Statistical Genetics & Bioinformatics

Works Published in 2006

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Displaying all 5 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2006 conference paper

Three-dimensional tomosynthesis reconstruction from 1D and 2D X-ray source arrays

2006 ieee nuclear science symposium conference record, vol 1-6, 1670–1673.

By: D. Lalush n, R. Rajaram n, E. Quan n, J. Zhang n, J. Lu n & O. Zhou n

TL;DR: In a tomosynthesis system such as that described here, a 2D source array will outperform a 1D array in terms of contrast-to-noise and resolution, while also increasing the usable field-of-view, and that further studies encompassing the effects of scatter will be needed to optimize such systems. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2006 conference paper

A faster ordered-subset convex algorithm for iterative reconstruction

2006 ieee nuclear science symposium conference record, vol 1-6, 3424–3427.

By: E. Quan n & D. Lalush n

TL;DR: A faster iterative reconstruction algorithm based on the ordered-subset convex (OSC) algorithm for transmission CT, modified such that it calculates the normalization term before the iterative process in order to save computational cost. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Dependence among sites in RNA evolution

MOLECULAR BIOLOGY AND EVOLUTION, 23(8), 1525–1537.

author keywords: RNA secondary structure; dependence among sites; substitution rate
MeSH headings : Animals; Computer Simulation; Evolution, Molecular; Markov Chains; Nucleic Acid Conformation; Phylogeny; RNA / chemistry; RNA / genetics; RNA, Ribosomal / chemistry; RNA, Ribosomal / genetics; Sequence Analysis, RNA
TL;DR: An evolutionary model and a Bayesian inference procedure that are aimed at filling the gap in probabilistic models of genotype evolution are proposed and potential applications, including improved ancestral sequence inference and location of functionally interesting sites, are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B

CANCER RESEARCH, 66(20), 10179–10187.

By: A. Cranston*, C. Carniti*, K. Oakhill*, E. Radzio-Andzelm*, E. Stone n, A. McCallion*, S. Hodgson*, S. Clarke* ...

MeSH headings : Amino Acid Sequence; Base Sequence; Binding Sites; Cell Transformation, Neoplastic / genetics; Enzyme Activation; Female; Humans; Middle Aged; Models, Molecular; Molecular Sequence Data; Multiple Endocrine Neoplasia Type 2b / enzymology; Multiple Endocrine Neoplasia Type 2b / genetics; Mutation; Pedigree; Protein Conformation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-ret / chemistry; Proto-Oncogene Proteins c-ret / genetics; Proto-Oncogene Proteins c-ret / metabolism; Sequence Alignment; Sequence Homology, Amino Acid
TL;DR: It is predicted that RET804 constitutes a critical gatekeeper residue that, when mutated in combination with RET805, induces a conformational change in the hinge region that locks the active site in a position permissive for ATP hydrolysis. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Testing for spatial clustering of amino acid replacements within protein tertiary structure

JOURNAL OF MOLECULAR EVOLUTION, 62(6), 682–692.

author keywords: protein tertiary structure; protein evolution; spatial clustering
MeSH headings : Amino Acid Substitution; Cluster Analysis; Evolution, Molecular; Protein Structure, Tertiary; Statistics, Nonparametric
TL;DR: Two simple and not very parametric hypothesis tests are introduced that help distinguish three possibilities of spatial clustering of amino acid replacements during evolution and these findings need to be reconciled with the common practice of basing evolutionary inferences on models that assume independent change among sites. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

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