Works Published in 2001
Displaying works 21 - 40 of 108 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2001 journal article
Early postnatal ethanol exposure selectively decreases BDNF and truncated TrkB-T2 receptor mRNA expression in the rat cerebellum
Molecular Brain Research, 93(1), 46–55.
Contributors: K. Light*, Y. Ge * & S. Belcher*
author keywords: cerebellum; truncated TrkB; TrkC; ethanol-exposure; RT-PCR; mRNA
MeSH headings : Actins / genetics; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor / genetics; Central Nervous System Depressants / pharmacology; Cerebellum / drug effects; Cerebellum / physiology; DNA Primers; Ethanol / pharmacology; Female; Gene Expression Regulation, Developmental / drug effects; Isomerism; Pregnancy; RNA, Messenger / analysis; Rats; Rats, Sprague-Dawley; Receptor, trkB / chemistry; Receptor, trkB / genetics; Receptor, trkC / genetics; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
The current study defines the impact of ethanol exposure at the onset of ethanol vulnerability on the relative concentrations of mRNA encoding the neurotrophic factor receptors TrkB and TrkC and identifies a specific decrease in overall TrkB receptor mRNA expression that is primarily a function of the TrkB-T2 receptor isoform.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2001 journal article
Estrogenic actions in the brain: Estrogen, phytoestrogens, and rapid intracellular signaling mechanisms
Journal of Pharmacology and Experimental Therapeutics, 299(2), 408–414. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034768705&partnerID=MN8TOARS
Contributors: S. Belcher & A. Zsarnovszky
Source: ORCID
Added: March 5, 2021
2001 journal article
Estrogen receptor β immunoreactivity in differentiating cells of the developing rat cerebellum
Journal of Comparative Neurology, 430(3), 396–409.
Contributors: R. Jakab*, J. Wong* & S. Belcher*
author keywords: differentiation; development; glia; granule cells; growth; immunocytochemistry; migration; neurons; Purkinje cells
TL;DR:
The results suggest that ERβ may play a role in growth‐related mechanisms during differentiation of cerebellar neurons and glia during migration.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2001 journal article
Evolution of the Simulated Data Problem
Genetic Epidemiology, 21(S1), S325–S331.
author keywords: complex diseases; linkage disequilibrium; pedigree data; population genetics; simulation
MeSH headings : Chromosome Mapping; Computer Simulation; Genetics, Population; Genotype; Humans; Phenotype
TL;DR:
The simulated data problem was designed via an interactive process by the Simulation Problem Organizing Committee and the selected data simulators and a population genetics model was used to generate the simulated genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2021
2001 journal article
Dwarf8 polymorphisms associate with variation in flowering time
Nature Genetics, 28(3), 286–289.
MeSH headings : Genes, Plant; Linkage Disequilibrium; Phenotype; Plant Proteins / genetics; Plant Shoots / genetics; Plant Shoots / growth & development; Polymorphism, Genetic; Quantitative Trait, Heritable; Reproduction / genetics; Zea mays / genetics; Zea mays / growth & development
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2021
2001 journal article
Association mapping: where we’ve been, where we’re going
Expert Review of Molecular Diagnostics, 1(3), 334–342.
MeSH headings : Analysis of Variance; Case-Control Studies; Chromosome Mapping; Family Health; Genetic Markers; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Molecular Diagnostic Techniques; Phenotype; Quantitative Trait, Heritable
TL;DR:
The basis of association mapping is described, and a number of the commonly used techniques used for localizing – or mapping – genes affecting a trait of interest are discussed.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID
Added: January 25, 2021
2001 journal article
Applying Data Mining Techniques to the Mapping of Complex Disease Genes
Genetic Epidemiology, 21(S1), S435–S440.
MeSH headings : Chromosome Mapping / statistics & numerical data; Data Collection / statistics & numerical data; Decision Trees; Gene Frequency; Genetic Markers / genetics; Genetic Predisposition to Disease / genetics; Genotype; Humans; Models, Genetic; Polymorphism, Single Nucleotide / genetics; Regression Analysis
TL;DR:
The result of incorporating data mining techniques with more classical methods is an improvement in the analysis, both by correctly classifying the affection status of more individuals and by locating more single nucleotide polymorphisms related to the disease, relative to analyses that use classical methods alone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2021
2001 journal article
GAW12: Simulated Genome Scan, Sequence, and Family Data for a Common Disease
Genetic Epidemiology, 21(S1), S332–S338.
