Works Published in 1999

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Displaying works 81 - 100 of 144 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

1999 journal article

An automated microscale chemistry workstation capable of parallel, adaptive experimentation

CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 48(2), 181–203.

By: H. Du n, L. Corkan n, K. Yang n, P. Kuo n & J. Lindsey n

author keywords: automated workstation; parallel experimentation; microscale chemistry
TL;DR: A 3rd-generation chemistry workstation and accompanying software for automated experimentation in relatively clean domains of chemistry is designed for flexible, high-throughput, microscale chemistry and includes a reaction station with 60 reaction vessels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

A multihit, multistage model of chemical carcinogenesis

CARCINOGENESIS, 20(9), 1837–1844.

By: D. Owens, S. Wei* & R. Smart*

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Acetone / toxicity; Animals; Carcinogens / toxicity; Carcinoma, Squamous Cell / chemically induced; Carcinoma, Squamous Cell / pathology; Cell Transformation, Neoplastic / chemically induced; Cell Transformation, Neoplastic / genetics; Cocarcinogenesis; DNA Mutational Analysis; DNA, Neoplasm / genetics; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Keratinocytes / drug effects; Keratinocytes / pathology; Keratins / biosynthesis; Keratins / genetics; Mice; Models, Biological; Neoplasm Proteins / biosynthesis; Neoplasm Proteins / genetics; Papilloma / chemically induced; Papilloma / pathology; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; S Phase; Skin Neoplasms / chemically induced; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / toxicity
TL;DR: Promotion between the first and second hits has a profound outcome on carcinogenesis, presumably by increasing the probability that a second hit will occur in a previously initiated cell; continued promotion after the second hit is required for full expression of malignancy; and the classic initiation-promotion protocol can be extended to a multihit, multistage model. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Synthesis and properties of star-shaped multiporphyrin-phthalocyanine light-harvesting arrays

JOURNAL OF ORGANIC CHEMISTRY, 64(25), 9090–9100.

By: J. Li n, . Diers n, J. Seth n, S. Yang n, D. Bocian n, D. Holten n, J. Lindsey n

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Platelet-associated immunoglobulin (antiplatelet antibody) in canine Rocky Mountain spotted fever and ehrlichiosis

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 35(1), 56–61.

By: C. Grindem n, E. Breitschwerdt*, P. Perkins*, L. Cullins, T. Thomas & B. Hegarty*

MeSH headings : Animals; Antibodies, Bacterial / blood; Autoantibodies / blood; Blood Platelets / immunology; Dog Diseases / blood; Dog Diseases / immunology; Dogs; Ehrlichia / immunology; Ehrlichiosis / blood; Ehrlichiosis / immunology; Ehrlichiosis / veterinary; Flow Cytometry / veterinary; Fluorescent Antibody Technique, Indirect / veterinary; Immunoglobulin G / blood; Rickettsia rickettsii / immunology; Rocky Mountain Spotted Fever / blood; Rocky Mountain Spotted Fever / immunology; Rocky Mountain Spotted Fever / veterinary; Thrombocytopenia / blood; Thrombocytopenia / immunology; Thrombocytopenia / veterinary
TL;DR: Results of this study indicate an immunological component for rickettsial thrombocytopenia, and current therapeutic recommendations, especially regarding avoiding the use of immunosuppressive drugs in patients with ricksettsial diseases, need to be critically reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Overexpression of protein kinase C-[alpha] in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2, and TNF-[alpha] but not tumor promotion

Journal of Cell Science, 112(20), 3497–3506.

By: H. Wang & R. Smart

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

1999 journal article

Multiple interval mapping for quantitative trait loci

Genetics, 152(3), 1203–1216.

By: C. Kao, Z. Zeng & R. Teasdale

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Implementation of the multidirectional search algorithm on an automated chemistry workstation. A parallel yet adaptive approach for reaction optimization

CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 48(2), 235–256.

