Works Published in 2020
Displaying all 12 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 journal article
Associations between maternal cadmium exposure with risk of preterm birth and low after birth weight effect of mediterranean diet adherence on affected prenatal outcomes
Toxics, 8(4), 1–12.
Contributors: S. Gonzalez-Nahm *, K. Nihlani*, J. House* , R. Maguire n, H. Skinner n & C. Hoyo n
TL;DR:
The findings suggest that adherence to a Mediterranean dietary pattern during pregnancy may not mitigate cadmium exposure effects, and that larger studies are required to clarify these findings.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: April 11, 2023
2020 article
The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning
MedRxiv.
Contributors: S. Marvel n, J. House* , M. Wheeler *, K. Song n, Y. Zhou n, F. Wright n, W. Chiu *, I. Rusyn *, A. Motsinger-Reif *, D. Reif n
TL;DR:
The Pandemic Vulnerability Index (PVI) presents a visual synthesis of county-level vulnerability indicators that can be compared in a regional, state, or nationwide context to enable more effective and coordinated action to combat the pandemic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: April 11, 2023
2020 journal article
Fibrate pharmacogenomics: Expanding past the genome
Pharmacogenomics, 21(4), 293–306.
Contributors: J. House* & A. Motsinger-Reif *
MeSH headings : Cardiovascular Diseases / blood; Cardiovascular Diseases / drug therapy; Cardiovascular Diseases / genetics; Fibric Acids / therapeutic use; Genome / genetics; Genome-Wide Association Study / methods; Humans; Hypolipidemic Agents / therapeutic use; Pharmacogenetics / methods; Polymorphism, Single Nucleotide / genetics; Risk Factors; Triglycerides / blood
TL;DR:
Heterogeneity in response to fibrate treatment is well established, and this variation is heritable, but recent innovations in technological platforms and advances in statistical methodologies are revolutionizing the use and integration of other 'omes' in pharmacogenomics studies.
(via Semantic Scholar)
Source: ORCID
Added: April 11, 2023
2020 journal article
Complete Genome Sequences of Six Lactobacilli Isolated from American Quarter Horses
MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 9(47).
TL;DR:
The complete circular genome sequences of six Lactobacillus strains and their plasmids, if any, from the fecal material of quarter horses at different ages are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: January 4, 2021
2020 journal article
Exploring the Limits of Combined Image/'omics Analysis for Non-cancer Histological Phenotypes
FRONTIERS IN GENETICS, 11.
author keywords: imaging; genomics; pathology; prediction; integration; histology; machine learning; embedding
TL;DR:
This study surveys the evidence for genomic association and prediction of histology, and uses the results to test the limits of prediction accuracy using machine learning methods applied to the imaging data, genomics data, and their combination.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 24, 2020
2020 journal article
Synonymous Site-to-Site Substitution Rate Variation Dramatically Inflates False Positive Rates of Selection Analyses: Ignore at Your Own Peril
MOLECULAR BIOLOGY AND EVOLUTION, 37(8), 2430–2439.
author keywords: evolutionary model; synonymous rate variation; codon model; episodic selection
MeSH headings : Animals; Models, Genetic; Phylogeny; Rhodopsin / genetics; Selection, Genetic; Silent Mutation; Vertebrates / genetics
TL;DR:
It is found that failing to account for even moderate levels of SRV in selection testing is likely to produce intolerably high false positive rates and add to a growing literature establishing that tests of selection are much more sensitive to certain model assumptions than previously believed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: October 19, 2020
2020 journal article
Genomic analyses of a livestock pest, the New World screwworm, find potential targets for genetic control programs
COMMUNICATIONS BIOLOGY, 3(1).
MeSH headings : Animals; Calliphoridae / genetics; Calliphoridae / pathogenicity; Evolution, Molecular; Gene Expression Regulation / genetics; Genomics / methods; Host-Parasite Interactions / genetics; Larva / genetics; Larva / growth & development; Livestock / genetics; Livestock / parasitology; Pest Control, Biological; RNA-Seq; Screw Worm Infection / genetics; Screw Worm Infection / parasitology; South America
TL;DR:
The genome of the New World screwworm is reported, using transcriptomic analysis of the insect’s developmental stages combined with genomic analyses to identify genes that may be important for its parasitic lifestyle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: September 7, 2020
2020 journal article
Equiprobable discrete models of site-specific substitution rates underestimate the extent of rate variability
PLOS ONE, 15(3).
