TY - JOUR TI - Genetic alterations cooperate with v-Ha-ras to accelerate multistage carcinogenesis in TG.AC transgenic mouse skin AU - Owens, D.M. AU - Spalding, J.W. AU - Tennant, R.W. AU - Smart, R.C. T2 - Cancer Research DA - 1995/// PY - 1995/// VL - 55 IS - 14 SP - 3171–3178 ER - TY - JOUR TI - Lack of effect of retinoic acid and fluocinolone acetonide on mirex tumor promotion indicates a novel mirex mechanism AU - Kim, Tae-Won AU - Smart, Robert C. T2 - Carcinogenesis AB - Journal Article Lack of effect of retinoic acid and fluocinolone acetonide on mirex tumor promotion indicates a novel mirex mechanism Get access Tae-Won Kim, Tae-Won Kim Department of Toxicology, North Carolina State UniversityRaleigh, NC 27695-7633, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert C. Smart Robert C. Smart 1 Department of Toxicology, North Carolina State UniversityRaleigh, NC 27695-7633, USA 1To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Carcinogenesis, Volume 16, Issue 9, September 1995, Pages 2199–2204, https://doi.org/10.1093/carcin/16.9.2199 Published: 01 September 1995 Article history Received: 17 March 1995 Revision received: 11 May 1995 Accepted: 25 May 1995 Published: 01 September 1995 DA - 1995/// PY - 1995/// DO - 10.1093/carcin/16.9.2199 VL - 16 IS - 9 SP - 2199-2204 J2 - Carcinogenesis LA - en OP - SN - 0143-3334 1460-2180 UR - http://dx.doi.org/10.1093/carcin/16.9.2199 DB - Crossref ER - TY - CONF TI - On computing greatest common divisors with polynomials given by black boxes for their evaluations AU - Díaz, Angel AU - Kaltofen, Erich T2 - ISSAC95: International Symposium on Symbolic and Algebraic Computation A2 - Levelt, A.H.M. AB - Article On computing greatest common divisors with polynomials given by black boxes for their evaluations Share on Authors: Angel Díaz Department of Computer Science, Rensselaer Polytechnic Institute, Troy, New York Department of Computer Science, Rensselaer Polytechnic Institute, Troy, New YorkView Profile , Erich Kaltofen Department of Computer Science, Rensselaer Polytechnic Institute, Troy, New York Department of Computer Science, Rensselaer Polytechnic Institute, Troy, New YorkView Profile Authors Info & Claims ISSAC '95: Proceedings of the 1995 international symposium on Symbolic and algebraic computationApril 1995 Pages 232–239https://doi.org/10.1145/220346.220375Online:01 April 1995Publication History 11citation268DownloadsMetricsTotal Citations11Total Downloads268Last 12 Months3Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access C2 - 1995/// C3 - Proceedings of the 1995 international symposium on Symbolic and algebraic computation - ISSAC '95 CY - Montreal Quebec Canada DA - 1995/// PY - 1995/7/10/ DO - 10.1145/220346.220375 PB - ACM Press SN - 0897916999 9780897916998 UR - http://dx.doi.org/10.1145/220346.220375 ER - TY - JOUR TI - Intraerythrocytic presence of bartonella henselae AU - Kordick, D.L. AU - Breitschwerdt, E.B. T2 - Journal of Clinical Microbiology DA - 1995/// PY - 1995/// VL - 33 IS - 6 SP - 1655-1656 ER - TY - JOUR TI - Erythrocyte fragility and chronic intermittent pigmenturia in a dog AU - LeGrange, S.N. AU - Breitschwerdt, E.B. AU - Grindem, C.B. AU - Beutler, E. T2 - Journal of American Veterinary Medical Association DA - 1995/// PY - 1995/// VL - 206 IS - 7 SP - 1002-1006 ER - TY - JOUR TI - Prolonged bartonella bacteremia in cats associated with cat-scratch disease patients AU - Kordick, D.L. AU - Wilson, K.H. AU - Sexton, D.J. AU - Hadfield, T.L. AU - Berkhoff, H.A. AU - Breitschwerdt, E.B. T2 - Journal of Clinical Microbiology DA - 1995/// PY - 1995/// VL - 33 IS - 12 SP - 3245-3251 ER - TY - JOUR TI - RNA-protein interactions of the bacteriophage RB69 RegA translational repressor protein AU - Jozwik, C.E. AU - Miller, E.S. T2 - Nucleic Acids Symposium Series DA - 1995/// PY - 1995/// VL - 33 SP - 256-257 ER - TY - JOUR TI - Diagnostic and therapeutic considerations in a hypercalcemic dog with multiple endocrine neoplasia AU - Wright, KN AU - Breitschwerdt, EB AU - Feldman, JM AU - Berry, CR AU - Meuten, DJ AU - Spodnick, GJ T2 - Journal of the American Animal Hospital Association AB - Hypercalcemia was found in a dog examined for episodic weakness and disorientation. A right adrenal mass identified on abdominal ultrasonographic examination was diagnosed as a pheochromocytoma based on increased 1231-metaiodobenzylguanidine uptake and characteristic histopathological features. Serum intact parathyroid hormone (iPTH), total serum calcium, and ionized serum calcium were increased prior to surgery. Although both total and ionized serum calcium concentrations decreased to within normal reference ranges following surgery through postoperative day 17, subsequent high concentrations with increased serum iPTH concentrations confirmed concurrent primary hyperparathyroidism. A right parathyroid tumor was suspected based on a technetium-99m-sestamibi (99mTc-sestamibi) scan. DA - 1995/3// PY - 1995/3// DO - 10.5326/15473317-31-2-156 VL - 31 IS - 2 SP - 156-162 J2 - Journal of the American Animal Hospital Association LA - en OP - SN - 0587-2871 1547-3317 UR - http://dx.doi.org/10.5326/15473317-31-2-156 DB - Crossref ER - TY - JOUR TI - Analysis of Coppersmith’s block Wiedemann algorithm for the parallel solution of sparse linear systems AU - Kaltofen, Erich T2 - Mathematics of Computation AB - By using projections by a block of vectors in place of a single vector it is possible to parallelize the outer loop of iterative methods for solving sparse linear systems. We analyze such a scheme proposed by Coppersmith for Wiedemann’s coordinate recurrence algorithm, which is based in part on the Krylov subspace approach. We prove that by use of certain randomizations on the input system the parallel speed up is roughly by the number of vectors in the blocks when using as many processors. Our analysis is valid for fields of entries that have sufficiently large cardinality. Our analysis also deals with an arising subproblem of solving a singular block Toeplitz system by use of the theory of Toeplitz-like matrices. DA - 1995/5/1/ PY - 1995/5/1/ DO - 10.1090/s0025-5718-1995-1270621-1 VL - 64 IS - 210 SP - 777-777 J2 - Math. Comp. LA - en OP - SN - 0025-5718 UR - http://dx.doi.org/10.1090/s0025-5718-1995-1270621-1 DB - Crossref ER - TY - JOUR TI - Integer division in residue number systems AU - Hitz, M.A. AU - Kaltofen, E. T2 - IEEE Transactions on Computers AB - This contribution to the ongoing discussion of division algorithm for residue number systems (RNS) is based on Newton iteration for computing the reciprocal. An extended RNS with twice the number of moduli provides the range required for multiplication and scaling. Separation of the algorithm description from its RNS implementation achieves a high level of modularity, and makes the complexity analysis more transparent. The number of iterations needed is logarithmic in the size of the quotient for a fixed start value. With preconditioning it becomes the logarithm of the input bit size. An implementation of the conversion to mixed radix representation is outlined in the appendix.< > DA - 1995/// PY - 1995/// DO - 10.1109/12.403714 VL - 44 IS - 8 SP - 983-989 J2 - IEEE Trans. Comput. OP - SN - 0018-9340 UR - http://dx.doi.org/10.1109/12.403714 DB - Crossref KW - INTEGER DIVISION KW - RECIPROCAL KW - NEWTON ITERATION KW - EXTENDED RESIDUE NUMBER SYSTEM KW - MIXED RADIX CONVERSION KW - BASE EXTENSION ER - TY - JOUR TI - Process Scheduling in DSC and the Large Sparse Linear Systems Challenge AU - Dı́az, A. AU - Hitz, M. AU - Kaltofen, E. AU - Lobo, A. AU - Valente, T. T2 - Journal of Symbolic Computation AB - New features of our DSC system for distributing a symbolic computation task over a network of processors are described. A new scheduler sends parallel subtasks to those compute nodes that are best suited in handling the added load of CPU usage and memory. Furthermore, a subtask can communicate back to the process that spawned it by a co-routine style calling mechanism. Two large