By: H. Du n, S. Jindal n & J. Lindsey n

author keywords: multidirectional search; simplex; automated chemistry workstation
TL;DR: An experiment-planning module for applying a powerful new pattern search algorithm toward the problems of reaction investigation and optimization and includes options for specifying initial points, stop criteria, and early-termination processes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Geminiviruses: Models for plant DNA replication, transcription, and cell cycle regulation {review}

Critical Reviews in Plant Sciences, 18(1), 71–106.

By: L. Hanley-Bowdoin n, S. Settlage n, B. Orozco n, S. Nagar n & D. Robertson n

UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Evolution of bHLH transcription factors: Modular evolution by domain shuffling?

MOLECULAR BIOLOGY AND EVOLUTION, 16(12), 1654–1663.

author keywords: modular evolution; molecular evolution; basic helix-loop-helix domain; transcription factors; sequence alignment; phylogeny
MeSH headings : DNA-Binding Proteins / genetics; Evolution, Molecular; Helix-Loop-Helix Motifs / genetics; Phylogeny; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Transcription Factors / genetics
TL;DR: Drawing on several lines of evidence, it is suggested that modular evolution by domain shuffling may have played an important role in the evolution of this large group of transcriptional regulators. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Duplication of the Brassica oleracea APETALA1 floral homeotic gene and the evolution of domesticated cauliflower

Journal of Heredity, 90(5), 514–520.

By: A. Lowman & M. Purugganan

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

A planning module for performing grid search, factorial design, and related combinatorial studies on an automated chemistry workstation

CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 48(2), 219–234.

By: P. Kuo n, H. Du n, L. Corkan n, K. Yang n & J. Lindsey n

author keywords: grid search; factorial design; automated chemistry workstation
TL;DR: Experimental plans can be readily composed and implemented for fundamental studies of chemical reactions, generating response surfaces, performing parallel screening procedures, and creating indexed combinatorial chemical libraries. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Workflow and end-user quality of service issues in Web-based education

IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING, 11(4), 673–687.

author keywords: network-based education; end-user quality of service; Web lecture system; NovaNET; education workflows; distance education; computer-based training; system reliability; keystroke response time; Web-based instruction
TL;DR: This paper discusses some major issues that, although mostly solved for NBE, still face Web-based education (WEE), and suggests that a successful WEE system will have a sound auto-adaptive knowledge assessment component, a "virtual" laboratory capability, and a set of strong collaborative functions. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Transient and sustained increases in inositol 1,4,5-hisphosphate precede the differential growth response in gravistimulated maize pulvini

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(10), 5838–5843.

MeSH headings : Cell Membrane / metabolism; Cell Size; Gravitation; Inositol 1,4,5-Trisphosphate / metabolism; Inositol Polyphosphate 5-Phosphatases; Phosphatidylinositol 4,5-Diphosphate / metabolism; Phosphoric Monoester Hydrolases / metabolism; Phosphotransferases (Alcohol Group Acceptor) / metabolism; Pulvinus / growth & development; Second Messenger Systems; Time Factors; Zea mays / metabolism
TL;DR: The data indicate the involvement of IP3 and inositol phospholipids in both short- and long-term responses to gravistimulation, as a diffusible second messenger providing a mechanism to transmit and amplify the signal from the perceiving to the responding cells in the pulvinus, coordinating a synchronized growth response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Tomato spotted wilt tospovirus adapts to the TSWV N gene-derived resistance by genome reassortment

PHYTOPATHOLOGY, 89(7), 575–582.

By: W. Qiu & J. Moyer*

author keywords: genomic marker
TL;DR: The hypothesis that TSWV utilizes genome reassortment to adapt to new host genotypes rapidly and that elements from two or more segments of the genome are involved in suppression of the resistance reaction is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1999 article

The incidence of ehrlichial and rickettsial infection in patients with unexplained fever and recent history of tick bite in central North Carolina

Carpenter, C. F., Gandhi, T. K., Kong, L. K., Corey, G. R., Chen, S. M., Walker, D. H., … al. (1999, September). JOURNAL OF INFECTIOUS DISEASES, Vol. 180, pp. 900–903.

