Zahid N Rabbani

Works (4)

Updated: July 5th, 2023 15:33

2022 journal article

Mapping glycine uptake and its metabolic conversion to glutathione in mouse mammary tumors using functional mass spectrometry imaging

FREE RADICAL BIOLOGY AND MEDICINE, 193, 677–684.

By: A. Mellinger n, R. Kibbe n, Z. Rabbani n, D. Meritet n, D. Muddiman n  & M. Gamcsik n

MeSH headings : Mice; Animals; Glycine; Biological Transport; Glutathione; Mammary Neoplasms, Animal; Mass Spectrometry
TL;DR: A novel functional mass spectrometry imaging (fMSI) method that can map the variations in the conversion of glycine to glutathione metabolic activity across tumor tissue sections by tracking the fate of three glycine isotopologues administered in a timed sequence to tumor-bearing anesthetized mice is developed. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 23, 2023

2022 journal article

Multiple Infusion Start Time Mass Spectrometry Imaging of Dynamic SIL-Glutathione Biosynthesis Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization

JOURNAL OF PROTEOME RESEARCH, 21(3), 747–757.

By: A. Mellinger n, K. Garrard  n, S. Khodjaniyazova n, Z. Rabbani n, M. Gamcsik n & D. Muddiman n 

author keywords: IR-MALDESI; mass spectrometry imaging; stable isotope labeling; glutathione; kinetic metabolism
MeSH headings : Animals; Glutathione; Glycine; Lasers; Mice; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: A study combining a multiple infusion start time protocol, stable isotope labeling technology, infrared matrix-assisted laser desorption electrospray ionization, and high-resolution accurate mass-mass spectrometry imaging to study spatial changes in glutathione kinetics across in sectioned mouse liver tissues is presented. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2019 journal article

Flow-Encoded Oxygen Control to Track the Time-Dependence of Molecular Changes Induced by Static or Cycling Hypoxia

ANALYTICAL CHEMISTRY, 91(23), 15032–15039.

By: M. Yao n, Z. Rabbani n, T. Sattler n, K. Nguyen  n, D. Zaharoff n, G. Walker n, M. Gamcsik n

MeSH headings : Aldehyde Dehydrogenase / metabolism; Caco-2 Cells; Cell Hypoxia; Cell Line, Tumor; Glucose / pharmacokinetics; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / drug effects; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Oxygen / metabolism; Oxygen / pharmacology; Pancreatic Neoplasms / pathology; Time Factors
TL;DR: A manifold designed to use flow-encoding to produce sequential changes in gas mixtures delivered to a permeable-bottom 96-well plate is fabricated and shown how this manifold and plate design can be used to expose cells to either static or cycling hypoxic conditions for eight different time periods thereby facilitating the study of the time-response of cells to altered oxygen environments. (via Semantic Scholar)
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Added: December 30, 2019

2018 journal article

Mixing and delivery of multiple controlled oxygen environments to a single multiwell culture plate

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 315(5), C766–C775.

By: M. Yao n, T. Sattler n, Z. Rabbani n, T. Pulliam  n, G. Walker n & M. Gamcsik n

author keywords: cell culture; cycling hypoxia; finite element analysis; oxygen diffusion; permeability
MeSH headings : Caco-2 Cells; Cell Culture Techniques / instrumentation; Cell Hypoxia / genetics; Cell Proliferation / genetics; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / chemistry; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; MCF-7 Cells; Oxygen / chemistry; Oxygen / metabolism
TL;DR: A 96-well plate-based device that is capable of delivering eight static or dynamically changing oxygen environments to different rows on a single plate that is amenable to multiwell Plate-based molecular assays or drug dose-response studies in static or cycling hypoxia conditions. (via Semantic Scholar)
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Source: Web Of Science
Added: December 10, 2018

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