Works Published in 2016
Displaying works 41 - 60 of 239 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2016 journal article
Left–right analysis of mammary gland development in retinoid X receptor-α +/− mice
Philosophical Transactions of the Royal Society B: Biological Sciences, 371(1710), 20150416.
author keywords: breast cancer; ductal epithelium; left-right asymmetry; mammary gland development; retinoid X receptor alpha; symmetry
MeSH headings : Animals; Body Patterning / genetics; Female; Mammary Glands, Animal / embryology; Mice; Organogenesis; Retinoid X Receptor alpha / genetics; Retinoid X Receptor alpha / metabolism
TL;DR:
It is demonstrated that mammary glands exhibit differential A–P sensitivity to RXRα heterozygosity, with ductal network symmetry markedly compromised in anterior but not posterior glands, raising the possibility that for some women, breast cancer risk may initiate with subtle axial patterning defects that result in L–R asymmetric growth and pattern of the mammary ductal epithelium.
(via Semantic Scholar)
royalsocietypublishing.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 28, 2019
2016 journal article
The perivascular environment along the vertebral artery governs segment-specific structural and mechanical properties
Acta Biomaterialia, 45, 286–295.
author keywords: Arterial mechanics; Elasticity; Vertebral artery; Continuum mechanics; Structure-motivated constitutive model
MeSH headings : Animals; Biomechanical Phenomena; Male; Models, Theoretical; Pressure; Stress, Mechanical; Sus scrofa; Vertebral Artery / anatomy & histology; Vertebral Artery / physiology
TL;DR:
Speculation that segmental differences in wall structure and geometry are a consequence of a previously introduced principle of optimal operation of arteries is allowed, which ensures effective bearing of physiological load and a favorable mechanical environment for mechanosensitive vascular smooth muscle cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 28, 2019
2016 journal article
The carnivore guild circa 1.98 million years: biodiversity and implications for the palaeoenvironment at Malapa, South Africa
Palaeobiodiversity and Palaeoenvironments, 96(4), 611–616.
author keywords: Paleoecology; Carnivore; Malapa; Australopithecus sediba
TL;DR:
The Malapa carnivorans support widespread shifts in carnivore turnover circa 2.0 Ma in Africa and suggest, together with other lines of evidence, the occurrence of a regional transitioning environment during the time of Au.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 28, 2019
2016 journal article
Differential Interactions of the Flame Retardant Triphenyl Phosphate within the PPAR Signaling Network
MOJ Toxicology, 2(3).
Sources: Crossref, NC State University Libraries
Added: September 28, 2019
2016 journal article
Nonmajors' Shifts in Attitudes & Perceptions of Biology & Biologists Following an Active-Learning Course
Nonmajors' Shifts in Attitudes & Perceptions of Biology & Biologists Following an Active-Learning Course. The American Biology Teacher, 78(1), 43–48.
Source: NC State University Libraries
Added: September 28, 2019
2016 journal article
Assessing toxicity of contaminants in riverine suspended sediments to freshwater mussels
Environmental Toxicology and Chemistry, 36(2), 395–407.
author keywords: Unionoida; Water quality; Ammonia; Metal; Polycyclic aromatic hydrocarbon
MeSH headings : Agriculture; Ammonia / analysis; Ammonia / toxicity; Animals; Environmental Monitoring / methods; Geologic Sediments / analysis; Geologic Sediments / chemistry; Metals, Heavy / analysis; Metals, Heavy / toxicity; Mining; Polycyclic Aromatic Hydrocarbons / analysis; Polycyclic Aromatic Hydrocarbons / toxicity; Rivers / chemistry; Tennessee; Unionidae / drug effects; Virginia; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
TL;DR:
It is found that sediments collected with sediment traps over relatively short deployment durations can help elucidate recent contaminant influx and its potential for inducing toxicity in benthic organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Crossref, ORCID
Added: September 28, 2019
2016 journal article
Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss
Environmental Health Perspectives, 124(3), 321–328.
MeSH headings : Abortion, Spontaneous / chemically induced; Abortion, Spontaneous / urine; Adult; Benzhydryl Compounds / toxicity; Benzhydryl Compounds / urine; Environmental Pollutants / toxicity; Environmental Pollutants / urine; Female; Fertility / drug effects; Follicular Phase / drug effects; Humans; Luteal Phase / drug effects; Phenols / toxicity; Phenols / urine; Phthalic Acids / toxicity; Phthalic Acids / urine; Pregnancy; Pregnancy Trimester, First
TL;DR:
Menstrual cycle–specific estimates of urinary BPA and phthalate metabolites were not associated with detrimental alterations in follicular-phase length, time to pregnancy, or early pregnancy loss, and in fact, DEHP [di(2-ethylhexyl)phthalate] metabolites and ΣDEHP were associated with reduced early loss.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 17, 2019
2016 journal article
High pesticide exposure events and DNA methylation among pesticide applicators in the agricultural health study
Environmental and Molecular Mutagenesis, 58(1), 19–29.
