Zhenhua Li

Works (33)

Updated: August 23rd, 2025 05:04

2025 article

Microneedle Delivery of Small Extracellular Vesicles From Young Blood to Treat Endothelial Senescence

Hu, S., Li, Z., Zhu, D., Liu, S., Xing, M., & Cheng, K. (2025, August 5). Advanced Materials.

By: S. Hu n , Z. Li n, D. Zhu n , S. Liu n, M. Xing * & K. Cheng *

author keywords: endothelium senescence; extracellular vesicles; microneedle patch; microRNA; umbilical cord plasma
topics (OpenAlex): Extracellular vesicles in disease; Photoacoustic and Ultrasonic Imaging; Cardiovascular Disease and Adiposity; Advancements in Transdermal Drug Delivery
Source: Web Of Science
Added: August 18, 2025

2023 article

A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus

Wang, Z., Li, Z., Shi, W., Zhu, D., Hu, S., Dinh, P.-U. C., & Cheng, K. (2023, June 23). Science Advances, Vol. 9.

By: Z. Wang n, Z. Li n, W. Shi  n, D. Zhu n , S. Hu n , P. Dinh n, K. Cheng n

MeSH headings : Cricetinae; Animals; Humans; Mice; Influenza Vaccines; SARS-CoV-2; Influenza, Human; Influenza A Virus, H1N1 Subtype; Pandemics; COVID-19 / prevention & control; COVID-19 Vaccines; Influenza A virus
topics (OpenAlex): Influenza Virus Research Studies; SARS-CoV-2 and COVID-19 Research; Respiratory viral infections research
TL;DR: The Flu-RBD VLP vaccine is a promising candidate for combating COVID-19, influenza A, and coinfection and elicited a strong neutralization activity against both SARS-CoV-2 Delta pseudovirus and wild-type influenza A H1N1 inactivated virus in mice. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 24, 2023

2023 journal article

Intrapericardial long non-coding RNA–Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair

European Heart Journal, 44(19), 1748–1760.

By: D. Zhu n , S. Liu n, K. Huang n , J. Li n, X. Mei n, Z. Li n, K. Cheng n

author keywords: Myocardial infarction; Adverse remodelling; Mesenchymal stem cell; EVs; lncRNA; Tcf21
MeSH headings : Mice; Animals; Swine; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; RNA, Antisense / genetics; RNA, Antisense / metabolism; Ventricular Remodeling; Myocardial Infarction / genetics; Myocardial Infarction / therapy; Myocardial Infarction / metabolism; Fibrosis; Demethylation
topics (OpenAlex): Cardiac Valve Diseases and Treatments; Cardiac Fibrosis and Remodeling; Cancer-related molecular mechanisms research
TL;DR: Novel mechanisms underlying EV therapy for improving adverse remodelling are established and a lncRNA therapy for cardiac fibrosis is proposed, which could be a promising way to treat myocardial fibrosis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: April 4, 2023

2023 article

Pericardial Delivery of SDF‐1α Puerarin Hydrogel Promotes Heart Repair and Electrical Coupling

Luo, L., Li, Y., Bao, Z., Zhu, D., Chen, G., Li, W., … Li, Z. (2023, September 4). Advanced Materials, Vol. 9.

By: L. Luo *, Y. Li *, Z. Bao*, D. Zhu n , G. Chen *, W. Li*, Y. Xiao*, Z. Wang n ...

author keywords: cardiac arrhythmias; electrical coupling; endogenous repair; inflammation regulation; myocardial infarction; SDF-1
MeSH headings : Humans; Chemokine CXCL12 / metabolism; Hydrogels; Myocardial Infarction / metabolism; Myocytes, Cardiac / metabolism; Inflammation
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Cardiac Fibrosis and Remodeling
TL;DR: SDF‐1α‐encapsulated Puerarin (PUE) hydrogel (SDF‐1α@PUE) is capable of enhancing endogenous stem cell homing and simultaneously polarizing the recruited monocyte/macrophages into a repairing phenotype, demonstrating a promising therapeutic platform for MI that not only facilitates heart regeneration but also reduces the risk of cardiac arrhythmias. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023

2022 article

Detachable Microneedle Patches Deliver Mesenchymal Stromal Cell Factor-Loaded Nanoparticles for Cardiac Repair

Hu, S., Zhu, D., Li, Z., & Cheng, K. (2022, September 23). ACS Nano, Vol. 9.