experiments are described in this improved setting. In the first we have implemented an algorithm that can prove a number of more than 1,000 decimal digits prime in about 2 months elapsed time on some 20 computers. In the second a parallel version of a sparse linear system solver is used to compute the solution of sparse linear systems over finite fields. We are able to find the solution of a 100,000 by 100,000 linear system with about 10.3 million non-zero entries over the Galois field with 2 elements using 3 computers in about 54 hours CPU time. DA - 1995/1// PY - 1995/1// DO - 10.1006/jsco.1995.1015 VL - 19 IS - 1-3 SP - 269-282 J2 - Journal of Symbolic Computation LA - en OP - SN - 0747-7171 UR - http://dx.doi.org/10.1006/jsco.1995.1015 DB - Crossref ER - TY - JOUR TI - Effective Noether Irreducibility Forms and Applications AU - Kaltofen, E. T2 - Journal of Computer and System Sciences AB - Using recent absolute irreducibility testing algorithms, we derive new irreducibility forms. These are integer polynomials in variables which are the generic coefficients of a multivariate polynomial of a given degree. A (multivariate) polynomial over a specific field is said to be absolutely irreducible if it is irreducible over the algebraic closure of its coefficient field. A specific polynomial of a certain degree is absolutely irreducible, if and only if all the corresponding irreducibility forms vanish when evaluated at the coefficients of the specific polynomial. Our forms have much smaller degrees and coefficients than the forms derived originally by Emmy Noether. We can also apply our estimates to derive more effective versions of irreducibility theorems by Ostrowski and Deuring and of the Hilbert irreducibility theorem. We also give an effective estimate on the diameter of the neighborhood of an absolutely irreducible polynomial with respect to the coefficient space in which absolute irreducibility is preserved. Furthermore, we can apply the effective estimates to derive several factorization results in parallel computational complexity theory: we show how to compute arbitrary high precision approximations of the complex factors of a multivariate integral polynomial and how to count the number of absolutely irreducible factors of a multivariate polynomial with coefficients in a rational function field, both in the complexity class NC. The factorization results also extend to the case where the coefficient field is a function field. DA - 1995/4// PY - 1995/4// DO - 10.1006/jcss.1995.1023 VL - 50 IS - 2 SP - 274-295 J2 - Journal of Computer and System Sciences LA - en OP - SN - 0022-0000 UR - http://dx.doi.org/10.1006/jcss.1995.1023 DB - Crossref ER - TY - JOUR TI - Nucleotide sequence and expression of kerA, the gene encoding a keratinolytic protease of Bacillus licheniformis PWD-1. AU - Lin, X AU - Kelemen, D W AU - Miller, E S AU - Shih, J C T2 - Applied and environmental microbiology AB - Bacillus licheniformis PWD-1 (ATCC 53757) secretes keratinase, a proteolytic enzyme which is active on whole feathers. By amino acid sequence similarity and phenylmethylsulfonyl fluoride inhibition, the keratinase was demonstrated to be a serine protease. The entire nucleotide sequence of the coding and flanking regions of the keratinase structure gene, kerA, was determined. A fixed oligonucleotide primer derived from the N-terminal sequence of the purified enzyme and a second random oligonucleotide primer were used in a procedure called PCR walking, which was developed to amplify and sequence the upstream and downstream regions of kerA. Another method, PCR screening, was conducted with a lambda phage vector with inserted PWD-1 genomic DNA fragments as templates and with the known sequences of the vector arms and the N-terminal sequence of the enzyme as primers. PCR amplification and sequence analysis of the lambda library completed the entire kerA sequence and established a set of gene deletions. The kerA gene shares a 97% sequence identity with the gene encoding