Works Published in 2014

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Displaying works 81 - 100 of 270 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2014 journal article

Reliability of triclosan measures in repeated urine samples from Norwegian pregnant women

Journal of Exposure Science & Environmental Epidemiology, 24(5), 517–521.

By: R. Bertelsen*, S. Engel*, T. Jusko*, A. Calafat*, J. Hoppin*, S. London*, M. Eggesbø*, H. Aase* ...

Contributors: R. Bertelsen*, S. Engel*, T. Jusko*, A. Calafat*, J. Hoppin*, S. London*, M. Eggesbø*, H. Aase* ...

author keywords: biomarkers; MoBa; intraclass correlation coefficient; pregnancy; reliability; triclosan
MeSH headings : Anti-Infective Agents, Local / urine; Female; Humans; Norway; Pregnancy; Reproducibility of Results; Triclosan / urine
TL;DR: The reliability of TCS concentrations in repeated urine samples from pregnant Norwegian women was reasonably good, suggesting a single urine sample can adequately represent TCS exposure during pregnancy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019

2014 journal article

Perfluoroalkyl Substances During Pregnancy and Validated Preeclampsia Among Nulliparous Women in the Norwegian Mother and Child Cohort Study

American Journal of Epidemiology, 179(7), 824–833.

By: A. Starling, S. Engel, D. Richardson, D. Baird, L. Haug, A. Stuebe, K. Klungsoyr, Q. Harmon ...

Contributors: A. Starling, S. Engel, D. Richardson, D. Baird, L. Haug, A. Stuebe, K. Klungsøyr, Q. Harmon ...

author keywords: Norwegian Mother and Child Cohort Study; perfluoroalkyl substances; perfluorooctanoic acid; perfluorooctane sulfonate; perfluoroundecanoic acid; preeclampsia
MeSH headings : Adolescent; Adult; Alkanesulfonic Acids / blood; Caprylates / blood; Cohort Studies; Environmental Exposure / adverse effects; Environmental Exposure / analysis; Environmental Pollutants / adverse effects; Environmental Pollutants / blood; Fatty Acids / blood; Female; Fluorocarbons / blood; Humans; Norway; Parity; Pre-Eclampsia / blood; Pre-Eclampsia / etiology; Pregnancy; Proportional Hazards Models; Young Adult
TL;DR: The findings do not support an increased risk of preeclampsia among nulliparous Norwegian women with background levels of PFAS exposure, and an inverse association between preeClampsia and the highest quartile of perfluoroundecanoic acid concentration relative to the lowest quartile is found. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019

2014 journal article

Long-Term Exposure to Fine Particulate Matter: Association with Nonaccidental and Cardiovascular Mortality in the Agricultural Health Study Cohort

Environmental Health Perspectives, 122(6), 609–615.

MeSH headings : Adult; Agriculture / statistics & numerical data; Air Pollutants / analysis; Air Pollutants / toxicity; Cardiovascular Diseases / mortality; Cohort Studies; Environmental Exposure / analysis; Environmental Exposure / statistics & numerical data; Female; Humans; Iowa / epidemiology; Male; Mortality; North Carolina / epidemiology; Particulate Matter / analysis; Particulate Matter / toxicity; Risk Factors; Rural Population; Sex Factors
TL;DR: Positive associations were observed between ambient PM2.5 and cardiovascular mortality among men, and these associations were strongest among men who did not move from their enrollment address, while similar associations were not observed among women. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019

2014 journal article

Exacerbation of symptoms in agricultural pesticide applicators with asthma

International Archives of Occupational and Environmental Health, 87(4), 423–432.

MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / epidemiology; Agricultural Workers' Diseases / etiology; Asthma, Occupational / epidemiology; Asthma, Occupational / etiology; Female; Humans; Male; Middle Aged; Occupational Exposure / adverse effects; Pesticides / adverse effects; Risk Factors; Severity of Illness Index; Surveys and Questionnaires; United States; Young Adult
TL;DR: The inverse associations with two pesticides and specific farm activities are consistent with the possibility that asthma cases prone to exacerbation may avoid exposures that trigger symptoms, and suggest that use of specific pesticides may contribute to exacerbate of asthma among individuals with allergies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: September 13, 2019

2014 journal article

Perfluoroalkyl substances and lipid concentrations in plasma during pregnancy among women in the Norwegian Mother and Child Cohort Study

Environment International, 62, 104–112.

