Works Published in 2013
Displaying works 101 - 120 of 230 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2013 journal article
Perspectives on validation of high-throughput assays supporting 21st century toxicity testing.
Altex, 30(1), 51–66. http://europepmc.org/abstract/med/23338806
Contributors: R. Judson, R. Kavlock, M. Martin, D. Reif , K. Houck, T. Knudsen, A. Richard, R. Tice
Source: ORCID
Added: May 14, 2019
2013 journal article
In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis.
Toxicological Sciences, 131(1), 40–55.
Contributors: N. Kleinstreuer *, D. Dix*, K. Houck *, R. Kavlock*, T. Knudsen *, M. Martin*, K. Paul*, D. Reif*
author keywords: cancer hallmarks; carcinogenesis; predictive toxicology; in vitro and alternatives; bioinformatics
MeSH headings : Animals; Biomarkers, Tumor / analysis; Biomarkers, Tumor / genetics; Carcinogenicity Tests; Carcinogens / chemistry; Carcinogens / toxicity; Databases, Factual; Endpoint Determination; High-Throughput Screening Assays; In Vitro Techniques; Mice; Neoplasms / chemically induced; Neoplasms / genetics; Predictive Value of Tests; Rats; Species Specificity; Thyroid Neoplasms / chemically induced; Thyroid Neoplasms / genetics
TL;DR:
A model was developed in which genes/pathways function as hypothetical enhancers or promoters of rat thyroid tumors, acting secondary to the key initiating event of thyroid hormone disruption, which represents a chemical carcinogenicity prioritization tool supporting targeted testing and functional validation of cancer pathways.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2013 journal article
Decision tree-based method for integrating gene expression, demographic, and clinical data to determine disease endotypes.
BMC Systems Biology, 7, 119.
Contributors: C. Williams-DeVane *, D. Reif* , E. Cohen Hubal*, P. Bushel*, E. Hudgens*, J. Gallagher*, S. Edwards*
author keywords: Asthma; Endotypes; Gene Expression; Integrated analysis
MeSH headings : Adolescent; Asthma / blood; Asthma / genetics; Child; Cluster Analysis; Computational Biology / methods; Decision Trees; Demography; Gene Expression Profiling; Genome-Wide Association Study; Humans
TL;DR:
A multi-step decision tree-based method is described for defining endotypes based on gene expression, clinical covariates, and disease indicators using childhood asthma as a case study and it gives the best segregation of asthmatics and non-asthmatics.
(via Semantic Scholar)
bmcsystbiol.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2013 journal article
Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer’s disease from normal cognitive aging
Acta Neuropathologica Communications, 1(1), 28.
author keywords: Alzheimer's disease; Dementias; Metabolomics; Cerebrospinal fluid biomarkers; Stepwise logistic regression
MeSH headings : Aged; Aging / cerebrospinal fluid; Aging / drug effects; Aging / pathology; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / diagnosis; Alzheimer Disease / drug therapy; Alzheimer Disease / pathology; Amyloid beta-Peptides / cerebrospinal fluid; Area Under Curve; Biomarkers / cerebrospinal fluid; Chromatography, Liquid; Cognition; Diagnosis, Differential; Female; Gas Chromatography-Mass Spectrometry; Humans; Logistic Models; Male; Metabolomics / methods; Neuropsychological Tests; tau Proteins / cerebrospinal fluid
TL;DR:
Several CSF small-molecule metabolites that discriminated especially well between clinically diagnosed AD and control groups appear to be suitable for further confirmatory and validation studies, and show the potential to provide predictive performance for AD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2013 article
ToxCast: Predicting Toxicity Potential Through High-Throughput Bioactivity Profiling
Houck, K. A., Richard, A. M., Judson, R. S., Martin, M. T., Reif, D. M., & Shah, I. (2013, February). High-Throughput Screening Methods in Toxicity Testing, Vol. 2, p. 1â31.
Contributors: K. Houck *, A. Richard *, R. Judson *, M. Martin*, D. Reif* & I. Shah *
Source: ORCID
Added: May 14, 2019
2013 journal article
Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays
Chem. Res. Toxicol., 26(6), 878â895.