subtilisin Carlsberg from B. licheniformis NCIMB 6816. The putative promoters, ribosome binding sites, and transcriptional terminators are also similar in these two bacteria. The deduced amino acid sequences indicate only three amino acid differences between the two mature proteases. Northern (RNA) analysis demonstrates that transcriptional regulation controls kerA expression on different growth media. DA - 1995/// PY - 1995/// DO - 10.1128/aem.61.4.1469-1474.1995 VL - 61 IS - 4 SP - 1469-1474 LA - en OP - SN - 0099-2240 UR - http://dx.doi.org/10.1128/aem.61.4.1469-1474.1995 DB - Crossref ER - TY - JOUR TI - A geminivirus induces expression of a host DNA synthesis protein in terminally differentiated plant cells. AU - Nagar, S AU - Pedersen, T J AU - Carrick, K M AU - Hanley-Bowdoin, L AU - Robertson, D T2 - The Plant Cell AB - Geminiviruses are plant DNA viruses that replicate through DNA intermediates in plant nuclei. The viral components required for replication are known, but no host factors have yet been identified. We used immunolocalization to show that the replication proteins of the geminivirus tomato golden mosaic virus (TGMV) are located in nuclei of terminally differentiated cells that have left the cell cycle. In addition, TGMV infection resulted in a significant accumulation of the host DNA synthesis protein proliferating cell nuclear antigen (PCNA). PCNA, an accessory factor for DNA polymerase delta, was not present at detectable levels in healthy differentiated cells. The TGMV replication protein AL1 was sufficient to induce accumulation of PCNA in terminally differentiated cells of transgenic plants. Analysis of the mechanism(s) whereby AL1 induces the accumulation of host replication machinery in quiescent plant cells will provide a unique opportunity to study plant DNA synthesis. DA - 1995/6// PY - 1995/6// DO - 10.1105/tpc.7.6.705 VL - 7 IS - 6 SP - 705-719 J2 - Plant Cell LA - en OP - SN - 1040-4651 1532-298X UR - http://dx.doi.org/10.1105/tpc.7.6.705 DB - Crossref ER - TY - JOUR TI - Tracking ancient epidemics: Survey of plant pathogens of preceramic Peru AU - Ristaino, JB AU - Abad, ZG AU - Ugent, D T2 - Phytophthora infestans DA - 1995/// PY - 1995/// VL - 150 SP - 226-231 ER - TY - JOUR TI - Inhibition of Aspergillus parasiticus NRRL 2999 by polen and propolis extracts. AU - Hwang, BK AU - Kim, CH AU - Jones, JB AU - Stall, RE AU - Zitter, TA AU - Ristaino, JB AU - Johnstan, SB AU - Matheron, ME AU - Matajka, JC AU - Gisi, U AU - others T2 - Plant Pathology Journal DA - 1995/// PY - 1995/// VL - 4 IS - 1 SP - 221-227 ER - TY - JOUR TI - Detection and quantification of Phytophthora capsici in soil AU - Larkin, Robert P AU - Ristaino, Jean B AU - Campbell, C Lee AU - others T2 - Phytopathology DA - 1995/// PY - 1995/// VL - 85 IS - 10 SP - 1057-1063 ER - TY - RPRT TI - Characterisation of Phytophthora infestans isolates from tomato and potato in Norther Carolina, USA, 1993-1995 AU - Fraser, Dawn E AU - Shoemaker, PB AU - Ristaino, JB A3 - Boole Press Ltd. DA - 1995/// PY - 1995/// PB - Boole Press Ltd. ER - TY - JOUR TI - Detection and quantification of Phytophthora capsici in soil AU - Larkin, R.P. AU - Ristaino, J.B. AU - Campbell, C.L. T2 - Phytopathology DA - 1995/// PY - 1995/// VL - 85 IS - 10 SP - 1057-1063 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-0029173961&partnerID=MN8TOARS ER - TY - JOUR TI - Geostatistical analysis of Phytophthora epidemic development in commercial bell pepper fields AU - Larkin, R.P. AU - Gumpertz, M.L. AU - Ristaino, J.B. T2 - Phytopathology DA - 1995/// PY - 1995/// VL - 85 IS - 2 SP - 191-203 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-0029157859&partnerID=MN8TOARS ER - TY - JOUR TI - Mapping of body weight loci on mouse Chromosome X AU - Dragani, T. A. AU - Zeng, Z.