keywords: Drug delivery; Stimuli-responsive; Cancer therapy; Transformable formulation
MeSH headings : Animals; Drug Delivery Systems / methods; Extracellular Space / chemistry; Humans; Intracellular Space / chemistry; Microbubbles; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasms / diagnosis; Neoplasms / pathology
TL;DR: This review describes the recently developed intracelluarly and extracellularly transformable DDSs, especially associated with assembly or disassociation of the original formulation units, for achieving various functionalities, including prolonged retention time, inhibited endocytosis and enhanced cytotoxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy

ACS NANO, 12(6), 5995–6005.

author keywords: salmonella; polydopamine; hypoxia targeting; photothermal therapy; malignant melanoma
MeSH headings : Animals; Antineoplastic Agents / adverse effects; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Cell Survival / drug effects; Hypoxia / metabolism; Indoles / adverse effects; Indoles / metabolism; Indoles / pharmacology; Lasers; Melanoma, Experimental / metabolism; Melanoma, Experimental / pathology; Melanoma, Experimental / therapy; Mice; Phototherapy; Polymers / adverse effects; Polymers / metabolism; Polymers / pharmacology; Salmonella / growth & development; Salmonella / metabolism; Tissue Distribution; Tumor Cells, Cultured
TL;DR: Both VNP and pDA potentiate the therapeutic ability of each other, resulting in a superior anticancer effect, which eliminated the tumors without relapse or metastasis with only one injection and laser irradiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Biodegradable Gelatin Methacryloyl Microneedles for Transdermal Drug Delivery

Advanced Healthcare Materials, 8(3), 1801054.

author keywords: gelatin methacryloyl; microneedle; sustained release; transdermal drug delivery
MeSH headings : Administration, Cutaneous; Animals; Biocompatible Materials / chemistry; Biocompatible Materials / pharmacology; Doxorubicin / chemistry; Doxorubicin / pharmacology; Gelatin / chemistry; Gelatin / pharmacology; Hydrogels / chemistry; Hydrogels / pharmacology; Melanoma, Experimental / drug therapy; Melanoma, Experimental / metabolism; Melanoma, Experimental / pathology; Mice; Needles; Skin Neoplasms / drug therapy; Skin Neoplasms / metabolism; Skin Neoplasms / pathology
TL;DR: An innovative biodegradable MNs patch for the sustained delivery of drugs using a polymer patch, which can adjust delivery rates based on its crosslinking degree, is reported. (via Semantic Scholar)
Source: Crossref
Added: January 19, 2020

2018 journal article

Bioresponsive Microneedles with a Sheath Structure for H2O2 and pH Cascade-Triggered Insulin Delivery

SMALL, 14(14).

author keywords: diabetes; drug delivery; insulin; microneedles; stimuli-responsive
MeSH headings : Animals; Drug Delivery Systems / methods; Humans; Hydrogen Peroxide / chemistry; Hydrogen-Ion Concentration; Insulin / administration & dosage; Insulin / chemistry; Mice; Oxidation-Reduction
TL;DR: The resulting microneedle patch can release insulin with rapid responsiveness under hyperglycemic conditions owing to an oxidative and acidic environment because of glucose oxidation, and can therefore effectively regulate blood glucose levels within a normal range on a chemically induced type 1 diabetic mouse model with enhanced biocompatibility. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2018 review

Blood sampling using microneedles as a minimally invasive platform for biomedical diagnostics

[Review of ]. APPLIED MATERIALS TODAY, 13, 144–157.

author keywords: Blood sampling; Microneedle; Minimally invasive; Hemotological analysis; Point-of-care test
TL;DR: This review highlights the characteristics of skin structures and the existing blood sampling techniques in clinics and in nature, focusing on several critical aspects of microneedle platforms for transdermal blood extraction and analysis, including materials composition, actuator fabrication, sensing methods and the future prospects toward clinical translation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 31, 2018

2018 journal article

Cancer Immunotherapy: PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy (Adv. Mater. 22/2018)

Advanced Materials, 30(22), 1870152.

By: X. Zhang n, C. Wang n, J. Wang n, Q. Hu n, B. Langworthy*, Y. Ye n, W. Sun n, J. Lin* ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: December 19, 2020

2018 journal article

Cardiac cell-integrated microneedle patch for treating myocardial infarction

SCIENCE ADVANCES, 4(11).

By: J. Tang n, J. Wang n, K. Huang n, Y. Ye n, T. Su n, L. Qiao n, M. Hensley n, T. Caranasos* ...

MeSH headings : Animals; Cells, Cultured; Microtechnology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Needles; Rats; Rats, Inbred WKY; Regeneration; Stromal Cells / cytology; Stromal Cells / transplantation; Swine; Tissue Engineering / instrumentation
TL;DR: The microneedle patch integrated with cardiac stromal cells (MN-CSCs) represents an innovative approach delivering therapeutic cells for heart regeneration and polymeric MNs are used to create “channels” between host myocardium and therapeutic CSCs to promote heart repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 31, 2018

2018 journal article

Cationic lipid-assisted nanoparticles for delivery of mRNA cancer vaccine

Biomaterials Science, 6(11), 3009–3018.

MeSH headings : Animals; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / immunology; Cancer Vaccines / chemistry; Cancer Vaccines / genetics; Cancer Vaccines / immunology; Cell Line; Dendritic Cells / cytology; Dendritic Cells / immunology; Drug Carriers / chemistry; Lipids / chemistry; Lymphoma / pathology; Lymphoma / prevention & control; Mice; Mice, Inbred C57BL; Nanoparticles / chemistry; RNA, Messenger / chemistry; RNA, Messenger / genetics; RNA, Messenger / immunology
TL;DR: Investigation of cationic lipid-assisted nanoparticles (CLAN) found that CLAN encapsulating mRNA encoding antigen could effectively stimulate the maturation of dendritic cells and promote the activation and proliferation of antigen-specific T cells both in vitro and in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: January 19, 2020

2018 review

Cellular Bioparticulates with Therapeutics for Cancer Immunotherapy

[Review of ]. BIOCONJUGATE CHEMISTRY, 29(3), 702–708.

By: C. Wang n, D. Wen n & Z. Gu n

MeSH headings : Animals; Antigen-Presenting Cells / cytology; Antigen-Presenting Cells / immunology; Blood Platelets / cytology; Blood Platelets / immunology; Cell Engineering / methods; Drug Delivery Systems / methods; Erythrocytes / cytology; Erythrocytes / immunology; Humans; Immunologic Factors / administration & dosage; Immunologic Factors / immunology; Immunologic Factors / therapeutic use; Immunotherapy / methods; Microbiota; Neoplasms / immunology; Neoplasms / microbiology; Neoplasms / therapy; T-Lymphocytes / cytology; T-Lymphocytes / immunology
TL;DR: This Topical Review highlights recently reported studies utilizing bioparticulates for cancer immunotherapy, including engineered red blood cells (RBC) and RBC membrane coated particles, engineered T-cells, engineered platelets, and engineered microbes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

NATURE BIOMEDICAL ENGINEERING, 2(11), 831–840.

By: Q. Hu n, W. Sun*, J. Wang n, H. Ruan n, X. Zhang*, Y. Ye n, S. Shen*, C. Wang n ...

MeSH headings : Animals; Antibodies / chemistry; Antibodies / immunology; Blood Platelets / chemistry; Blood Platelets / cytology; Blood Platelets / metabolism; Cell Line, Tumor; Chemokines / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / chemistry; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / metabolism; Leukemia / therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Receptor / deficiency; Programmed Cell Death 1 Receptor / genetics; Programmed Cell Death 1 Receptor / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology; T-Lymphocytes / metabolism
TL;DR: It is shown that systemically delivered blood platelets decorated with anti-PD-1 antibodies and conjugated to haematopoietic stem cells reduce the growth and recurrence of leukaemia in mice and significantly augment the therapeutic efficacy of checkpoint blockade. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 26, 2018

2018 journal article

Core–Shell Microneedle Gel for Self-Regulated Insulin Delivery

ACS Nano, 12(3), 2466–2473.

By: J. Wang n, Y. Ye n, J. Yu n, A. Kahkoska*, X. Zhang n, C. Wang n, W. Sun n, R. Corder n ...

