Works Published in 2018
Displaying all 16 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Periconceptional maternal mediterranean diet is associated with favorable offspring behaviors and altered CpG methylation of imprinted genes
Frontiers in Cell and Developmental Biology, 6(SEP), 107.
Contributors: J. House n , M. Mendez*, R. Maguire n, S. Gonzalez-Nahm *, Z. Huang *, J. Daniels *, S. Murphy *, B. Fuemmeler *, F. Wright n, C. Hoyo n
TL;DR:
In this ethnically diverse cohort, maternal adherence to a Mediterranean diet in early pregnancy was associated with favorable neurobehavioral outcomes in early childhood and with sex-dependent methylation differences of MEG3, IGF2, and SGCE/PEG10 DMRs.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: January 21, 2019
2018 journal article
A Human Population-Based Organotypic In Vitro Model for Cardiotoxicity Screening
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 35(4), 441–452.
Contributors: F. Grimm*, A. Blanchette*, J. House n , K. Ferguson *, N. Hsieh *, C. Dalaijamts *, A. Wright*, B. Anson*
MeSH headings : Cardiotoxicity / genetics; Cardiovascular Agents / pharmacology; Cardiovascular Agents / toxicity; Cell Differentiation / drug effects; Cell Differentiation / genetics; Female; Healthy Volunteers; Humans; In Vitro Techniques; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / drug effects; Male; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Phenotype; Reproducibility of Results
TL;DR:
iPSC-derived cardiomyocytes exhibited reproducible donor-specific differences in baseline function and drug-induced effects, demonstrating the feasibility of using a panel of population-based organotypic cells from healthy donors as an animal replacement experimental model to quantify inter-individual variability in xenobiotic responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 10, 2018
2018 journal article
Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam
MeSH headings : Animals; Animals, Newborn / physiology; Diet, High-Fat; Female; Maternal Behavior / physiology; Maternal Exposure; Mice / physiology; Mice, Inbred C57BL; Pregnancy
TL;DR:
In utero exposure to HF diet programmes physiological changes in the offspring which influence the maternal behaviours of their dam after birth are suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: December 10, 2018
2018 journal article
C/EBP beta deletion in oncogenic Ras skin tumors is a synthetic lethal event
CELL DEATH & DISEASE, 9(11).
Contributors: Z. Messenger*, J. Hall*, D. Jima*, J. House* , H. Tam, D. Tokarz*, R. Smart
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / administration & dosage; Animals; Apoptosis / drug effects; Apoptosis / genetics; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / genetics; Cell Differentiation; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Gene Expression Regulation, Neoplastic; Genes, Lethal; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Mice; Mice, Knockout; Receptors, Death Domain / genetics; Receptors, Death Domain / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / administration & dosage; Tetradecanoylphorbol Acetate / analogs & derivatives; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism; ras Proteins / genetics; ras Proteins / metabolism
TL;DR:
The results show that oncogenic Ras tumors display a significant DNA damage/replicative stress phenotype and these tumors have acquired a dependence on C/EBPβ for their survival, making it a promising target for future potential anticancer therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 29, 2018
2018 journal article
Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip
SCIENTIFIC REPORTS, 8(1).
Contributors: C. Sakolish*, E. Weber*, E. Kelly *, J. Himmelfarb *, R. Mouneimne*, F. Grimm*, J. House n , T. Wade *
MeSH headings : Anti-Bacterial Agents / toxicity; Cell Culture Techniques / instrumentation; Cell Line; Cell Survival / drug effects; Drug Development / instrumentation; Drug Evaluation, Preclinical / instrumentation; Humans; Kidney Tubules, Proximal / cytology; Kidney Tubules, Proximal / drug effects; Kidney Tubules, Proximal / metabolism; Lab-On-A-Chip Devices; Polymyxin B / toxicity; Technology Transfer; Vitamin D / metabolism
TL;DR:
While the overall transferability of this advanced tissue chip platform was a success, the reproducibility with the original report was greatly dependent on the cell source, demonstrating critical importance of developing microphysiological platforms using renewable cell sources.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2018
2018 journal article
Polyphasic characterization of four soil-derived phenanthrene-degrading Acidovorax strains and proposal of Acidovorax carolinensis sp nov.
SYSTEMATIC AND APPLIED MICROBIOLOGY, 41(5), 460–472.
author keywords: Acidovorax; Phenanthrene; Polycyclic aromatic hydrocarbons
MeSH headings : Biodegradation, Environmental; Comamonadaceae / chemistry; Comamonadaceae / classification; Comamonadaceae / genetics; Comamonadaceae / physiology; DNA, Bacterial; Genes, Bacterial; Genome, Bacterial / genetics; Metabolic Networks and Pathways / genetics; North Carolina; Phenanthrenes / metabolism; Phylogeny; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Soil Microbiology; Soil Pollutants / metabolism
TL;DR:
Four bacterial strains identified as members of the Acidovorax genus were isolated from two geographically distinct but similarly contaminated soils in North Carolina, USA, characterized, and their genomes sequenced, indicating that they likely represent a single species within the genus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
no blokes Is Essential for Male Viability and X Chromosome Gene Expression in the Australian Sheep Blowfly
CURRENT BIOLOGY, 28(12), 1987-+.
