Works Published in 2005
Displaying works 1 - 20 of 133 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2005 journal article
Identification of Cyclic AMP-Regulated Genes in Mycobacterium tuberculosis Complex Bacteria under Low-Oxygen Conditions
Journal of Bacteriology, 187(8), 2681–2692.
europepmc.org (repository)
Source: ORCID
Added: April 3, 2024
2005 journal article
Conditional expression of the mutant Ki- rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model
Carcinogenesis, 26(12), 2196–2206.
MeSH headings : Adenoma / etiology; Adenoma / metabolism; Adenoma / pathology; Alleles; Animals; Bronchi; Cell Transformation, Neoplastic; Doxycycline / pharmacology; Genes, ras / genetics; Genes, ras / physiology; Humans; Hyperplasia / etiology; Hyperplasia / metabolism; Hyperplasia / pathology; Intracellular Signaling Peptides and Proteins; Lung Neoplasms / etiology; Lung Neoplasms / metabolism; Lung Neoplasms / pathology; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3 / metabolism; Mutation / genetics; Phosphorylation; Protein Serine-Threonine Kinases / metabolism; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Ribosomal Protein S6 Kinases, 90-kDa / metabolism; Signal Transduction; Tumor Cells, Cultured; p38 Mitogen-Activated Protein Kinases / metabolism; ral GTP-Binding Proteins
TL;DR:
A novel mouse lung tumor model demonstrating benign tumor development in the absence of tumor progression is described, which will provide a new tool for understanding the early stages of lung tumor pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 2, 2023
2005 report
Understanding the Agricultural Health Study. An accredited online course for private pesticide applicator certification training in North Carolina
Raleigh, NC: North Carolina State University Cooperative Extension Service and North Carolina Department of Agriculture & Consumer Services.
Source: NC State University Libraries
Added: September 23, 2022
2005 report
Pesticide Related Illness and Health Issues
[Online course]. Greenville, NC: Eastern Area Health Education Center, Office of Continuing Medical Education, Brody School of Medicine, East Carolina University.
Source: NC State University Libraries
Added: September 23, 2022
2005 journal article
2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Induces Organ- Specific Differential Gene Expression in Male Japanese Medaka (Oryzias latipes)
Toxicological Sciences, 85(1), 572–584.
author keywords: Japanese medaka; TCDD; gene expression; brain; liver; testis
MeSH headings : Animals; Brain / drug effects; Brain / metabolism; Brain / pathology; Environmental Pollutants / toxicity; Gene Expression / drug effects; Gene Expression Profiling; Injections, Intraperitoneal; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Oligonucleotide Array Sequence Analysis; Organ Specificity; Oryzias / genetics; Polychlorinated Dibenzodioxins / toxicity; Reverse Transcriptase Polymerase Chain Reaction; Testis / drug effects; Testis / metabolism; Testis / pathology
TL;DR:
In this study, suppression subtractive hybridization was exploited as a screening tool to assess qualitative gene expression changes in whole brain, liver, and testis of adult male Japanese medaka exposed for 48 h to a single intraperitoneal-injected dose of TCDD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 15, 2022
2005 journal article
Measures of human population structure show heterogeneity among genomic regions
Genome Research, 15(11), 1468–1476.
MeSH headings : Chromosomes, Human / genetics; Ethnicity / genetics; Genetic Heterogeneity; Genetics, Population; Genome, Human / genetics; Genomics / methods; Haplotypes / genetics; Humans; Linkage Disequilibrium / genetics; Polymorphism, Single Nucleotide / genetics; United States
TL;DR:
Estimates of genetic population structure (F(ST) were constructed from all autosomes in two large SNP data sets, and it is shown that individual-marker estimates are too variable to be useful.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: March 5, 2021
2005 journal article
Rapid estrogenic regulation of extracellular signal-regulated kinase 1/2 signaling in cerebellar granule cells involves a G protein- and protein kinase A-dependent mechanism and intracellular activation of protein phosphatase 2A
Endocrinology, 146(12), 5397–5406.
Contributors: S. Belcher* , H. Le*, L. Spurling* & J. Wong*
MeSH headings : Animals; Cells, Cultured; Cerebellum / cytology; Cerebellum / metabolism; Cyclic AMP-Dependent Protein Kinases / physiology; Enzyme Activation / physiology; Estradiol / pharmacology; Estrogens / physiology; Extracellular Signal-Regulated MAP Kinases / metabolism; Female; GTP-Binding Proteins / physiology; Intracellular Membranes / enzymology; Male; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3 / metabolism; Neurons / metabolism; Pertussis Toxin / pharmacology; Phosphoprotein Phosphatases / metabolism; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Signal Transduction / drug effects; Signal Transduction / physiology; Time Factors
TL;DR:
The presented evidence indicates that the rapid effects of estrogens on ERK signaling in cerebellar granule cells are induced through a novel G protein-coupled receptor mechanism that requires PKA and Src-kinase activity to link E(2) to the ERK/MAPK signaling module.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2005 journal article
Ontogeny of rapid estrogen-mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: Potent nongenomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A
Endocrinology, 146(12), 5388–5396.