MeSH headings : Animals; Blood Glucose / analysis; Blood Glucose / metabolism; Delayed-Action Preparations / metabolism; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Diabetes Mellitus, Type 1 / metabolism; Drug Delivery Systems / instrumentation; Enzymes, Immobilized / metabolism; Equipment Design; Humans; Hydrogels / metabolism; Hydrogen Peroxide / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / therapeutic use; Insulin / administration & dosage; Insulin / therapeutic use; Male; Mice; Mice, Inbred C57BL; Needles; Transdermal Patch
TL;DR: It is demonstrated that this smart insulin patch with a bioresponsive core and protective shell could effectively regulate the blood glucose levels within a normal range with improved biocompatibility. (via Semantic Scholar)
Source: Crossref
Added: January 19, 2020

2018 journal article

Delivery Strategies for Immune Checkpoint Blockade

ADVANCED HEALTHCARE MATERIALS, 7(20).

By: Q. Chen n, C. Wang n, G. Chen n, Q. Hu n & Z. Gu n

author keywords: biomaterials; cancer therapy; drug delivery; immune checkpoint blockade; immunotherapy
MeSH headings : Autoimmune Diseases / immunology; Autoimmune Diseases / therapy; Humans; Immunotherapy / methods; Neoplasms / immunology; Neoplasms / therapy
TL;DR: A brief review summarizes strategies to increase the antitumor immunity, including the local and targeted delivery of checkpoint inhibitors, and a combination of different checkpoint inhibitors or with other therapeutic treatments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 19, 2018

2018 journal article

Drug-Bearing Supramolecular MMP Inhibitor Nanofibers for Inhibition of Metastasis and Growth of Liver Cancer

Advanced Science, 5(8), 1700867.

By: Y. Ji*, Y. Xiao*, L. Xu*, J. He*, C. Qian*, W. Li*, L. Wu*, R. Chen* ...

author keywords: doxorubicin; liver cancer; metastasis; matrix metalloproteinase (MMP) inhibitor; peptide drug conjugates
TL;DR: This hexapeptide‐based supermolecule system represents a promising nanoscale platform to sustain drug release with high loading capacity for intratumoral administration and simultaneously inhibits metastasis and tumor growth to achieve synergistic effects for metastatic HCC therapy. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2018 journal article

Engineering PD-1-Presenting Platelets for Cancer Immunotherapy

NANO LETTERS, 18(9), 5716–5725.

By: X. Zhang n, J. Wang n, Z. Chen n, Q. Hu n, C. Wang n, J. Yan n, G. Dotti*, P. Huang*, Z. Gu n

author keywords: Drug delivery; platelet; immune checkpoint blockade; immunotherapy; nanomedicine
TL;DR: This work genetically engineered platelets from megakaryocyte progenitor cells to express the programmed cell death protein 1 (PD-1) and found that the PD-1 platelet and its derived microparticle could accumulate within the tumor surgical wound and revert exhausted CD8+ T cells, leading to the eradication of residual tumor cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 16, 2018

2018 article

Glucose-responsive insulin by molecular and physical design (vol 9, pg 937, 2017)

Bakh, N. A., Cortinas, A. B., Weiss, M. A., Langer, R. S., Anderson, D. G., Gu, Z., … Strano, M. S. (2018, January). NATURE CHEMISTRY, Vol. 10, pp. 109–109.

TL;DR: This corrects the article DOI: 10.1038/nchem.2857 to indicate that the author of the paper is a doctor of medicine, not a scientist, as previously reported. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Glucose-responsive oral insulin delivery for postprandial glycemic regulation

Nano Research, 12(7), 1539–1545.

author keywords: diabetes; drug delivery; glucose-responsive; insulin; nanomedicine
TL;DR: In vivo studies on chemically-induced type 1 diabetic mice show this oral glucose-responsive delivery approach can effectively reduce postprandial blood glucose excursions, and is the first demonstration of an oral insulin delivery system directly triggered by increasing postPRandial glucose concentrations in the intestine to provide an on-demand insulin release with ease of administration. (via Semantic Scholar)
Source: Crossref
Added: January 19, 2020

2018 journal article

Hierarchical Nanoassemblies-Assisted Combinational Delivery of Cytotoxic Protein and Antibiotic for Cancer Treatment

NANO LETTERS, 18(4), 2294–2303.

By: M. Liu, S. Shen*, D. Wen n, M. Li*, T. Li*, X. Chen*, Z. Gu n, R. Mo*

author keywords: Drug delivery; protein therapy; radical polymerization; cancer stem-like cells; combination cancer therapy
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Breast Neoplasms / drug therapy; Breast Neoplasms / pathology; Cell Line, Tumor; Cell Survival / drug effects; Delayed-Action Preparations / chemistry; Doxycycline / administration & dosage; Doxycycline / pharmacokinetics; Doxycycline / pharmacology; Doxycycline / therapeutic use; Drug Delivery Systems; Female; Humans; Mice; Nanostructures / chemistry; Neoplastic Stem Cells / drug effects; Ribonuclease, Pancreatic / administration & dosage; Ribonuclease, Pancreatic / pharmacokinetics; Ribonuclease, Pancreatic / pharmacology; Ribonuclease, Pancreatic / therapeutic use
TL;DR: It is shown that a hierarchically assembled nanocomposite can self-adaptively transform its particulate property in response to endogenous tumor-associated signals to overcome the sequential barriers and achieve an enhanced antitumor efficacy by killing CSCs and bulk tumor cells synchronously. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

SCIENCE TRANSLATIONAL MEDICINE, 10(429).

By: C. Wang n, J. Wang n, X. Zhang n, S. Yu n, D. Wen n, Q. Hu n, Y. Ye n, H. Bomba n ...

MeSH headings : Animals; Cell Line, Tumor; Combined Modality Therapy; Deoxycytidine / analogs & derivatives; Deoxycytidine / therapeutic use; Female; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Immunotherapy / methods; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor / metabolism; Gemcitabine
TL;DR: A ROS-responsive hydrogel scaffold controls release of gemcitabine and immune checkpoint inhibitor for enhanced antitumor activity and promotes an immune-mediated tumor regression in the tumor-bearing mice, with prevention of tumor recurrence after primary resection. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade

Advanced Materials, 30(28), 1801527.

By: S. Yu n, C. Wang n, J. Yu n, J. Wang n, Y. Lu n, Y. Zhang n, X. Zhang n, Q. Hu n ...

author keywords: checkpoint blockade; drug delivery; hydrogel; immunotherapy; stimuli responsive
MeSH headings : Gels; Humans; Immunotherapy; Melanoma; Tumor Microenvironment
TL;DR: A combination immunotherapy strategy is developed based on a thermogelling reactive oxygen species‐responsive polypeptide gel for sustained release of anti‐programmed cell death‐ligand 1 antibody and dextro‐1‐methyl tryptophan with leveraging the ROS level in the tumor microenvironment to enhance anti‐melanoma efficacy in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: December 19, 2020

2018 journal article

Leverage physiology for precision medications

Nanomedicine: Nanotechnology, Biology and Medicine, 14(5), 1883–1884.

By: Z. Gu n

Source: Crossref
Added: January 19, 2020

2018 review

Leveraging Engineering of Cells for Drug Delivery

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 51(3), 668–677.

By: Z. Chen n, Q. Hu n & Z. Gu n

MeSH headings : Animals; Cell Engineering; Drug Delivery Systems; Humans
TL;DR: This Account summarizes the recent contribution to the field of cell engineering methodologies and exploits a targeted checkpoint antibody delivery strategy for treatment of postsurgical cancer recurrence and metastatic spread by covalent binding of platelets' cell surfaces with a monoclonal antibody against programmed-death ligand 1. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Local generation of hydrogen for enhanced photothermal therapy

Nature Communications, 9(1).

MeSH headings : Catalysis; Hydrogen / chemistry; Nanoparticles / chemistry; Nanostructures / chemistry; Photoacoustic Techniques; Phototherapy / methods; Spectroscopy, Near-Infrared
TL;DR: The authors demonstrate the anticancer effects of cubic Pd hydride nanocrystals with photoacoustic imaging properties that can release hydrogen under an NIR trigger and have photothermal effects. (via Semantic Scholar)
Source: Crossref
Added: January 19, 2020

2018 journal article

Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles

ACS NANO, 12(2), 994–1005.

