Works Published in 2022
Displaying all 20 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2022 journal article
143-OR: Mapping Genetic Determinants of Blood Glucose Control in the Action to Control Cardiovascular Risk in Diabetes Study Group (ACCORD)
Diabetes, 71(Supplement_1).
TL;DR:
This work identified and replicated variants that merit further study in the development of precision medicine for treatment of T2D and stratified analyses highlight the potential importance of heterogeneity in these efforts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 21, 2023
2022 journal article
Questionnaire-Based Polyexposure Assessment Outperforms Polygenic Scores for Classification of Type 2 Diabetes in a Multiancestry Cohort
Diabetes Care, 11, dc220295.
MeSH headings : Humans; Diabetes Mellitus, Type 2 / epidemiology; Diabetes Mellitus, Type 2 / genetics; Hypertension / complications; Environmental Exposure; Multifactorial Inheritance / genetics; Surveys and Questionnaires; Genome-Wide Association Study; Risk Factors
TL;DR:
The findings in a multiancestry cohort elucidate how type 2 diabetes odds can be attributed to clinical, genetic, and environmental factors and emphasize the need for exposome data in disease-risk association studies.
(via Semantic Scholar)
doi.org (repository)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
Abstract PR011: Characterization of the precancerous and cancer microenvironment in a zebrafish sarcoma model
Clinical Cancer Research, 28(18_Supplement), PR011–PR011.
TL;DR:
Using RNA-seq, the transcriptomes of microenvironmental cells from the zebrafish MPNST model are profiled and it is determined that the precancerous and cancerous microenvironments exhibit broad activation of inflammatory and immune-associated signaling networks.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
Longitudinal Serological Surveillance for COVID-19 Antibodies after Infection and Vaccination
Microbiology Spectrum, 10(5).
Ed(s): O. Laeyendecker
MeSH headings : Humans; COVID-19 / prevention & control; Pandemics; Ad26COVS1; Vaccination; Antibodies; Antibodies, Viral
TL;DR:
It is concluded that, in a real-life setting, vaccination and social distancing behavior are positively correlated and the observed effect of vaccination in preventing COVID-19 may include both vaccine-mediated protection and the associated more cautious behavior exhibited by vaccinated individuals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
LBMON114 Enrichment Of Rare Sequence Variants In Genes That Communicate Metabolic Signals To The GnRH System In Hypothalamic Amenorrhea
Journal of the Endocrine Society, 6(Supplement_1), A466–A467.
TL;DR:
These data suggest that RSVs in genes involved in phenotypes or signaling pathways that link metabolism to GnRH secretion may predispose to development of HA in the setting of decreased energy balance, but not for stress-related genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
Social isolation exacerbates acute ozone inhalation induced pulmonary and systemic health outcomes
Toxicology and Applied Pharmacology, 457, 116295.
TL;DR:
Collectively, psychosocial stressors, especially SI, affected the neuroendocrine system and induced adverse metabolic and inflammatory effects that were exacerbated by ozone exposure.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
Stress Drivers of Glucose Dynamics during Ozone Exposure Measured Using Radiotelemetry in Rats
Environmental Health Perspectives, 130(12).
MeSH headings : Rats; Male; Animals; Glucose; Receptors, Glucocorticoid; Blood Glucose Self-Monitoring; Irritants; Blood Glucose; Rats, Inbred WKY; Corticosterone; Ozone / toxicity; Air Pollutants / toxicity; Adrenergic Agents
TL;DR:
The temporality of neuroendocrine-stress–mediated biological sequalae responsible for ozone-induced glucose metabolic dysfunction and mechanism in a rodent model is demonstrated and may be useful in identifying interactions among irritant pollutants and stress-related illnesses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
Maternal Periconceptional Stressors, Mediterranean Diet Adherence, and Child Outcomes
Current Developments in Nutrition, 6, 650.
TL;DR:
The data suggest that maternal Mediterranean diet adherence provides a potent avenue by which effects of prenatal stressors on maternal and fetal outcomes can be mitigated to reduce ethnic disparities in childhood obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023
2022 journal article
Adrenal Stress Hormone Regulation of Hepatic Homeostatic Function After an Acute Ozone Exposure in Wistar-Kyoto Male Rats
Toxicological Sciences, 189(1), 73–90.
MeSH headings : Animals; Corticosterone; Homeostasis; Insulin; Male; Ozone / toxicity; RNA, Messenger; Rats; Rats, Inbred WKY
TL;DR:
The critical role of adrenal stress hormones in ozone-induced hepatic homeostasis is demonstrated and necessitate further research elucidating their role in propagating environmentally driven diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 11, 2023
2022 journal article
Questionnaire-based exposome-wide association studies (ExWAS) reveal expected and novel risk factors associated with cardiovascular outcomes in the Personalized Environment and Genes Study
Environmental Research, 212, 113463.
