@article{xu_laber_staicu_lascelles_2021, title={Novel approach to modeling high-frequency activity data to assess therapeutic effects of analgesics in chronic pain conditions}, volume={11}, ISSN={["2045-2322"]}, DOI={10.1038/s41598-021-87304-w}, abstractNote={Abstract}, number={1}, journal={SCIENTIFIC REPORTS}, author={Xu, Zekun and Laber, Eric and Staicu, Ana-Maria and Lascelles, B. Duncan X.}, year={2021}, month={Apr} }
 @article{zura_xu_della rocca_mehta_steen_2017, title={When Is a Fracture Not "Fresh"? Aligning Reimbursement With Patient Outcome After Treatment With Low-Intensity Pulsed Ultrasound}, volume={31}, ISSN={["1531-2291"]}, DOI={10.1097/bot.0000000000000778}, abstractNote={
            Objective:
            The clinical value of low-intensity pulsed ultrasound (LIPUS) for fresh fracture is known. Yet, in the absence of a definition of what “fresh” is, payers have adopted study inclusion criteria drawn from randomized clinical trials as de facto definitions of which patients should be treated, with “fresh” defined as <1 week old. Patients with fracture may thus be ineligible for LIPUS treatment after week 1, which potentially denies access to patients who could benefit from LIPUS. We seek to characterize the inflection point at which heal rate declines.
          }, number={5}, journal={JOURNAL OF ORTHOPAEDIC TRAUMA}, author={Zura, Robert and Xu, Zekun and Della Rocca, Gregory J. and Mehta, Samir and Steen, R. Grant}, year={2017}, month={May}, pages={248–251} }
 @article{nolte_anderson_strauss_wang_hu_xu_steen_2016, title={Heal rate of metatarsal fractures: A propensity-matching study of patients treated with low-intensity pulsed ultrasound (LIPUS) vs. surgical and other treatments}, volume={47}, ISSN={["1879-0267"]}, DOI={10.1016/j.injury.2016.09.023}, abstractNote={Whether to treat metatarsal fractures conservatively or surgically is controversial. We test a hypothesis that metatarsal fractures treated conservatively with non-invasive low-intensity pulsed ultrasound (LIPUS) obtain heal rates comparable to current surgical techniques.This is a retrospective observational cohort study, using patient outcomes from a prospectively-collected LIPUS registry required by the U.S. Food & Drug Administration. Registry data were collected over a 5-year period and were reviewed and validated by a registered nurse. Data required for analysis were days-to-treatment (DTT) with LIPUS and a dichotomous outcome of healed versus failed, as assessed by clinical and radiographic criteria. Registry patients (DTT<365days) were propensity-matched to metatarsal fracture patients from a health claims database that includes medical and drug expenses for ∼90.1 million patients. The propensity match was based on patient demographic data (age, gender, body weight, fracture severity, and smoking status).A total of 594 metatarsal fractures were treated with LIPUS, including 161 Jones fractures. Compared to patients in the claims database, LIPUS-treated patients were more likely to: be overweight or obese; be male; have open fracture; and smoke (all, P<0.0001), suggesting that these variables were perceived as nonunion risk factors by prescribing physicians. After propensity-matching, none of these differences between the registry and the health claims database remained significant. The heal rate with LIPUS treatment was 97.3%, comparable to the heal rate of 95.3% among claims patients in 2011 who did not receive LIPUS (P=0.0654). When fresh fractures (0-90days) and delayed unions (91-365days) were analyzed separately, the LIPUS fresh fracture heal rate was superior to claims patients (P=0.0381), and the delayed union heal rate was comparable. After exclusion of registry patients who received surgery, heal rate with LIPUS alone (97.4%) was significantly better (P<0.0097) than the heal rate for matched patients in 2011 (94.2%).LIPUS significantly improved the heal rate of metatarsal fractures <1year old without surgery (P=0.0097). Metatarsal fractures treated with LIPUS alone have a heal rate comparable to fractures treated by surgical intervention.}, number={11}, journal={INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED}, author={Nolte, Peter and Anderson, Robert and Strauss, Elton and Wang, Zhe and Hu, Liuyi and Xu, Zekun and Steen, R. Grant}, year={2016}, month={Nov}, pages={2584–2590} }