By: Y. Luo*, C. Xu*, H. Li*, Z. Cao*, J. Liu*, J. Wang*, X. Du*, X. Yang*, Z. Gu n, J. Wang*

author keywords: CRISPR/Cas9; specific gene editing; nanomedicine; specific promoter; type 2 diabetes
MeSH headings : Animals; CRISPR-Cas Systems / genetics; Cations / chemistry; Cells, Cultured; Diabetes Mellitus, Experimental / chemically induced; Diabetes Mellitus, Experimental / genetics; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Type 2 / chemically induced; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / metabolism; Diet, High-Fat; Gene Editing; HEK293 Cells; Humans; Lipids / chemistry; Macrophages / chemistry; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Nanoparticles / chemistry; Netrin-1 / genetics; Netrin-1 / metabolism; Polymers / chemistry; RAW 264.7 Cells
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Nanomedicine for obesity treatment

Science China Life Sciences, 61(4), 373–379.

author keywords: drug delivery; nanomedicine; obesity; browning; fat absorption; energy expenditure
MeSH headings : Anti-Obesity Agents / pharmacology; Anti-Obesity Agents / therapeutic use; Drug Delivery Systems / trends; Energy Metabolism / drug effects; Humans; Models, Biological; Nanomedicine; Obesity / drug therapy; Obesity / metabolism
TL;DR: Recent advances in nanomedicine are surveyed as an emerging strategy for obesity treatment with an emphasis on the enhanced therapeutic efficiency and minimized side effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: January 19, 2020

2018 journal article

PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy

ADVANCED MATERIALS, 30(22).

By: X. Zhang n, C. Wang n, J. Wang n, Q. Hu n, B. Langworthy*, Y. Ye n, W. Sun n, J. Lin* ...

author keywords: cancer immunotherapy; cell therapy; drug delivery; immune checkpoint blockade; nanomedicine
MeSH headings : Humans; Immunotherapy; Lymphocytes, Tumor-Infiltrating; Neoplasms / therapy; Programmed Cell Death 1 Receptor; T-Lymphocytes; Tumor Microenvironment
TL;DR: E engineered cellular nanovesicles (NVs) presenting PD‐1 receptors on their membranes, which enhance antitumor responses by disrupting thePD‐1/PD‐L1 immune inhibitory axis, are reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

PDT-Driven Highly Efficient Intracellular Delivery and Controlled Release of CO in Combination with Sufficient Singlet Oxygen Production for Synergistic Anticancer Therapy

Advanced Functional Materials, 28(41), 1804324.

author keywords: carbon monoxide; combination therapy; nanogels; peptide dendrimers; photodynamic therapy
TL;DR: Along with the simultaneous generation of large amounts of 1O2 and CO in cells, the combination of PDT and CO gas therapy offers significant synergistic anticancer effects and superior therapeutic safety both in vitro and in vivo. (via Semantic Scholar)
Source: Crossref
Added: January 19, 2020

2018 review

Polymeric microneedles for transdermal protein delivery

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 127, 106–118.

By: Y. Ye n, J. Yu n, D. Wen n, A. Kahkoska* & Z. Gu n

author keywords: Drug delivery; Transdermal; Microneedle; Protein delivery; Vaccine
MeSH headings : Administration, Cutaneous; Drug Delivery Systems; Humans; Microinjections; Needles; Polymers / chemistry; Proteins / administration & dosage; Proteins / metabolism; Proteins / pharmacokinetics; Skin / metabolism
TL;DR: This review surveys the current design and use of polymeric MNs for transdermal protein delivery and discusses the clinical potential and future translation of MNs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

ROS-Responsive Microneedle Patch for Acne Vulgaris Treatment

Advanced Therapeutics, 1(3), 1800035.

author keywords: acne vulgaris; drug delivery; microneedle patch; stimuli responsive
TL;DR: A new method of drug administration using a reactive oxygen species (ROS)‐responsive microneedle (MN) patch for anti‐acne therapy and in vivo studies demonstrated this bioresponsive patch with adsorption capability could efficiently reduce the skin swelling and inhibit the bacterial growth. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: December 19, 2020

2018 journal article

ROS-Responsive Microneedle Patch for Acne Vulgaris Treatment (Adv. Therap. 3/2018)

Advanced Therapeutics, 1(3), 1870006.

By: Y. Zhang, P. Feng, J. Yu, J. Yang, J. Zhao, J. Wang, Q. Shen, Z. Gu*

Source: Crossref
Added: December 19, 2020

2018 journal article

Strategies of Combination Drug Delivery for Immune Checkpoint Blockades

Advanced Healthcare Materials, 1801099.

author keywords: cancer immunity circles; cancer immunotherapy; combination delivery; drug delivery; immune checkpoint blockades
MeSH headings : Animals; Antigens, Neoplasm / immunology; Antigens, Neoplasm / therapeutic use; Drug Delivery Systems; Humans; Immunotherapy; Lymphocyte Activation / drug effects; Neoplasms / immunology; Neoplasms / pathology; Neoplasms / therapy; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Cytotoxic / pathology
TL;DR: Recent advances in combination of immune checkpoint blockades with therapies that participate in different stages of cancer immune cycle, including tumor antigen release, tumor antigen presentation, T‐cell activation, recognition of cancer cells by T‐cells, and tumor‐killing activity are summarized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: January 19, 2020

2018 journal article

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

NATURE BIOMEDICAL ENGINEERING, 2(1), 17–26.

By: J. Tang n, T. Su n, K. Huang, P. Dinh n, Z. Wang*, A. Vandergriff n, M. Hensley n, J. Cores n ...

TL;DR: The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

Nature Communications, 9(1).

By: C. Xu*, Z. Lu*, Y. Luo*, Y. Liu*, Z. Cao*, S. Shen*, H. Li*, J. Liu* ...

MeSH headings : Amino Acid Sequence; Animals; Apoptosis Regulatory Proteins / metabolism; CRISPR-Cas Systems; Calcium-Binding Proteins / metabolism; Caspase Activation and Recruitment Domain; Female; Gene Editing; Genetic Therapy; Inflammasomes / genetics; Inflammation / therapy; Male; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Peritonitis / immunology; Protein Conformation
TL;DR: This study inactivate NLRP3 in macrophages using CRISPR/Cas9 encapsulated in nanoparticles, and shows that administration in mice is effective in preventing septic shock and peritonitis, and in improving diabetes-associated inflammation and insulin resistance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: January 19, 2020

2018 article

The potential of a microneedle patch for reducing obesity

EXPERT OPINION ON DRUG DELIVERY, Vol. 15, pp. 431–433.

By: Y. Zhang n, J. Yu n, D. Wen n, G. Chen n & Z. Gu n

author keywords: Obesity; browning; microneedle; intradermal delivery
TL;DR: This work presents a novel approach to drug delivery called “nanotechnology in drug delivery” that combines “ nanofiltration” and “ Nanolysis” techniques. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 article

Towards Enhancing Skin Drug Delivery

Gu, Z., & Chen, X. (2018, March 1). ADVANCED DRUG DELIVERY REVIEWS, Vol. 127, pp. 1–2.

By: Z. Gu n & X. Chen*

MeSH headings : Administration, Cutaneous; Animals; Drug Delivery Systems; Humans; Skin / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

A melanin-mediated cancer immunotherapy patch

SCIENCE IMMUNOLOGY, 2(17).

By: Y. Ye n, C. Wang n, X. Zhang n, Q. Hu n, Y. Zhang n, Q. Liu n, D. Wen n, J. Milligan n ...

MeSH headings : Animals; Cancer Vaccines / immunology; Cancer Vaccines / metabolism; Cell Line, Tumor; Dendritic Cells / immunology; Dendritic Cells / metabolism; Female; Immunotherapy / instrumentation; Immunotherapy / methods; Infrared Rays; Kaplan-Meier Estimate; Melanins / immunology; Melanins / metabolism; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Needles; Neoplasms, Experimental / immunology; Neoplasms, Experimental / pathology; Neoplasms, Experimental / therapy; Transdermal Patch; Tumor Burden / immunology
TL;DR: It is found that the spatiotemporal photoresponsive immunotherapy increases infiltration of polarized T cells and local cytokine release in mice after tumor challenge and elicited antitumor effects toward established primary tumor and distant tumor. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Anaerobe-Inspired Anticancer Nanovesicles

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(10), 2588–2593.

By: C. Qian n, P. Feng*, J. Yu n, Y. Chen*, Q. Hu n, W. Sun n, X. Xiao*, X. Hu n ...

author keywords: drug delivery; nanomedicines; photodynamic therapy
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Cell Death / drug effects; Cell Proliferation / drug effects; Clostridium / chemistry; Clostridium / metabolism; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Hypoxia / metabolism; Imidazoles / chemistry; Imidazoles / pharmacology; Nanoparticles / chemistry; Prodrugs / chemistry; Prodrugs / pharmacology; Salmonella / chemistry; Salmonella / metabolism; Tirapazamine / chemistry; Tirapazamine / pharmacology
TL;DR: An anaerobe nanovesicle mimic that can not only be activated in THRs but also induce hypoxia in tumors by themselves is presented and provides a new strategy for engineering stimuli-responsive drug delivery systems in a bioinspired and synergistic fashion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 review

Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs

[Review of ]. THERANOSTICS, 7(14), 3504–3516.