By: C. Carpenter, T. Gandhi, L. Kong, G. Corey*, S. Chen, D. Walker*, J. Dumler*, E. Breitschwerdt n ...

MeSH headings : Adult; Animals; Antibodies, Bacterial / blood; Comorbidity; Ehrlichia chaffeensis / isolation & purification; Ehrlichiosis / blood; Ehrlichiosis / epidemiology; Fever of Unknown Origin / blood; Fever of Unknown Origin / etiology; Fever of Unknown Origin / microbiology; Humans; Incidence; Insect Bites and Stings; Leukocyte Count; North Carolina / epidemiology; Platelet Count; Polymerase Chain Reaction; Rickettsia / isolation & purification; Rickettsia Infections / blood; Rickettsia Infections / epidemiology; Ticks
TL;DR: It is concluded that ehrlichial infections may be as common as spotted fever group rickettsial infections in febrile patients from central North Carolina with a recent history of tick bite. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Synthesis of beta-substituted porphyrin building blocks and conversion to diphenylethyne-linked porphyrin dimers

TETRAHEDRON, 55(22), 6771–6784.

author keywords: alkynes; orbital effects; porphyrins; pyrroles
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 review

Phosphoinositide kinases and the synthesis of polyphosphoinositides in higher plant cells

[Review of ]. INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 189, 189, 95–130.

By: B. Drobak*, R. Dewey n & W. Boss n

author keywords: phosphatidylinositol; kinases; inositol; plants; biosynthesis; cell signaling; phosphatidylinositol transfer proteins; phospholipids
MeSH headings : Animals; Eukaryotic Cells / metabolism; Humans; Phosphatidylinositol 3-Kinases / metabolism; Phosphatidylinositol Phosphates / biosynthesis; Phosphatidylinositols / metabolism; Phosphotransferases / metabolism; Plant Cells; Plants / metabolism
TL;DR: The author focuses on the phosphoinositide kinases responsible for the synthesis of all phosphorylated forms of phosphatidylinositol, which, in his opinion, are most likely to provide a suitable starting point for further research into the role of phosphorusoinositides in plants. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Molecular analysis of a spontaneous dystrophin 'knockout' dog

NEUROMUSCULAR DISORDERS, 9(5), 289–295.

By: S. Schatzberg, N. Olby*, M. Breen, L. Anderson, C. Langford, H. Dickens, S. Wilton, C. Zeiss ...

author keywords: dystrophin; Duchenne muscular dystrophy; canine; animal models; fluorescence in situ hybridization; polymerase chain reaction
MeSH headings : Animals; Biopsy; Blotting, Western; Chromosome Deletion; Creatine Kinase / blood; DNA / genetics; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Dystrophin / genetics; In Situ Hybridization, Fluorescence; Male; Muscle, Skeletal / metabolism; Muscle, Skeletal / pathology; Muscular Dystrophy, Animal / genetics; Muscular Dystrophy, Animal / pathology; Mutation; Polymerase Chain Reaction; X Chromosome / genetics
TL;DR: The molecular basis for skeletal myopathy and dilated cardiomyopathy in two male German short-haired pointer (GSHP) littermates is determined and a visible deletion in the p21 region of the affected canine X chromosome is confirmed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 patent

Methods for within family selection of disease resistance in woody perennials using genetic markers

Washington, DC: U.S. Patent and Trademark Office.

By: H. Amerson, P. Wilcox, R. Sederoff, E. Kuhlman, D. O'Malley & D. Grattapaglia

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Investigation and refinement of palladium-coupling conditions for the synthesis of diarylethyne-linked multiporphyrin arrays

CHEMISTRY OF MATERIALS, 11(10), 2974–2983.

By: R. Wagner n, Y. Ciringh n, C. Clausen n & J. Lindsey n

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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