Works Published in 2017

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Displaying works 61 - 79 of 79 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2017 journal article

Bartonella henselae in canine cavitary effusions: prevalence, identification, and clinical associations

Veterinary Clinical Pathology, 46(2), 326–330.

By: A. Weeden*, N. Cherry*, E. Breitschwerdt n, A. Cheves* & H. Wamsley*

author keywords: Bartonellosis; dog; peritoneal effusion; pleural effusion; seasonal variation
MeSH headings : Angiomatosis, Bacillary / diagnosis; Angiomatosis, Bacillary / epidemiology; Angiomatosis, Bacillary / pathology; Angiomatosis, Bacillary / veterinary; Animals; Ascitic Fluid / microbiology; Bartonella henselae; Dog Diseases / diagnosis; Dog Diseases / epidemiology; Dog Diseases / microbiology; Dog Diseases / pathology; Dogs; Female; Male; Pericardial Effusion / etiology; Pericardial Effusion / microbiology; Pericardial Effusion / veterinary; Pleural Effusion / etiology; Pleural Effusion / microbiology; Pleural Effusion / veterinary; Prevalence; Seasons
TL;DR: Viable B henselae organisms occur in pleural and peritoneal effusions of dogs; the clinical relevance of which remains unclear and may represent opportunistic infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Synthesis and photophysical characterization of bacteriochlorins equipped with integral swallowtail substituents

NEW JOURNAL OF CHEMISTRY, 41(11), 4360–4376.

By: Y. Liu n, S. Allu n, M. Reddy n, D. Hood*, J. Diers*, D. Bocian*, D. Holten*, J. Lindsey n

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Response of Turkish and Trojan fir to Phytophthora cinnamomi and P.cryptogea

SCANDINAVIAN JOURNAL OF FOREST RESEARCH, 32(5), 406–411.

author keywords: Abies; disease resistance; North Carolina; root rot
TL;DR: Rankings of resistance in fir species confirmed previous single-isolate-based results; momi fir was the most resistant, followed by Turkish, Trojan, and Fraser fir, while Turkish and Trojan fir families appear to possess resistance to Phytophthora species common in North Carolina. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Increased diversity of Phytophthora species in Fraser fir Christmas tree plantations in the Southern Appalachians

SCANDINAVIAN JOURNAL OF FOREST RESEARCH, 32(5), 412–420.

author keywords: Abies fraseri; North Carolina; Phytophthora cinnamomi; root rot; survey
TL;DR: During 2014, Fraser fir Christmas tree plantations in the Southern Appalachians of North Carolina, Tennessee and Virginia were surveyed to determine the occurrence of pathogenic root-rotting species of Phytophthora and the pathogenicity of P. citrophthora was confirmed based on completion of Koch's postulates. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Construction of the Bacteriochlorin Macrocycle with Concomitant Nazarov Cyclization To Form the Annulated Isocyclic Ring: Analogues of Bacteriochlorophyll a

JOURNAL OF ORGANIC CHEMISTRY, 82(5), 2489–2504.

By: S. Zhang n & J. Lindsey n

MeSH headings : Bacteriochlorophyll A / chemistry; Macrocyclic Compounds / chemistry; Porphyrins / chemistry; Spectrum Analysis / methods
TL;DR: A general route to stable, synthetic bacteriochlorophyll analogues is described, which includes condensation between the α-position of pyrrole ring A and theα-acetal unit attached to pyrroline ring B and a double ring-closure process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Vibrio Phage KVP40 Encodes a Functional NAD(+) Salvage Pathway

JOURNAL OF BACTERIOLOGY, 199(9).

author keywords: NAD; bacteriophages; genomics; metabolism
MeSH headings : Bacteriophage T4 / genetics; Escherichia coli / genetics; Genomics; Metabolic Networks and Pathways / genetics; NAD / metabolism; Nicotinamide-Nucleotide Adenylyltransferase / genetics; Nicotinamide-Nucleotide Adenylyltransferase / metabolism; Nucleotides; Pyridines / chemistry; Pyrophosphatases / metabolism; Vibrio parahaemolyticus / virology
TL;DR: It is shown that phage KVP40 encodes a functional pyridine nucleotide scavenging pathway that is expressed during the metabolic period of the infection cycle, and the pathway is conserved in other large, dsDNA phages in which the two genes, nadV and natV, share an evolutionary history in their respective phage-host group. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Tissue and cell-type co-expression networks of transcription factors and wood component genes in Populus trichocarpa

PLANTA, 245(5), 927–938.

author keywords: Wood formation; Transcriptome; Fiber cells; Vessel elements; Cell wall biosynthesis; Co-expression network
MeSH headings : Cell Wall / metabolism; Cellulose / metabolism; Cluster Analysis; Gene Expression Regulation, Plant; Lignin / metabolism; Molecular Sequence Annotation; Organ Specificity; Phloem / genetics; Phloem / growth & development; Plant Leaves / genetics; Plant Leaves / growth & development; Plant Proteins / genetics; Populus / genetics; Populus / growth & development; Sequence Analysis, RNA; Transcription Factors / genetics; Transcriptome; Wood / genetics; Wood / growth & development; Xylem / genetics; Xylem / growth & development
TL;DR: The co-expression networks revealed here suggest a well-structured transcriptional homeostasis for cell wall component biosynthesis during wood formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