Contributors: N. Sipes *, M. Martin*, P. Kothiya *, D. Reif* , R. Judson *, A. Richard *, K. Houck *, D. Dix*, R. Kavlock*, T. Knudsen *
MeSH headings : Animals; Enzymes / metabolism; Guinea Pigs; High-Throughput Screening Assays; Humans; Membrane Transport Proteins / metabolism; Organic Chemicals / toxicity; Rats; Receptors, G-Protein-Coupled / antagonists & inhibitors; Receptors, G-Protein-Coupled / metabolism; Signal Transduction / drug effects
TL;DR:
Analyzes 976 chemicals in Phases I and II of the U.S. EPA’s ToxCast project across 331 cell-free enzymatic and ligand-binding high-throughput screening (HTS) assays to find novel findings for previously unreported chemical–target combinations clustered with known chemical– target interactions.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2013 journal article
Meta-analysis of toxicity and teratogenicity of 133 chemicals from zebrafish developmental toxicity studies.
Reproductive Toxicology, 41, 98–108.
Contributors: N. Ducharme*, L. Peterson*, E. Benfenati *, D. Reif* , C. McCollum*, J. Gustafsson *, M. Bondesson *
author keywords: Developmental toxicity; Zebrafish; ToxPi; Teratogen; Meta-analysis
MeSH headings : 1-Octanol / chemistry; Animals; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / drug effects; Teratogens / chemistry; Teratogens / toxicity; Toxicity Tests; Water / chemistry; Zebrafish
TL;DR:
It was found that the physical properties of chemicals did not fully predict lethality or developmental outcomes, and individual outcomes such as pericardial edema and yolk sac edema were more reliable indicators of developmental toxicity.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2013 journal article
High-throughput models for exposure-based chemical prioritization in the ExpoCast project.
Environmental Science and Technology, 47(15), 8479–8488.
Contributors: J. Wambaugh *, R. Setzer*, D. Reif* , S. Gangwal*, J. Mitchell-Blackwood*, J. Arnot *, O. Joliet*, A. Frame*
MeSH headings : Environmental Exposure; Environmental Pollutants / classification; Models, Theoretical
TL;DR:
An analysis was conducted that predicts human exposure potential for chemicals and estimates uncertainty in these predictions by comparison to biomonitoring data, and a framework for high-throughput exposure assessment is proposed.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2013 journal article
Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate.
Toxicological Sciences, 136(2), 308–327.
Contributors: J. Wambaugh *, R. Setzer*, A. Pitruzzello*, J. Liu *, D. Reif* , N. Kleinstreuer *, N. Wang*, N. Sipes *
author keywords: perfluorooctanoate; perfluorooctanoic acid; perfluorooctanesulfonate; perfluorooctanesulfonic acid; compartment model; saturable resorption model; pharmacokinetics; statistical analysis; Bayesian analysis; ToxCast; in vitro-in vivo extrapolation
MeSH headings : Alkanesulfonic Acids / pharmacokinetics; Alkanesulfonic Acids / toxicity; Animals; Caprylates / pharmacokinetics; Caprylates / toxicity; Dose-Response Relationship, Drug; Female; Fluorocarbons / pharmacokinetics; Fluorocarbons / toxicity; In Vitro Techniques; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley
TL;DR:
In vitro assay results for PFOA and PFOS from EPA's ToxCast project were examined and it was found that most in vitro bioactivity occurs at concentrations lower than the predicted concentrations for the in vivo LOELs and higher than the expected concentrations forthe in vivo NOELs, for a variety of nonimmunological effects.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2013 journal article
A Computational Model Predicting Disruption of Blood Vessel Development
PLoS Comput Biol, 9(4), e1002996.
Contributors: N. Kleinstreuer *, D. Dix*, M. Rountree*, N. Baker *, N. Sipes *, D. Reif* , R. Spencer*, T. Knudsen *
Ed(s): S. Peirce
MeSH headings : Algorithms; Animals; Blood Vessels / embryology; Chemokines / metabolism; Chemotaxis; Computer Simulation; Endothelial Cells / cytology; Endothelium, Vascular / pathology; Humans; Inflammation; Models, Theoretical; Neovascularization, Physiologic; Phenotype; Signal Transduction; Software; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
The model was shown to recapitulate stereotypical capillary plexus formation and structural emergence of non-coded cellular behaviors, such as a heterologous bridging phenomenon linking endothelial tip cells together during formation of polygonal endothelial cords, which support the utility of cell agent-based models for simulating a morphogenetic series of events and for the first time demonstrate the applicability of these models for predictive toxicology.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2013 journal article
Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity
EPIGENETICS, 8(11), 1128–1132.
