Works Published in 2012
Displaying works 101 - 120 of 260 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Witnessing Phenotypic and Molecular Evolution in the Fruit Fly
Evolution: Education and Outreach, 5(4), 629–634.
TL;DR:
This multi-day exercise is designed for a college genetics and evolution laboratory to demonstrate concepts of inheritance and phenotypic and molecular evolution using a live model organism, Drosophila simulans, to track the spread of this advantageous trait over several generations.
(via Semantic Scholar)
evolution-outreach.biomedcentral.com (publisher PDF)
Source: ORCID
Added: September 12, 2019
2012 journal article
Mentor vs. Monolith
American Scientist, 100(6), 450.
Source: ORCID
Added: September 12, 2019
2012 journal article
Recombination Modulates How Selection Affects Linked Sites in Drosophila
PLoS Biology, 10(11), e1001422.
Ed(s): N. Barton
MeSH headings : Animals; Base Sequence; Chromosome Mapping; Chromosomes, Insect / genetics; Codon / genetics; Confidence Intervals; Conserved Sequence; Drosophila / genetics; Evolution, Molecular; Genetic Linkage; Genetic Variation; Genetics, Population / methods; Genome, Insect; Linear Models; Recombination, Genetic; Selection, Genetic; Species Specificity; Telomere / genetics
TL;DR:
Recombination rate in Drosophila species shapes the impact of selection in the genome and is positively correlated with nucleotide diversity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: September 12, 2019
2012 book
Yeast as a window into changes in genome complexity due to polyploidization
In Polyploidy and Genome Evolution (Vol. 9783642314421, pp. 293–308).
Contributors: C. Hudson * & G. Conant*
TL;DR:
The role of the WGD in shaping several complex metabolic and regulatory phenotypes is explored, including the dosage balance hypothesis as it applies to the yeast WGD and the selective forces that act on the W GD-produced paralogs and shape their patterns of loss and retention.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2012 journal article
Metabolic and evolutionary costs of herbivory defense: Systems biology of glucosinolate synthesis
New Phytologist, 196(2), 596–605.
Contributors: M. Bekaert *, P. Edger *, C. Hudson *, J. Pires * & G. Conant*
author keywords: adaptation; Arabidopsis thaliana; costly traits; flux balance analysis; metabolic network
MeSH headings : Amino Acids / metabolism; Arabidopsis / genetics; Arabidopsis / immunology; Arabidopsis / metabolism; Biological Evolution; Biomass; Biosynthetic Pathways / genetics; Gene Duplication; Gene Expression Regulation, Plant; Glucosinolates / biosynthesis; Herbivory / genetics; Metabolome / genetics; Models, Biological; Photons; Systems Biology
TL;DR:
It is found that glucosinolate production can increase photosynthetic requirements by at least 15% and that this cost is specific to the suite of glucos inolates found in A. thaliana, with other combinations of glucOSinolates being even more costly.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2012 journal article
Cloning and characterization of the peptidoglycan recognition protein genes in the mosquito, Armigeres subalbatus (Diptera: Culicidae)
Journal of Medical Entomology, 49(3), 656–671.
Contributors: S. Wang *, G. Conant* , R. Ou* & B. Beerntsen *
author keywords: peptidoglycan recognition protein; Armigeres subalbatus; mosquito; AsPGRP; immune response
MeSH headings : Animals; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cloning, Molecular; Culicidae / genetics; Culicidae / physiology; Evolution, Molecular; Female; Insect Proteins / genetics; Insect Proteins / metabolism; Life Cycle Stages; Male; Phylogeny; Protein Isoforms / genetics; Protein Isoforms / metabolism; Sequence Alignment; Sequence Analysis, DNA
TL;DR:
Phylogenetic analysis indicated that PGRPs represent an ancient gene family that has primarily diverged through speciation events among these Dipterans, with only a limited number of lineage specific gene duplications.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2012 journal article
Very low rate of gene conversion in the yeast genome
Molecular Biology and Evolution, 29(12), 3817–3826.
Contributors: C. Casola *, G. Conant* & M. Hahn*
author keywords: gene duplication; Saccharomyces cerevisiae; interlocus gene conversion
MeSH headings : Base Sequence; Computational Biology; Evolution, Molecular; Gene Conversion / genetics; Gene Duplication / genetics; Genome, Fungal / genetics; Likelihood Functions; Models, Genetic; Molecular Sequence Data; Phylogeny; Saccharomyces cerevisiae / genetics; Sequence Alignment; Species Specificity
TL;DR:
This work applies four different methodologies-including one approach that closely mirrors Gao and Innan's method-to estimate the level of interlocus gene conversion in Scer, and points to a maximum conversion level of 13% between paralogs in this species, in close agreement with most estimates of IGC in eukaryotes.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2012 journal article
Long identical multispecies elements in plant and animal genomes
Proceedings of the National Academy of Sciences of the United States of America, 109(19).