By: S. Hu n , D. Zhu n , Z. Li n & K. Cheng n

author keywords: mesenchymal stromal cell; secreted factors; microneedle patch; elastin-like peptide gel; hyaluronic acid gel; myocardial infarction; cardiac repair
MeSH headings : Animals; Rats; Elastin; Polylactic Acid-Polyglycolic Acid Copolymer; Hyaluronic Acid; Mesenchymal Stem Cells; Myocytes, Cardiac; Myocardium; Nanoparticles; Peptides
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Nerve injury and regeneration; Neuroscience and Neural Engineering
TL;DR: A detachable therapeutic microneedle patch, which is comprised of mesenchymal stromal cell-secreted factors (MSCF)-loaded poly(lactic-co-glycolic acid) nanoparticles (NP) in MN tips made of elastin-like polypeptide gel, provides a promising treatment approach for cardiac diseases. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 11, 2022

2022 article

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Wang, Z., Popowski, K. D., Zhu, D., Juan Abad, B. L., Wang, X., Liu, M., … Cheng, K. (2022, July 4). Nature Biomedical Engineering, Vol. 7.

By: Z. Wang n, K. Popowski n , D. Zhu n , B. Juan Abad n, X. Wang  n, M. Liu n, H. Lutz  n, N. Naeyer* ...

MeSH headings : Animals; Antibodies, Neutralizing; CD8-Positive T-Lymphocytes; COVID-19 / prevention & control; COVID-19 Vaccines; Exosomes; Humans; Mice; Mice, Inbred BALB C; SARS-CoV-2; Viral Vaccines
topics (OpenAlex): SARS-CoV-2 and COVID-19 Research; Extracellular vesicles in disease; Inhalation and Respiratory Drug Delivery
TL;DR: The design and preclinical testing of an inhalable virus-like-particle as a COVID-19 vaccine that, after lyophilisation, is stable at room temperature for over three months and elicits systemic and mucosal immune responses in small animals is reported. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 11, 2022

2022 article

Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3

Zhu, D., Liu, S., Huang, K., Wang, Z., Hu, S., Li, J., … Cheng, K. (2022, October 13). Circulation Research, Vol. 10, pp. E135–E150.

By: D. Zhu n , S. Liu n, K. Huang n , Z. Wang n, S. Hu n , J. Li n, Z. Li n, K. Cheng n

author keywords: exosomes; immunomodulation; mesesnchymal stem cell; myocardial infarction; regulatory T cell
MeSH headings : Humans; Exosomes / metabolism; Forkhead Box Protein O3 / genetics; Forkhead Box Protein O3 / metabolism; Mesenchymal Stem Cells / metabolism; Myocardial Infarction / pathology; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Heart Injuries / metabolism
topics (OpenAlex): Heat shock proteins research; Cardiac Fibrosis and Remodeling; Extracellular vesicles in disease
TL;DR: A novel mechanism underlying the immunomodulation effects of MSC exosomes is revealed and provides a promising candidate (PP2A/p-Akt/Foxo3 signaling pathway) with a favorable delivery route (intrapericardial injection) for cardiac repair. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 14, 2022

2022 article

Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy

Zhang, C., Zhang, W., Zhu, D., Li, Z., Wang, Z., Li, J., … Zhong, B. (2022, January 15). Journal of Nanobiotechnology, Vol. 1.

By: C. Zhang  n, W. Zhang *, D. Zhu n , Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu *, K. Cheng n, B. Zhong *

Contributors: C. Zhang  n, W. Zhang *, D. Zhu n , Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu *, K. Cheng n, B. Zhong *

author keywords: Osteoporosis; CXCR4; Secretome; Mesenchymal stem cells; Bone targeting; Nanoparticles
MeSH headings : Animals; Cell Membrane / chemistry; Cell Membrane / metabolism; Disease Models, Animal; Endothelial Cells / chemistry; Endothelial Cells / metabolism; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / metabolism; Nanoparticle Drug Delivery System; Nanoparticles; Osteoporosis / metabolism; Rats; Receptors, CXCR4 / metabolism; Secretome / metabolism
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Nanoplatforms for cancer theranostics; Graphene and Nanomaterials Applications
TL;DR: In a rat model of osteoporosis, MSC-Sec/CXCR4 NP were found to accumulate in bone, and such treatment inhibited osteoclast differentiation while promoting osteogenic proliferation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 24, 2022

2021 article

A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs

Mei, X., Zhu, D., Li, J., Huang, K., Hu, S., Li, Z., … Cheng, K. (2021, November 1). Med, Vol. 11, pp. 1253–1268.e4.

