Works Published in 2004
Displaying works 21 - 40 of 134 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2004 journal article
Comprehensive analysis of arsenic metabolites by pH-specific hydride generation atomic absorption spectrometry
J. Anal. At. Spectrom., 19(11), 1460–1467.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: January 21, 2021
2004 journal article
Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes
Toxicology and Applied Pharmacology, 201(2), 166–177.
author keywords: arsenic; metabolism; methylation; variation; human; hepatocyte; cyt19
MeSH headings : Adult; Aromatase / biosynthesis; Aromatase / genetics; Arsenic / metabolism; Cell Differentiation / drug effects; Cells, Cultured; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Genotype; Hepatocytes / metabolism; Humans; Infant; Male; Methylation; Middle Aged; Poisons / metabolism; RNA, Messenger / biosynthesis; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
Genetic polymorphism of cyt19 along with other cellular factors is likely responsible for interindividual differences in the capacity of primary human hepatocytes to retain and metabolize iAs(III).
(via Semantic Scholar)
Source: Crossref
Added: January 21, 2021
2004 journal article
Reversal of P-glycoprotein mediated vincristine resistance of L1210/VCR cells by analogues of pentoxifylline
European Journal of Pharmaceutical Sciences, 21(2-3), 283–293.
author keywords: P-glycoprotein; L1210 cell line; multidrug resistance; xanthines; pentoxifylline analogues; vincristine; structure-activity relationship
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism; Animals; Antineoplastic Agents, Phytogenic / chemistry; Antineoplastic Agents, Phytogenic / pharmacology; Cell Line, Tumor; Crystallization; Drug Resistance, Neoplasm / drug effects; Inhibitory Concentration 50; Leukemia L1210; Linear Models; Mice; Models, Biological; Pentoxifylline / analogs & derivatives; Pentoxifylline / chemistry; Pentoxifylline / pharmacology; Quantitative Structure-Activity Relationship; Vincristine / chemistry; Vincristine / pharmacology
TL;DR:
The results indicate that for an effective reversal of P-gp mediated MDR of the authors' cells the existence of a longer polar substituent in the position N1 plays a crucial role and the molar refractivity influences the effectiveness of xanthine positively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: January 21, 2021
2004 journal article
Involvement of ASK1 in Ca 2+ ‐induced p38 MAP kinase activation
EMBO Reports, 5(2), 161–166.
MeSH headings : Animals; Calcium / metabolism; Calcium / pharmacology; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Cells, Cultured; Fibroblasts / drug effects; Fibroblasts / metabolism; Glutathione Transferase / analysis; MAP Kinase Kinase Kinase 5 / metabolism; MAP Kinase Kinase Kinase 5 / physiology; MAP Kinase Signaling System / physiology; Marine Toxins / pharmacology; Mice; Mice, Inbred C57BL; Oxocins / pharmacology; Phosphorylation; Potassium Channels, Calcium-Activated / metabolism; RNA, Small Interfering / pharmacology; Synaptosomes / drug effects; Synaptosomes / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
It is shown that Ca2+ signalling regulates the ASK1–p38 MAP kinase cascade, which is a critical intermediate of Ca2- signalling between CaMKII and p38 MAP Kinase.
(via Semantic Scholar)
europepmc.org (repository)
Source: Crossref
Added: January 5, 2021
2004 journal article
Evolutionary origins of the RNA-guided nucleotide-modification complexes: from the primitive translation apparatus?
Trends in Biochemical Sciences, 29(7), 343–350.
MeSH headings : Amino Acid Sequence; Conserved Sequence; DNA Methylation; Evolution, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Protein Biosynthesis; Protein Conformation; RNA / genetics; RNA / physiology; Ribonucleoproteins / chemistry; Ribonucleoproteins / genetics; Ribonucleotides / metabolism; Ribosomes / chemistry; Ribosomes / genetics
TL;DR:
The trans -acting, RNA-guided nucleotide-modification complexes of the modern RNP world seem to have evolved from cis -acting RNA or RNP elements contained in the primitive translation apparatus during the transition from the ancient RNA world to the modernRNP world.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: December 8, 2020
2004 journal article
Analyses of the effects of Rck2p mutants on Pbs2pDD-induced toxicity in Saccharomyces cervisiae identify a MAP kinase docking motif, and unexpected functional inactivation due to acidic substitution of T379
Molecular Genetics and Genomics, 271(2), 208–219.