By: C. Wang n, W. Sun n, Y. Ye n, H. Bomba n & Z. Gu n

author keywords: artificial immune cells; lymphoid organs
MeSH headings : Animals; Antigen-Presenting Cells / immunology; Artificial Cells / chemistry; Artificial Cells / immunology; Biomimetic Materials / chemistry; Humans; Lymphoid Tissue / cytology; Lymphoid Tissue / immunology
TL;DR: This review surveys the latest studies on engineering biomimetic materials for immunotherapy, focusing on the perspectives of bioengineering artificial antigen presenting cells and lymphoid organs. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 review

Bioresponsive materials

[Review of ]. NATURE REVIEWS MATERIALS, 2(1).

By: Y. Lu n, A. Aimetti, R. Langer* & Z. Gu*

TL;DR: This Review highlights recent advances in the design of smart materials capable of responding to the physiological environment, to biomarkers and to biological particulates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 review

Bioresponsive transcutaneous patches

[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 48, 28–32.

By: J. Yu n, Y. Zhang n, A. Kahkoska* & Z. Gu n

MeSH headings : Administration, Cutaneous; Animals; Drug Delivery Systems / methods; Drug Monitoring / methods; Humans; Needles; Skin; Transdermal Patch
TL;DR: Recent advances in the development and use of bioresponsive transcutaneous patches for on-demand smart and precise drug delivery, exploiting different physiological signals including pH, serum glucose levels, and enzyme activity are surveyed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 review

Conjugated polymer nanomaterials for theranostics

[Review of ]. ACTA PHARMACOLOGICA SINICA, 38(6), 764–781.

By: Q. Cheng-gen*, Y. Chen*, P. Feng*, X. Xiao*, M. Dong*, J. Yu n, Q. Hu n, Q. Shen*, Z. Gu n

author keywords: conjugated polymer; theranostics; biomedical imaging; photodynamic therapy; photothermal therapy; stimuli; responsive drug delivery
MeSH headings : Drug Delivery Systems; Nanostructures / chemistry; Photochemotherapy; Polymers / chemistry; Theranostic Nanomedicine
TL;DR: This review highlights the recent advances in the utilization of CPNs in theranostics, and introduces CPN-based in vivo imaging techniques, including near-infrared (NIR), two-photon (TP) imaging, photoacoustic (PA), and multimodal (MM) imaging. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 review

Engineering platelet-mimicking drug delivery vehicles

[Review of ]. FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING, 11(4), 624–632.

By: Q. Hu n, H. Bomba n & Z. Gu n

author keywords: drug delivery; platelets; nanomedicine; bio-inspired; biomimetic
TL;DR: This review highlights recent advancements made in the platelet-mimicking strategies and discusses the future opportunities and translational challenges. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species

NANO LETTERS, 17(2), 928–937.

By: P. Ma*, H. Xiao*, C. Yu*, J. Liu*, Z. Cheng*, H. Song*, X. Zhang*, C. Li* ...

author keywords: Drug delivery; cisplatin; iron oxide; Fenton's reaction; reactive oxygen species
MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Cell Line, Tumor; Cell Survival; Cisplatin / chemistry; Cisplatin / pharmacology; Cisplatin / therapeutic use; Drug Carriers; Drug Liberation; Electromagnetic Fields; Ferric Compounds / chemistry; Humans; Liver Neoplasms / diagnostic imaging; Liver Neoplasms / drug therapy; Metal Nanoparticles / chemistry; Mice, Inbred BALB C; Oxidation-Reduction; Particle Size; Reactive Oxygen Species / metabolism; Surface Properties; Tissue Distribution
TL;DR: Tumor site-specific conversion of ROS generation induced by released cisplatin and Fe2+/Fe3+ from iron-oxide nanocarriers with cisPlatin(IV) prodrugs for enhanced anticancer activity but minimized systemic toxicity is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Enhanced Endosomal Escape by Light-Fueled Liquid-Metal Transformer

NANO LETTERS, 17(4), 2138–2145.

By: Y. Lu n, Y. Lin n, Z. Chen n, Q. Hu n, Y. Liu n, S. Yu n, W. Gao n, M. Dickey n, Z. Gu n

author keywords: Drug delivery; liquid metal; stimuli-responsive; morphological transformation; endosomal escape
TL;DR: A light-fueled liquid-metal transformer for effective endosomal escape-facilitated cargo delivery via a chemical-mechanical process and equipped with graphene quantum dots provides a new strategy for facilitating effective endOSomal escape to achieve spatiotemporally controlled drug delivery with enhanced efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Glucose-responsive insulin by molecular and physical design

NATURE CHEMISTRY, 9(10), 937–943.

MeSH headings : Diabetes Mellitus / drug therapy; Diabetes Mellitus / metabolism; Glucose / metabolism; Humans; Insulin / metabolism; Insulin / therapeutic use; Models, Biological
TL;DR: A forward-looking viewpoint is provided, which asks if there are new approaches that could spur innovation in this area as well as to encourage synthetic chemists and chemical engineers to address the challenges and promises offered by this therapeutic approach. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery

ACS NANO, 11(1), 613–620.

author keywords: drug delivery; vesicles; polymersome; glucose-responsive; insulin; diabetes
MeSH headings : Animals; Diabetes Mellitus, Experimental / chemically induced; Diabetes Mellitus, Experimental / drug therapy; Drug Carriers / chemical synthesis; Drug Carriers / chemistry; Drug Delivery Systems / methods; Glucose / analysis; Glucose / metabolism; Glucose Oxidase / metabolism; Hydrogen Peroxide / chemistry; Hypoglycemia / drug therapy; Insulin / administration & dosage; Insulin / chemistry; Insulin / pharmacology; Kinetics; Male; Mice; Mice, Inbred C57BL; Polymers / chemical synthesis; Polymers / chemistry; Streptozocin; Transdermal Patch
TL;DR: In vivo testing indicates that a single patch can regulate glucose levels effectively with reduced risk of hypoglycemia and its kinetics can be modulated by adjusting the concentration of GOx loaded into the microneedles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery

NANO LETTERS, 17(2), 733–739.

author keywords: Drug delivery; diabetes; insulin; glucose-responsive; hypoxia-sensitive; H2O2-sensitive
MeSH headings : Animals; Blood Glucose / metabolism; Cell Hypoxia; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Type 1 / drug therapy; Diabetes Mellitus, Type 1 / metabolism; Drug Carriers / chemistry; Drug Liberation; Glucose / metabolism; Glucose Oxidase / metabolism; HeLa Cells; Humans; Hydrogen Peroxide / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / chemistry; Insulin / administration & dosage; Insulin / chemistry; Male; Mice, Inbred C57BL; Nitroimidazoles / chemistry; Oxidation-Reduction; Peptides / chemistry; Polyethylene Glycols / chemistry
TL;DR: In vivo experiments indicated that this smart insulin patch could efficiently regulate the blood glucose in the chemically induced type 1 diabetic mice for 10 h and eliminate the excess H2O2, which may lead to free radical-induced damage to skin tissue during the long-term usage and reduce the activity of GOx. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

Nature Biomedical Engineering, 1(2).

By: C. Wang n, W. Sun n, Y. Ye n, Q. Hu n, H. Bomba n & Z. Gu n

TL;DR: It is shown that conjugating anti-PDL1 (engineered monoclonal antibodies against programmed-death ligand 1) to the surface of platelets can reduce post-surgical tumour recurrence and metastasis, and that the administration of platelet-bound anti- PDL1 significantly prolonged overall mouse survival after surgery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: December 19, 2020

2017 journal article

Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody

Advanced Materials, 29(15).

By: C. Wang, W. Sun, G. Wright, A. Wang & Z. Gu*

TL;DR: This work presents a novel approach to drug delivery by utilizing nanofiltration technology for the first time in a clinical trial and shows real-world applications in the field of oncology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: December 19, 2020

2017 journal article

Injectable Thermosensitive Polypeptide-Based CDDP-Complexed Hydrogel for Improving Localized Antitumor Efficacy

Biomacromolecules, 18(12), 4341–4348.