author keywords: population isolate; quantitative trait; simulation
MeSH headings : Adolescent; Adult; Aged; Child; Chromosome Mapping / statistics & numerical data; Female; Genetic Markers / genetics; Genetic Variation / genetics; Genetics, Population; Genome, Human; Humans; Lod Score; Male; Microsatellite Repeats; Middle Aged; Models, Genetic; Phenotype; Polymorphism, Genetic; Quantitative Trait, Heritable; Recombination, Genetic
TL;DR:
The Genetic Analysis Workshop (GAW) 12 simulated data involves a common disease defined by imposing a threshold on a quantitative liability distribution Associated with the disease are five quantitative risk factors, a quantitative environmental exposure, and a dichotomous environmental variable.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: September 5, 2020
2001 journal article
Association Studies under General Disease Models
Theoretical Population Biology, 60(3), 253–263.
MeSH headings : Alleles; Apolipoproteins E / genetics; Chromosome Mapping / methods; Cytochrome P-450 CYP2D6 / genetics; Genetic Markers; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Models, Genetic; Phenotype
TL;DR:
A general framework to examine association mapping methods is adopted which helps to clarify the nature of case-control and transmission/disequilibrium-type tests and reveals the relationship between measures of association and coefficients of linkage disequilibrium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: September 5, 2020
2001 journal article
Low Exposure Concentration Effects of Methoprene on Endocrine-Regulated Processes in the Crustacean Daphnia magna
Toxicological Sciences, 62(2), 268–273.
author keywords: methoprene; daphnid; crustacea; endocrine disruption; methyl farnesoate
MeSH headings : Animals; Daphnia / drug effects; Daphnia / growth & development; Daphnia / physiology; Dose-Response Relationship, Drug; Endocrine Glands / drug effects; Endocrine Glands / physiology; Fertility; Juvenile Hormones / toxicity; Methoprene / toxicity; Reproduction
TL;DR:
It is demonstrated that methoprene elicits significant toxicity to endocrine-related processes in the 5-50 nM concentration range, and molting and reproduction were impacted at significantly lower meethoprene concentrations, with a distinct concentration response and a threshold of < or =0.2 nM.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 28, 2020
2001 journal article
The 14th annual international mammalian genome society conference: A glimpse into the future of murine functional genomics
Genesis, 29(4), 153–155.
MeSH headings : Animals; Forecasting; Genomics / trends; Mice / genetics
TL;DR:
The atmosphere of the 14 th annual International Mouse Genome Conference (IMGC) can only be described as one of anticipation and preparation for research in the murine postgenomic era, and there was no doubt in any of the attendees’ minds that the availability of the Murine genome sequence will revolutionize mouse-based research.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2001 journal article
A molecular model for the evolution of endothermy in the theropod-bird lineage
Journal of Experimental Zoology, 291(4), 317–338.
MeSH headings : Adaptation, Physiological; Animals; Biological Evolution; Birds / physiology; Body Temperature; Dinosaurs / physiology; Models, Molecular
TL;DR:
The model begins with simple changes in a single gene of a common ancestor, and it includes a series of concomitant physiological and morphological changes, beginning perhaps as early as the first archosaurian common ancestor of dinosaurs and crocodiles.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019
2001 journal article
AGRICULTURAL EXPOSURE HISTORY AMONG AFRICAN-AMERICAN FARMERS IN GEORGIA
Journal of Toxicology and Environmental Health, Part A, 63(4), 237–241.
Contributors: J. Hoppin* , J. Guzman*, P. Tolbert* & E. Flagg*
MeSH headings : Adult; Black or African American; Aged; Aged, 80 and over; Agricultural Workers' Diseases / epidemiology; Data Collection; Georgia / epidemiology; Humans; Male; Middle Aged; Occupational Exposure / statistics & numerical data; Pesticides; Surveys and Questionnaires
TL;DR:
A pilot study was conducted to explore the breadth and diversity of farming practices over time among African-American farmers in Georgia whose exposures may differ in important ways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2001 journal article
Effects of nucleotide composition bias on the success of the parsimony criterion in phylogenetic inference
Molecular Biology and Evolution, 18(6), 1024–1033. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034983477&partnerID=MN8TOARS
Contributors: G. Conant & P. Lewis
Source: ORCID
Added: September 12, 2019
2001 journal article
Cross-species and interassay comparisons of phytoestrogen action.
Environmental Health Perspectives, 109(suppl 1), 5–20.
