Works Published in 2010
Displaying works 61 - 80 of 183 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
Identification of Iowa Live Births in the Agricultural Health Study
Archives of Environmental & Occupational Health, 65(3), 154–162.
Contributors: P. Romitti *, S. Watanabe-Galloway *, W. Budelier*, C. Lynch *, S. Puzhankara*, D. Wong-Gibbons*, J. Hoppin* , M. Alavanja*
author keywords: children; occupational exposures; pesticides; pregnancy; prospective cohort
MeSH headings : Agricultural Workers' Diseases / epidemiology; Agriculture / statistics & numerical data; Birth Certificates; Family Characteristics; Female; Health Surveys; Humans; Iowa / epidemiology; Live Birth / epidemiology; Male; Occupational Exposure / adverse effects; Occupational Exposure / statistics & numerical data; Parity; Pregnancy
TL;DR:
A probabilistic and deterministic approach was used to link available demographic data from 31,707 households and information on live births from 13,599 households with 1,014,916 Iowa birth certificates, producing an expanded cohort of live-born children among Iowa participants.
(via Semantic Scholar)
europepmc.org (repository)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2010 journal article
Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts
Cancer Causes & Control, 21(8), 1305–1314.
Contributors: L. Jiao *, A. Berrington De Gonzalez *, P. Hartge*, R. Pfeiffer *, Y. Park *, D. Freedman*, M. Gail *, M. Alavanja*
author keywords: Pancreatic cancer; Body mass index; Pooled analysis; Prospective cohort; Effect modification
MeSH headings : Age Factors; Body Mass Index; Cohort Studies; Effect Modifier, Epidemiologic; Female; Humans; Male; Middle Aged; Pancreatic Neoplasms / epidemiology; Pancreatic Neoplasms / etiology; Proportional Hazards Models; Prospective Studies; Risk Factors; Sex Factors
TL;DR:
The present evidence suggests that a high BMI is an independent risk factor of pancreatic cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2010 journal article
Assessment of a pesticide exposure intensity algorithm in the agricultural health study
Journal of Exposure Science and Environmental Epidemiology, 20(6), 559–569.
Contributors: K. Thomas *, M. Dosemeci*, J. Coble*, J. Hoppin* , L. Sheldon*, G. Chapa*, C. Croghan*, P. Jones *
author keywords: 2,4-D; chlorpyrifos; exposure measurement; occupational exposure; Agricultural Health Study
MeSH headings : 2,4-Dichlorophenoxyacetic Acid / analysis; 2,4-Dichlorophenoxyacetic Acid / urine; Agriculture; Air Pollutants, Occupational / analysis; Air Pollutants, Occupational / urine; Algorithms; Biomarkers / urine; Chlorpyrifos / analysis; Chlorpyrifos / urine; Cohort Studies; Environmental Exposure / analysis; Environmental Monitoring / methods; Gas Chromatography-Mass Spectrometry; Humans; Iowa; Linear Models; North Carolina; Occupational Exposure / analysis; Pesticides / analysis; Pesticides / urine; Risk Assessment / methods; Skin Absorption; Surveys and Questionnaires
TL;DR:
The results of the measurements support the use of the algorithm for estimating questionnaire-based exposure intensities in the AHS for liquid pesticide products and refine the algorithm may be possible using the results from this and other measurement studies.
(via Semantic Scholar)
Source: ORCID
Added: September 13, 2019
2010 journal article
Body mass index, agricultural pesticide use, and cancer incidence in the Agricultural Health Study cohort
Cancer Causes & Control, 21(11), 1759–1775.