By: X. Mei n, D. Zhu n , J. Li n, K. Huang n , S. Hu n , Z. Li n, B. Juan Abad n, K. Cheng n

Contributors: X. Mei n, D. Zhu n , J. Li n, K. Huang n , S. Hu n , Z. Li n, B. Juan Abad  n, K. Cheng n

MeSH headings : Animals; Cell- and Tissue-Based Therapy; Heart; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells; Myocardial Infarction / surgery; Rats; Swine
topics (OpenAlex): Nerve injury and regeneration; Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications
TL;DR: A fluid-driven heart pouch with a memory-shaped microfabricated lattice structure inspired by origami allowed minimally invasive delivery of the pouch to the heart with two small incisions and can be refilled multiple times with the therapeutic of choice. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 3, 2021

2021 article

A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency

Zhang, S., Zhu, D., Li, Z., Huang, K., Hu, S., Lutz, H., … Cheng, K. (2021, January 1). Theranostics, Vol. 11, pp. 8894–8908.

By: S. Zhang n, D. Zhu n , Z. Li n, K. Huang n , S. Hu n , H. Lutz  n, M. Xie n, X. Mei n ...

Contributors: S. Zhang n, D. Zhu n , Z. Li n, K. Huang n , S. Hu n , H. Lutz  n, M. Xie n, X. Mei n ...

author keywords: primary ovarian insufficiency; ovarian regenerative patch; regenerative medicine; mesenchymal stem cells; acellular therapy; fertility
MeSH headings : Animals; Apoptosis; Cell-Derived Microparticles / metabolism; Disease Models, Animal; Female; Hydrogels / pharmacology; Infertility, Female / therapy; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Ovary / pathology; Primary Ovarian Insufficiency / therapy; Rats; Rats, Sprague-Dawley; Regenerative Medicine / methods; Secretome; Stem Cells / metabolism; Tissue Scaffolds
topics (OpenAlex): Reproductive Biology and Fertility; Tissue Engineering and Regenerative Medicine; Ovarian function and disorders
TL;DR: In a rat model of POI, implantation of ORP rescued fertility by restoring sexual hormone secretion, estrus cycle duration, and follicle development and represents a cell-free, off-the-shelf, and clinically feasible treatment for POI. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2021

2021 article

Exosome-eluting stents for vascular healing after ischaemic injury

Hu, S., Li, Z., Shen, D., Zhu, D., Huang, K., Su, T., … Cheng, K. (2021, April 5). Nature Biomedical Engineering, Vol. 4, pp. 1174–1188.

By: S. Hu n , Z. Li n, D. Shen n, D. Zhu n , K. Huang n , T. Su n, P. Dinh n, J. Cores n, K. Cheng n

Contributors: S. Hu n , Z. Li n, D. Shen n, D. Zhu n , K. Huang n , T. Su n, P. Dinh n, J. Cores n, K. Cheng n

MeSH headings : Animals; Drug-Eluting Stents; Endothelial Cells; Endothelium, Vascular; Exosomes; Ischemia; Rats; Stents
topics (OpenAlex): Coronary Interventions and Diagnostics; Extracellular vesicles in disease; Infectious Aortic and Vascular Conditions
TL;DR: It is shown that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhance vascular healing in rats with renal ischaemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 6, 2021

2021 article

Injection of ROS‐Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair

Li, Z., Zhu, D., Hui, Q., Bi, J., Yu, B., Huang, Z., … Wang, X. (2021, February 4). Advanced Functional Materials, Vol. 31.

By: Z. Li n, D. Zhu n , Q. Hui *, J. Bi *, B. Yu *, Z. Huang *, S. Hu n , Z. Wang n ...