-B. AU - Canzian, F. AU - Gariboldi, M. AU - Ghilarducci, M. T. AU - Manenti, G. AU - Pierotti, M. A. T2 - Mammalian Genome DA - 1995/11// PY - 1995/11// DO - 10.1007/bf00539002 VL - 6 IS - 11 SP - 778-781 J2 - Mammalian Genome LA - en OP - SN - 0938-8990 1432-1777 UR - http://dx.doi.org/10.1007/bf00539002 DB - Crossref ER - TY - JOUR TI - The Effects of Cyclosporine Versus Standard Care in Dogs With Naturally Occurring Glomerulonephritis AU - Vaden, Shelly L. AU - Breitschwerdt, Edward B. AU - Armstrong, P. Jane AU - Correa, Maria T. AU - Brown, Cathy AU - Polzin, David J. AU - Brace, James J. AU - DiBartola, Stephen P. AU - Barsanti, Jeanne A. AU - Crowell, Wayne AU - Jans, Heather AU - Dimski, Donna S. AU - Bartges, Joseph T2 - Journal of Veterinary Internal Medicine AB - Glomerulonephritis (GN) is a leading cause of chronic renal failure in dogs. However, little is known about the efficacy of available treatment options for GN in this species. The purpose of this study was to determine the effects of cyclosporine (Cy) administration on the outcome of naturally occurring GN in dogs. Thirteen dogs from 4 institutions were included in the study. Randomization of dogs into placebo-versus Cy-treated groups was stratified according to initial morphological diagnosis and contributing institution. Seven and 6 dogs were assigned to be given placebo or Cy, respectively. The initial Cy dose of 10 mg/kg every 24 hours was adjusted to maintain 24-hour trough, whole blood Cy concentrations between 250 and 400 ng/mL. There were no statistically significant differences between placebo- and Cy-treated groups with respect to serum total protein, albumin, urea nitrogen and creatinine, and plasma protein concentrations; platelet count; urine protein-creatinine ratio; endogenous creatinine clearance; 24-hour urine protein concentrations; or 24-hour urine protein-endogenous creatinine clearance ratio. However, PCV was significantly lower in the Cy-treated group. Decreased appetite, diarrhea, vomiting, weight loss, involuntary shaking, and thrombocytopenia were noted in both treatment groups; however, clinical signs in Cy-treated dogs subjectively were more severe. One Cy-treated dog developed gingival hyperplasia.(ABSTRACT TRUNCATED AT 250 WORDS) DA - 1995/7// PY - 1995/7// DO - 10.1111/j.1939-1676.1995.tb01077.x VL - 9 IS - 4 SP - 259-266 LA - en OP - SN - 0891-6640 1939-1676 UR - http://dx.doi.org/10.1111/j.1939-1676.1995.tb01077.x DB - Crossref ER - TY - CONF TI - A nuclear scaffold attachment region from tobacco greatly increases transgene expression in plant cells AU - Thompson, W.F. AU - Allen, G.C. AU - Hall, G. AU - Michalowski, S. AU - Newman, W. AU - Spiker, S. AU - Weissinger, A. A2 - Phillips, R. A2 - Oono, K. C2 - 1995/// C3 - Proceedings of the US-Japan Symposium on Modification of Gene Expression and Non-Mendelian Inheritance DA - 1995/// SP - 281–295 ER - TY - JOUR TI - Individual Members of the Cab Gene Family Differ Widely in Fluence Response AU - White, M. J. AU - Kaufman, L. S. AU - Horwitz, B. A. AU - Briggs, W. R. AU - Thompson, W. F. T2 - Plant Physiology AB - Chlorophyll a/b-binding protein genes (Cab genes) can be extremely sensitive to light. Transcript accumulation following a red light pulse increases with fluence over 8 orders of magnitude (L.S. Kaufman, W.F. Thompson, W.R. Briggs [1984] Science 226: 1447–1449). We have constructed fluence-response curves for individual Cab genes. At least two Cab genes (Cab-8 and AB96) show a very low fluence response to a single red light pulse. In contrast, two other Cab genes (AB80 and AB66) fail to produce detectable transcript following a single pulse of either red or blue light but are expressed in continuous red light. Thus, very low fluence responses and high irradiance responses occur in the same gene family. DA - 1995/1/1/ PY - 1995/1/1/ DO - 10.1104/pp.107.1.161 VL - 107 IS - 1 SP - 161-165 J2 - Plant Physiol. LA - en OP - SN - 0032-0889 1532-2548 UR - http://dx.doi.org/10.1104/pp.107.1.161 DB - Crossref ER - TY - JOUR TI - Light-regulated expression of the Arabidopsis thaliana ferredoxin gene requires sequences upstream and downstream of the transcription initiation site AU - Bovy, Arnaud AU - Van Den