author keywords: yeast; RCK2; PBS2; HOG1; MAP kinases
MeSH headings : Alleles; Amino Acid Motifs / genetics; Amino Acid Sequence; Binding Sites / genetics; DNA Primers; Gene Deletion; Gene Expression Regulation, Fungal; Immunoblotting; Mitogen-Activated Protein Kinase Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; Mutation, Missense / genetics; Plasmids / genetics; Precipitin Tests; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / physiology; Saccharomyces cerevisiae Proteins / metabolism
TL;DR:
The structural and functional basis for the role of Rck2p in mediating the growth arrest phenotype associated with overexpression of Pbs2pDD is studied and the effect of replacing the predicted T379 and established S520 phosphorylation sites in Rck1p by glutamic acid is studied.
(via Semantic Scholar)
Source: Crossref
Added: November 17, 2020
2004 journal article
Pendimethalin exposure and cancer risk among pesticide applicators: a report from the U.S.-based agricultural health study
Annals of Epidemiology, 14(8), 608.
TL;DR:
The findings suggest a possible association between pendimethalin exposure and incidence of rectum and lung cancers among pesticide applicators in the U.S. Agricultural Health Study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, ORCID
Added: September 10, 2020
2004 journal article
Effect of Two- and Three-Locus Linkage Disequilibrium on the Power to Detect Marker/Phenotype Associations
Genetics, 168(2), 1029–1040.
MeSH headings : Case-Control Studies; Computational Biology / methods; Computational Biology / statistics & numerical data; Genetic Markers / genetics; Genetic Variation / genetics; Genotype; Haplotypes; Humans; Linkage Disequilibrium / genetics; Phenotype; Polymorphism, Genetic / genetics; Quantitative Trait, Heritable
TL;DR:
This work examines many different patterns of LD defined by both pairwise and joint multilocus LD terms, and examines how changes in these patterns affect the power to detect association when performing single-marker and haplotype-based case-control tests.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: September 5, 2020
2004 journal article
Phthalate exposure and pulmonary function.
Environmental Health Perspectives, 112(5), 571–574.
author keywords: monobutyl phthalate; pulmonary function; urine samples
MeSH headings : Adult; Biomarkers; Environmental Exposure; Female; Humans; Linear Models; Lung / drug effects; Lung / physiology; Male; Middle Aged; Nutrition Surveys; Phthalic Acids / toxicity; Phthalic Acids / urine; Respiratory Function Tests; Sex Factors
TL;DR:
It is suggested that MBP and MEP, but not MEHP, may influence pulmonary function among adult males, and the metabolite of the plasticizer commonly used in medical tubing was not adversely associated with any of the pulmonary function parameters evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: September 3, 2020
2004 journal article
Cancer risk and parental pesticide application in children of Agricultural Health Study participants.
Environmental Health Perspectives, 112(5), 631–635.
author keywords: agricultural workers; cancer; children; occupational exposure; pesticides
MeSH headings : Adolescent; Adult; Agriculture; Child; Child, Preschool; Female; Humans; Incidence; Infant; Iowa; Lymphoma / chemically induced; Lymphoma / epidemiology; Male; Maternal Exposure / adverse effects; Neoplasms / chemically induced; Neoplasms / epidemiology; Paternal Exposure / adverse effects; Pesticides / toxicity; Prospective Studies; Retrospective Studies; Risk
TL;DR:
Analysis of childhood cancer risk and associations with parental pesticide application in Iowa suggests that farm exposures including pesticides may play a role in the etiology of childhood lymphoma.
(via Semantic Scholar)
Source: Crossref
Added: September 3, 2020
2004 journal article
Of mice and missing data: what we know (and need to learn) about male sexual behavior
Physiology & Behavior, 83(2), 217–232.
