Works Published in 2010
Displaying works 81 - 100 of 183 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals.
Journal of Toxicology and Environmental Health - Part B: Critical Reviews, 13(2-4), 329–346.
Contributors: D. Rotroff *, A. Beam, D. Dix*, A. Farmer, K. Freeman, K. Houck *, R. Judson *, E. Lecluyse
MeSH headings : Adult; Animals; Cell Shape / drug effects; Cells, Cultured; Cholesterol / biosynthesis; Environmental Pollutants / chemistry; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Gene Expression Regulation / drug effects; Hepatocytes / cytology; Hepatocytes / drug effects; Hepatocytes / enzymology; Hepatocytes / metabolism; Humans; Male; Middle Aged; Models, Biological; Rats; Signal Transduction / drug effects; Xenobiotics / chemistry; Xenobiotics / metabolism; Xenobiotics / toxicity
TL;DR:
Gene expression results identified various ToxCast chemicals that were potent or efficacious inducers of one or more of the 14 genes, and by inference the 5 nuclear receptor signaling pathways, as well as the five major receptor pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2010 journal article
Research needs for community-based risk assessment: findings from a multi-disciplinary workshop
J Expos Sci Environ Epidemiol, 20(2), 186â195.
Contributors: Y. Sanchez*, K. Deener*, E. Hubal*, C. Knowlton*, D. Reif* & D. Segal*
author keywords: population-based studies; epidemiology; exposure modeling; analytical methods; empirical/statistical modeling; PBPK modeling
MeSH headings : Humans; Needs Assessment; Research; Risk Assessment; United States; United States Environmental Protection Agency
TL;DR:
This paper summarizes an Environmental Protection Agency (EPA) sponsored workshop, “Research Needs for Community-Based Risk Assessment,” and presents identified research needs, and explores future research opportunities in this emerging field.
(via Semantic Scholar)
www.nature.com (publisher PDF)
Source: ORCID
Added: May 14, 2019
2010 journal article
Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.
Toxicological Sciences, 117(2), 348–358.
Contributors: D. Rotroff *, B. Wetmore *, D. Dix*, S. Ferguson, H. Clewell*, K. Houck *, E. LeCluyse, M. Andersen *
author keywords: reverse dosimetry; human exposure; ToxCast; high-throughput screening
MeSH headings : Cells, Cultured; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Hepatocytes / drug effects; Hepatocytes / metabolism; High-Throughput Screening Assays / methods; Humans; Male; Metabolic Clearance Rate; Protein Binding / drug effects; Risk Assessment; Toxicity Tests; Xenobiotics / classification; Xenobiotics / metabolism; Xenobiotics / toxicity
Source: ORCID
Added: May 14, 2019
2010 journal article
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.
Chemical Research in Toxicology, 23(3), 578–590.
Contributors: M. Martin*, D. Dix*, R. Judson *, R. Kavlock*, D. Reif* , A. Richard *, D. Rotroff *, S. Romanov*
MeSH headings : Animals; Biosensing Techniques / economics; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Environmental Pollutants / adverse effects; Hep G2 Cells; Rabbits; Rats; Receptors, Cytoplasmic and Nuclear / genetics; Response Elements / drug effects; Transcription Factors / genetics; Transcription, Genetic / drug effects
TL;DR:
A novel cellular biosensor system that enables rapid, high-content assessment of a compound's impact on gene regulatory networks and it is demonstrated that Nrf2 activity, a marker of oxidative stress, is highly correlated to the overall promiscuity of a chemical.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2010 journal article
Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data
Environ Health Perspect, 118(12), 1714â1720.
Contributors: D. Reif* , M. Martin*, S. Tan*, K. Houck *, R. Judson *, A. Richard *, T. Knudsen *, D. Dix*, R. Kavlock*
author keywords: androgen; chemical prioritization; data integration; endocrine disruption; estrogen; screening; ToxCast; toxicity profile; ToxPi
MeSH headings : Decision Support Techniques; Endocrine Disruptors / classification; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Signal Transduction / drug effects; Toxicity Tests / methods
TL;DR:
A flexible method to facilitate the rational prioritization of chemicals for further evaluation is developed and its application as a candidate decision-support tool for EDSP is demonstrated.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2010 journal article
Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity.
Environmental Science and Technology, 44(15), 5979–5985.
Contributors: R. Judson *, M. Martin*, D. Reif* , K. Houck *, T. Knudsen *, D. Rotroff *, M. Xia *, S. Sakamuru *
MeSH headings : Chemical Hazard Release; Endocrine Disruptors / analysis; Environmental Restoration and Remediation; Lipids / toxicity; Receptors, Estrogen / metabolism; Surface-Active Agents / toxicity; Water Pollutants, Chemical / toxicity
TL;DR:
A series of in vitro high-throughput assays on eight commercial dispersants focused on the estrogen and androgen receptors (ER and AR), but also included a larger battery of assays probing other biological pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2010 report
Integrating learning, discovery, and engagement through the scholarship of engagement
In Technical Report- Not held in TRLN member libraries. Raleigh, NC: NCSU Office of Extension, Engagement, and Economic Development.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Making scents of behavioural genetics: lessons from Drosophila
GENETICS RESEARCH, 92(5-6), 349–359.