Contributors: J. Reneker*, E. Lyons *, G. Conant* , J. Pires *, M. Freeling *, C. Shyu*, D. Korkin *
author keywords: extreme conservation; repetitive elements
MeSH headings : Amino Acid Sequence; Animals; Arabidopsis / genetics; Base Sequence; Cell Nucleus / genetics; Chromosome Mapping; Chromosomes, Mammalian / genetics; Chromosomes, Plant / genetics; Conserved Sequence / genetics; Evolution, Molecular; Gene Regulatory Networks; Genome / genetics; Genome, Mitochondrial / genetics; Genome, Plant / genetics; Humans; Mice; Models, Genetic; Molecular Sequence Data; Rats; Species Specificity; Synteny
TL;DR:
Despite the common presence of LIMEs in both animal and plant lineages, the evolutionary processes involved in the creation and maintenance of these elements differ in the two groups and are likely attributable to several mechanisms, including transfer of genetic material from organellar to nuclear genomes, de novo sequence manufacturing, and purifying selection.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2012 journal article
Altered patterns of fractionation and exon deletions in Brassica rapa support a two-step model of paleohexaploidy
Genetics, 190(4), 1563–1574.
Contributors: H. Tang *, M. Woodhouse *, F. Cheng *, J. Schnable *, B. Pedersen *, G. Conant* , X. Wang *, M. Freeling *, J. Pires *
MeSH headings : Arabidopsis / genetics; Brassica rapa / classification; Brassica rapa / genetics; Cell Nucleus / genetics; Chromosomes, Plant / genetics; Computer Simulation; DNA, Plant / genetics; Evolution, Molecular; Exons; Genome, Plant; Models, Genetic; Molecular Sequence Data; Phylogeny; Polyploidy; Recombination, Genetic; Repetitive Sequences, Nucleic Acid; Sequence Deletion
TL;DR:
It is concluded that the observed patterns of the triplicated regions in the Brassica genome are best explained by a two-step fractionation model, which could influence the potential to generate morphological diversity—a hallmark of the Brassicas genus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: September 12, 2019
2012 journal article
Essential Functions of C Terminus of Drosophila Topoisomerase IIIα in Double Holliday Junction Dissolution
Journal of Biological Chemistry.
MeSH headings : Animals; DNA Helicases / genetics; DNA Helicases / metabolism; DNA Topoisomerases, Type I / genetics; DNA Topoisomerases, Type I / metabolism; DNA, Cruciform / genetics; DNA, Cruciform / metabolism; Drosophila Proteins; Drosophila melanogaster; Mutation; Protein Structure, Tertiary
TL;DR:
The data suggest that the Top3α C terminus has an important role in dHJ dissolution (by providing an interaction interface for Blm and DNA, which are critical to the dissolution reaction) and an essential function in vivo.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2012 journal article
The stability of "Maximum Ingested Bite Size" over time
American Journal of Physical Anthropology, 147, 122. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300498700186&KeyUID=WOS:000300498700186
Contributors: T. Criste, A. Hartstone-Rose , E. Simpler, A. Heckler & J. Perry
Source: ORCID
Added: September 12, 2019
2012 journal article
The role of tooth enamel mechanical properties in primate dietary adaptation
American Journal of Physical Anthropology, 148(2), 171–177.
Contributors: P. Constantino *, J. Lee*, Y. Gerbig *, A. Hartstone-Rose* , M. Talebi *, B. Lawn *, P. Lucas*
author keywords: dental ecology; elastic modulus; hardness; nanoindentation; diet
MeSH headings : Adaptation, Physiological; Animals; Dental Enamel / chemistry; Dental Enamel / physiology; Diet; Elastic Modulus; Hardness; Humans; Primates / anatomy & histology; Primates / physiology
TL;DR:
Differences in the load-bearing capacity of primate molar teeth are more a function of morphology-particularly tooth size and enamel thickness-than of underlying mechanical properties.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2012 journal article
The mechanical properties of maximum ingested bite size
American Journal of Physical Anthropology, 147, 161. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300498700358&KeyUID=WOS:000300498700358
Contributors: A. Hartstone-Rose , T. Criste, K. Macneill, N. Yasika, L. Passmore & J. Perry
Source: ORCID
Added: September 12, 2019
2012 journal article
The clavicles of Smilodon fatalis and Panthera atrox (mammalia: Felidae) from Rancho La Brea, Los Angeles, California
Journal of Morphology, 273(9), 981–991.