MeSH headings : Algorithms; Amino Acid Substitution; Evolution, Molecular; Likelihood Functions; Models, Genetic; Mutation Rate; Phylogeny; Sequence Alignment; Sequence Analysis, DNA / methods
TL;DR:
It is demonstrated that the variance of this discretized distribution has an upper bound determined solely by the choice of K and the mean of the distribution, which can introduce biases into statistical inference when estimating parameters governing site-to-site variability of substitution rates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: June 15, 2020
2020 journal article
Low-Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells
SMALL, 16(21).
Contributors: J. House n , E. Bouzos*, K. Fahy *, V. Francisco*, D. Lloyd n, F. Wright n, A. Motsinger-Reif*, P. Asuri *, K. Wheeler*
author keywords: nanotoxicity; silver nanoparticles; transcriptomics
MeSH headings : Gene Expression / drug effects; Hepatocytes / drug effects; Humans; Metal Nanoparticles / chemistry; Silver; Surface Properties; Time Factors
TL;DR:
Universal to all surface coatings, AgNP-treated cells responded by inactivating proliferation and enabling cell cycle checkpoints, which provide a foundation for understanding hepatic response to low-dose AgNPs for future risk assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 14, 2020
2020 journal article
HyPhy 2.5-A Customizable Platform for Evolutionary Hypothesis Testing Using Phylogenies
MOLECULAR BIOLOGY AND EVOLUTION, 37(1), 295–299.
author keywords: evolutionary analysis; natural selection; hypothesis testing; statistical inference; software engineering
MeSH headings : Genetic Techniques; Phylogeny; Software
TL;DR:
The 2.5 release of Hyphy includes a completely re-engineered computational core and analysis library that introduces new classes of evolutionary models and statistical tests, delivers substantial performance and stability enhancements, improves usability, streamlines end-to-end analysis workflows, makes it easier to develop custom analyses, and is mostly backwards compatible with previous HyPhy releases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: March 10, 2020
2020 journal article
A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes
CLINICAL PHARMACOLOGY & THERAPEUTICS, 107(6), 1383–1393.
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents / adverse effects; Antineoplastic Agents / pharmacology; Child; Child, Preschool; Female; Gene Expression Regulation / genetics; Genetic Variation; Genome-Wide Association Study; Genotype; Humans; Hypolipidemic Agents / pharmacology; Infant; Liver / metabolism; Male; Middle Aged; Phenotype; Proprotein Convertase 9 / genetics; Quantitative Trait Loci / genetics; Receptors, G-Protein-Coupled / genetics; Sex Factors; Young Adult
TL;DR:
Translational relevance of these results is evidenced by linking DPYD eQTLs to differences in safety of chemotherapy, linking the sex‐biased regulation of PCSK9 expression to anti‐lipid therapy, and identifying the G‐protein coupled receptor GPR180 as a novel drug target for hypertriglyceridemia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: February 10, 2020
2020 journal article
Tissue-Engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs
TOXICOLOGICAL SCIENCES, 173(1), 65–76.
Contributors: C. Sakolish*, J. House n , A. Chramiec*, Y. Liu *, Z. Chen *, S. Halligan *, G. Vunjak-Novakovic*, I. Rusyn *
author keywords: tissue chip; alternatives to animal testing < in vitro and alternatives; toxicogenomics < methods; safety evaluation; bone < systems toxicology
MeSH headings : Antineoplastic Agents / therapeutic use; Bone Neoplasms / drug therapy; Bone Neoplasms / metabolism; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cisplatin; Doxorubicin; Humans; Imidazoles; Osteoblasts; Pyrazines; Sarcoma, Ewing / drug therapy; Tissue Engineering / methods; Tumor Microenvironment; Vincristine
TL;DR:
It is shown that a bioengineered human bone tumor can be used as a microphysiological model for pre-clinical studies of anticancer drugs and has predictive power in preclinical studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 3, 2020
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