Contributors: G. Andreotti *, L. Hou *, L. Beane Freeman*, R. Mahajan*, S. Koutros *, J. Coble*, J. Lubin*, A. Blair*, J. Hoppin* , M. Alavanja*
author keywords: Obesity; Body mass index; Pesticides; Cancer; Agriculture
MeSH headings : Agriculture; Body Mass Index; Breast Neoplasms / complications; Breast Neoplasms / epidemiology; Cohort Studies; Colonic Neoplasms / complications; Colonic Neoplasms / epidemiology; Female; Humans; Incidence; Male; Neoplasms / epidemiology; Neoplasms / etiology; Obesity / complications; Obesity / epidemiology; Overweight / epidemiology; Pesticides / adverse effects; Prospective Studies; Surveys and Questionnaires
TL;DR:
It is suggested that certain pesticides may modify the effects of BMI on the risks of colon and lung cancers and not in non-users of these pesticides.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2010 journal article
An Update of Cancer Incidence in the Agricultural Health Study
Journal of Occupational and Environmental Medicine, 52(11), 1098–1105.
Contributors: S. Koutros, M. Alavanja, J. Lubin, D. Sandler, J. Hoppin* , C. Lynch, C. Knott, A. Blair, L. Freeman
MeSH headings : Adult; Aged; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Air Pollutants, Occupational / adverse effects; Female; Humans; Incidence; Male; Middle Aged; Neoplasms / chemically induced; Neoplasms / epidemiology; North Carolina / epidemiology; Occupational Exposure / adverse effects; Pesticides / adverse effects; Prospective Studies; Registries; Spouses / statistics & numerical data
TL;DR:
Although lower rates of smoking and increased physical activity probably contribute to the lower overall cancer incidence, agricultural exposures including pesticides, viruses, bacteria, sunlight, and other chemicals may increase risks for specific cancer sites.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2010 journal article
Body-Mass Index and Mortality among 1.46 Million White Adults
New England Journal of Medicine, 363(23), 2211–2219.
Contributors: A. De Gonzalez *, P. Hartge*, J. Cerhan *, A. Flint*, L. Hannan*, R. MacInnis *, S. Moore*, G. Tobias *
MeSH headings : Adult; Body Mass Index; Cause of Death; Confounding Factors, Epidemiologic; Exercise; Female; Follow-Up Studies; Humans; Male; Mortality / ethnology; Overweight / mortality; Proportional Hazards Models; Smoking / adverse effects; Socioeconomic Factors; Thinness / mortality; White People / statistics & numerical data
TL;DR:
In white adults, overweight and obesity (and possibly underweight) are associated with increased all-cause mortality and the hazard ratios for the men were similar.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2010 journal article
The T box regulatory element controlling expression of the class i lysyl-tRNA synthetase of Bacillus cereus strain 14579 is functional and can be partially induced by reduced charging of asparaginyl-tRNA<sup>Asn</sup>
BMC Microbiology, 10.
Contributors: N. Foy*, B. Jester*, G. Conant* & K. Devine*
MeSH headings : Amino Acid Sequence; Bacillus cereus / chemistry; Bacillus cereus / enzymology; Bacillus cereus / genetics; Bacillus cereus / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Gene Expression Regulation, Enzymologic; Lysine-tRNA Ligase / chemistry; Lysine-tRNA Ligase / genetics; Lysine-tRNA Ligase / metabolism; Molecular Sequence Data; RNA, Transfer, Amino Acyl / metabolism; RNA, Transfer, Asn / metabolism; Regulatory Elements, Transcriptional; Sequence Alignment
TL;DR:
The T box element controlling lysK (encoding LysRS1) expression in B. cereus strain 14579 is functional, but unusually responds to depletion of charged tRNALys and tRNAAsn.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: September 12, 2019
2010 journal article
Rapid reorganization of the transcriptional regulatory network after genome duplication in yeast
Proceedings of the Royal Society B: Biological Sciences, 277(1683), 869–876.