NF-kappa B activation is cell type-specific in the heart

VIROLOGY, 502, 133–143.

author keywords: NF-kappa B; Myocarditis; Cardiac myocyte; Cardiac fibroblast; Cardiomyocyte; Golgi; Reovirus; Heart
MeSH headings : Animals; Cell Line; Cells, Cultured; Fibroblasts / metabolism; Fibroblasts / virology; Golgi Apparatus / metabolism; Golgi Apparatus / virology; Heart / virology; Humans; Mammalian orthoreovirus 3 / physiology; Mice; Mice, Inbred C57BL; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; NF-kappa B / genetics; NF-kappa B / metabolism; Organ Specificity; Reoviridae Infections / genetics; Reoviridae Infections / metabolism; Reoviridae Infections / virology; Signal Transduction
TL;DR: Results indicate that NF-κB-dependent signaling in the heart is cardiac cell type-specific, likely reflecting mechanisms that have evolved to balance responses that can be either protective or damaging to the heart. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade

CHROMOSOME RESEARCH, 25(2), 129–143.

By: H. Mochizuki n, R. Thomas n, S. Moroff & M. Breen n

author keywords: Cancer; Comparative genomic hybridization; Digital PCR; Dog; Mastocytosis; Pug
MeSH headings : Animals; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dogs; Genome / genetics; Mastocytosis, Cutaneous / diagnosis; Mastocytosis, Cutaneous / genetics; Mastocytosis, Cutaneous / pathology; Mutation; Predictive Value of Tests; Proto-Oncogene Proteins c-kit / genetics; Sensitivity and Specificity
TL;DR: Characterization of genomic alterations in canine MCTs may identify genomic regions and/or genes responsible for their development and progression, facilitating the discovery of new therapeutic targets and improved clinical management of this heterogeneous cancer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Generation of LIF-independent induced pluripotent stem cells from canine fetal fibroblasts

THERIOGENOLOGY, 92, 75–82.

By: N. Goncalves, F. Bressan*, K. Roballo, F. Meirelles*, P. Xavier, H. Fukumasu, C. Williams n, M. Breen n ...

author keywords: iPSC; Canine; Stem cells; Pluripotency; Cellular reprogramming
MeSH headings : Animals; Dogs; Fetus / cytology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / physiology; Gene Expression Regulation / physiology; Leukemia Inhibitory Factor / pharmacology; Mice; Mice, Inbred BALB C; Mice, Nude; Pluripotent Stem Cells / physiology; Polymerase Chain Reaction / veterinary
TL;DR: This report is the first to describe the ability to reprogram canine somatic cells via lentiviral vectors without supplementation and with resistance to enzymatic action, thereby demonstrating the pluripotency of these cell lines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies

LEUKEMIA & LYMPHOMA, 58(7), 1702–1710.

By: D. Seelig*, D. Ito*, C. Forster*, U. Yoon*, M. Breen n, L. Burns*, V. Bachanova*, K. Lindblad-Toh* ...

author keywords: Diffuse large B-cell lymphoma; alternative NF-kappa B pathway; canine model; targeting therapy; comparative pathology
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Cell Survival / drug effects; Disease Models, Animal; Dogs; Gene Expression; Genes, Reporter; Humans; Lymphoma, Large B-Cell, Diffuse / drug therapy; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Molecular Targeted Therapy; NF-kappa B / metabolism; Signal Transduction / drug effects
TL;DR: It is demonstrated that dogs with spontaneous DLBCL can provide a useful large animal model to study therapies targeting the ANFκBP and that a small interfering RNA inhibits the activation of the NFκB pathway and induces apoptosis in canineDLBCL cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases

Journal of Veterinary Internal Medicine, 31(2), 279–294.

By: M. Lappin*, J. Blondeau, D. Boothe*, E. Breitschwerdt n, L. Guardabassi*, D. Lloyd*, M. Papich n, S. Rankin* ...

author keywords: Bronchitis; Pneumonia; Pyothorax; Rhinitis
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / veterinary; Cat Diseases / drug therapy; Cats; Dog Diseases / drug therapy; Dogs; Respiratory Tract Diseases / drug therapy; Respiratory Tract Diseases / veterinary
TL;DR: The International Society for Companion Animal Infectious Diseases convened a Working Group of clinical microbiologists, pharmacologists, and internists to share experiences, examine scientific data, review clinical trials, and develop these guidelines to assist veterinarians in making antimicrobial treatment choices. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Variation among Loblolly Pine Seed Sources across Diverse Environments in the Southeastern United States

FOREST SCIENCE, 63(1), 39–48.

By: A. Farjat*, A. Chamblee, F. Isik*, R. Whetten* & S. McKeand*

author keywords: Pinus taeda; seed source; provenance test; genotype x environment interaction; multienvironmental trial analysis
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 review

Synthetic Chlorins, Possible Surrogates for Chlorophylls, Prepared by Derivatization of Porphyrins

[Review of ]. CHEMICAL REVIEWS, 117(2), 344–535.