Contributors: Z. Li n, D. Zhu n , Q. Hui *, J. Bi *, B. Yu *, Z. Huang *, S. Hu n , Z. Wang n ...

author keywords: bFGF; heart repair; intrapericardial delivery; pericardial cavity; ROS responsive hydrogels
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Cardiac Structural Anomalies and Repair; Electrospun Nanofibers in Biomedical Applications
TL;DR: A ROS‐sensitive cross‐linked poly(vinyl alcohol) (PVA) hydrogel is synthesized to deliver basic fibroblast growth factor (bFGF) for myocardial repair and protects cardiac function and reduces fibrosis in the post‐I/R heart, with enhanced angiomyogenesis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 22, 2021

2021 article

Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction

Li, J., Lv, Y., Zhu, D., Mei, X., Huang, K., Wang, X., … Wang, J. (2021, August 10). Chemical Engineering Journal, Vol. 1, p. 131581.

By: J. Li n, Y. Lv *, D. Zhu n , X. Mei n, K. Huang n , X. Wang  n, Z. Li n, S. Zhang n ...

Contributors: J. Li n, Y. Lv *, D. Zhu n , X. Mei n, K. Huang n , X. Wang  n, Z. Li n, S. Zhang n ...

author keywords: Mesenchymal stem cells; Hydrogel; Myocardial infarction; Intrapericardial; Intramyocardial
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Mesenchymal stem cell research
TL;DR: Intrapericardial cavity injection gave a promising solution for the low retention issue of MSCs in the infarcted heart and the feasibility and safety of IPC injection were demonstrated in a porcine model with minimally invasive procedure. (via Semantic Scholar)
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Added: January 3, 2022

2021 article

Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

Zhu, D., Li, Z., Huang, K., Caranasos, T. G., Rossi, J. S., & Cheng, K. (2021, March 3). Nature Communications, Vol. 12.

By: D. Zhu n , Z. Li n, K. Huang n , T. Caranasos *, J. Rossi * & K. Cheng n

Contributors: D. Zhu n , Z. Li n, K. Huang n , T. Caranasos *, J. Rossi * & K. Cheng n

MeSH headings : Animals; Cardiac Surgical Procedures; Cardiovascular Agents / administration & dosage; Cell Differentiation / physiology; Drug Delivery Systems / methods; Exosomes / metabolism; Extracellular Matrix / chemistry; Hydrogels / administration & dosage; Hydrogels / chemistry; Induced Pluripotent Stem Cells / transplantation; Male; Materials Testing; Mesenchymal Stem Cells / cytology; Mice; Minimally Invasive Surgical Procedures / methods; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Pericardium; Rats; Swine
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Cardiac Structural Anomalies and Repair
TL;DR: In rodent models of myocardial infarction, it is demonstrated that intrapericardial injection is an effective and safe method to deliver hydrogels containing induced pluripotent stem cells-derived cardiac progenitor cells or mesenchymal stem Cells-derived exosomes. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2021 article

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

Hu, S., Wang, X., Li, Z., Zhu, D., Cores, J., Wang, Z., … Cheng, K. (2021, June 8). Nano Today, Vol. 8.

By: S. Hu n , X. Wang  n, Z. Li n, D. Zhu n , J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

Contributors: S. Hu n , X. Wang  n, Z. Li n, D. Zhu n , J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
topics (OpenAlex): Extracellular vesicles in disease; Cardiovascular Effects of Exercise
TL;DR: It is found that encapsulation by the platelet membranes induces macropinocytosis, enhancing the cellular uptake of exosomes by endothelial cells and cardiomyocytes strikingly and boosting the cardiac targeting ability of hybrid exosome in a mice model with myocardial infarction injury. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2021

2020 article

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse

Xie, M., Li, J., Zhang, S., Zhu, D., Mei, X., Wang, Z., … Cheng, K. (2020, December 3). Bioactive Materials, Vol. 6, pp. 1777–1788.

By: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

Contributors: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

author keywords: Contraceptive; Hydrogel; Anti-viral; Libido; Erectile function
topics (OpenAlex): Ovarian function and disorders; Reproductive Biology and Fertility; Sperm and Testicular Function
TL;DR: A novel TGN contraceptive gel consisting of three agents: tenofovir, gossypol acetate, and nitroglycerin (TGN) yielded a higher contraceptive success rate than that of the commercial contraceptive gel (Contragel®), and has the added benefits to prevent sexually transmitted diseases and improve male libido and erection function during sexual intercourse. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2020 article

Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy

Zhang, S., Zhu, D., Mei, X., Li, Z., Li, J., Xie, M., … Cheng, K. (2020, December 25). Bioactive Materials, Vol. 6, pp. 1957–1972.