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Biocompatible Materials / chemistry; Biodegradable Plastics / chemistry; Cell Line, Tumor; Cisplatin / chemistry; Cisplatin / pharmacology; Drug Carriers / chemistry; Female; Glutamic Acid / chemistry; HeLa Cells; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Injections / methods; MCF-7 Cells; Mice; Mice, Inbred BALB C; Peptides / chemistry; Polyethylene Glycols / chemistry; Rats; Rats, Sprague-Dawley
TL;DR: The new type of injectable CDDP-complexed hydrogel may serve as an efficient platform for sustained CDDP delivery in localized tumor therapy and improve the cisplatin (CDDP) release behavior and enhancing the localized antitumor efficiency. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: December 19, 2020

2017 journal article

Inside Cover: Anaerobe-Inspired Anticancer Nanovesicles (Angew. Chem. Int. Ed. 10/2017)

Angewandte Chemie International Edition, 56(10), 2516–2516.

By: C. Qian n, P. Feng*, J. Yu n, Y. Chen*, Q. Hu n, W. Sun n, X. Xiao*, X. Hu n ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: December 19, 2020

2017 journal article

Insulin-Responsive Glucagon Delivery for Prevention of Hypoglycemia

Small, 13(19), 1603028.

MeSH headings : Animals; Blood Glucose / metabolism; Glucagon / metabolism; Humans; Hypoglycemia / metabolism; Insulin / therapeutic use; Mice
TL;DR: This study reports an insulin-responsive glucagon delivery method based on a microneedle (MN)-array patch that is able to prevent hypoglycemia following a high-dose insulin injection in a chemically induced type 1 diabetic mouse model. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2017 journal article

Insulin-responsive glucagon delivery for prevention of hypoglycemia

Small (Weinheim An Der Bergstrasse, Germany), 13(19).

By: J. Yu n, Y. Zhang n, W. Sun n, A. Kahkoska*, J. Wang n, J. Buse*, Z. Gu n

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Investigation and intervention of autophagy to guide cancer treatment with nanogels

NANOSCALE, 9(1), 150–163.

By: X. Zhang n, X. Liang*, J. Gu*, D. Chang*, J. Zhang*, Z. Chen n, Y. Ye n, C. Wang n ...

MeSH headings : Animals; Autophagy; Chloroquine / administration & dosage; Doxorubicin / administration & dosage; Drug Delivery Systems; Endocytosis; Endosomes; Exocytosis; Female; Gels; Humans; MCF-7 Cells; Mice; Mice, SCID; Nanoparticles; Neoplasms, Experimental / drug therapy; Rhodamines; Xenograft Model Antitumor Assays; rab GTP-Binding Proteins / metabolism
TL;DR: Investigation and intervention of the autophagy pathway could provide a new method to improve the therapeutic effect of anticancer nanogels and be sequestered in autophagosomes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 article

KIDNEY PHYSIOLOGYA size bandpass filter

Lu, Y., & Gu, Z. (2017, November). NATURE NANOTECHNOLOGY, Vol. 12, pp. 1023–1025.

By: Y. Lu n & Z. Gu n

MeSH headings : Animals; Glomerular Filtration Rate; Humans; Kidney Glomerulus / metabolism; Nanoparticles; Particle Size
TL;DR: The next-generation precision medications and diagnostic tools developed in this study will help improve the quality of life for patients and improve the efficiency of existing treatments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

KO of 5-InsP(7) kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(45), 11968–11973.

By: C. Gu*, H. Nguyen*, D. Ganini*, Z. Chen n, H. Jessen*, Z. Gu n, H. Wang*, S. Shears*

author keywords: bioenergetics; signaling; inositol pyrophosphates
MeSH headings : Adenosine Triphosphate / metabolism; CRISPR-Cas Systems; Cell Line, Tumor; Colonic Neoplasms / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / biosynthesis; G1 Phase Cell Cycle Checkpoints / genetics; Gene Knockout Techniques; Glycolysis / genetics; Glycolysis / physiology; HCT116 Cells; HEK293 Cells; Humans; Inositol Phosphates / metabolism; Mitochondria / metabolism; Phosphotransferases (Phosphate Group Acceptor) / genetics; Phosphotransferases (Phosphate Group Acceptor) / metabolism; Signal Transduction; Tumor Suppressor Protein p53 / biosynthesis
TL;DR: It is concluded that 5-InsP7 regulates p53 expression, whereas 1,5-Insp8 regulates ATP levels, which attribute hitherto unsuspected functionality for 1-5- InsP8 to bioenergetic homeostasis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 review

LEVERAGING PHYSIOLOGY FOR PRECISION DRUG DELIVERY

[Review of ]. PHYSIOLOGICAL REVIEWS, 97(1), 189–225.

By: W. Sun n, Q. Hu n, W. Ji n, G. Wright n & Z. Gu n

TL;DR: A large number of drug delivery platforms have been devised ranging from macro- to micro-based systems, but how these are implemented and how they are implemented are still in the early stages. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Leveraging H2O2Levels for Biomedical Applications

Advanced Biosystems, 1(9), 1700084.

By: J. Wang n, Y. Zhang n, E. Archibong n, F. Ligler n & Z. Gu n

author keywords: diagnosis; drug delivery; H2O2-responsive; oxidation-responsive; polymers
TL;DR: The development of H2O2‐responsive functional groups for constructing H1N1‐responsive formulations, as well as the guidance for designing suitable formulations to treat each specific pathological condition are overviewed. (via Semantic Scholar)
Source: Crossref
Added: November 30, 2020

2017 journal article

Local delivery of checkpoints antibodies

HUMAN VACCINES & IMMUNOTHERAPEUTICS, 13(1), 245–248.

By: C. Wang n, Y. Ye n & Z. Gu n

author keywords: biomaterials; cancer immunotherapy; drug delivery; immune checkpoint inhibitors; microneedle
MeSH headings : Antibodies / administration & dosage; Biomedical Research / trends; Humans; Immunologic Factors / administration & dosage; Immunotherapy / methods; Molecular Targeted Therapy / methods; Neoplasms / immunology; Neoplasms / therapy
TL;DR: Recent efforts utilizing immunoengineering for local delivery of these immune checkpoint antibodies are introduced in the field of cancer immunotherapy. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment

ACS NANO, 11(9), 9223–9230.

By: Y. Zhang n, Q. Liu*, J. Yu n, S. Yu n, J. Wang n, L. Qiang*, Z. Gu n

author keywords: drug delivery; microneedle patch; obesity; browning agent; adipose tissue
MeSH headings : Adipocytes, White / drug effects; Adipose Tissue, White / drug effects; Animals; Anti-Obesity Agents / administration & dosage; Anti-Obesity Agents / therapeutic use; Drug Delivery Systems / instrumentation; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / therapeutic use; Male; Mice, Inbred C57BL; Obesity / drug therapy; Rosiglitazone / administration & dosage; Rosiglitazone / therapeutic use; Transdermal Patch
TL;DR: A transcutaneous browning agent patch is developed to locally induce adipose tissue transformation and reduces treated fat pad size, increases whole body energy expenditure, and improves type-2 diabetes in vivo in a diet-induced obesity mouse model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 review

Photoacoustic Drug Delivery

[Review of ]. SENSORS, 17(6).

By: Y. Zhang n, J. Yu n, A. Kahkoska* & Z. Gu n

author keywords: photoacoustic imaging; drug delivery; chemotherapy; photothermal therapy
MeSH headings : Drug Delivery Systems; Humans; Optical Imaging; Photoacoustic Techniques; Spectrum Analysis; Theranostic Nanomedicine
TL;DR: This review focuses on the recent development of PAI-mediated drug delivery systems and provides an overview of the design of different PAI agents for drug delivery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Red Blood Cells for Drug Delivery

Small Methods, 1(12), 1700270.

author keywords: interface engineering; layer-by-layer assembly; multilayer thin films; optoelectronic devices
TL;DR: The loading methods and loading therapeutics by RBC carriers are surveyed, and recent advances in the design of stimuli-triggered R BC carriers highlighted, and an outlook is presented. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2017 journal article

Red Blood Cells for Glucose-Responsive Insulin Delivery

ADVANCED MATERIALS, 29(18).

MeSH headings : Erythrocytes; Glucose; Insulin
TL;DR: This work is the first demonstration of utilizing RBC membrane to achieve smart insulin delivery with fast responsiveness and the binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of BG level in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy

ADVANCED MATERIALS, 29(13).