By: M. Taniguchi n & J. Lindsey n

MeSH headings : Chlorophyll / chemistry; Porphyrins / chemistry; Stereoisomerism
TL;DR: The synthesis and spectral properties of the vast collection of compounds described herein are expected to illuminate the scope to which synthetic chlorins can serve as surrogates for chlorophylls and be exploited in diverse ways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Pyogranulomatous Pancarditis with Intramyocardial Bartonella henselae San Antonio 2 (BhSA2) in a Dog

JOURNAL OF VETERINARY INTERNAL MEDICINE, 31(1), 142–148.

By: T. Donovan*, P. Fox*, N. Balakrishnan n, M. Ericson*, V. Hooker* & E. Breitschwerdt n

author keywords: Canine; Myocarditis; Nephritis; Stealth; Vasculitis
MeSH headings : Animals; Bartonella Infections / microbiology; Bartonella Infections / pathology; Bartonella Infections / veterinary; Bartonella henselae / isolation & purification; Dog Diseases / microbiology; Dog Diseases / pathology; Dogs; Endocarditis, Bacterial / veterinary; Female; Myocarditis / microbiology; Myocarditis / veterinary; Pericarditis / veterinary
TL;DR: A 6-year-old, female, spayed American Pitbull terrier was presented for progressive lethargy, weakness, and anorexia of 3-weeks duration, and found to have metabolic acidosis and Lyme quantitative C6 ELISA was negative. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

The Porphobilinogen Conundrum in Prebiotic Routes to Tetrapyrrole Macrocycles

ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES, 47(1), 93–119.

author keywords: delta-aminolevulinic acid; Porphyrinogen; Porphyrin; DFT; Biosynthesis; Biomimetic
MeSH headings : Aminolevulinic Acid / analogs & derivatives; Aminolevulinic Acid / chemistry; Evolution, Chemical; Kinetics; Origin of Life; Porphobilinogen / chemistry; Tetrapyrroles / chemistry
TL;DR: The results suggest efforts toward a biomimetic, enzyme-free route to tetrapyrroles from ALA should turn away from structure-directed reactions and focus on catalysts that orient the two aminoketones to form PBG in a kinetically controlled process, thereby avoiding formation of pseudo-PBG. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Soybean cyst nematode culture collections and field populations from North Carolina and Missouri reveal high incidences of infection by viruses

PLOS ONE, 12(1).

MeSH headings : Animals; DNA-Directed RNA Polymerases / metabolism; Gene Expression Regulation, Plant; Incidence; Life Cycle Stages / genetics; Missouri; North Carolina; Plant Diseases / parasitology; Plant Diseases / statistics & numerical data; Plant Diseases / virology; Plant Viruses / physiology; Real-Time Polymerase Chain Reaction; Soybeans / genetics; Soybeans / parasitology; Soybeans / virology; Species Specificity; Tylenchoidea / growth & development; Tylenchoidea / physiology; Virus Replication / physiology
TL;DR: Viral titers within SCN greenhouse cultures were similar throughout juvenile development, and the presence of viral anti-genomic RNAs within egg, second-stage juvenile (J2), and pooled J4 stages suggests active viral replication within the nematode. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Bartonellosis, One Health and all creatures great and small

Veterinary Dermatology, 28(1), 96–e21.

By: E. Breitschwerdt n

MeSH headings : Animals; Bartonella; Bartonella Infections / diagnosis; Bartonella Infections / etiology; Bartonella Infections / therapy; Bartonella Infections / veterinary; Communicable Diseases, Emerging / diagnosis; Communicable Diseases, Emerging / therapy; Communicable Diseases, Emerging / veterinary; Humans; Zoonoses / diagnosis; Zoonoses / microbiology; Zoonoses / therapy; Zoonoses / transmission
TL;DR: This review serves as an update on comparative medical aspects of this disease, including the epidemiology, pathogenesis, clinical diagnosis, treatment and challenges, and concludes that directed Bartonella research could substantially reduce a spectrum of chronic and debilitating animal and human diseases, and thereby reduce suffering throughout the world. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Antibacterial efficacy and cytotoxicity of low intensity direct current activated silver-titanium implant system prototype

BIOMETALS, 30(1), 113–125.

author keywords: Low intensity direct current; Silver-titanium implant; Orthopaedic application; Antimicrobial efficacy; Cytotoxicity
MeSH headings : Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Cell Proliferation / drug effects; Ions / chemistry; Methicillin-Resistant Staphylococcus aureus / drug effects; Methicillin-Resistant Staphylococcus aureus / pathogenicity; Silver / chemistry; Silver / pharmacology; Staphylococcal Infections / drug therapy; Staphylococcal Infections / microbiology; Titanium / chemistry; Titanium / pharmacology
TL;DR: The in vitro antibacterial efficacy and cytotoxicity of a low intensity direct current (LIDC)-activated silver–titanium implant system prototype designed for localized generation and delivery of silver ions at the implantation site showed high antimicrobial efficacy against MRSA, but was also toxic to human cells immediately surrounding the electrodes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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