By: S. Zhang n, D. Zhu n , X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Lutz  n, S. Wang *, K. Cheng n

Contributors: S. Zhang n, D. Zhu n , X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Xie, S. Wang *, K. Cheng n

author keywords: Stem cells; Primary ovarian insufficiency; Cell therapy; Biomaterials
topics (OpenAlex): Reproductive Biology and Fertility; Tissue Engineering and Regenerative Medicine; Pluripotent Stem Cells Research
TL;DR: A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies. (via Semantic Scholar)
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5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2020 journal article

Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs

ACS Biomaterials Science & Engineering, 6(11), 6309–6320.

By: T. Su n, K. Huang n , K. Mathews n , V. Scharf n, S. Hu n , Z. Li n, B. Frame*, J. Cores n ...

Contributors: T. Su n, K. Huang n , K. Mathews n , V. Scharf n, S. Hu n , Z. Li n, B. Frame*, . al.

author keywords: microfluidics; cardiac patch; cardiac stromal cells; myocardial infarction; porcine model
MeSH headings : Animals; Microvessels; Myocardial Infarction / therapy; Myocytes, Cardiac; Neovascularization, Physiologic; Rats; Stromal Cells; Swine
topics (OpenAlex): Cardiac Fibrosis and Remodeling; Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications
TL;DR: It is shown that BMV-CSC patch transplantation significantly promoted cardiac function, reduced scar size, increased viable myocardial tissue, promoted neovascularization, and suppressed inflammation in rat and porcine MI models, demonstrating enhanced therapeutic efficacy compared to conventional cardiac stromal cell patches. (via Semantic Scholar)
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Added: December 11, 2020

2020 article

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

Hu, S., Li, Z., Lutz, H., Huang, K., Su, T., Cores, J., … Cheng, K. (2020, July 24). Science Advances, Vol. 6.

By: S. Hu n , Z. Li n, H. Lutz  n, K. Huang n , T. Su n, J. Cores n, P. Dinh n, K. Cheng n

MeSH headings : Cells, Cultured; Exosomes; Hair; Hair Follicle; MicroRNAs / genetics; Regeneration; beta Catenin / genetics
topics (OpenAlex): Hair Growth and Disorders; Skin and Cellular Biology Research; Wound Healing and Treatments
TL;DR: Results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment, and it was demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes. (via Semantic Scholar)
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Added: August 10, 2020

2020 article

Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis

Liang, H., Li, Z., Ren, Z., Jia, Q., Guo, L., Li, S., … Cheng, K. (2020, June 13). Nano Research, Vol. 13, pp. 2197–2202.

By: H. Liang*, Z. Li n, Z. Ren *, Q. Jia*, L. Guo *, S. Li *, H. Zhang *, S. Hu n  ...

Contributors: H. Liang*, Z. Li n, Z. Ren *, Q. Jia*, L. Guo *, S. Li *, H. Zhang *, S. Hu n  ...

author keywords: liver fibrosis; nitric oxide (NO); hepatic stellate cells (HSC); nanoparticles; near infrared light (NIR)-controlled release
topics (OpenAlex): Liver physiology and pathology; Organ Transplantation Techniques and Outcomes; Liver Disease Diagnosis and Treatment
TL;DR: A targeted and controlled release method that triggers HSC apoptosis and reverses the liver fibrosis is provided the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis. (via Semantic Scholar)
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Added: June 29, 2020

2020 article

Self-Propelled and Near-Infrared-Phototaxic Photosynthetic Bacteria as Photothermal Agents for Hypoxia-Targeted Cancer Therapy

Zheng, P., Fan, M., Liu, H., Zhang, Y., Dai, X., Li, H., … Li, Z. (2020, November 25). ACS Nano, Vol. 15, pp. 1100–1110.

By: P. Zheng *, M. Fan*, H. Liu*, Y. Zhang *, X. Dai *, H. Li *, X. Zhou *, S. Hu n  ...