Contributors: A. Zsarnovszky*, H. Le*, H. Wang* & S. Belcher*
MeSH headings : Aging / metabolism; Animals; Animals, Newborn; Benzhydryl Compounds; Cerebellar Cortex / enzymology; Dose-Response Relationship, Drug; Drug Combinations; Endocrine System / drug effects; Estradiol / administration & dosage; Estradiol / pharmacology; Estrogens, Non-Steroidal / administration & dosage; Estrogens, Non-Steroidal / pharmacology; Extracellular Signal-Regulated MAP Kinases / metabolism; Female; Immunohistochemistry; Male; Phenols / administration & dosage; Phenols / pharmacology; Rats; Rats, Sprague-Dawley; Signal Transduction / drug effects
TL;DR:
It is shown that ERK1/2 signaling in the cerebellum of neonatal and mature rats was rapidly responsive to E(2) and during development to the environmental estrogen bisphenol A (BPA) and the ability of BPA to act as a highly potent E( 2) mimetic and to also disrupt the rapid actions of E(3) at very low concentrations during cerebellar development highlights the potential low-dose impact of xenoestrogens on the developing
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2005 journal article
Measures of human population structure show heterogeneity among genomic regions
Genome Res, 15(11), 1468–1476.
Source: ORCID
Added: January 25, 2021
2005 journal article
Impact of urine preservation methods and duration of storage on measured levels of environmental contaminants
Journal of Exposure Science & Environmental Epidemiology, 16(1), 39–48.
author keywords: sample storage and shipment; cohort studies; analytical chemistry; urine
MeSH headings : Environmental Exposure; Environmental Pollutants / urine; Humans; Mass Spectrometry; Reproducibility of Results; Specimen Handling; Temperature; Time Factors; Urinalysis / methods
TL;DR:
In general, most analytes were stable under all conditions with changes in mean concentration over time, temperature, and preservative being generally less than 20%, with the exception of the OP metabolites in the presence of boric acid.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
2005 journal article
Analysis of the RELN gene as a genetic risk factor for autism
Molecular Psychiatry, 10(6), 563–571.
author keywords: autism; candidate gene; chromosome 7q; RELN; association
MeSH headings : 5' Untranslated Regions / genetics; Autistic Disorder / genetics; Cell Adhesion Molecules, Neuronal / genetics; Chromosomes, Human, Pair 7 / genetics; Extracellular Matrix Proteins / genetics; Female; Genetic Predisposition to Disease / genetics; Genotype; Humans; Infant; Linkage Disequilibrium; Male; Nerve Tissue Proteins / genetics; Pedigree; Polymorphism, Single Nucleotide / genetics; Reelin Protein; Serine Endopeptidases / genetics; White People / genetics
TL;DR:
Combined analyses show the potential of RELN as an important contributor to genetic risk in autism and test for association of single-locus markers and multilocus haplotypes with autism.
(via Semantic Scholar)
Source: Crossref
Added: November 2, 2020
2005 conference paper
One pretty amazing T.rex : A presentation for "100 years of tyrannosaurus rex
(K. Carpenter & P. Larson, Eds.).
Ed(s): K. Carpenter & P. Larson
Event: 100 years of Tyrannosaurus rex symposium at Black Hills Museum of Natural History on June 10-11, 2005
Source: NC State University Libraries
Added: October 30, 2020
2005 journal article
Feasibility of using subject-collected dust samples in epidemiological and clinical studies of indoor allergens
Journal of Allergy and Clinical Immunology, 115(2), S97.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 10, 2020
2005 journal article
Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery
American Journal of Kidney Diseases, 45(3), 519–530.
author keywords: acute renal failure (ARF); polymorphism; genetic; postoperative; intensive care; cardiopulmonary bypass (CPB); heart surgery; cardiac surgery; human; angiotensin-converting enzyme (ACE); associate study; candidate genes
MeSH headings : Acute Kidney Injury / blood; Acute Kidney Injury / epidemiology; Acute Kidney Injury / ethnology; Acute Kidney Injury / genetics; Black or African American / genetics; Aged; Alleles; Angiotensins / genetics; Apolipoproteins E / genetics; Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / surgery; Coronary Artery Bypass; Creatinine / blood; Cytokines / genetics; DNA Mutational Analysis; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase Type III; North Carolina / epidemiology; Polymorphism, Genetic; Postoperative Complications / epidemiology; Prospective Studies; Pulmonary Disease, Chronic Obstructive / epidemiology; Receptor, Angiotensin, Type 1 / genetics; Risk; White People / genetics
TL;DR:
It is identified that genetic polymorphisms that collectively provide 2- to 4-fold improvement over preoperative clinical factors alone in explaining post-cardiac surgery renal dysfunction are associated with increased renal inflammatory and/or vasoconstrictor responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 5, 2020
2005 journal article
Genetic Polymorphisms and the Risk of Stroke After Cardiac Surgery
Stroke, 36(9), 1854–1858.