By: Q. Hu n, W. Sun n, C. Qian n, H. Bomba n, H. Xin n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Biomimetic Materials / chemistry; Blood Vessels / drug effects; Blood Vessels / metabolism; Cell Line, Tumor; Cell Survival / drug effects; Cells, Cultured; Dextrans / chemistry; Drug Delivery Systems; Human Umbilical Vein Endothelial Cells / drug effects; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Mice, Nude; Microtubules / enzymology; Microtubules / metabolism; Nanostructures / chemistry; Neoplasm Transplantation; Neoplasms / blood supply; Neoplasms / drug therapy; Neoplasms / metabolism; Oligopeptides / chemistry; Paclitaxel / administration & dosage; Paclitaxel / pharmacokinetics; Tumor Necrosis Factor-alpha / chemistry; Tumor Necrosis Factor-alpha / pharmacokinetics
TL;DR: A "relay drug delivery" system based on two distinct modules that can specifically induce tumor blood vessel inflammation generation and an execution biomimetic nanocarrier B that can accumulate at the tumor site by receiving the broadcasting signals generated by NCA is developed for amplifying active tumor targeting signal and enhancing antitumor therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Smart materials and systems as artificial pancreas for diabetes treatment

Smart Materials for Tissue Engineering: Applications, 25, 358–381.

By: Y. Zhang, M. Wang, J. Yu & Z. Gu

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Stimuli-Responsive Polymersomes for Biomedical Applications

BIOMACROMOLECULES, 18(3), 649–673.

MeSH headings : Biomimetic Materials / chemistry; Diagnostic Imaging; Drug Carriers / chemistry; Drug Delivery Systems; Hydrogen-Ion Concentration; Membranes, Artificial; Nanoparticles / chemistry; Polymers / chemistry; Reactive Oxygen Species / metabolism
TL;DR: This Perspective focuses on recent advances in stimuli-responsive polymersomes and their potential biomedical applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Synthetic beta cells for fusion-mediated dynamic insulin secretion

Nature Chemical Biology, 14(1), 86–93.

MeSH headings : Animals; Artificial Cells; Biomimetic Materials / chemistry; Blood Glucose / analysis; Cell Engineering / methods; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Hydrogen-Ion Concentration; Insulin / blood; Insulin / metabolism; Insulin Secretion; Insulin-Secreting Cells / metabolism; Male; Membrane Fusion; Mice, Inbred C57BL
TL;DR: The construction of artificial beta cells with a multicompartmental 'vesicles-in-vesicle' superstructure equipped with a glucose-metabolism system and membrane-fusion machinery is described, which can effectively distinguish between high and normal glucose levels. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

ADVANCED MATERIALS, 29(29).

By: C. Wang n, Y. Ye n, Q. Hu n, A. Bellotti n & Z. Gu n

author keywords: biomaterials; cancer immunotherapy; cell therapy; drug delivery
MeSH headings : Animals; Antigen-Presenting Cells / cytology; Antigen-Presenting Cells / metabolism; Antigens / genetics; Antigens / immunology; Antigens / metabolism; Biocompatible Materials / chemistry; Cell- and Tissue-Based Therapy; Humans; Immunologic Factors / metabolism; Immunologic Factors / therapeutic use; Immunotherapy; Nanostructures / chemistry; Neoplasms / therapy
TL;DR: An overview of the latest studies on engineering biomaterials for the enhancement of anticancer immunity is given, including the perspectives of delivery of immunomodulatory therapeutics, engineering immune cells, and constructing immune‐modulating scaffolds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 review

Tailoring non-viral delivery vehicles for transporting genome-editing tools

[Review of ]. Science China-Materials, 60(6), 511–515.

By: W. Sun n & Z. Gu n

TL;DR: The recent advances in the development of non-viral delivery systems for CRISPR-Cas9 are surveyed and challenges and future directions in this field are discussed. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Thrombin-responsive transcutaneous patch for auto-anticoagulant regulation

Advanced Materials, 29(4).

By: Y. Zhang n, J. Yu n, J. Wang n, N. Hanne n, Z. Cui n, C. Qian n, C. Wang n, H. Xin n ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules

Nano Research, 10(4), 1393–1402.

By: J. Di n, J. Yu n, Q. Wang*, S. Yao n, D. Suo n, Y. Ye n, M. Pless n, Y. Zhu n, Y. Jing n, Z. Gu n

author keywords: controlled drug delivery; focused ultrasound; diabetes; nanocapsule; microgel
TL;DR: It is demonstrated that this ultrasound-triggered insulin delivery system, when activated by 30 s ultrasound administration, could effectively achieve glycemic control for up to one week in a noninvasive, localized, and pulsatile manner. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 article

ATP-Responsive Drug Delivery Systems

Sun, W., & Gu, Z. (2016, March 3). EXPERT OPINION ON DRUG DELIVERY, Vol. 13, pp. 311–314.

By: W. Sun n & Z. Gu n

MeSH headings : Adenosine Triphosphate / metabolism; Drug Carriers / chemistry; Drug Delivery Systems; Humans
TL;DR: An emerging strategy utilizing the “molecular unit of currency” in biological energy transfer - ATP - as a trigger for therapeutic delivery is discussed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging

THERANOSTICS, 6(7), 1053–1064.

By: C. Qian*, Y. Chen, S. Zhu, J. Yu*, L. Zhang, P. Feng, X. Tang, Q. Hu* ...

author keywords: drug delivery; nanomedicine; stimuli-responsive; ATP-responsive; theranostics; conjugated polymers
MeSH headings : Adenosine Triphosphate / metabolism; Antineoplastic Agents / administration & dosage; Boronic Acids / metabolism; Doxorubicin / administration & dosage; Drug Carriers / administration & dosage; Hep G2 Cells; Humans; Liver Neoplasms / diagnostic imaging; Liver Neoplasms / drug therapy; Nanoparticles / administration & dosage; Optical Imaging / methods; Theranostic Nanomedicine / methods
TL;DR: In vivo studies validate that this adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drugs and real-time imaging exhibits promising capability for inhibition of tumor growth. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Anticancer Therapy: Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy (Adv. Mater. 17/2016)

Advanced Materials, 28(17), 3226–3226.

TL;DR: A conjugated-polymer-based nanocarrier can be activated by photoirradiation, producing singlet oxygen and inducing hypoxia to promote release of its cargo inside tumor cells for enhanced anticancer efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: April 3, 2022

2016 conference paper

Cell membrane-mediated anticancer drug delivery

Nanotechnology: delivering on the promise, vol 2, 1224, 197–211.

By: Q. Hu & Z. Gu

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Drug Delivery: Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery (Adv. Mater. 16/2016)

Advanced Materials, 28(16), 3223–3223.

By: Y. Ye n, J. Yu n, C. Wang n, N. Nguyen n, G. Walker n, J. Buse*, Z. Gu n

TL;DR: A bio-responsive microneedle-based patch, integrated with a rhodamine-stained glucose-signal amplifier and calcein-AM-stained pancreatic β-cell capsules, effectively regulates the blood glucose level of type-1 diabetic mice, achieving a reduction for over 10 h. (via Semantic Scholar)
Source: Crossref
Added: December 17, 2020

2016 journal article

Dual targeted nanocarrier for brain ischemic stroke treatment

JOURNAL OF CONTROLLED RELEASE, 233, 64–71.

By: Y. Zhao*, Y. Jiang*, W. Lv*, Z. Wang*, L. Lv*, B. Wang*, X. Liu*, Y. Liu* ...

author keywords: Stroke; Stroke homing peptide; Dual-targeting liposomes; ZL006; Neuroprotection
TL;DR: T7&SHp-P-LPs could be used as a safe and effective dual targeted nanocarrier for ischemic stroke treatment and could enhance the ability of in vivo anti-ischemic stroke of MCAO rats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Elastic drug delivery: could treatments be triggered by patient movement?

NANOMEDICINE, Vol. 11, pp. 323–325.

By: Y. Zhang n, J. Yu n, Y. Zhu n & Z. Gu n

author keywords: drug delivery; mechanical-responsive; nanoparticle; wearable devices
MeSH headings : Drug Delivery Systems; Elasticity; Humans; Movement; Patients
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus

ADVANCED MATERIALS, 28(43), 9573-+.