By: A. Starling*, S. Engel*, K. Whitworth*, D. Richardson*, A. Stuebe*, J. Daniels*, L. Haug*, M. Eggesbø* ...

Contributors: A. Starling*, S. Engel*, K. Whitworth*, D. Richardson*, A. Stuebe*, J. Daniels*, L. Haug*, M. Eggesbø* ...

author keywords: The Norwegian Mother and Child Cohort Study MoBa; Perfluoroalkyl substances; Perfluorooctanoic acid; Perfluorooctane sulfonate
MeSH headings : Adult; Alkanesulfonic Acids / blood; Cholesterol / blood; Cohort Studies; Cross-Sectional Studies; Environmental Pollutants / blood; Female; Fluorocarbons / blood; Humans; Linear Models; Lipids / blood; Mothers; Norway
TL;DR: Plasma concentrations of PFASs were positively associated with HDL cholesterol, and PFOS was positivelyassociated with total cholesterol in this sample of pregnant Norwegian women, suggesting a mechanism by which PFAS exposure leads to certain adverse pregnancy outcomes, including preeclampsia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019

2014 journal article

Dietary fat intake, pesticide use, and Parkinson's disease

Parkinsonism & Related Disorders, 20(1), 82–87.

By: F. Kamel, S. Goldman, D. Umbach, H. Chen, G. Richardson, M. Barber, C. Meng, C. Marras ...

Contributors: F. Kamel, S. Goldman, D. Umbach, H. Chen, G. Richardson, M. Barber, C. Meng, C. Marras ...

author keywords: Parkinson's disease; Dietary fat; Polyunsaturated fatty acids; Pesticides
MeSH headings : Adult; Aged; Aged, 80 and over; Case-Control Studies; Diet; Dietary Fats; Fatty Acids, Omega-3; Female; Humans; Male; Middle Aged; Parkinson Disease / epidemiology; Pesticides / adverse effects; Risk Factors
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019

2014 journal article

Association between Class III Obesity (BMI of 40–59 kg/m2) and Mortality: A Pooled Analysis of 20 Prospective Studies

PLoS Medicine, 11(7), e1001673.

Contributors: C. Kitahara*, A. Flint*, A. Gonzalez*, L. Bernstein*, M. Brotzman*, R. MacInnis*, S. Moore*, K. Robien* ...

Ed(s): K. Khaw

MeSH headings : Australia / epidemiology; Body Mass Index; Humans; Life Expectancy; Obesity / mortality; Prospective Studies; Risk Factors; Sweden / epidemiology; United States / epidemiology
TL;DR: In a pooled analysis of 20 prospective studies, Cari Kitahara and colleagues find that class III obesity is associated with excess rates of total mortality, particularly due to heart disease, cancer, and diabetes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019

2014 journal article

No Detectable Effect of the DNA Methyltransferase DNMT2 on Drosophila Meiotic Recombination

G3&Amp;#58; Genes|Genomes|Genetics, 4(11), 2095–2100.

By: C. Heil*

author keywords: DNA methylation; DNMT2; recombination; Drosophila; epigenetics
MeSH headings : Animals; Chromatin / genetics; DNA (Cytosine-5-)-Methyltransferases / genetics; DNA (Cytosine-5-)-Methyltransferases / metabolism; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Epigenesis, Genetic; Meiosis; Recombination, Genetic
TL;DR: It is concluded that other epigenetic effects are regulating recombination initiation in Drosophila. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2014 journal article

Estrogen alters the profile of the transcriptome in river snail Bellamya aeruginosa

Ecotoxicology, 24(2), 330–338.

author keywords: Bellamya aeruginosa; Transcriptome; 454 sequencing; GO; Estrogen
MeSH headings : Animals; Estradiol / toxicity; Estrogens / toxicity; Molecular Sequence Data; Snails / drug effects; Snails / genetics; Transcriptome / drug effects; Water Pollutants, Chemical / toxicity
TL;DR: Significant differences were found in gene expression in both liver and testicular tissues between control and E2-exposed organisms, which will help in understanding the molecular mechanisms of the response to physiological stress in the river snail exposed to estrogen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: NC State University Libraries, Crossref
Added: September 12, 2019

2014 journal article

Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa

Cell and Tissue Research, 356(1), 261–278.