MeSH headings : Drug Delivery Systems; Humans; Hyperthermia, Induced; Hypoxia; Neoplasms / drug therapy; Phototherapy
topics (OpenAlex): Nanoplatforms for cancer theranostics; Cancer Research and Treatments; Photodynamic Therapy Research Studies
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Added: March 29, 2021

2020 article

Targeted anti–IL-1β platelet microparticles for cardiac detoxing and repair

Li, Z., Hu, S., Huang, K., Su, T., Cores, J., & Cheng, K. (2020, February 6). Science Advances, Vol. 6.

By: Z. Li n, S. Hu n , K. Huang n , T. Su n, J. Cores n & K. Cheng n

MeSH headings : Animals; Apoptosis; Blood Platelets / metabolism; Cell-Derived Microparticles / metabolism; Cytokines / metabolism; Disease Models, Animal; Humans; Immunohistochemistry; Inflammation Mediators / metabolism; Interleukin-1beta / antagonists & inhibitors; Mice; Models, Biological; Myocardial Infarction / etiology; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocytes, Cardiac / metabolism; Protein Binding; Ventricular Remodeling
topics (OpenAlex): Cardiovascular Disease and Adiposity; Cardiovascular, Neuropeptides, and Oxidative Stress Research; Cardiac Ischemia and Reperfusion
TL;DR: IL1-PM is a promising cardiac detoxification agent that removes cytotoxic IL-1β during AMI and induces therapeutic cardiac repair and protects the cardiomyocytes from apoptosis by neutralizing IL–1β and decreasing IL- 1β–driven caspase-3 activity. (via Semantic Scholar)
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Added: March 2, 2020

2020 article

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

Qiao, L., Hu, S., Huang, K., Su, T., Li, Z., Vandergriff, A., … Cheng, K. (2020, January 1). Theranostics, Vol. 10, pp. 3474–3487.

By: L. Qiao  n, S. Hu n , K. Huang n , T. Su n, Z. Li*, A. Vandergriff n, J. Cores n, P. Dinh n ...

author keywords: exosome; homing; integrin; doxorubicin; cancer therapy
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / analogs & derivatives; Drug Delivery Systems; Exosomes / metabolism; HeLa Cells; Humans; Mice; Mice, Nude; Polyethylene Glycols / administration & dosage
topics (OpenAlex): Extracellular vesicles in disease; RNA Interference and Gene Delivery; Nanoplatforms for cancer theranostics
TL;DR: It is demonstrated that the exosomes' ability to target the parent cancer is a phenomenon that opens up new ways to devise targeted therapies to deliver anti-tumor drugs. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 30, 2020

2019 article

Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells

Shen, D., Li, Z., Hu, S., Huang, K., Su, T., Liang, H., … Cheng, K. (2019, February 18). Nano Letters, Vol. 19, pp. 1883–1891.

By: D. Shen n, Z. Li n, S. Hu n , K. Huang n , T. Su n, H. Liang n, F. Liu  n, K. Cheng n

author keywords: Myocardium infarction; platelets; endogenous stem cells; antibodies
MeSH headings : Animals; Antigens, CD34 / immunology; Blood Platelets / chemistry; Blood Platelets / immunology; Cell- and Tissue-Based Therapy; Disease Models, Animal; Heart Injuries / genetics; Heart Injuries / pathology; Heart Injuries / therapy; Humans; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / immunology; Myocardium / pathology; Stem Cells / immunology; Stem Cells / metabolism
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Cardiac Fibrosis and Remodeling
TL;DR: Taking advantage of the natural infarct-homing ability of platelets, CD34 antibody-linked platelets (P-CD34) are engineered to capture circulating CD34-positive endogenous stem cells and direct them to the injured heart for effective heart repair. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2019 article

Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells

Huang, K., Li, Z., Su, T., Shen, D., Hu, S., & Cheng, K. (2019, May 31). Advanced Therapeutics, Vol. 2.

By: K. Huang n , Z. Li n, T. Su n, D. Shen*, S. Hu n  & K. Cheng n

author keywords: bispecific antibodies; immunotherapy; myocardial infarction; stem cells
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; CAR-T cell therapy research
TL;DR: In vivo studies in a mouse model with heart ischemia/reperfusion injury demonstrate the safety and therapeutic potency of SCRD BsAb, which supports cardiac recovery by reducing scarring, promoting angiomyogenesis, and boosting cardiac function. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 27, 2020

2019 article

Chemical Engineering of Cell Therapy for Heart Diseases

Li, Z., Hu, S., & Cheng, K. (2019, May 24). Accounts of Chemical Research, Vol. 52, pp. 1687–1696.