Source: Crossref
Added: August 28, 2020
2004 journal article
Background matters: the effects of estrogen receptor α gene disruption on male sexual behavior are modified by background strain
Hormones and Behavior, 46(4), 482–490.
author keywords: sexual behavior; estrogen receptor; inbred strains; knockout mice; testosterone; aggression; lordosis; olfaction; DBA; BALB/c; C57BL/6J
MeSH headings : Analysis of Variance; Animals; Copulation / physiology; Ejaculation / physiology; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / physiology; Female; Fertility / genetics; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains / genetics; Mice, Inbred Strains / physiology; Mice, Knockout / genetics; Mice, Knockout / physiology; Sex Factors; Sexual Behavior, Animal / physiology; Species Specificity; Testosterone / physiology
TL;DR:
The data suggest that genetic background has dramatic effects on male sexual behavior and its dependence on the ERα gene.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2004 journal article
Of mice and missing data: what we know (and need to learn) about male sexual behavior
Physiology & Behavior, 83(2), 217–232.
author keywords: androgen receptor; estrogen receptor; inbred strain; knockout; mice; medial preoptic area; masculinization
MeSH headings : Animals; Gonadal Steroid Hormones / physiology; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Models, Animal; Rats; Receptors, Steroid / physiology; Sex Characteristics; Sexual Behavior, Animal / physiology; Species Specificity
TL;DR:
The current knowledge about the sexual behavior of male mice, with an emphasis on hormonal bases of these behaviors, is summarized and suggestions are made for the standardization of experimental protocols used in investigations of the sexual physiology and behavior ofmale mice.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2004 journal article
Altered expression of Bcl2, Bad and Bax mRNA occurs in the rat cerebellum within hours after ethanol exposure on postnatal day 4 but not on postnatal day 9
Molecular Brain Research, 129(1-2), 124–134.
Contributors: Y. Ge *, S. Belcher* , D. Pierce* & K. Light*
author keywords: apoptosis; Bcl2; Bad; Bax; RT-PCR; Purkinje; cerebellum; ethanol; mRNA
MeSH headings : Actins / metabolism; Animals; Animals, Newborn; Apoptosis / drug effects; Apoptosis / physiology; Calbindins; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cerebellum / cytology; Cerebellum / drug effects; Cerebellum / physiology; Dose-Response Relationship, Drug; Ethanol / administration & dosage; Ethanol / blood; Ethanol / pharmacology; Female; Humans; Male; Pregnancy; Proto-Oncogene Proteins c-bcl-2 / genetics; Proto-Oncogene Proteins c-bcl-2 / metabolism; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G / metabolism; bcl-2-Associated X Protein; bcl-Associated Death Protein
TL;DR:
The results of this study are in agreement with and provide further support for the hypothesis that ethanol interrupts the active suppression of apoptosis that is a crucial feature of Purkinje cell vulnerability during this time period.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2004 journal article
Alterations of cerebellar mRNA specific for BDNF, p75NTR, and TrkB receptor isoforms occur within hours of ethanol administration to 4-day-old rat pups
Developmental Brain Research, 151(1-2), 99–109.
Contributors: Y. Ge *, S. Belcher* & K. Light*
author keywords: Purkinje cell; TrkB isoform; ethanol exposure; RT-PCR; mRNA; neurotrophin; cerebellum; toxicity; apoptosis; BDNF signaling
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; Central Nervous System Depressants / pharmacology; Cerebellum / drug effects; Cerebellum / metabolism; Dose-Response Relationship, Drug; Ethanol / pharmacology; Female; Male; Pregnancy; RNA, Messenger / drug effects; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptor, trkB / genetics; Receptor, trkB / metabolism; Receptors, Nerve Growth Factor / genetics; Receptors, Nerve Growth Factor / metabolism; Reverse Transcriptase Polymerase Chain Reaction / methods; Time Factors
TL;DR:
The hypothesis that ethanol induces a disruption of BDNF-TrkB signaling that results in loss of apoptotic suppression in vulnerable Purkinje cells by growth factor withdrawal is supported.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2004 journal article
Spatial, temporal, and cellular distribution of the activated extracellular signal regulated kinases 1 and 2 in the developing and mature rat cerebellum
Developmental Brain Research, 150(2), 199–209.
