@article{liang_lin_pierce_2021, title={Stereoselective Synthesis of the Spirocyclic gamma-Lactam Core of the Ansalactams}, volume={23}, ISSN={["1523-7052"]}, url={https://doi.org/10.1021/acs.orglett.1c03782}, DOI={10.1021/acs.orglett.1c03782}, abstractNote={Ansalactam A is an ansa macrolide natural product that contains a densely functionalized spiro-γ-lactam core containing three contiguous stereocenters. This unusual motif distinguishes it from other members of this family and represents a significant synthetic challenge. Herein, we report the development of a stereoselective formal [3+2] cycloaddition reaction for the construction of this key spiro-γ-lactam motif for the first time, thereby enabling access to the northern domain of ansalactam A.}, number={24}, journal={ORGANIC LETTERS}, publisher={American Chemical Society (ACS)}, author={Liang, Zhanhao and Lin, You-Chen and Pierce, Joshua G.}, year={2021}, month={Dec}, pages={9559–9562} }