MeSH headings : Animals; Diptera / genetics; Diptera / physiology; Dosage Compensation, Genetic / genetics; Female; Gene Expression; Genes, Insect / genetics; Genes, X-Linked / genetics; Male; X Chromosome / genetics
TL;DR:
This study supports the hypothesis on the origin of the Drosophila 4th chromosome and that a POF-like protein was required for normal gene expression on the ancient X chromosome and suggests that NBL could be important for X chromosome dosage compensation in L. cuprina.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays
Scientific Reports, 8.
Source: NC State University Libraries
Added: August 6, 2018
2018 personal communication
Raw milk consumption and other early-life farm exposures and adult pulmonary function in the Agricultural Lung Health Study
Wyss, A. B., House, J. S., Hoppin, J. A., Richards, M., Hankinson, J. L., Long, S., … London, S. J. (2018, March).
Contributors: A. Wyss*, J. House n , J. Hoppin n , M. Richards*, J. Hankinson, S. Long*, P. Henneberger *, L. Beane Freeman*
author keywords: COPD epidemiology; Asthma Epidemiology; Allergic lung disease; Occupational Lung Disease; Respiratory Measurement
MeSH headings : Adult; Aged; Agriculture; Animals; Case-Control Studies; Child; Child, Preschool; Environmental Exposure; Farms / statistics & numerical data; Female; Humans; Lung / physiopathology; Male; Middle Aged; Milk / physiology; Prospective Studies; Respiratory Physiological Phenomena; Spirometry / methods; United States
TL;DR:
A novel association between raw milk consumption and higher pulmonary function that lasts into older adulthood is reported and did not find appreciable associations with other early-life farming exposures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
A zero-inflated beta-binomial model for microbiome data analysis
STAT, 7(1).
author keywords: count data; penalized generalized linear model; zero-inflated beta-binomial modelling
TL;DR:
A zero‐inflated beta‐binomial is introduced to model the distribution of microbiome count data and to determine association with a continuous or categorical phenotype of interest and has higher power than competing methods to detect taxa associated with phenotype.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 journal article
Improving wood properties for wood utilization through multi-omics integration in lignin biosynthesis
NATURE COMMUNICATIONS, 9.
MeSH headings : Gene Expression Regulation, Plant; Lignin / biosynthesis; Lignin / genetics; Plants, Genetically Modified / genetics; Populus / genetics; Populus / metabolism; Transcriptome / genetics; Trees / genetics; Trees / metabolism; Wood / chemistry; Wood / physiology; Xylem / metabolism
TL;DR:
A multi-omics quantitative integrative analysis of lignin biosynthesis can advance the strategic engineering of wood for timber, pulp, and biofuels and may lead to greater understanding of other pathways for improved growth and adaptation.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure
Cell Reports, 23(2), 327–336.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse
MAMMALIAN GENOME, 29(1-2), 168–181.
Contributors: A. Venkatratnam*, J. House n , K. Konganti*, C. McKenney n, D. Threadgill *, W. Chiu *, D. Aylor n, F. Wright n, I. Rusyn *
MeSH headings : Animals; Dose-Response Relationship, Drug; Genetics, Population; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Mice; Transcription, Genetic / drug effects; Transcriptome / genetics; Trichloroacetic Acid / metabolism; Trichloroethylene / toxicity
TL;DR:
The usefulness of mouse population-based studies in assessing inter-individual variation in toxicological responses is highlighted, but it is cautioned that genetic mapping may be challenging because of the complexity in gene exposure–dose relationships.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
Population genetic diversity in zebrafish lines
MAMMALIAN GENOME, 29(1-2), 90–100.
MeSH headings : Animals; Gene Frequency; Genetic Variation; Genetics, Population; Genome / genetics; Polymorphism, Single Nucleotide / genetics; Zebrafish / genetics
TL;DR:
T5D is established as a model that is representative of diversity levels within laboratory zebrafish lines and demonstrated that experimental design and analysis can exert major effects when characterizing genetic diversity in heterogeneous populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
On the substructure controls in rare variant analysis: Principal components or variance components?
GENETIC EPIDEMIOLOGY, 42(3), 276–287.
author keywords: population substructure; principal components analysis; rare variant association tests; variance components
MeSH headings : Computer Simulation; Confounding Factors, Epidemiologic; Genetic Association Studies; Genetic Variation; Humans; Models, Genetic; Principal Component Analysis
TL;DR:
Evaluating the performance of SKAT coupling with principal components (PC) or variance components (VC) based PS correction methods found that PC‐based methods can account for confounding effects in most scenarios except for admixture, although the number of sufficient PCs depends on the PS complexity and the type of variants used.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Airway mucosal host defense is key to genomic regulation of cystic fibrosis lung disease severity
American Journal of Respiratory and Critical Care Medicine, 197(1), 79–93.
Source: NC State University Libraries
Added: August 6, 2018
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