Works Published in 2016
Displaying works 181 - 200 of 239 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2016 journal article
Differences in mRNA populations of short and long bovine conceptuses on Day 15 of gestation
MOLECULAR REPRODUCTION AND DEVELOPMENT, 83(5), 424–441.
MeSH headings : Animals; Cattle; Female; Gestational Age; Morula / cytology; Morula / metabolism; Pregnancy; RNA, Messenger / metabolism
TL;DR:
Differences in gene expression were identified between conceptuses recovered on Day 15 of gestation, based on their length, which may be used to identify genes and cellular pathways involved in enhanced conceptus elongation that could serve as markers of successful pregnancy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Atomic layer deposition coating of carbon nanotubes with zinc oxide causes acute phase immune responses in human monocytes in vitro and in mice after pulmonary exposure
PARTICLE AND FIBRE TOXICOLOGY, 13.
author keywords: Atomic layer deposition; Carbon nanotubes; Pulmonary fibrosis; Inflammation
MeSH headings : Acute-Phase Reaction / chemically induced; Acute-Phase Reaction / immunology; Acute-Phase Reaction / metabolism; Acute-Phase Reaction / pathology; Air Pollutants / chemistry; Air Pollutants / toxicity; Animals; Cell Line; Cytokines / agonists; Cytokines / genetics; Cytokines / metabolism; Disease Progression; Gene Expression Regulation / drug effects; Humans; Inhalation Exposure / adverse effects; Lung / drug effects; Lung / immunology; Lung / metabolism; Lung / pathology; Male; Mice, Inbred C57BL; Microscopy, Electron, Scanning Transmission; Monocytes / drug effects; Monocytes / immunology; Monocytes / metabolism; Monocytes / pathology; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Nanotubes, Carbon / ultrastructure; Pulmonary Fibrosis / etiology; RNA, Messenger / metabolism; Respiratory Mucosa / drug effects; Respiratory Mucosa / immunology; Respiratory Mucosa / pathology; Surface Properties; Zinc Oxide / chemistry; Zinc Oxide / toxicity
TL;DR:
It is hypothesized that surface functionalization of multi-walled carbon nanotubes with polycrystalline ZnO by ALD would alter pro-inflammatory cytokine expression by human monocytes in vitro and modulate the lung and systemic immune response following oropharyngeal aspiration in mice.
(via Semantic Scholar)
particleandfibretoxicology.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 article
Assessment of sex specific endocrine disrupting effects in the prenatal and pre-pubertal rodent brain
Rebuli, M. E., & Patisaul, H. B. (2016, June). JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol. 160, pp. 148–159.
author keywords: Endocrine disrupting compounds; Neurodevelopment; Sex differences; Developmental exposure; Rodent; Bisphenol; BPA; Genistein; Xenoestrogen; EDC
MeSH headings : Animals; Brain / drug effects; Brain / embryology; Brain / growth & development; Endocrine Disruptors / pharmacology; Female; Male; Puberty / drug effects; Rodentia / embryology; Rodentia / growth & development; Sex Characteristics
TL;DR:
The developmental EDC exposure literature demonstrates evidence of altered neurodevelopment as early as fetal life, with sex specific effects observed throughout the brain even before puberty.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure
REPRODUCTIVE TOXICOLOGY, 62, 92–99.
Contributors: G. Zhang n, S. Marvel n, L. Truong *, R. Tanguay * & D. Reif n
author keywords: Developmental neurotoxicology; Chemical biology; Morphology; Zebrafish; High throughput screening; ToxCast; Multiplexed assays
MeSH headings : Animals; Embryo, Nonmammalian; Entropy; Flame Retardants / toxicity; High-Throughput Screening Assays; Models, Theoretical; Phenotype; Teratogens / toxicity; Zebrafish / embryology
TL;DR:
An information-theoretic method named Aggregate Entropy (AggE) is proposed and applied to scoring multiplexed, phenotypic endpoints measured in developing zebrafish across a broad concentration-response profile for a diverse set of 1060 chemicals, identifying chemicals with significant morphological effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Adapting Certified Safe Farm to North Carolina Agriculture: An Implementation Study
JOURNAL OF AGROMEDICINE, 21(3), 269–283.
author keywords: Agricultural health and safety; economic incentive; hazard reduction; injury and illness prevention; intervention; occupational health services; preventive health services; RE-AIM; research to practice; translational research
MeSH headings : Agriculture / standards; Farms; Humans; Iowa; Marketing; North Carolina; Occupational Health / standards; Program Evaluation; Safety / standards
TL;DR:
The CSF implementation process in North Carolina, as piloted on a large-scale in three agriculturally diverse and productive counties of NC, is described and its effectiveness using the Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) framework is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
A Comparison of Survey Techniques for Medium- to Large-sized Mammals in Forested Wetlands
SOUTHEASTERN NATURALIST, 15(1), 175–187.