By: Q. Hu n, C. Qian n, W. Sun n, J. Wang n, Z. Chen n, H. Bomba n, H. Xin n, Q. Shen*, Z. Gu n

MeSH headings : Animals; Biomimetic Materials / chemistry; Biomimetic Materials / pharmacokinetics; Biomimetics; Blood Platelets / cytology; Bone and Bones / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Cellular Microenvironment; Disease Models, Animal; Drug Carriers / chemistry; Drug Carriers / pharmacokinetics; Humans; Mice; Multiple Myeloma / complications; Multiple Myeloma / drug therapy; Multiple Myeloma / metabolism; Multiple Myeloma / pathology; Nanoparticles / chemistry; Thrombosis / complications; Thrombosis / drug therapy
TL;DR: A platelet-membrane-coated biomimetic nanocarrier, which can sequentially target the bone microenvironment and Myeloma cells to enhance the drug availability at the myeloma site and decrease off-target effects, is developed for inhibiting multiple myelomas growth and simultaneously eradicating thrombus complication. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Enhanced Antiglioblastoma Efficacy of Neovasculature and Glioma Cells Dual Targeted Nanoparticles

MOLECULAR PHARMACEUTICS, 13(10), 3506–3517.

By: L. Lv*, Y. Jiang*, X. Liu*, B. Wang*, W. Lv*, Y. Zhao*, H. Shi*, Q. Hu n ...

author keywords: glioma; antineovasculature; dual-targeted nanoparticle; drug delivery; paclitaxel
MeSH headings : Animals; Antineoplastic Agents, Phytogenic / chemistry; Antineoplastic Agents, Phytogenic / therapeutic use; Cell Line, Tumor; Drug Delivery Systems; Glioblastoma / drug therapy; Glioma / drug therapy; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles / chemistry; Paclitaxel / chemistry; Paclitaxel / therapeutic use; Polyesters / chemistry; Polyethylene Glycols / chemistry; Rats
TL;DR: The in vivo antiglioma efficacy and safety evaluation showed PC-NP-PTX significantly enhanced the antIGlioma effectiveness and displayed negligible acute toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

NANO LETTERS, 16(4), 2334–2340.

By: C. Wang n, Y. Ye n, G. Hochu n, H. Sadeghifar n & Z. Gu n

author keywords: Anti-PD-1; cancer immunotherapy; microneedle patch; melanoma; drug delivery
MeSH headings : Animals; Antibodies, Neoplasm / immunology; Antibodies, Neoplasm / pharmacology; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Immunotherapy / instrumentation; Immunotherapy / methods; Mice; Needles; Programmed Cell Death 1 Receptor / immunology; Skin Neoplasms / immunology; Skin Neoplasms / pathology; Skin Neoplasms / therapy
TL;DR: It is found that a single administration of the MN patch induces robust immune responses in a B16F10 mouse melanoma model compared to MN without degradation trigger or intratumoral injection of free aPD1 with the same dose. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Hypoxia-Sensitive Materials for Biomedical Applications

ANNALS OF BIOMEDICAL ENGINEERING, 44(6), 1931–1945.

By: J. Yu n, Y. Zhang n, X. Hu*, G. Wright n & Z. Gu n

author keywords: Hypoxia-responsive; Drug delivery; Bioimaging; Hypoxia inducible factor-1; Bioreductive molecule
MeSH headings : Animals; Cell Hypoxia; Humans; Hypoxia-Inducible Factor 1 / metabolism; Tissue Scaffolds / chemistry
TL;DR: Recent progress in the development of hypoxia-responsive systems for imaging, sensing and therapy was summarized and two types of hyp oxia-sensitive systems were reviewed with comments on their advantages and limitations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody

ADVANCED MATERIALS, 28(40), 8912–8920.

By: C. Wang n, W. Sun n, G. Wright n, A. Wang n & Z. Gu n

MeSH headings : Adjuvants, Immunologic; Animals; Antibodies; CpG Islands; Immunotherapy; Inflammation; Mice; Neoplasms / therapy; Programmed Cell Death 1 Receptor / immunology
TL;DR: Inflammation-triggered combination delivery of anti-PD-1 antibody and CpG oligodeoxynucleotides (CpG ODNs) has been demonstrated to prevent cancer relapse utilizing postsurgical inflammatory response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Internalized compartments encapsulated nanogels for targeted drug delivery

NANOSCALE, 8(17), 9178–9184.

By: J. Yu n, Y. Zhang n, W. Sun n, C. Wang n, D. Ranson n, Y. Ye n, Y. Weng*, Z. Gu n

MeSH headings : Doxorubicin / administration & dosage; Drug Delivery Systems; Ferrous Compounds; Hyaluronic Acid; Nanoparticles; Silicon Dioxide
TL;DR: This study illustrates the potential of utilizing an internalized compartments encapsulated formulation for targeted cancer therapy, and offers guidelines for developing a natural particulate-inspired drug delivery system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Introduction to special issue on “Responsive Materials and Systems: Toward Smart and Precision Medications”

Introduction to special issue on “Responsive Materials and Systems: Toward Smart and Precision Medications.” Bioengineering & Translational Medicine, 1(3), 235–236.

By: Z. Gu n

TL;DR: This issue highlights the exciting research work and key advances in leveraging responsive materials for smart and precision medications, the clinical translation of which would revolutionize health care, profoundly enhancing patients’ health and improving their quality of life. (via Semantic Scholar)
Source: Crossref
Added: August 16, 2021

2016 journal article

Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy

ADVANCED MATERIALS, 28(17), 3313–3320.

By: C. Qian n, J. Yu n, Y. Chen*, Q. Hu n, X. Xiao*, W. Sun n, C. Wang n, P. Feng*, Q. Shen*, Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Cell Hypoxia; Cell Survival / drug effects; Doxorubicin / chemistry; Doxorubicin / pharmacology; Doxorubicin / therapeutic use; Drug Carriers / chemistry; HeLa Cells; Humans; Hydrogen-Ion Concentration; Light; Mice; Mice, Nude; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles / chemistry; Neoplasms / diagnostic imaging; Neoplasms / drug therapy; Neoplasms / pathology; Optical Imaging; Polyvinyl Alcohol / chemistry; Singlet Oxygen / chemistry; Singlet Oxygen / metabolism; Transplantation, Heterologous
TL;DR: A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen and inducing hypoxide to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 review

Mechanical Force-Triggered Drug Delivery

[Review of ]. CHEMICAL REVIEWS, 116(19), 12536–12563.

By: Y. Zhang n, J. Yu n, H. Bomba n, Y. Zhu n & Z. Gu n

MeSH headings : Animals; Drug Carriers / chemistry; Drug Carriers / pharmacology; Drug Delivery Systems / methods; Liposomes / chemistry; Liposomes / pharmacology; Magnetic Phenomena; Mechanical Phenomena; Microbubbles; Nanoparticles / chemistry; Ultrasonic Waves
TL;DR: An overview of recent advances in mechanically activated DDS is provided and the opportunities and challenges regarding clinical translations are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery

Advanced Materials, 28(16), 3115–3121.

MeSH headings : Animals; Blood Glucose / analysis; Blood Glucose / metabolism; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Experimental / pathology; Insulin / metabolism; Insulin Secretion; Islets of Langerhans / metabolism; Mice; Needles; Time Factors
TL;DR: An innovative microneedle (MN)-based cell therapy is developed for glucose-responsive regulation of the insulin secretion from exogenous pancreatic β-cells without implantation that can quickly reduce the blood-sugar levels of chemically induced type-1 diabetic mice. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 journal article

Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration

ACS NANO, 10(1), 1292–1299.

By: D. Shi*, X. Xu*, Y. Ye n, K. Song*, Y. Cheng, J. Di n, Q. Hu n, J. Li ...

author keywords: drug delivery; tissue engineering; hydrogel; regenerative medicine; nanoparticles
TL;DR: The effect of an ultraviolet-reactive, rapidly cross-linkable scaffold integrated with kartogenin-loaded nanoparticles using an innovational one-step technology makes the chondrogenesis efficient and persistent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 review

Recent advances of cocktail chemotherapy by combination drug delivery systems

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 98, 19–34.

By: Q. Hu n, W. Sun n, C. Wang n & Z. Gu n

author keywords: Chemotherapy; Combination; Cancer; Nanocarriers; Drug delivery
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Drug Delivery Systems; Humans; Nanoparticles / administration & dosage; Nanoparticles / therapeutic use; Neoplasms / drug therapy
TL;DR: This review surveys the most recent advances in combination delivery of multiple small molecule chemotherapeutics using nanocarriers and highlights the sequential and site-specific co-delivery strategies, which provide new guidelines for development of programmable combination drug delivery systems. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Stimuli-responsive delivery of therapeutics for diabetes treatment

Bioengineering & Translational Medicine, 1(3), 323–337.