By: Z. Li n, S. Hu n  & K. Cheng n

MeSH headings : Animals; Biocompatible Materials / chemistry; Biomimetics / methods; Cardiomyopathy, Dilated / therapy; Cell- and Tissue-Based Therapy / methods; Chemical Engineering / methods; Exosomes; Humans; Hydrogels / chemistry; Myocardial Infarction / therapy; Stem Cells / chemistry; Stem Cells / metabolism
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Congenital heart defects research; Pluripotent Stem Cells Research
TL;DR: The third generation of therapeutic strategies are developed, which utilize cell-free approaches for cardiac cell therapies, and it is hoped that the designs will promote the use of chemical engineering approaches to transform, transport, and fabricate cell- free systems as novel cardiac cell therapeutic agents for clinical applications. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 15, 2019

2019 article

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell‐Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

Liu, F., Hu, S., Yang, H., Li, Z., Huang, K., Su, T., … Cheng, K. (2019, May 30). Advanced Healthcare Materials, Vol. 8.

By: F. Liu  n, S. Hu n , H. Yang  n, Z. Li n, K. Huang n , T. Su n, S. Wang *, K. Cheng n

author keywords: Asherman's syndrome; endometrial injury; hyaluronic acid; mesenchymal stem cells; secretome
MeSH headings : Animals; Disease Models, Animal; Electrocoagulation; Endometrium / injuries; Female; Gynatresia / therapy; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Hyaluronic Acid / chemistry; Hydrogels / chemistry; Mesenchymal Stem Cells / metabolism; Pregnancy; Rats, Sprague-Dawley
topics (OpenAlex): Body Contouring and Surgery; Hernia repair and management; Bone fractures and treatments
TL;DR: The HA gel/MSC‐Sec treatment paradigm creates a sustained release system that repairs endometrial injury in rats and promotes viable pregnancy, and holds great potential for the treatment of AS. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019

2019 article

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging

Hu, S., Li, Z., Cores, J., Huang, K., Su, T., Dinh, P.-U., & Cheng, K. (2019, August 26). ACS Nano, Vol. 13, pp. 11273–11282.

By: S. Hu n , Z. Li n, J. Cores n, K. Huang n , T. Su n, P. Dinh n, K. Cheng n

author keywords: needle free injection; dermal fibroblasts; spheroids; exosomes; skin aging; microRNA
MeSH headings : Animals; Biopolymers / metabolism; Cell Proliferation / radiation effects; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Exosomes / metabolism; Fibroblasts / metabolism; Humans; Mice; Mice, Nude; Skin / cytology; Skin / radiation effects; Skin Aging / radiation effects; Spheroids, Cellular / cytology; Spheroids, Cellular / radiation effects; Tissue Inhibitor of Metalloproteinase-1 / metabolism; Transforming Growth Factor beta / metabolism; Tumor Necrosis Factor-alpha / metabolism; Ultraviolet Rays; Wound Healing / radiation effects
topics (OpenAlex): Skin Protection and Aging; Dermatologic Treatments and Research; Wound Healing and Treatments
TL;DR: Results indicate that exosomes from 3D cultured HDF spheroids have anti-skin-aging properties and the potential to prevent and treat cutaneous aging. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 11, 2019

2019 article

microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential

Qiao, L., Hu, S., Liu, S., Zhang, H., Ma, H., Huang, K., … Cheng, K. (2019, April 28). Journal of Clinical Investigation, Vol. 129, pp. 2237–2250.

By: L. Qiao  n, S. Hu n , S. Liu *, H. Zhang *, H. Ma*, K. Huang n , Z. Li n, T. Su n ...