author keywords: cardiac surgical procedures; C-reactive protein; interleukin-6; polymorphism; stroke
MeSH headings : Aged; Alleles; C-Reactive Protein / genetics; Cardiopulmonary Bypass; Female; Genetic Predisposition to Disease; Genetic Variation; Humans; Inflammation; Interleukin-6 / genetics; Male; Middle Aged; Models, Genetic; Multivariate Analysis; Mutation; Odds Ratio; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Postoperative Complications; Risk; Sex Factors; Stroke / genetics; Thoracic Surgery
TL;DR:
It is demonstrated that common genetic variants of CRP (3′UTR 1846C/T) and IL-6 (−174G/C) are significantly associated with the risk of stroke after cardiac surgery, suggesting a pivotal role of inflammation in post–cardiac surgery stroke.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 5, 2020
2005 journal article
Commonalities in Metabolism of Arsenicals
Environmental Chemistry, 2(3), 161.
author keywords: arsenic; bioavailability; contaminant uptake; metabolism-affecting agents
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2005 journal article
Metabolism and toxicity of arsenic in human urothelial cells expressing rat arsenic (+3 oxidation state)-methyltransferase
Toxicology and Applied Pharmacology, 207(2), 147–159.
author keywords: As; methyltransferase; AS3MT; metabolism; toxicity; urinary bladder; human
MeSH headings : Animals; Arsenic / metabolism; Arsenic / toxicity; Cell Line; Cell Survival / drug effects; Methylation; Methyltransferases / physiology; Rats; Urinary Bladder / drug effects; Urinary Bladder / metabolism
TL;DR:
The resistance of UROtsa/F35 cells to moderate concentrations of MAs(III) was linked to its rapid conversion to DMAs and efflux of DMAs, which is a key factor contributing to the toxicity of acute iAs exposures in methylating cells.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype
Toxicology and Applied Pharmacology, 204(2), 164–169.
author keywords: arsenic; inorganic arsenic; oxidation state
MeSH headings : Animals; Arsenic / metabolism; Base Sequence / genetics; Chromosomes, Human, Pair 8 / genetics; Cysteine / chemistry; Cysteine / genetics; Evolution, Molecular; Gene Deletion; Gene Expression Profiling / methods; Genotype; Humans; Methylation; Methyltransferases / genetics; Methyltransferases / metabolism; Mice; Models, Molecular; Molecular Sequence Data; Oxidation-Reduction; Pan troglodytes / genetics; Pan troglodytes / metabolism; Phenotype; Rats; Species Specificity; Time Factors
TL;DR:
The null phenotype for inorganic arsenic methylation in the chimpanzee is likely due to the deletion in the gene for arsenic (+3 oxidation state) methyltransferase that yields an inactive truncated protein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2005 journal article
A previously uncharacterized role for estrogen receptor : Defeminization of male brain and behavior
Proceedings of the National Academy of Sciences, 102(12), 4608–4612.
author keywords: developmental neurobiology; neuroendocrinology; sexual differentiation
MeSH headings : Animals; Brain / physiology; Estrogen Receptor beta / deficiency; Estrogen Receptor beta / genetics; Estrogen Receptor beta / physiology; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Neurological; Orchiectomy; Sex Characteristics; Sexual Behavior, Animal / physiology; Smell / physiology; Testis / physiology
TL;DR:
It is hypothesized that ERbeta is involved in defeminization of brain and behavior, and this aspect of ERbeta function may lead to developments in the understanding of neural-based sexually dimorphic human behaviors.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
Effects of galanin-like peptide (GALP) on locomotion, reproduction, and body weight in female and male mice
Hormones and Behavior, 48(2), 141–151.
author keywords: sexual behavior; energy balance; motor control; coordination; exploration; luteinizing hormone; gonadotropin-releasing hormone
MeSH headings : Animals; Body Weight / drug effects; Energy Metabolism / drug effects; Female; Galanin-Like Peptide / pharmacology; Gonadotropin-Releasing Hormone / physiology; Injections, Intraventricular; Luteinizing Hormone / blood; Male; Mice; Mice, Inbred C57BL; Motor Activity / drug effects; Ovariectomy; Postural Balance / drug effects; Reproduction / drug effects; Sexual Behavior, Animal / drug effects; Stereotaxic Techniques
TL;DR:
Data indicate that in female mice, GALP stimulates LH release via GnRH, and decreases body weight, motor control, and locomotor activity via Gn RH-independent pathways, and species-specific differences in the mechanism and/or location of GALp action in the brains of rats and mice are suggested.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
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