author keywords: DNA methylation; pesticides; exposure; Agricultural Health Study; epigenetics
MeSH headings : Air Pollutants, Occupational / toxicity; Antigens, CD; Cadherins / genetics; DNA / blood; DNA Methylation / drug effects; DNA Methylation / genetics; DNA Modification Methylases / genetics; DNA Repair Enzymes / genetics; Farmers; Glutathione S-Transferase pi / genetics; Humans; Iowa; Male; North Carolina; Occupational Exposure / adverse effects; Occupational Exposure / analysis; Occupational Health; Pesticides / toxicity; Promoter Regions, Genetic; Prospective Studies; Surveys and Questionnaires; Tumor Suppressor Proteins / genetics
TL;DR:
Evaluated association between experiencing unusually high pesticide exposure events (HPEEs) and DNAm among pesticide applicators in the Agricultural Health Study, a prospective study of applicators from Iowa and North Carolina found non‐specific HPEEs may contribute to increasedDNAm in GSTp1, and in some groups, reduced DNAm in MGMT and LINE‐1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, Crossref
Added: September 13, 2019
2016 journal article
Greater Coronary Heart Disease Risk With Lower Intensity and Longer Duration Smoking Compared With Higher Intensity and Shorter Duration Smoking: Congruent Results Across Diverse Cohorts
Nicotine & Tobacco Research, 19(7), ntw290.
MeSH headings : Aged; Cohort Studies; Coronary Disease / epidemiology; Coronary Disease / mortality; Double-Blind Method; Finland / epidemiology; Humans; Male; Middle Aged; Risk Factors; Smoking / epidemiology; Smoking Cessation / methods; Time Factors; Tobacco Products / statistics & numerical data
TL;DR:
In inverse smoking intensity effects in multiple cohorts with differing smoking patterns and other characteristics are observed, suggesting a common underlying phenomenon that offers clues to better understanding biological mechanisms and reinforces the importance of cessation rather than smoking less to reduce CHD risk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: NC State University Libraries, Crossref
Added: September 13, 2019
2016 article
Experimental evolution reveals favored adaptive routes to cell aggregation in yeast
(Vol. 12). Vol. 12.
Source: ORCID
Added: September 12, 2019
2016 journal article
Some assembly required: evolutionary and systems perspectives on the mammalian reproductive system
Cell and Tissue Research, 363(1), 267–278.
Contributors: B. Mordhorst*, M. Wilson * & G. Conant*
author keywords: Evolution; Reproduction; Systems biology; Metabolic modeling; Selection
MeSH headings : Animals; Biological Evolution; Genitalia / physiology; Genomics; Humans; Reproduction; Sex Chromosomes / genetics; Systems Biology
TL;DR:
The way that insights from evolutionary theory and systems biology shed light on form and function in mammalian reproductive systems is discussed, including the Warburg effect, whereby glucose is fermented to lactate and alanine rather than respired to carbon dioxide.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2016 book
Robust Yet Fragile: Expression Noise, Protein Misfolding, and Gene Dosage in the Evolution of Genomes
In Annual Review of Genetics (Vol. 50, pp. 113–131).
Contributors: J. Pires & G. Conant*
author keywords: dosage balance; gene expression noise; polyploidy; robustness; aneuploidy; gene duplication
MeSH headings : Aneuploidy; Animals; Biological Evolution; Gene Dosage; Gene Duplication; Gene Expression; Genome; Phenotype; Protein Folding
TL;DR:
It is proposed that noise in gene expression and evolutionary strategies for its suppression play a role in generating dosage phenotypes, and an unappreciated mechanism for the preservation of duplicate genes, namely preservation to limit expression noise is outlined, arguing that it is particularly relevant in polyploid organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: September 12, 2019
2016 journal article
Convergent Evolution and the Origin of Complex Phenotypes in the Age of Systems Biology
International Journal of Plant Sciences, 177(4), 305–318.
Contributors: J. Washburn *, K. Bird *, G. Conant* & J. Pires *
author keywords: convergent evolution; parallel evolution; systems biology; comparative genomics; yeast; cancer; polyploidy; domestication; heterosis; C-4 photosynthesis
TL;DR:
Although examples of convergence are known from many domains of life, green plants in particular have remarkable promise for the study of convergence because they are experimentally tractable, have considerable “-omics” and systems biology resources available, and show convergence in a number of important and complex traits.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 12, 2019
2016 journal article
Escherichia coli RadD Protein Functionally Interacts with the Single-stranded DNA-binding Protein
Journal of Biological Chemistry.
author keywords: ATPase; DNA repair; protein-DNA interaction; protein-protein interaction; radiation biology; SSB; helicase
MeSH headings : Adenosine Triphosphatases / genetics; Adenosine Triphosphatases / metabolism; DNA Damage; DNA, Bacterial / genetics; DNA, Bacterial / metabolism; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Escherichia coli / genetics; Escherichia coli / metabolism; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Protein Binding
TL;DR:
The RadD gene was recently identified as having an unspecified role in repair of radiation damage and, more specifically, DNA double-strand breaks, and it is likely that the repair function of RadD is mediated through interaction with SSB at the site of damage.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2016 journal article
A Role for Human Skin Mast Cells in Dengue Virus Infection and Systemic Spread
The Journal of Immunology.