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Use of Dieselized Farm Equipment and Incident Lung Cancer: Findings from the Agricultural Health Study Cohort
Environmental Health Perspectives, 124(5), 611–618.
MeSH headings : Agricultural Workers' Diseases / epidemiology; Agriculture / statistics & numerical data; Farmers; Iowa / epidemiology; Lung Neoplasms / epidemiology; North Carolina / epidemiology; Occupational Exposure / statistics & numerical data; Vehicle Emissions
TL;DR:
Preliminary evidence of an increased risk of lung adenocarcinoma among daily drivers of diesel tractors is provided and it is suggested that exposure to endotoxins may modify the impact of diesel exposure on lung cancer risk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
The adaptor molecule Trif contributes to murine host defense during Leptospiral infection
IMMUNOBIOLOGY, 221(9), 964–974.
author keywords: Leptospira interrogans; Leptospirosis; Innate immunity; TRIF
MeSH headings : Adaptor Proteins, Vesicular Transport / genetics; Adaptor Proteins, Vesicular Transport / immunology; Animals; Cytokines / blood; Cytokines / genetics; Cytokines / immunology; Immunoglobulin A / immunology; Immunoglobulin M / immunology; Kidney / immunology; Leptospira / immunology; Leptospirosis / immunology; Lung / immunology; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger / metabolism
TL;DR:
Multiple components of the innate immune responses were dampened in response to leptospiral infection including transcription and production of cytokines, and the humoral response, which suggested that TRIF contributes to expression and productionof cytokines important for the host defense against L. interrogans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
TAK1 regulates hepatic lipid homeostasis through SREBP
ONCOGENE, 35(29), 3829–3838.
MeSH headings : Animals; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / metabolism; Cell Line; Fatty Liver / genetics; Fatty Liver / metabolism; Female; HEK293 Cells; Hep G2 Cells; Hepatocytes / metabolism; Homeostasis; Humans; Immunoblotting; Lipid Metabolism; Liver / metabolism; Liver Neoplasms / genetics; Liver Neoplasms / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Male; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Protein Binding; RNA Interference; Risk Factors; Sterol Regulatory Element Binding Proteins / genetics; Sterol Regulatory Element Binding Proteins / metabolism
TL;DR:
It is demonstrated that SREBPs are regulated by a previously uncharacterized mechanism through transforming growth factor-β activated kinase 1 (TAK1), a signaling molecule of inflammation, which critically contributes to the maintenance of liver homeostasis to prevent steatosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 review
Systematics, phylogeny and palaeobiogeography of the ankylosaurid dinosaurs
[Review of ]. Journal of Systematic Palaeontology, 14(5), 385–444.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Specializations of the mandibular anatomy and dentition of Segnosaurus galbinensis (Theropoda: Therizinosauria)
PeerJ, 4, e1885.
author keywords: Cretaceous; Dinosaur; Theropod; Anatomy; Ecomorphology; Therizinosaur; Dentition; Evolution; Dietary specializations; Herbivory
TL;DR:
The dentition of S. galbinensis is indicative of niche partitioning in food acquisition, processing, or resources among known therizinosaurids inhabiting Asian ecosystems in the Late Cretaceous, adding novel information to the understanding of ecomorphology in theropods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2016 journal article
Sharing the Roles: An Assessment of Japanese Medaka Estrogen Receptors in Vitellogenin Induction
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 50(16), 8886–8895.
MeSH headings : Animals; Biological Assay; Estradiol / metabolism; Estrogens / metabolism; Gene Expression / drug effects; Oryzias / metabolism; Receptors, Estrogen / metabolism; Up-Regulation / drug effects; Vitellogenins / metabolism
TL;DR:
Investigation of putative roles of three ER subtypes in Japanese medaka shows that all three medaka ERs are capable of initiating transactivation of both VTG I and II, and suggests that preferential ligand/receptor/promoter interactions may have direct implications for VTG gene expression and other ER-mediated regulatory functions that are relevant to the risk assessment of estrogenic compounds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Secondary metabolites from fungal endophytes of Echinacea purpurea suppress cytokine secretion by macrophage-type cells
Natural Product Communications, 11(8), 1143–1146.