MeSH headings : Animals; Biological Assay / methods; Bone Density / drug effects; Breast / drug effects; Breast / pathology; Cell Division / drug effects; Diet; Dose-Response Relationship, Drug; Endocrine System / drug effects; Estrogens / agonists; Humans; Hypothalamo-Hypophyseal System / drug effects; Plant Growth Regulators / pharmacology; Urogenital System / drug effects; Urogenital System / pathology
TL;DR:
The similarity of reported proliferative and antiproliferative doses illustrates the need for fuller examination of dose-response relationships and multiple end points in assessing phytoestrogen actions.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2001 journal article
Coumestrol Antagonizes Neuroendocrine Actions of Estrogen via the Estrogen Receptor α
Experimental Biology and Medicine, 226(4), 301–306.
author keywords: phytoestrogen; progesterone receptor; luteinizing hormone; nutrition; estrogen receptor beta
MeSH headings : Animals; Brain / drug effects; Brain / metabolism; Coumestrol / administration & dosage; Coumestrol / pharmacology; Drug Evaluation, Preclinical; Estradiol / administration & dosage; Estradiol / pharmacology; Estrogen Receptor alpha; Estrogens, Non-Steroidal / pharmacology; Female; Hypothalamus / drug effects; Hypothalamus / metabolism; Luteinizing Hormone / blood; Mice; Mice, Knockout; Ovariectomy; Receptors, Estrogen / antagonists & inhibitors; Receptors, Estrogen / deficiency; Receptors, Estrogen / genetics; Receptors, Progesterone / analysis
TL;DR:
Results show that coumestrol has anti-estrogenic actions in the brain and pituitary and that ERα mediates these effects.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2001 journal article
Soy Isoflavone Supplements Antagonize Reproductive Behavior and Estrogen Receptor α- and β-Dependent Gene Expression in the Brain*
Endocrinology, 142(7), 2946–2952.
MeSH headings : Animals; Brain / physiology; Chromatography, High Pressure Liquid; Estradiol / metabolism; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression / drug effects; Isoflavones / analysis; Isoflavones / pharmacology; Male; RNA, Messenger / metabolism; Rats; Rats, Long-Evans; Receptors, Estrogen / genetics; Receptors, Estrogen / physiology; Receptors, Oxytocin / metabolism; Sexual Behavior, Animal / drug effects; Soybeans / chemistry; Uterus / drug effects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2001 journal article
Posttranscriptional silencing of cytochrome P4501A1 (CYP1A1) during zebrafish (Danio rerio) development
Developmental Dynamics, 222(4), 645–654.
author keywords: cytochrome P450; monooxygenase; zebrafish; Ah receptor; dioxin
MeSH headings : Aging / metabolism; Animals; Base Sequence / genetics; Cloning, Molecular; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A1 / metabolism; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / physiology; Environmental Pollutants / poisoning; Gene Expression Regulation; Gene Expression Regulation, Developmental; Gene Silencing; Molecular Sequence Data; Polychlorinated Dibenzodioxins / poisoning; RNA, Messenger / metabolism; Transcription, Genetic; Zebrafish / embryology; Zebrafish / genetics; Zebrafish / metabolism
TL;DR:
The data suggest that TCDD‐mediated induction of CYP1A1 activity is regulated differentially in developing and mature systems.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 10, 2019
2001 journal article
Green fluorescent protein (GFP) as a marker of aryl hydrocarbon receptor (AhR) function in developing zebrafish (Danio rerio).
Environmental Health Perspectives, 109(8), 845–849.
MeSH headings : Animals; Biomarkers / analysis; Cytochrome P-450 CYP1A1 / genetics; Eye Abnormalities / chemically induced; Green Fluorescent Proteins; Luminescent Proteins / biosynthesis; Models, Animal; Morphogenesis / drug effects; Polychlorinated Dibenzodioxins / toxicity; Receptors, Aryl Hydrocarbon / genetics; Spine / abnormalities; Transcription, Genetic; Transfection; Zebrafish / embryology
TL;DR:
An inducible in vivo reporter system to examine expression of the aryl hydrocarbon receptor (AhR) during development in zebrafish (Danio rerio) and whether AhR-regulated GFP expression correlated with sites of TCDD toxicity is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 10, 2019
2001 chapter
QTL Mapping
In Encyclopedia of Genetics (pp. 1587–1593).
Source: Crossref
Added: July 20, 2019
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