author keywords: neurodevelopmental toxicity; bisphenol A; chloride shift; KCC2; SLC12A5
MeSH headings : Air Pollutants, Occupational / adverse effects; Animals; Benzhydryl Compounds / adverse effects; Cerebral Cortex / metabolism; Chlorides / metabolism; Epigenesis, Genetic / drug effects; Female; Humans; Male; Nerve Tissue Proteins / metabolism; Neurons / metabolism; Phenols / adverse effects; Response Elements; Symporters / biosynthesis
TL;DR:
This commentary highlights recent discoveries in the arena of research at the interface of environmental toxicology and developmental neuroscience relating to toxicity mechanisms of bisphenol A, including the discovery that BPA disrupts the chloride shift in a sex-specific manner by recruiting epigenetics mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
USE OF RECONSTITUTED WATERS TO EVALUATE EFFECTS OF ELEVATED MAJOR IONS ASSOCIATED WITH MOUNTAINTOP COAL MINING ON FRESHWATER INVERTEBRATES
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 32(12), 2826–2835.
author keywords: Invertebrate toxicology; Mussels; Mayfly; Major ion toxicity
MeSH headings : Amphipoda / drug effects; Animals; Appalachian Region; Bicarbonates / toxicity; Chlorides / toxicity; Cladocera / drug effects; Coal Mining; Insecta / drug effects; Ions; Metals, Alkali / toxicity; Metals, Alkaline Earth / toxicity; Rivers; Sulfates / toxicity; Toxicity Tests, Chronic; Unionidae / drug effects; Water Pollutants, Chemical / toxicity
TL;DR:
Results indicate that, although elevated TDS can be correlated with toxicity, the specific major ion composition of the water is important and the choice of test organism is critical, particularly if a test species is to be used as a surrogate for a range of faunal groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Research tools to investigate movements, migrations, and life history of sturgeons (Acipenseridae), with an emphasis on marine-oriented populations
PLoS One, 8(8), e71552.
Source: NC State University Libraries
Added: August 6, 2018
2013 review
Intracolony vibroacoustic communication in social insects
[Review of ]. INSECTES SOCIAUX, 60(4), 403–417.
author keywords: Ants; Apis; Behavior; Johnston's organ; Polistes; Social bees; Social wasps; Subgenual organ; Stridulation; Substrate vibration; Termites; Waggle dance
TL;DR:
This review describes the modalities and their behavioral contexts rather than electrophysiological aspects, therefore placing emphasis on the adaptive roles of vibroacoustic communication.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Immunohistochemical characterization of the hepatic progenitor cell compartment in medaka (oryzias latipes) following hepatic injury
Journal of Comparative Pathology, 149(4), 434–445.
MeSH headings : Animals; Animals, Genetically Modified; Cell Differentiation / physiology; Disease Models, Animal; Female; Hepatocytes / cytology; Hepatocytes / ultrastructure; Immunohistochemistry; Liver / injuries; Liver Regeneration / physiology; Male; Microscopy, Electron, Transmission; Oryzias; Stem Cells / cytology; Stem Cells / ultrastructure
TL;DR:
The present study defines the process of OC differentiation in fish liver using histopathology, immunohistochemistry and transmission electron microscopy and confirms the presence of, and support the putative bipotential lineage capabilities of, the fish OC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Identification of a Novel Polymorphism in X-Linked Sterol-4-Alpha-Carboxylate 3-Dehydrogenase (Nsdhl) Associated with Reduced High-Density Lipoprotein Cholesterol Levels in I/LnJ Mice
G3-GENES GENOMES GENETICS, 3(10), 1819–1825.
author keywords: QTL; genomics; HDL cholesterol; Nsdhl
MeSH headings : 3-Hydroxysteroid Dehydrogenases / genetics; Animals; Animals, Inbred Strains; Apolipoprotein A-II / genetics; Cholesterol, HDL / blood; Cholesterol, HDL / genetics; Genetic Linkage; Lipid Metabolism / genetics; Mice; Polymorphism, Single Nucleotide; Quantitative Trait Loci; X Chromosome / genetics
TL;DR:
There are additional genes left to be identified that control lipid levels and that can provide new pharmaceutical targets, including sterol-4-alpha-carboxylate 3-dehydrogenase in the cholesterol synthesis pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Effects of environmental endocrine disruptors and phytoestrogens on the Kisspeptin system
Kisspeptin Signaling in Reproductive Biology, 784, 455–479.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Use of the robust design to estimate seasonal abundance and demographic parameters of a coastal bottlenose dolphin (Tursiops aduncus) population
PLoS One, 8(10).
Source: NC State University Libraries
Added: August 6, 2018
2013 conference paper
The dynamics of alternative pathways to compensatory substitution
BMC Bioinformatics, 14.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Signals of historical interlocus gene conversion in human segmental duplications
PLoS One, 8(10).
Source: NC State University Libraries
Added: August 6, 2018
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