Contributors: G. Conant*
author keywords: whole-genome duplication; network evolution; regulatory evolution
MeSH headings : Computational Biology; Evolution, Molecular; Gene Duplication; Gene Regulatory Networks / genetics; Gene Regulatory Networks / physiology; Genome, Fungal / genetics; Genome, Fungal / physiology; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / physiology
TL;DR:
The reorganization of the yeast transcriptional regulatory network after whole-genome duplication is studied, and it is found that genes targeted by many TFs appear to be preferentially retained in duplicate after WGD, an effect I attribute to selection to maintain dosage balance in the regulatory networkAfter WGD.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2010 journal article
Nonrandom survival of gene conversions among yeast ribosomal proteins duplicated through genome doubling.
Genome Biology and Evolution, 2, 826–834. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952199263&partnerID=MN8TOARS
Contributors: A. Evangelisti & G. Conant
Source: ORCID
Added: September 12, 2019
2010 journal article
Selective translocation of Ca2+/calmodulin protein kinase II (CaMKII ) to inhibitory synapses
Proceedings of the National Academy of Sciences, 107(47), 20559–20564.
MeSH headings : Animals; Calcineurin / metabolism; Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism; Hippocampus / cytology; Image Processing, Computer-Assisted; Immunohistochemistry; Long-Term Potentiation / physiology; Microscopy, Fluorescence; Neurons / metabolism; Rats; Receptors, GABA-A / metabolism; Receptors, N-Methyl-D-Aspartate / metabolism; Synapses / metabolism
TL;DR:
It is shown that CaMKIIα translocates to inhibitory but not excitatory synapses in response to more moderate NMDAR-activating stimuli that trigger GABAA-receptor (GABAAR) insertion and enhance inhibitory transmission.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2010 journal article
THE PLIO-PLEISTOCENE ANCESTOR OF WILD DOGS, LYCAON SEKOWEI N. SP
Journal of Paleontology, 84(2), 299–308. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000275689000008&KeyUID=WOS:000275689000008
Contributors: A. Hartstone-Rose , L. Werdelin, D. De Ruiter, L. Berger & S. Churchill
Source: ORCID
Added: September 12, 2019
2010 journal article
Maximum Ingested Food Size in Captive Strepsirrhine Primates: Scaling and the Effects of Diet
American Journal of Physical Anthropology, 142(4), 625–635.
Contributors: J. Perry* & A. Hartstone-Rose*
author keywords: lemur; allometry; ingestion; mastication; bite
MeSH headings : Analysis of Variance; Animals; Basal Metabolism; Body Weight / physiology; Feeding Behavior / physiology; Female; Fruit; Male; Mandible / anatomy & histology; Mastication; Particle Size; Phylogeny; Regression Analysis; Strepsirhini / anatomy & histology; Strepsirhini / metabolism; Strepsirhini / physiology; Vegetables
TL;DR:
This study provides the first data on ingested food size in strepsirrhine primates using a captive sample of 17 species and found that maximum V(b) scales isometrically with body mass and mandible length.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2010 journal article
Extracting ecological information from the mechanical properties and structure of primate teeth
American Journal of Physical Anthropology, 84. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000275295200146&KeyUID=WOS:000275295200146
Contributors: P. Constantino, J. Lee, D. Morris, A. Hartstone-Rose , T. Smith, B. Lawn, P. Lucas
Source: ORCID
Added: September 12, 2019
2010 journal article
Digestive physiology, and use of carbohydrates by arboreal, frugivorous Carnivora (Arctictis binturong, Potos flavus): a test of convergent evolution with the primate pattern
American Journal of Physical Anthropology, 150–151. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000275295200436&KeyUID=WOS:000275295200436
Contributors: J. Lambert, A. Hartstone-Rose & V. Fellner
Source: ORCID
Added: September 12, 2019
2010 chapter
Understanding environment-disease connections: An introduction to the comparative toxicogenomics database (ctd)
In Nature Pathway Interaction Database.
Source: NC State University Libraries
Added: August 10, 2019
2010 journal article
2,3,7,8-Tetrachlorodibenzo-p-dioxin Upregulates FoxQ1b in Zebrafish Jaw Primordium
Chemical Research in Toxicology, 23(3), 480–487.