MeSH headings : Animals; Exosomes / genetics; Exosomes / metabolism; Exosomes / pathology; Female; Heart / physiology; Heart Failure / genetics; Heart Failure / metabolism; Heart Failure / pathology; Human Umbilical Vein Endothelial Cells / metabolism; Human Umbilical Vein Endothelial Cells / pathology; Humans; Male; Mice; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Physiologic; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Regeneration; Signal Transduction; Stromal Cells / metabolism; Stromal Cells / pathology
topics (OpenAlex): Extracellular vesicles in disease; MicroRNA in disease regulation; Circular RNAs in diseases
TL;DR: The heart failure pathological condition altered the miR cargos of cardiac-derived exosomes and impaired their regenerative activities, and mechanistic studies revealed that miR-21-5p augmented Akt kinase activity through the inhibition of phosphatase and tensin homolog. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2019

2018 article

Biomimetic O2-Evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor

Gao, S., Zheng, P., Li, Z., Feng, X., Yan, W., Chen, S., … Zhang, J. (2018, June 7). Biomaterials.

By: S. Gao *, P. Zheng *, Z. Li n, X. Feng*, W. Yan *, S. Chen *, W. Guo *, D. Liu * ...

author keywords: O-2-evolving; Metal-organic framework; Photodynamic therapy; Long circulation; ABC membrane
MeSH headings : Animals; Biomimetic Materials / chemistry; Cell Survival / drug effects; Erythrocytes / drug effects; Erythrocytes / metabolism; Humans; Indocyanine Green / pharmacology; MCF-7 Cells; Metal-Organic Frameworks / chemistry; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Oxygen / chemistry; Photochemotherapy; RAW 264.7 Cells; Spheroids, Cellular / drug effects; Spheroids, Cellular / metabolism; Spheroids, Cellular / pathology; Superoxides / chemistry; Tissue Distribution; Tumor Hypoxia / drug effects
topics (OpenAlex): Nanoplatforms for cancer theranostics; Photodynamic Therapy Research Studies; Advanced Nanomaterials in Catalysis
TL;DR: Owing to the advantages of long circulation and O2 self-sufficient, the designed nanotherapeutic agent can improve the efficiency of treatment against hypoxia tumor via PDT and provides a new avenue to eliminate hypoxic tumors. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 19, 2018

2018 article

Platelets and their biomimetics for regenerative medicine and cancer therapies

Li, Z., Hu, S., & Cheng, K. (2018, January 1). Journal of Materials Chemistry B, Vol. 6, pp. 7354–7365.

By: Z. Li n, S. Hu n  & K. Cheng n

MeSH headings : Animals; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Biomimetic Materials / metabolism; Blood Platelets / chemistry; Blood Platelets / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Drug Carriers / chemistry; Humans; Nanoparticles / chemistry; Regenerative Medicine / methods
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Extracellular vesicles in disease; Periodontal Regeneration and Treatments; Nanoplatforms for cancer theranostics; Nanoparticle-Based Drug Delivery
TL;DR: This review will highlight the recent progress made in the development of disease-targeting platelets- and platelet-mimicking-vehicles as therapeutic platforms. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 10, 2018

2018 article

Platelet‐Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury

Su, T., Huang, K., Ma, H., Liang, H., Dinh, P. U., Chen, J., … Cheng, K. (2018, November 13). Advanced Functional Materials, Vol. 29.

By: T. Su n, K. Huang n , H. Ma *, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen  n ...

author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Tissue Engineering and Regenerative Medicine; Cardiac and Coronary Surgery Techniques
TL;DR: A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced, which represents a promising therapeutic delivery platform for treating myocardial ischemia/reperfusion injury. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019

2018 article

Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair

Li, Z., Shen, D., Hu, S., Su, T., Huang, K., Liu, F., … Cheng, K. (2018, December 4). ACS Nano, Vol. 12, pp. 12193–12200.

By: Z. Li n, D. Shen*, S. Hu n , T. Su n, K. Huang n , F. Liu  n, L. Hou *, K. Cheng n

author keywords: pretargeting; bioorthogonal click chemistry; heart repair; endogenous stem cells; engineered antibodies
MeSH headings : Animals; Antibodies / administration & dosage; Antibodies / metabolism; Blood Vessels / metabolism; Blood Vessels / pathology; Cells, Cultured; Click Chemistry; Collagen / chemistry; Collagen / metabolism; Disease Models, Animal; Endothelial Progenitor Cells / cytology; Endothelial Progenitor Cells / metabolism; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Mice; Mice, Inbred C57BL; Molecular Structure; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Congenital heart defects research
TL;DR: In a mouse model of acute myocardial infarction, the in vivo results of cardiac function, heart morphometry, and immunohistochemistry assessment all confirmed effective heart repair by the PTBC system. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 14, 2019

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