TL;DR:
The results of this study are particularly interesting given that they show the presence of compounds with cytokine-suppressive activity in endophytes from a botanical used to treat inflammation.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Nonmajors' Shifts in Attitudes & Perceptions of Biology & Biologists Following an Active-Learning Course: An Exploratory Study
Nonmajors' Shifts in Attitudes & Perceptions of Biology & Biologists Following an Active-Learning Course: An Exploratory Study. AMERICAN BIOLOGY TEACHER, 78(1), 43–48.
author keywords: Nonmajors; biology students; attitudes; perceptions
TL;DR:
Results revealed changes along various measured attitude variables, most notably, participants saw significant positive shifts in their perceptions of biology as a scientific field that contrasted with their relatively stable perceptions of biologists as scientists.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science; OpenAlex)
Sources: ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018
2016 journal article
Multiwalled Carbon Nanotube Functionalization with High Molecular Weight Hyaluronan Significantly Reduces Pulmonary Injury
ACS NANO, 10(8), 7675–7688.
author keywords: multiwalled carbon nanotubes; hyaluronan; lung; inflammation; fibrosis; mucous metaplasia; differentiated human bronchial epithelia
MeSH headings : Fibroblasts; Humans; Hyaluronic Acid; Lung; Lung Injury / prevention & control; Macrophages, Alveolar; Molecular Weight; Nanotubes, Carbon
TL;DR:
Results demonstrate the effectiveness of HA functionalization as a safer design approach to eliminate MWCNT-induced lung injury and suggest thatHA functionalization works by reducing MWC NT-induced epithelial injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains
Clinical Epigenetics, 8.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood
ENVIRONMENTAL HEALTH PERSPECTIVES, 124(5), 666–673.
MeSH headings : Cell Cycle Proteins / metabolism; Child Development / physiology; Child, Preschool; DNA Methylation; Environmental Exposure / statistics & numerical data; Environmental Pollutants / blood; Female; Humans; Infant; Infant, Newborn; Insulin-Like Growth Factor II / metabolism; Lead / blood; Male; Transcription Factors / metabolism; Tumor Suppressor Proteins / metabolism
TL;DR:
Evidence is provided that early childhood lead exposure results in sex-dependent and gene-specific DNA methylation differences in the DMRs of PEG3, IGF2/H19, and PLAGL1/HYMAI in adulthood.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes
ARCHIVES OF TOXICOLOGY, 90(6), 1459–1470.
Contributors: D. Reif n , L. Truong *, D. Mandrell*, S. Marvel n, G. Zhang n & R. Tanguay *
author keywords: Developmental neurotoxicology; Alternative testing; Chemical biology; Behavior; Zebrafish; High-throughput screening; Bioinformatics; Data integration; ToxCast; Bioactivity
MeSH headings : Animals; Behavior, Animal / drug effects; Dose-Response Relationship, Drug; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / physiopathology; Hazardous Substances / toxicity; High-Throughput Screening Assays; Predictive Value of Tests; Teratogens / toxicity; Zebrafish / abnormalities; Zebrafish / embryology
TL;DR:
This high-throughput screening system using a vertebrate organism can provide rapid characterization of chemical-elicited behavioral responses at an early developmental stage that are predictive of observable adverse effects later in life.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Generating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics Database
PLOS ONE, 11(5).
MeSH headings : Computational Biology; Databases, Genetic; Disease / genetics; Drug Repositioning; Gene Ontology; Humans; Toxicogenetics
TL;DR:
This inference set should aid researchers, bioinformaticists, and pharmaceutical drug makers in finding commonalities in disease mechanisms, which in turn could help identify new therapeutics, new indications for existing pharmaceuticals, potential disease comorbidities, and alerts for side effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Establishing Standards for Side-by-Side Radiographic Comparisons
AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY, 37(2), 86–94.
author keywords: forensic radiology; decedent identification; cranium; chest; femur
MeSH headings : Coroners and Medical Examiners; Decision Trees; Femur / diagnostic imaging; Forensic Anthropology / standards; Humans; Likelihood Functions; Radiography / standards; Skull / diagnostic imaging; Spine / diagnostic imaging
TL;DR:
This study established the minimum number of concordant areas needed to confirm positive identifications in 3 standard radiographic views.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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