By: S. Zimmerman*, Y. Yi*, M. Sutovsky*, F. Van Leeuwen*, G. Conant* & P. Sutovsky*

Contributors: S. Zimmerman*, Y. Yi*, M. Sutovsky*, F. Van Leeuwen*, G. Conant* & P. Sutovsky*

author keywords: Ubiquitin; Proteasome; UBR7; C14ORF130; Spermatozoa; Fertilization; Zona pellucida; Pig; Mouse
MeSH headings : Acrosome / drug effects; Acrosome / metabolism; Animals; Antibodies, Blocking / pharmacology; Blotting, Western; Fertilization in Vitro; Fluorescent Antibody Technique; Humans; Male; Mice; Phylogeny; Protein Transport / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Spermatids / cytology; Spermatids / drug effects; Spermatids / metabolism; Spermatozoa / cytology; Spermatozoa / drug effects; Spermatozoa / enzymology; Swine; Testis / drug effects; Testis / metabolism; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism
TL;DR: Genomic analysis indicated a high degree of evolutionary conservation, remarkably constant purifying selection and conserved testis expression of the UBR7 gene, which provides the first evidence of ubiquitin ligase activity in mammalian spermatozoa and indicate U BR7 involvement in spermiogenesis. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2014 journal article

Secondary structure analyses of the nuclear rRNA internal transcribed spacers and assessment of its phylogenetic utility across the brassicaceae (mustards)

PLoS ONE, 9(7).

MeSH headings : Brassicaceae / genetics; DNA, Ribosomal Spacer / chemistry; Genes, rRNA; Nucleic Acid Conformation; Phylogeny
TL;DR: These analyses of ITS1 and ITS2 for 50 species suggest that both sequences are instead under selective constraints to preserve proper secondary structure, likely to maintain complete self-splicing functions, and thus are not neutrally-evolving phylogenetic markers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: September 12, 2019

2014 journal article

Gene duplication and phenotypic changes in the evolution of mammalian metabolic networks

PLoS ONE, 9(1).

Contributors: M. Bekaert* & G. Conant*

MeSH headings : Algorithms; Animals; Cluster Analysis; Gene Dosage; Gene Duplication; Genomics; Humans; Isoenzymes / chemistry; Mammals / genetics; Metabolic Networks and Pathways / genetics; Mice; Phenotype; Principal Component Analysis; Selection, Genetic
TL;DR: This work infer enzyme orthology networks for sixteen mammals as well as for their common ancestors using a phylogenetically-aware comparative genomics approach, and finds that the pattern of isoenzymes copy-number alterations (CNAs) in these networks is suggestive of natural selection acting on the retention of certain gene duplications. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2014 journal article

The yeast protein interaction network has a capacity for self-organization

FEBS Journal, 281(15), 3420–3432.

By: A. Dhroso*, D. Korkin* & G. Conant*

Contributors: A. Dhroso*, D. Korkin* & G. Conant*

author keywords: metabolic channeling; protein interaction network; robustness; self-assembly
MeSH headings : Computer Simulation; Fungal Proteins / chemistry; Fungal Proteins / physiology; Models, Molecular; Phosphorylation; Protein Interaction Maps; Protein Processing, Post-Translational; Saccharomyces / metabolism
TL;DR: A lattice model of molecular crowding is used, together with literature‐derived protein interactions and abundances, to describe the molecular organization and stoichiometry of local cellular regions, showing that physical protein–protein interactions induce emergent structures not seen when random interaction networks are modeled. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2014 journal article

Large-Scale Pairwise Alignments on GPU Clusters: Exploring the Implementation Space

Journal of Signal Processing Systems, 77(1-2), 131–149.

By: H. Truong*, D. Li*, K. Sajjapongse*, G. Conant* & M. Becchi*

Contributors: H. Truong*, D. Li*, K. Sajjapongse*, G. Conant* & M. Becchi*

author keywords: Heterogeneous system; Sequence alignment; GPU
TL;DR: This work presents four GPU implementations for large-scale pairwise sequence alignment, and suggests that LazyRScan-mNW is the preferred solution for applications that require performing the trace-back operation only on a subset of the considered sequence pairs. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2014 journal article

Diet alters both the structure and taxonomy of the ovine gut microbial ecosystem

DNA Research, 21(2), 115–125.

