Statistical Genetics & Bioinformatics

Works Published in 2012

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Displaying all 6 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2012 journal article

The interface of protein structure, protein biophysics, and molecular evolution

Protein Science, 21(6), 769–785.

By: D. Liberles*, S. Teichmann*, I. Bahar*, U. Bastolla*, J. Bloom*, E. Bornberg-Bauer*, L. Colwell*, A. de Koning* ...

author keywords: evolutionary modeling; domain evolution; sequence-structure-function relationships; protein dynamics; protein thermodynamics; gene duplication; protein expression; ancestral sequence reconstruction
MeSH headings : Amino Acid Sequence; Animals; Evolution, Molecular; Humans; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Folding; Proteins / chemistry; Proteins / genetics; RNA, Messenger / genetics; Sequence Alignment
TL;DR: The relationship between modeling and needed high‐throughput experimental data as well as experimental examination of protein evolution using ancestral sequence resurrection and in vitro biochemistry are presented, towards an aim of ultimately generating better models for biological inference and prediction. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2012 journal article

Age-specific variation in immune response in drosophila melanogaster has a genetic basis

Genetics, 191(3), 989–584.

By: T. Felix, K. Hughes, E. Stone, J. Drnevich & J. Leips

Source: NC State University Libraries
Added: August 6, 2018

2012 review

The interface of protein structure, protein biophysics, and molecular evolution

[Review of ]. Protein Science, 21(6), 769–785.

By: D. Liberles, S. Teichmann, I. Bahar, U. Bastolla, J. Bloom, E. Bornberg-Bauer, L. Colwell, A. Koning ...

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Effect of sexual recombination on population diversity in aflatoxin production by Aspergillus flavus and evidence for cryptic heterokaryosis

MOLECULAR ECOLOGY, 21(6), 1453–1476.

By: R. Olarte n, B. Horn*, J. Dorner*, J. Monacell n, R. Singh n, E. Stone n, I. Carbone n

author keywords: array comparative genome hybridization; biological control; heritability; multilocus sequence typing; non-Mendelian segregation; vegetative compatibility group
MeSH headings : Aflatoxins / biosynthesis; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Comparative Genomic Hybridization; Fungal Proteins / genetics; Genes, Mating Type, Fungal / genetics; Genetic Variation; Karyotyping; Molecular Sequence Data; Multigene Family; Recombination, Genetic; Sequence Analysis, DNA
TL;DR: Results from experimental matings indicate that sexual recombination is driving genetic and functional hyperdiversity in A. flavus, and have significant implications for managing AF contamination of crops and for improving biocontrol strategies using nonaflatoxigenic strains of A. Flavus. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Joint genotyping on the fly: Identifying variation among a sequenced panel of inbred lines

GENOME RESEARCH, 22(5), 966–974.

By: E. Stone n

MeSH headings : Algorithms; Animals; Chromosome Mapping; Computer Simulation; Drosophila melanogaster / genetics; Genetic Variation; Genotyping Techniques / standards; Inbreeding; Likelihood Functions; Models, Genetic; Polymorphism, Single Nucleotide; Reference Standards; Sequence Analysis, DNA
TL;DR: This work presents the Joint Genotyper for Inbred Lines (JGIL) as a method for obtaining genotypes and identifying variation among a large panel of inbred strains or lines, and illustrates how JGIL is robust to moderate levels of error. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Eigenvector decomposition of full-spectrum x-ray computed tomography

PHYSICS IN MEDICINE AND BIOLOGY, 57(5), 1309–1323.

MeSH headings : Absorption; Algorithms; Contrast Media / pharmacology; Humans; Image Processing, Computer-Assisted; Models, Statistical; Phantoms, Imaging; Photons; Radiographic Image Interpretation, Computer-Assisted / methods; Scattering, Radiation; Tomography, X-Ray Computed / methods; X-Rays
TL;DR: It is concluded that the noise–resolution trade off along the energy axis was significantly improved using the eigenvalue decomposition basis functions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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