Berg, Claudia AU - De Vrieze, Geert AU - Thompson, William F. AU - Weisbeek, Peter AU - Smeekens, Sjef T2 - Plant Molecular Biology DA - 1995/1// PY - 1995/1// DO - 10.1007/bf00019176 VL - 27 IS - 1 SP - 27-39 J2 - Plant Mol Biol LA - en OP - SN - 0167-4412 1573-5028 UR - http://dx.doi.org/10.1007/bf00019176 DB - Crossref KW - ARABIDOPSIS THALIANA KW - CHIMERIC GENES KW - FERREDOXIN KW - LIGHT REGULATION KW - NICOTIANA TABACUM ER - TY - CONF TI - Clonal variation in four-year-old lobloly pine in coastal North Carolina AU - Frampton, L. J., Jr. AU - Huber, D. A. C2 - 1995/// C3 - Proceedings, 23rd Southern Forest Tree Improvement Conference, June 20-22, 1995, Asheville, North Carolina DA - 1995/// ER - TY - JOUR TI - TRANSFERRIN SECRETION BY LENS EPITHELIAL-CELLS IN CULTURE AU - MCGAHAN, MC AU - HARNED, J AU - GORALSKA, M AU - SHERRY, B AU - FLEISHER, LN T2 - EXPERIMENTAL EYE RESEARCH AB - Transferrin (Tf), the plasma iron transport protein which supports cell proliferation and differentiation and has bacteriostatic, antioxidant and anti-inflammatory activity, has been found in relatively high concentrations in the intraocular fluids. Intraocular synthesis of Tf has recently been demonstrated, although the intraocular tissue(s) responsible have not been identified. We designed this study to determine whether certain ocular tissues can make and secrete transferrin. Transferrin content of aqueous and vitreous humors and whole lenses was determined by ELISA. Transferrin secretion by cultured epithelia from lens and ciliary body was also measured. In addition, Northern blots of RNA from cultured lens epithelial cells, ciliary body pigmented and non-pigmented epithelial cells, and from whole iris, ciliary body and retina were probed with riboprobes for Tf mRNA and 18S rRNA. Transferrin made up 23% and 16% of total canine aqueous and vitreous protein. All ocular tissues and cultured cells tested contained mRNA for Tf, however Tf was secreted into the bathing medium from lens epithelial cell cultures, but not from either the pigmented or non-pigmented epithelial cells of the ciliary body Cycloheximide inhibited secretion of Tf from the lens epithelial cells. Lenses from inflamed eyes contained higher levels of Tf than their contralateral controls. This is the first experimental demonstration that an intraocular tissue can make and secrete Tf. Transferrin secretion by the lens may contribute significantly to the IOF content of this important intraocular protein. DA - 1995/6// PY - 1995/6// DO - 10.1016/S0014-4835(05)80008-9 VL - 60 IS - 6 SP - 667-673 SN - 0014-4835 KW - TRANSFERRIN KW - LENS KW - ANTIOXIDANTS KW - GROWTH FACTORS KW - AQUEOUS HUMOR ER - TY - CONF TI - Variance component and genetic gain estimates from 6-year-old diallel tests of loblolly pine AU - McKeand, S. E. AU - Bridgwater, F. E. C2 - 1995/// C3 - Proceedings of the 23rd Southern Forest Tree Improvement Conference DA - 1995/// SP - 197-203 ER - TY - CONF TI - Phenological variation in height and diameter growth in provenances and families of loblolly pine AU - Jayawickrama, K. J. S. AU - McKeand, S. E. AU - Jett, J. B. C2 - 1995/// C3 - Proceedings of the 23rd Southern Forest Tree Improvement Conference DA - 1995/// SP - 33-39 ER - TY - CONF TI - Genetic improvement of Christmas trees: progress and possibilities AU - McKinley, C. R. AU - McKeand, S. E. C2 - 1995/// C3 - Proceedings of the 23rd Southern Forest Tree Improvement Conference DA - 1995/// SP - 48-54 ER - TY - JOUR TI - 1994 seed collection from natural stands of Fraser fir and plans for breeding and genetics research at NCSU AU - McKeand, S. AU - Bridgwater, F. AU - McKinley, C. AU - Jett, J. B. AU - Arnold, R. T2 - Limbs & Needles DA - 1995/// PY - 1995/// VL - 22 SP - 4-7 ER - TY - CONF TI - Detection of QTLs for economically important traits in loblolly pine AU - Crane, B. S. AU - O'Malley, D. M. AU - McKeand, S. E. AU - Sederoff, R. R. C2 - 1995/// C3 - Proceedings of the 23rd Southern Forest Tree Improvement Conference DA - 1995/// SP - 119 ER - TY - JOUR TI - Obligations to animals are based on rights AU - Regan, T. T2 - Journal of Agricultural & Environmental Ethics (Online) DA - 1995/// PY - 1995/// VL - 8 IS - 2 SP - 171 ER - TY - JOUR TI - THE GENETIC-BASIS OF QUANTITATIVE VARIATION - NUMBERS OF SENSORY BRISTLES OF DROSOPHILA-MELANOGASTER AS A MODEL SYSTEM AU - MACKAY, TFC T2 - TRENDS IN GENETICS AB - The numbers of sensory hairs of Drosophila melanogaster present an ideal model system to elucidate the genetic basis of morphological quantitative variation. Loci affecting bristle number can be identified and their properties studied by accumulating spontaneous mutations, by P element mutagenesis, by mapping factors causing divergence between selection lines and by the association of phenotypic variation with molecular variation at candidate neurogenic loci. The consensus emerging from the application of all approaches is that much of the mutational and segregating variation affecting bristle number is attributable to alleles with large phenotypic effects at a small number of candidate loci. DA - 1995/12// PY - 1995/12// DO - 10.1016/S0168-9525(00)89154-4 VL - 11 IS - 12 SP - 464-470 SN - 0168-9525 ER - TY - JOUR TI - Fungal resistance to photosensitizers that generate singlet oxygen AU - Daub, M. E. AU - Jenns, A. E. AU - Ehrenshaft, M. T2 - Light activated pest control DA - 1995/// PY - 1995/// SP - 201 ER - TY - JOUR TI - Evaluation of the pathogenic potential of Rickettsia canada and Rickettsia prowazekii organisms in dogs AU - Breitschwerdt, E. B. AU - Hegarty, B. C. AU - Davidson, M. G. AU - Szabados, N. S. T2 - Journal of the American Veterinary Medical Association DA - 1995/// PY - 1995/// VL - 207 IS - 1 SP - 58 ER - TY - JOUR TI - Endocarditis in a dog due to infection with a novel Bartonella subspecies AU - Breitschwerdt, E. AU - Kordick, D. L. AU - Malarkey, D. E. AU - Keene, B. AU - Hadfield, T. L. AU - Wilson, K. T2 - Journal of Clinical Microbiology DA - 1995/// PY - 1995/// VL - 33 IS - 1 SP - 154 ER - TY - JOUR TI - Bartonellosis AU - Breitschwerdt, E. B. AU - Kordick, D. L. T2 - Journal of the American Veterinary Medical Association DA - 1995/// PY - 1995/// VL - 206 IS - 12 SP - 1928 ER - TY - PAT TI - System for encoding and decoding of convolutionally encoded data AU - Bitzer, D. L. AU - Vouk, M. A. AU - Srinivasan, V. AU - Lo, S. K. AU - Dholakia, A. AU - Gonzalez, E. M. AU - Lee, T. M. AU - Wang, L. AU - Koorapaty, H. C2 - 1995/// DA - 1995/// PY - 1995/// ER - TY - PAT TI - Modified unF-13 protein and gene AU - Levings, C. S. AU - Dewey, R. E. AU - Braun, C. J. C2 - 1995/// DA - 1995/// PY - 1995/// ER - TY - PAT TI - Root specific gene promoter AU - Conkling, M. A. AU - Yamamoto, Y. T. C2 - 1995/// DA - 1995/// PY - 1995/// ER - TY - JOUR TI - The dual role of mannitol as osmoprotectant and photoassimilate in celery AU - Pharr, D. M. AU - Stoop, J. M. H. AU - Williamson, J. D. AU - Feusi, M. E. S. AU - Massel, M. O. AU - Conkling, M. A. T2 - HortScience DA - 1995/// PY - 1995/// VL - 30 IS - 6 SP - 1182-1188 ER - TY - JOUR TI - SEQUENCE-ANALYSIS OF A MANNITOL DEHYDROGENASE CDNA FROM PLANTS REVEALS A FUNCTION FOR THE PATHOGENESIS-RELATED PROTEIN ELI3 AU - WILLIAMSON, JD AU - STOOP, JMH AU - MASSEL, MO AU - CONKLING, MA AU - PHARR, DM T2 - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA AB - Mannitol is the most abundant sugar alcohol in nature, occurring in bacteria, fungi, lichens, and many species of vascular plants. Celery (Apium graveolens L.), a plant that forms mannitol photosynthetically, has high photosynthetic rates thought to results from intrinsic differences in the biosynthesis of hexitols vs. sugars. Celery also exhibits high salt tolerance due to the function of mannitol as an osmoprotectant. A mannitol catabolic enzyme that oxidizes mannitol to mannose (mannitol dehydrogenase, MTD) has been identified. In celery plants, MTD activity and tissue mannitol concentration are inversely related. MTD provides the initial step by which