Contributors: A. Zsarnovszky* & S. Belcher*
author keywords: neurotransmitters, modulators, transporters and receptors; second messengers and phosphorylation; Bergmann glia; cerebellum; development; active EPK1/2; glia; granule cell; neuron; immunohistochemistry; kinase; MAPK; Purkinje cell; signal transduction
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Cell Count / methods; Cerebellum / enzymology; Cerebellum / growth & development; Cerebellum / metabolism; Glial Fibrillary Acidic Protein / metabolism; Immunohistochemistry / methods; Indoles / metabolism; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases / metabolism; Purkinje Cells / metabolism; Rats; Rats, Sprague-Dawley
TL;DR:
A high degree of developmental plasticity was observed in the spatiotemporal distribution of cerebellar pERK-IR suggesting that the ERK-pathway plays a dynamic role in regulating neuronal and glial migration, proliferation and differentiation in the developing cerebellum.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2004 journal article
Genes Regulated by Mating, Sperm, or Seminal Proteins in Mated Female Drosophila melanogaster
Current Biology, 14(16), 1509–1514.
MeSH headings : Animals; DNA Primers; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Gene Expression Regulation / physiology; Genes, Insect / genetics; Male; Oligonucleotide Array Sequence Analysis; Oligonucleotides; Reverse Transcriptase Polymerase Chain Reaction; Seminal Plasma Proteins / metabolism; Seminal Plasma Proteins / physiology; Sexual Behavior, Animal / physiology; Spermatozoa / metabolism; Spermatozoa / physiology
TL;DR:
The mating-dependent genes that the authors have identified contribute to many biological processes including metabolism, immune defense, and protein modification.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Crossref
Added: August 28, 2020
2004 journal article
Analysis of medaka cytochrome P450 3A homotropic and heterotropic cooperativity
Marine Environmental Research, 58(2-5), 469–473.
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / metabolism; Catalysis; Coumarins / metabolism; Cytochrome P-450 CYP3A; Fluorescence; Kinetics; Models, Chemical; Oryzias / metabolism; Oxidoreductases, N-Demethylating / metabolism; Phenols / metabolism; Protein Binding; Substrate Specificity
TL;DR:
This study demonstrates that medaka CYP3A catalysis exhibits unusual kinetic behaviors consistent with allosteric interaction which cannot be described by hyperbolic kinetic models, and describes both homotropic and heterotropic cooperative interactions.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2004 journal article
Role of a Bacterial Organic Hydroperoxide Detoxification System in Preventing Catalase Inactivation
Journal of Biological Chemistry, 279(50), 51908–51914.
MeSH headings : Antioxidants / metabolism; Base Sequence; Catalase / antagonists & inhibitors; Catalase / genetics; Catalase / metabolism; DNA, Bacterial / genetics; Genes, Bacterial; Helicobacter pylori / genetics; Helicobacter pylori / metabolism; Helicobacter pylori / pathogenicity; Heme / metabolism; Humans; Hydrogen Peroxide / metabolism; In Vitro Techniques; Lipid Peroxides / metabolism; Mutation; Oxidative Stress; Peroxidases / genetics; Peroxidases / metabolism; Peroxiredoxins
TL;DR:
The findings reveal a novel role of the organic hydroperoxide detoxification system in preventing catalase inactivation and compare the level of lipid peroxidation found in ahpC mutant cells with that found in wild type cells.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2004 journal article
Gene expression profiling of the developing Drosophila CNS midline cells
Developmental Biology, 275(2), 473–492.
author keywords: CNS; development; Drosophila; gene expression; mesectoderm; midline; midline glia; neurogenesis
MeSH headings : Animals; Central Nervous System / cytology; Central Nervous System / embryology; DNA Primers; DNA Transposable Elements / genetics; Drosophila / embryology; Drosophila / genetics; Drosophila Proteins / metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental; Immunohistochemistry; In Situ Hybridization; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Sequence Analysis, DNA
TL;DR:
This work provides the basis for future research that will generate a complete cellular and molecular map of CNS midline development, thus allowing for detailed genetic and molecular studies of neuronal and glial development and function.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
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