Contributors: A. Planchart* & C. Mattingly*
MeSH headings : Animals; Embryo, Nonmammalian / metabolism; Enhancer Elements, Genetic; Environmental Pollutants / pharmacology; Forkhead Transcription Factors / genetics; Gene Expression Regulation, Developmental / drug effects; Jaw / metabolism; Jaw / pathology; Jaw Abnormalities / chemically induced; Polychlorinated Dibenzodioxins / pharmacology; Receptors, Aryl Hydrocarbon / metabolism; Up-Regulation / drug effects; Zebrafish / genetics; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
FoxQ1b is specifically expressed in the jaw primordium where it discretely outlines a developing jaw structure known as Meckel's cartilage--a conserved structure in all jawed vertebrates that develops abnormally in the presence of TCDD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 10, 2019
2010 journal article
The Comparative Toxicogenomics Database: update 2011
Nucleic Acids Research, 39(Database), D1067–D1072.
MeSH headings : Databases, Factual; Disease / etiology; Disease / genetics; Environmental Exposure; Gene Regulatory Networks; Genes; Hazardous Substances / toxicity; Humans; Software; Toxicogenetics
TL;DR:
Since 2009, the content of CTD has dramatically increased the content to 1.4 million chemical–gene–disease data points and added many features, statistical analyses and analytical tools, including GeneComps and ChemComps, to help users generate testable hypotheses about the molecular mechanisms of environmental diseases.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 7, 2019
2010 journal article
Glycine and a Glycine Dehydrogenase (GLDC) SNP as Citalopram/Escitalopram Response Biomarkers in Depression: Pharmacometabolomics-Informed Pharmacogenomics
Clinical Pharmacology & Therapeutics, 89(1), 97–104.
MeSH headings : Biomarkers, Pharmacological / blood; Cell Line; Chromosomes, Human, Pair 9 / genetics; Citalopram / therapeutic use; DNA-Binding Proteins / metabolism; Depressive Disorder, Major / blood; Depressive Disorder, Major / drug therapy; Depressive Disorder, Major / genetics; Drug Monitoring / methods; Female; Genetic Association Studies; Glycine / blood; Glycine / metabolism; Glycine Dehydrogenase (Decarboxylating) / genetics; Humans; Introns / genetics; Linkage Disequilibrium; Male; Metabolome / drug effects; Nuclear Proteins / metabolism; Polymorphism, Single Nucleotide; Selective Serotonin Reuptake Inhibitors / therapeutic use
TL;DR:
A possible role for glycine in SSRI response is highlighted and the use of pharmacometabolomics‐informed pharmacogenomic research strategy to identify citalopram/escitaloprams treatment outcome biomarkers is illustrated to “inform” pharmacogenomics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: July 28, 2019
2010 journal article
Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study
Metabolomics, 6(2), 191–201.
author keywords: Cardiovascular disease; Lipidomics; Metabolomics; Pharmacogenomics; Pharmacometabolomics; Simvastatin
TL;DR:
There was no overlap of lipids whose changes correlated with LDL-C or CRP responses to simvastatin suggesting that distinct metabolic pathways govern statin effects on these two biomarkers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: July 20, 2019
2010 journal article
In vitro screening of environmental chemicals for targeted testing prioritization: The toxcast project
Environmental Health Perspectives, 118(4), 485–492.
Contributors: R. Judson *, K. Houck *, R. Kavlock*, T. Knudsen *, M. Martin*, H. Mortensen *, D. Reif* , D. Rotroff *
author keywords: in vitro screening; liver proliferative lesions; liver tumors; pathways; ToxCast
MeSH headings : Animals; Cell Line; Cells, Cultured; Computer Simulation; Environmental Pollutants / toxicity; Humans; Rats; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
A statistically significant inverse association between the number of pathways perturbed by a chemical at low in vitro concentrations and the lowest in vivo dose at which a chemical causes toxicity is found.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
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