translocated mannitol is committed to central metabolism and, by regulating mannitol pool size, is important in regulating salt tolerance at the cellular level. We have now isolated, sequenced, and characterized a Mtd cDNA from celery. Analyses showed that Mtd RNA was more abundant in cells grown on mannitol and less abundant in salt-stressed cells. A protein database search revealed that the previously described ELI3 pathogenesis-related proteins from parsley and Arabidopsis are MTDs. Treatment of celery cells with salicylic acid resulted in increased MTD activity and RNA. Increased MTD activity results in an increased ability to utilize mannitol. Among other effects, this may provide an additional source of carbon and energy for response to pathogen attack. These responses of the primary enzyme controlling mannitol pool size reflect the importance of mannitol metabolism in plant responses to divergent types of environmental stress. DA - 1995/8/1/ PY - 1995/8/1/ DO - 10.1073/pnas.92.16.7148 VL - 92 IS - 16 SP - 7148-7152 SN - 0027-8424 KW - SALT STRESS KW - CARBOHYDRATE METABOLISM KW - POLYOLS KW - CELERY KW - SALICYLATE ER - TY - JOUR TI - LIGNIN BIOSYNTHESIS AU - WHETTEN, R AU - SEDEROFF, R T2 - PLANT CELL DA - 1995/7// PY - 1995/7// DO - 10.2307/3870053 VL - 7 IS - 7 SP - 1001-1013 SN - 1532-298X ER - TY - JOUR TI - Cellular interaction in germinal-centers - roles of cd40 ligand and b7-2 in established germinal-centers AU - Han, S. H. AU - Hathcock, K. AU - Zheng, B. AU - Kepler, T. B. AU - Hodes, R. AU - Kelsoe, G. T2 - Journal of Immunology DA - 1995/// PY - 1995/// VL - 155 IS - 2 SP - 556-567 ER - TY - JOUR TI - Multiple-trait analysis of genetic-mapping for quantitative trait loci AU - Jiang, C. J. AU - Zeng, Z. B. T2 - Genetics DA - 1995/// PY - 1995/// VL - 140 IS - 3 SP - 1111-1127 ER - TY - JOUR TI - PURIFICATION OF NAD-DEPENDENT MANNITOL DEHYDROGENASE FROM CELERY SUSPENSION-CULTURES AU - STOOP, JMH AU - WILLAMSON, JD AU - CONKLING, MA AU - PHARR, DM T2 - PLANT PHYSIOLOGY AB - Mannitol dehydrogenase, a mannitol:mannose 1-oxidoreductase, constitutes the first enzymatic step in the catabolism of mannitol in nonphotosynthetic tissues of celery (Apium graveolens L.). Endogenous regulation on the enzyme activity in response to environmental cues is critical in modulating tissue concentration of mannitol, which, importantly, contribute to stress tolerance of celery. The enzyme was purified to homogeneity from celery suspension cultures grown on D-mannitol as the carbon source. Mannitol dehydrogenase was purified 589-fold to a specific activity of 365 mumol h-1 mg-1 protein with a 37% yield of enzyme activity present in the crude extract. A highly efficient and simple purification protocol was developed involving polyethylene glycol fractionation, diethylaminoethyl-anion-exchange chromatography, and NAD-agarose affinity chromatography using NAD gradient elution. Sodium dodecylsulfate gel electrophoresis of the final preparation revealed a single 40-kD protein. The molecular mass of the native protein was determined to be approximately 43 kD, indicating that the enzyme is a monomer. Polyclonal antibodies raised against the enzyme inhibited enzymatic activity of purified mannitol dehydrogenase. Immunoblots of crude protein extracts from mannitol-grown celery cells and sink tissues of celery, celeriac, and parsley subjected to sodium dodecyl sulfate gel electrophoresis showed a single major immuno-reactive 40-kD protein. DA - 1995/7// PY - 1995/7// DO - 10.1104/pp.108.3.1219 VL - 108 IS - 3 SP - 1219-1225 SN - 0032-0889 ER - TY - CHAP TI - Mannitol catabolism in plant sink tissues AU - Pharr, D.M. AU - Stoop, J.M.H. AU - Studer Feusi, M.E. AU - Williamson, J.D. AU - Massel, M.O. AU - Conkling, M.A. T2 - Carbon Partitioning and Source-Sink Interactions in Plants, Current Topics in Plant Physiology, Vol. 13 (Madore, MA and Lucas, WJ, eds.) A2 - Madore, MA A2 - Lucas, WJ PY - 1995/// SP - 180-194 PB - American Society of Plant Physiologists, Rockville, MD ER -