Works Published in 2011
Displaying all 15 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Pharmacogenomic characterization of US FDA-approved cytotoxic drugs
PHARMACOGENOMICS, 12(10), 1407–1415.
author keywords: cancer; cell line; chemotherapy; cytotoxicity; pharmacogenetics; pharmacogenomic; QTL
MeSH headings : Antineoplastic Agents / pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Approval; Genetic Linkage; Humans; Pharmacogenetics; Quantitative Trait Loci / genetics; United States; United States Food and Drug Administration
TL;DR:
The results of this systematic study highlight the variable role that genetics plays in response to cytotoxic drugs, and inform the prioritization of chemotherapeutic drugs with a sizable genetic response component for future investigation.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Microarray Analysis of Human Adipose-Derived Stem Cells in Three-Dimensional Collagen Culture: Osteogenesis Inhibits Bone Morphogenic Protein and Wnt Signaling Pathways, and Cyclic Tensile Strain Causes Upregulation of Proinflammatory Cytokine Regulators and Angiogenic Factors
TISSUE ENGINEERING PART A, 17(21-22), 2615–2627.
MeSH headings : Adipose Tissue / cytology; Adult; Angiogenesis Inducing Agents / metabolism; Bone Morphogenetic Proteins / genetics; Bone Morphogenetic Proteins / metabolism; Cells, Cultured; Collagen / metabolism; Cytokines / genetics; Cytokines / metabolism; Humans; Insulin-Like Growth Factor I / genetics; Middle Aged; Oligonucleotide Array Sequence Analysis / methods; Osteogenesis / genetics; Osteogenesis / physiology; Platelet-Derived Growth Factor / genetics; Signal Transduction / genetics; Signal Transduction / physiology; Stem Cells / cytology; Stem Cells / metabolism; Wnt Signaling Pathway / genetics; Wnt Signaling Pathway / physiology
TL;DR:
This first study to investigate the effects of both 3D culture and mechanical load on hASC osteogenic differentiation and response to mechanical stimuli identified specific genes and pathways associated with mechanical response and osteogenic potential of hASC, thus providing significant information toward improved understanding of its use for functional bone tissue engineering applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
The non-random clustering of non-synonymous substitutions and its relationship to evolutionary rate
BMC GENOMICS, 12.
MeSH headings : Amino Acid Sequence; Amino Acid Substitution; Animals; Cluster Analysis; Evolution, Molecular; Humans; Molecular Sequence Data; Proteins / chemistry; Proteins / genetics; Sequence Alignment
TL;DR:
It is shown that clustering is a non-redundant predictor of evolutionary rate, and it is speculated that conflicting signals of clustering and constraint may be indicative of a historical period of relaxed selection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Identification of RNA binding motif proteins essential for cardiovascular development
BMC DEVELOPMENTAL BIOLOGY, 11.
MeSH headings : Animals; Animals, Genetically Modified; Binding Sites; Cardiovascular System / embryology; Embryo, Nonmammalian / metabolism; Gene Expression Regulation, Developmental; Morphogenesis / genetics; RNA / metabolism; RNA-Binding Proteins / genetics; RNA-Binding Proteins / metabolism; Zebrafish / embryology; Zebrafish / genetics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
The functional data support the hypothesis that rbm24a and rBM24b are key developmental cardiac genes with unequal roles in cardiovascular formation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Genomic Profiling in CEPH Cell Lines Distinguishes between the Camptothecins and Indenoisoquinolines
MOLECULAR CANCER THERAPEUTICS, 10(10), 1839–1845.
MeSH headings : Antineoplastic Agents, Phytogenic / pharmacology; Camptothecin / pharmacology; Cell Line; Drug Evaluation, Preclinical / methods; Gene Expression Profiling; Genomics / methods; Humans; Isoquinolines / pharmacology; Oligonucleotide Array Sequence Analysis; Quantitative Trait Loci; Topoisomerase I Inhibitors / pharmacology
TL;DR:
In vitro sensitivity of the same panel of CEPH cell lines to the indenisoquinolones, a structurally distinct class of Top1 inhibitors, is characterized, revealing a pattern of 7 quantitative trait loci (QTL) shared by all of the camptothecins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Coordinated Genome-Wide Modifications within Proximal Promoter Cis-regulatory Elements during Vertebrate Evolution
GENOME BIOLOGY AND EVOLUTION, 3, 66–74.
author keywords: gene expression; transcriptional regulation; protein-DNA coevolution; cis-regulatory evolution
MeSH headings : Animals; Evolution, Molecular; Gene Expression; Genome; Humans; Mice; Models, Genetic; Models, Statistical; Phylogeny; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Transcriptional Activation; Vertebrates / genetics
TL;DR:
It is found that a surprisingly large number of cis-regulatory elements have been subject to coordinated genome-wide modifications during vertebrate evolution, such that the motif frequency changes on a single branch of vertebrate phylogeny.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Why the Phylogenetic Regression Appears Robust to Tree Misspecification
SYSTEMATIC BIOLOGY, 60(3), 245–260.