Contributors: A. Hartstone-Rose* , R. Long, A. Farrell & C. Shaw
author keywords: Smilodon fatalis; Panthera atrox; Felidae; clavicle; functional morphology; pectoral girdle
MeSH headings : Acinonyx / genetics; Animals; California; Clavicle / anatomy & histology; Felidae / anatomy & histology; Felidae / classification; Felidae / genetics; Fossils; Lions / anatomy & histology; Lions / classification; Lions / genetics; Los Angeles; Phylogeny; Skeleton
TL;DR:
This study includes a reevaluation of clavicles that have been previously assigned to S. fatalis, which are more likely to be those of Panthera atrox, and the description of pantherine catClavicles, and reports distinctive morphology of the clavicle morph of Acinonyx jubatus.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2012 journal article
METHODS FOR ESTIMATING CHEWING MUSCLE SIZE, BITE FORCE AND GAPE IN FOSSIL PRIMATES
Journal of Vertebrate Paleontology, 32, 156. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000313496400459&KeyUID=WOS:000313496400459
Contributors: J. Perry, K. MacNeill, A. Heckler & A. Hartstone-Rose
Source: ORCID
Added: September 12, 2019
2012 book
Body size in African Middle Pleistocene Homo
In African Genesis: Perspectives on Hominin Evolution (Vol. 62, pp. 319–346). http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BCI&KeyUT=BCI:BCI201400137813&KeyUID=BCI:BCI201400137813
Contributors: S. Churchill, L. Berger, A. Hartstone-Rose , B. Zondo, S. Reynolds & A. Gallagher
Source: ORCID
Added: September 12, 2019
2012 journal article
Bite Force Estimation and the Fiber Architecture of Felid Masticatory Muscles
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 295(8), 1336–1351.
Contributors: A. Hartstone-Rose* , J. Perry* & C. Morrow*
author keywords: Felidae; bite force; fiber length; physiological cross-sectional area; mastication; muscle architecture
MeSH headings : Animals; Biomechanical Phenomena; Bite Force; Body Size; Diet; Felidae / anatomy & histology; Felidae / classification; Jaw / anatomy & histology; Jaw / physiology; Masticatory Muscles / anatomy & histology; Masticatory Muscles / physiology
TL;DR:
Though the mechanical properties of felid diets are relatively similar across species, the most durophagous species in the sample appears to have relatively higher force production capabilities, and the relationship between FL and relative prey size suggests an adaptive signal related to gape.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 12, 2019
2012 journal article
Anthropoids take smaller bites than strepsirrhines
American Journal of Physical Anthropology, 147, 235–236. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300498701068&KeyUID=WOS:000300498701068
Contributors: J. Perry, A. Hartstone-Rose & M. Bastian
Source: ORCID
Added: September 12, 2019
2012 journal article
Neonatal Bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus
NeuroToxicology, 33(1), 23–36.
author keywords: Kisspeptin; Estrogen receptor; Sexual differentiation; Development; Brain; Endocrine disruption
MeSH headings : Age Factors; Analysis of Variance; Animals; Animals, Newborn; Benzhydryl Compounds; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Estrogens, Non-Steroidal / pharmacology; Female; Gene Expression Regulation, Developmental / drug effects; Hypothalamus / drug effects; Hypothalamus / growth & development; Hypothalamus / metabolism; Kisspeptins / genetics; Kisspeptins / metabolism; Male; Phenols / pharmacology; RNA, Messenger / metabolism; Rats; Rats, Long-Evans; Sex Characteristics
TL;DR:
Results show that neonatal hypothalamic ER and Kiss1 expression is sensitive to BPA exposure, and discordant effects of EB and BPA indicate that BPA likely disrupts hypothalamic organization by a mechanism other than simply acting as an estrogen mimic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Crossref, ORCID
Added: August 18, 2019
2012 journal article
Influence of ERβ selective agonism during the neonatal period on the sexual differentiation of the rat hypothalamic-pituitary-gonadal (HPG) axis
Biology of Sex Differences, 3(1), 2.
TL;DR:
The results indicate that selective agonism of ERβ is not sufficient to completely achieve male-typical HPG organization observed with EB or an ERα agonist.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: August 18, 2019
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