MeSH headings : Animals; Behavior, Animal; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Gene Regulatory Networks; Genetic Linkage; Genetics, Behavioral; Humans; Olfactory Perception
TL;DR:
This review focuses on olfactory behaviour in Drosophila with the goal to illustrate how fundamental insights derived from studies on chemosensation can be applied to a wide range of behavioural phenotypes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
The ecology of a keystone seed disperser, the ant Rhytidoponera violacea
Journal of Insect Science (Tucson, AZ), 10.
MeSH headings : Animals; Ants / physiology; Appetitive Behavior / physiology; Diet; Nesting Behavior / physiology; Observation; Seed Dispersal / physiology; Western Australia
TL;DR:
R. violacea nesting habits, foraging behavior, and other life history characteristics complement their role as a mutualist that interacts with the seeds of many plant species.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
The Development and Validation of a LIPUS System With Preliminary Observations of Ultrasonic Effects on Human Adult Stem Cells
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 57(9), 1977–1984.
MeSH headings : Adipose Tissue / cytology; Adult; Adult Stem Cells / cytology; Adult Stem Cells / diagnostic imaging; Bone Marrow Cells / cytology; Calcium / analysis; Calcium / metabolism; Cell Growth Processes / physiology; Cells, Cultured; DNA / chemistry; Humans; Reproducibility of Results; Ultrasonics / instrumentation; Ultrasonics / methods; Ultrasonography
TL;DR:
The custom LIPUS system designed and validated by exploring the effects of using different pulse repetition frequency (PRF) parameters on human adipose derived adult stem cells and bone marrow derived mesenchymal stem cells was successfully designed to allow extreme parameter variation, specifically PRF, and encourages further studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Taxonomic revision of the ant genus Leptomyrmex Mayr (Hymenoptera: Formicidae)
Zootaxa, (2688), 1–67.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
TCDD Induced Pericardial Edema and Relative COX-2 Expression in Medaka (Oryzias Latipes) Embryos
TOXICOLOGICAL SCIENCES, 118(1), 213–223.
author keywords: COX-2; TCDD; medaka; pericardial edema
MeSH headings : Animals; Arachidonic Acid / pharmacology; Cyclooxygenase 2 / biosynthesis; Cyclooxygenase 2 / genetics; Cyclooxygenase Inhibitors / pharmacology; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / enzymology; Gene Expression Regulation, Developmental / drug effects; Gene Silencing; Nitrobenzenes / pharmacology; Oryzias / physiology; Pericardial Effusion / chemically induced; Pericardial Effusion / genetics; Pericardial Effusion / pathology; Polychlorinated Dibenzodioxins / toxicity; RNA, Messenger / metabolism; Sulfonamides / pharmacology; Teratogens / toxicity
TL;DR:
It is suggested that AhR activation results in stimulation of inflammation and "eicosanoid" pathways, which contribute to the observed developmental, cardiovascular phenotypes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Repeated evolution of crop theft in fungus-farming ambrosia beetles
Evolution, 64(11), 3205–3212.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
New genera of Palaeotropical Xyleborini (Coleoptera: Curculionidae: Scolytinae) based on congruence between morphological and molecular characters
Zootaxa, (2717), 1–33.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Guild-specific patterns of species richness and host specialization in plant-herbivore food webs from a tropical forest
Journal of Animal Ecology, 79(6), 1193–1203.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Effect of Ration Size Restriction on Compensatory Growth and Proximate Composition of Dark-banded Rockfish, Sebastes inermis
JOURNAL OF THE WORLD AQUACULTURE SOCIETY, 41(6), 923–930.
TL;DR:
It is suggested that the fish subjected to a proper pre-restricted feeding for 2 wk result in complete compensatory growth, while the fish experienced more severe feed restriction show a partial compensatorygrowth capacity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
The pharmacokinetics of enrofloxacin in adult African clawed frogs (Xenopus laevis)
Journal of the American Association for Laboratory Animal Science, 49(6), 800–804.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Taxonomic changes in palaeotropical Xyleborini (Coleoptera, Curculionidae, Scolytinae)
ZooKeys, (56), 105–119.
Source: NC State University Libraries
Added: August 6, 2018
2010 article
Predicting Evolution with Generalized Models of Divergent Selection: A Case Study with Poeciliid Fish
Langerhans, R. B. (2010, December). INTEGRATIVE AND COMPARATIVE BIOLOGY, Vol. 50, pp. 1167–1184.
MeSH headings : Animals; Biological Evolution; Cyprinodontiformes / anatomy & histology; Cyprinodontiformes / genetics; Cyprinodontiformes / physiology; Female; Food Chain; Male; Models, Biological; Selection, Genetic; Swimming; Zoology / methods
TL;DR:
The GMDS approach appears to represent a promising method of addressing the predictability of evolution and identifying environmental factors responsible for driving major patterns of replicated evolution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Modeling Path Dependence in Agricultural Adaptation to Climate Variability and Change
ANNALS OF THE ASSOCIATION OF AMERICAN GEOGRAPHERS, 100(4), 894–907.
author keywords: adaptation; agriculture; climate change and variability; path dependence; Southeast United States
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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