By: J. Yu n, Y. Zhang n, H. Bomba n & Z. Gu n

TL;DR: This review focuses on the different stimuli‐responsive systems to deliver therapeutics for diabetes treatment to improve patient comfort and prevent complications, and discusses advantages and limitations of current strategies, as well as future opportunities and challenges. (via Semantic Scholar)
Source: Crossref
Added: August 16, 2021

2016 journal article

Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors

ACS NANO, 10(9), 8956–8963.

By: Y. Ye n, J. Wang n, Q. Hu n, G. Hochu n, H. Xin n, C. Wang n, Z. Gu n

author keywords: drug delivery; immunotherapy; anti-PD1; IDO; microneedle
MeSH headings : Animals; Cell Cycle Checkpoints / drug effects; Drug Delivery Systems; Immunosuppression Therapy; Immunotherapy / methods; Indoleamine-Pyrrole 2,3,-Dioxygenase / therapeutic use; Melanoma / therapy; Programmed Cell Death 1 Receptor / therapeutic use; Skin Neoplasms / therapy; Tumor Microenvironment
TL;DR: This synergistic immunotherapy strategy locally targets the immunoinhibitory receptor programmed cell death protein 1 (PD1) and immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) for the treatment of melanoma through a microneedle-based transcutaneous delivery approach and achieves potent antitumor efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Thrombin-Responsive Transcutaneous Patch for Auto-Anticoagulant Regulation

Advanced Materials, 29(4), 1604043.

By: Y. Zhang n, J. Yu n, J. Wang n, N. Hanne n, Z. Cui n, C. Qian n, C. Wang n, H. Xin n ...

MeSH headings : Anticoagulants; Blood Coagulation; Heparin; Skin; Thrombin / administration & dosage
TL;DR: A thrombin-responsive closed-loop patch is developed for prolonged heparin delivery in a feedback-controlled manner that can sustainably regulate blood coagulation in response toThrombin. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 19, 2020

2016 journal article

Transformable DNA nanocarriers for plasma membrane targeted delivery of cytokine

BIOMATERIALS, 96, 1–10.

By: W. Sun n, W. Ji n, Q. Hu n, J. Yu n, C. Wang n, C. Qian n, G. Hochu n, Z. Gu n

author keywords: Cancer; Protein delivery; DNA structures; Cytokine; Nanomedicine
TL;DR: A tumor microenvironment-responsive and transformable nanocarrier for cell membrane targeted delivery of cytokine using a phospholipase A2 degradable liposome as a shell and complementary DNA nanostructures decorated with cytokines as the cores is reported. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

NANO LETTERS, 16(2), 1118–1126.

By: Q. Hu n, W. Sun n, Y. Lu n, H. Bomba n, Y. Ye n, T. Jiang*, A. Isaacson*, Z. Gu n

author keywords: Drug delivery; stimuli-responsive; tumor microenvironment; apoptosis; antiangiogenesis
MeSH headings : Angiogenesis Inhibitors / administration & dosage; Angiogenesis Inhibitors / chemistry; Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Apoptosis / drug effects; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Cell Line, Tumor; Cell Membrane Permeability / drug effects; Drug Delivery Systems; Endosomes / drug effects; Gene Transfer Techniques; Humans; Hyaluronoglucosaminidase / biosynthesis; Hyaluronoglucosaminidase / chemistry; Mice; Snake Venoms / administration & dosage; Snake Venoms / chemistry; TNF-Related Apoptosis-Inducing Ligand / administration & dosage; Tumor Microenvironment / drug effects; Xenograft Model Antitumor Assays
TL;DR: Equipped with an acid-degradable modality, the resulting CS-NG can substantially release combinational anticancer drugs-tumor necrosis factor-related apoptosis inducing ligand and antiangiogenic cilengitide toward the membrane of cancer cells and endothelial cells at the acidic tumor microenvironment, respectively. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Tumor microenvironment and intracellular signal-activated nanomaterials for anticancer drug delivery

MATERIALS TODAY, 19(5), 274–283.

By: R. Mo* & Z. Gu n

TL;DR: The focus is placed on design strategies and methods of formulating novel nanoscaled materials for anticancer drug delivery using tumor and endocytic acidities, hypoxia, enzyme overexpression, and high levels of intracellular glutathione, reactive oxygen species, and adenosine-5′-triphosphate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Versatile Protein Nanogels Prepared by In Situ Polymerization

MACROMOLECULAR CHEMISTRY AND PHYSICS, 217(3), 333–343.

By: Y. Ye n, J. Yu n & Z. Gu n

author keywords: drug delivery; in situ polymerization; nanogels; protein; stimuli-responsive
TL;DR: Allowing a range of stimuli-responsive formulations for on-demand release, in a spatial, temporal, and dosagecontrolled manner, is highlighted and future opportunities as well as challenges of protein nanogels are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment

NANOSCALE, 7(28), 12096–12103.

Contributors: D. Pacardo n, B. Neupane n, S. Rikard n, Y. Lu n, R. Mo n, S. Mishra n, J. Tracy n, G. Wang n, F. Ligler n, Z. Gu n

MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Drug Screening Assays, Antitumor; Gold / chemistry; Gold / pharmacology; HeLa Cells; Humans; Infrared Rays; Nanotubes / chemistry; Neoplasms / drug therapy; Photochemotherapy
TL;DR: This multifunctional AuNR-based system represents a novel theranostic strategy for spatiotemporal delivery of anticancer therapeutics and demonstrates enhanced anticancer efficacy through the synergistic combination of promoted drug release upon ultraviolet (UV) light irradiation and photothermal therapy upon infrared (IR) irradiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

A temperature microsensor for measuring laser-induced heating in gold nanorods

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407(3), 719–725.

By: D. Pacardo n, B. Neupane n, G. Wang n, Z. Gu n, G. Walker n & F. Ligler n

author keywords: Microsensor; Gold nanorods; Temperature; Nanoparticles; Microfluidics
MeSH headings : Chemistry Techniques, Analytical / instrumentation; Chemistry Techniques, Analytical / methods; Equipment Design; Gold; Heating; Hot Temperature; Lasers; Microtechnology; Nanotubes / analysis
TL;DR: The results demonstrate the suitability of this simple temperature microsensor for determining laser-induced heating profiles of metallic nanomaterials; such measurements will be essential for optimizing therapeutic and catalytic applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

BIOMATERIALS, 50, 67–74.

By: R. Mo n, T. Jiang n, W. Sun n & Z. Gu n

author keywords: ATP responsive; Graphene oxide; DNA; Drug delivery; Nanomedicine
MeSH headings : Adenosine Triphosphate / pharmacology; Antineoplastic Agents / pharmacology; Cell Death / drug effects; DNA, Single-Stranded / chemistry; Doxorubicin / pharmacology; Drug Delivery Systems; Endocytosis / drug effects; Graphite / chemistry; HeLa Cells; Humans; Intracellular Space / metabolism; Nanoparticles / chemistry; Particle Size; Spectrometry, Fluorescence
TL;DR: This study applied adenosine-5'-triphosphate (ATP), the primary "energy molecule", as a trigger for enhanced release of preloaded drugs responding to the intracellular ATP concentration that is significantly higher than the extracellular level, for targeted on-demand delivery of anticancer drugs inside specific cells. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Accelerating the Translation of Nanomaterials in Biomedicine

ACS NANO, 9(7), 6644–6654.

By: S. Mitragotri*, D. Anderson*, X. Chen*, E. Chow*, D. Ho*, A. Kabanov*, J. Karp*, K. Kataoka* ...

MeSH headings : Nanomedicine / methods; Nanomedicine / trends; Translational Research, Biomedical
TL;DR: The current status and future potential of promising nanomaterials and their translation from the laboratory to the clinic are discussed, by highlighting a handful of successful examples. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Anticancer Platelet-Mimicking Nanovehicles

ADVANCED MATERIALS, 27(44), 7043-+.

By: Q. Hu n, W. Sun n, C. Qian n, C. Wang n, H. Bomba n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Blood Platelets / cytology; Cell Line, Tumor; Cell Membrane / chemistry; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Humans; Intracellular Space / metabolism; Mice; Nanomedicine / methods; Nanostructures / chemistry; TNF-Related Apoptosis-Inducing Ligand / chemistry; TNF-Related Apoptosis-Inducing Ligand / metabolism
TL;DR: A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Characterization of a novel N-acetylneuraminic acid lyase favoring N-acetylneuraminic acid synthesis

SCIENTIFIC REPORTS, 5.

By: W. Ji, W. Sun n, J. Feng*, T. Song*, D. Zhang*, P. Ouyang*, Z. Gu n, J. Xie*

MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Bacterial Proteins / g