By: M. Ellison*, G. Conant*, R. Cockrum*, K. Austin*, H. Truong*, M. Becchi*, W. Lamberson*, K. Cammack*

Contributors: M. Ellison*, G. Conant*, R. Cockrum*, K. Austin*, H. Truong*, M. Becchi*, W. Lamberson*, K. Cammack*

author keywords: Ovis aries; microbiome; 16S subunit
MeSH headings : Animals; Bacteria / classification; Bacteria / genetics; DNA, Ribosomal / genetics; Diet; Ecosystem; Metagenome; Rumen / microbiology; Sequence Analysis, DNA; Sheep / microbiology
TL;DR: Differences in taxonomic distributions appear to be grounded in an underlying common input of new microbial individuals into the rumen environment, with common organisms from one feed group being present in the other, but at much lower abundance. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2014 journal article

Dosage, duplication, and diploidization: clarifying the interplay of multiple models for duplicate gene evolution over time

Current Opinion in Plant Biology, 19, 91–98.

Contributors: G. Conant*, J. Birchler* & J. Pires*

MeSH headings : Diploidy; Evolution, Molecular; Gene Dosage; Gene Duplication; Plants / genetics
TL;DR: It is argued that dosage effects represent one aspect of an emerging pluralistic framework, a framework that will use biophysics, genomic technologies, and systems-level models of cells to broaden the view of how genomes evolve. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 12, 2019

2014 journal article

Comparative genomics as a time machine: How relative gene dosage and metabolic requirements shaped the time-dependent resolution of yeast polyploidy

Molecular Biology and Evolution, 31(12), 3184–3193.

By: G. Conant*

Contributors: G. Conant*

author keywords: protein interaction network; metabolic flux; gene dosage; transcriptional regulatory network; polyploidy; Saccharomyces cerevisiae
MeSH headings : Evolution, Molecular; Gene Dosage; Gene Duplication; Gene Expression Regulation, Fungal; Genes, Duplicate; Genes, Fungal; Models, Genetic; Phylogeny; Polyploidy; Protein Interaction Maps; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae Proteins / genetics
TL;DR: Using a phylogenetic model of evolution after genome duplication (i.e., polyploidy) and 12 yeast genomes with a shared genome duplication, it is shown that the loss of duplicate genes after that duplication occurred in three phases. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2014 journal article

Escherichia coli Genes and Pathways Involved in Surviving Extreme Exposure to Ionizing Radiation

Journal of Bacteriology.

Stefanie Chen

MeSH headings : Escherichia coli / genetics; Escherichia coli / metabolism; Escherichia coli / radiation effects; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Gene Expression Regulation, Bacterial / radiation effects; Radiation, Ionizing
TL;DR: The results reinforced the notion that survival after high doses of ionizing radiation does not depend on a single mechanism or process, but instead is multifaceted. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2014 journal article

Top3α Is Required during the Convergent Migration Step of Double Holliday Junction Dissolution

PLoS ONE.

Stefanie Chen

MeSH headings : Animals; DNA Helicases / metabolism; DNA Topoisomerases, Type I / metabolism; DNA, Cruciform / metabolism; DNA, Cruciform / ultrastructure; Drosophila; Drosophila Proteins / metabolism; Protein Binding; Substrate Specificity
TL;DR: It is shown that the presence of a topoisomerase is required for Blm to substantially migrate a topologically constrained Holliday junction and when Blm is together with Top3α, the dissolution reaction is processive with no pausing at a partially migrated structure. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2014 journal article

The Three-Dimensional Morphological Effects of Captivity

Plos One, 9(11).

By: A. Hartstone-Rose*, H. Selvey*, J. Villari*, M. Atwell* & T. Schmidt*

Contributors: A. Hartstone-Rose*, H. Selvey*, J. Villari*, M. Atwell* & T. Schmidt*

MeSH headings : Animals; Animals, Zoo; Diet; Female; Imaging, Three-Dimensional; Lions; Male; Principal Component Analysis; Sex Characteristics; Skull / anatomy & histology; Species Specificity; Tigers
TL;DR: The analyses show the ways in which captive specimens are different than their wild counterparts – findings that have implications for morphologists when considering anatomical samples. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

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