author keywords: Comparative method; independent contrasts; phylogenetic regression; robustness
MeSH headings : Animals; Biological Evolution; Computer Simulation; Linear Models; Models, Genetic; Phylogeny; Primates / classification
TL;DR:
This manuscript aims to elucidate how tree misspecification is propagated through a comparative analysis with a focus on the phylogenetic regression under a Brownian motion model of evolution and considers the effect of local phylogenetic perturbations on the regression fit.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
History Can Matter: Non-Markovian Behavior of Ancestral Lineages
SYSTEMATIC BIOLOGY, 60(3), 276–290.
author keywords: Ancestral lineage; ancestral process; Hill-Robertson effect; population genetics
MeSH headings : Computer Simulation; Evolution, Molecular; Genetic Fitness; Genetic Variation; Markov Chains; Models, Genetic; Polymorphism, Genetic; Selection, Genetic
TL;DR:
This work used the Wright-Fisher model of population genetics to simulate very many generations of mutation, natural selection, and genetic drift to show that the process by which a nonrecombining sequence changes over time can markedly deviate from the Markov assumption that is ubiquitous in molecular phylogenetics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Variation in genome-wide mutation rates within and between human families
Nature Genetics, 43(7), 712–137.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
The Effects of Weak Genetic Perturbations on the Transcriptome of the Wing Imaginal Disc and Its Association With Wing Shape in Drosophila melanogaster
GENETICS, 187(4), 1171–U314.
MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Insect; Genetic Variation; Genome, Insect; Genotype; Heterozygote; Linear Models; Multigene Family; Mutation; Phenotype; Transcriptional Activation; Wings, Animal / growth & development
TL;DR:
Weak mutational perturbations in genes affecting wing development in Drosophila melanogaster that influence wing shape relative to a co-isogenic wild type are used to examine overall patterns of covariation between phenotypic variables of interest and underlying aspects of gene activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees
PLoS One, 6(5).
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways
PLACENTA, 32(2), 175–182.
author keywords: Placenta; Preeclampsia; Maternal hypertension; Sialic acid acetylesterase
MeSH headings : Acetylesterase / biosynthesis; Antigens, CD / biosynthesis; Endoglin; Female; Genome-Wide Association Study; Humans; Infant, Newborn; Inhibins / biosynthesis; Male; Pre-Eclampsia / etiology; Pre-Eclampsia / metabolism; Pregnancy; Protein Array Analysis; Receptors, Cell Surface / biosynthesis; Trophoblasts / physiology; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1 / biosynthesis
TL;DR:
Evidence is found of preeclampsia-associated placental upregulation of sialic acid acetylesterase (SIAE), a gene functionally associated with autoimmune diseases, and changes in immune-associated signaling pathways, offering a potential upstream explanation for the shallow trophoblast invasion and inadequate uterine remodeling typically observed in pathogenesis of preeClampsia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Full-Spectrum CT Reconstruction Using a Weighted Least Squares Algorithm With an Energy-Axis Penalty
IEEE TRANSACTIONS ON MEDICAL IMAGING, 30(2), 173–183.
author keywords: Attenuation curve; cadmium zinc telluride (CZT) detectors; penalized weighted least squares (PWLS); X-ray computed tomography
MeSH headings : Algorithms; Cadmium; Image Processing, Computer-Assisted / methods; Least-Squares Analysis; Phantoms, Imaging; Reproducibility of Results; Tellurium; Tomography, X-Ray Computed / instrumentation; Tomography, X-Ray Computed / methods; Zinc
TL;DR:
This paper proposes a penalized weighted least squares (PWLS) algorithm for reconstruction of polychromatic energy-differentiated X-ray CT data and a unique experimental setup to take energy- differentiatedX-rayCT data, and concludes that this algorithm is an effective method for reconstructing energy-sensitive CT data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Efficient In Vivo Selection of a Novel Tumor-Associated Peptide from a Phage Display Library
MOLECULES, 16(1), 900–914.
author keywords: in vivo phage display; circulating bone marrow derived tumor homing cells; tumor-associated peptides; targeting neovascular growth; positron emission tomography (PET) imaging
MeSH headings : Amino Acid Sequence; Animals; Bacteriophages / genetics; Mice; Neoplasms, Experimental / genetics; Peptides / chemistry; Peptides / genetics; Peptides / isolation & purification
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
A population genetic approach to mapping neurological disorder genes using deep resequencing
PLoS Genetics, 7(2).
Source: NC State University Libraries
Added: August 6, 2018
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