MeSH headings : Animals; Cell Degranulation / immunology; Cytokines / immunology; Dengue / immunology; Dengue / pathology; Dengue Virus / immunology; Humans; Lymph Nodes / immunology; Lymph Nodes / pathology; Lymph Nodes / virology; Mast Cells / immunology; Mast Cells / pathology; Mast Cells / virology; Mice; Secretory Vesicles / immunology; Secretory Vesicles / pathology; Secretory Vesicles / virology; Skin / immunology; Skin / pathology; Skin / virology
TL;DR:
It is shown that mast cells are a target of DENV in human skin and thatDENV infection of skin mast cells induces degranulation and alters cytokine and growth factor expression profiles, and for the first time that DENV localizes within secretory granules in infected skin mast Cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: September 12, 2019
2016 journal article
Oral health correlates of captivity
Research in Veterinary Science, 107, 213–219.
author keywords: Panthera; P. leo; P. tigris; Gingivitis; Gum disease; Caries
MeSH headings : Animals; Animals, Zoo; Dental Calculus / prevention & control; Dental Calculus / veterinary; Diet; Lions; Oral Health; Periodontal Diseases / prevention & control; Periodontal Diseases / veterinary; Tigers
TL;DR:
It is found that the occurrence and severity of calculus buildup and periodontal disease was significantly higher in captive felids compared to their wild counterparts, and this suggests that food mechanical properties are significant factors contributing to oral health in felids.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: September 12, 2019
2016 journal article
Diverse diets of the Mio-Pliocene carnivorans of Langebaanweg, South Africa
South African Journal of Science.
author keywords: Carnivora; Agriotherium; Hayeanidae; Felidae; palaeodiet reconstruction
TL;DR:
Analysis of the radii-of-curvature and intercuspid notches present in the mandibulardentition of the Mio-Pliocene guild of carnivorans of Langebaanweg, South Africa found that the LBW carnivoran had less sharp premolars than do their modern confamilials - an indication of greater durophagy.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2016 journal article
The effect of captivity on the oral health of the critically endangered black-footed ferret (Mustela nigripes)
Canadian Journal of Zoology, 94(1), 15–22.
Contributors: T. Antonelli*, C. Leischner*, J. Ososky* & A. Hartstone-Rose*
author keywords: Mustela nigripes; black-footed ferret; calculus; periodontal disease; captivity
TL;DR:
An analysis of dentition of wild and captive black-footed ferrets reveals that calculus accumulation and periodontal diseases occurred with greater severity in captive animals than in the wild.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: September 12, 2019
2016 journal article
Megalictis, the Bone-Crushing Giant Mustelid (Carnivora, Mustelidae, Oligobuninae) from the Early Miocene of North America
Plos One, 11(4).
Contributors: A. Valenciano *, J. Baskin *, J. Abella *, A. Perez-Ramos *, M. Angeles Alvarez-Sierra*, J. Morales *, A. Hartstone-Rose*
MeSH headings : Animals; Fossils; Mandible / anatomy & histology; Mustelidae / anatomy & histology; Mustelidae / classification; Nebraska; Paleontology / methods; Phylogeny; Skull / anatomy & histology; Wyoming
TL;DR:
The phylogenetic hypothesis indicates that Ar4 specimens assigned to M. ferox constitute a monophyletic group and the results indicate that the Oligobuninae form the sister clade to the crown extant mustelids.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2016 journal article
A mechanical argument for the differential performance of coronary artery grafts
Journal of the Mechanical Behavior of Biomedical Materials, 54, 93–105.
Contributors: D. Prim*, B. Zhou *, A. Hartstone-Rose* , M. Uline *, T. Shazly* & J. Eberth *
author keywords: CABG; Bypass graft; Stress homeostasis; Mechanical compatibility
MeSH headings : Animals; Biomechanical Phenomena; Coronary Vessels / cytology; Homeostasis; Materials Testing; Mechanical Phenomena; Stress, Mechanical; Swine
TL;DR:
In this investigation, biaxial mechanical testing and histology were performed on the porcine left anterior descending artery (LAD) and analogs of common autografts, including the internal thoracic artery (ITA), radial artery (RA), great saphenous vein (GSV) and lateral saphenus vein (LSV), enabling prediction of the acute vessel mechanical response pre-transplantation and under coronary loading conditions.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
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