MeSH headings : Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / etiology; Coronary Artery Disease; Exposome; Heart Failure; Humans; Myocardial Infarction; Risk Factors; Stroke / epidemiology; Surveys and Questionnaires
TL;DR:
ExWAS analyses revealed novel associations that include blood type A (Rh-) with heart attack, and significant nonlinear effects of sleep disorder, regular intake of grapefruit, and a family history of blood clotting problems for multiple CVD outcomes, highlighting the importance of considering multiple exposures when examining CVD outcome.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 11, 2023
2022 journal article
Maternal Mediterranean Diet Adherence and Its Associations with Maternal Prenatal Stressors and Child Growth
CURRENT DEVELOPMENTS IN NUTRITION, 6(11).
author keywords: Mediterranean diet; stressors; child weight; birth outcomes; maternal diet
TL;DR:
If replicated in larger studies, the data suggest that MDA provides a potent avenue by which effects of prenatal stressors on maternal and fetal outcomes can be mitigated to reduce ethnic disparities in childhood obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 20, 2023
2022 journal article
Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies
AMERICAN JOURNAL OF HUMAN GENETICS, 109(9), 1638–1652.
MeSH headings : Anemia / drug therapy; Anemia / genetics; Coronary Artery Disease / genetics; Genome-Wide Association Study; Humans; Mendelian Randomization Analysis; Myocardial Infarction / genetics; Renal Insufficiency, Chronic / genetics
TL;DR:
A combination of genetic and functional studies provides a powerful approach to investigate the potential therapeutic profile of EPO-increasing therapies for treating anemia in CKD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 21, 2022
2022 journal article
Clomifene and Assisted Reproductive Technology in Humans Are Associated with Sex-Specific Offspring Epigenetic Alterations in Imprinted Control Regions
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(18).
author keywords: differentially methylated regions; adverse offspring outcomes; infertility
MeSH headings : Child; Clomiphene; DNA Methylation; Female; Genomic Imprinting; Humans; Male; Reproductive Techniques, Assisted / adverse effects; Retrospective Studies
TL;DR:
The results suggest that the increased risk of adverse outcomes in offspring conceived through ART may be due in part to altered methylation of ICRs, and larger studies utilizing epigenome-wide interrogation are warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 3, 2022
2022 journal article
A resource for integrated genomic analysis of the human liver
SCIENTIFIC REPORTS, 12(1).
MeSH headings : Bayes Theorem; Genome-Wide Association Study / methods; Genomics; Humans; Liver; Polymorphism, Single Nucleotide; Quantitative Trait Loci
TL;DR:
This study generated whole-transcriptome RNA-Seq from genotyped liver samples and used existing data from the GTEx Project and previous liver eQTL studies to create an enhanced transcriptomic sequence resource in the human liver, finding that MHC genes, and especially class II genes, are enriched for liver-specific eZTL patterns.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 19, 2022
2022 journal article
A Population-Based Human In Vitro Approach to Quantify Inter-Individual Variability in Responses to Chemical Mixtures
TOXICS, 10(8).
author keywords: population-wide; inter-individual variability; toxicodynamics; chemical mixtures; defined mixtures; human health risk assessment; uncertainty factors; genome-wide association study
TL;DR:
The data show that population variability of the mixtures is unlikely to exceed that of the most variable component, and that similarity in genome-wide associations among components may be used to accrue additional evidence for grouping of constituents in a mixture for cumulative assessments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: September 6, 2022
2022 journal article
Grouping of UVCB Substances with Dose-Response Transcriptomics Data from Human Cell-Based Assays
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 39(3), 388–404.
MeSH headings : Biological Assay; Endothelial Cells; Humans; Induced Pluripotent Stem Cells; Petroleum; Transcriptome
TL;DR:
The results further demonstrate the value of NAMs for grouping of UVCBs, identify informative cell lines, and provide data that could be used for justifying selection of substances for further testing that may be required for registration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 29, 2022
2022 article
Genomic map of candidate human imprint control regions: the imprintome
Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.
author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
TL;DR:
This draft of the human imprintome will allow for the systematic determination of the role of early-acquired imprinting dysregulation in the pathogenesis of human diseases and developmental and behavioural disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 11, 2022
2022 journal article
Comparison of National Vulnerability Indices Used by the Centers for Disease Control and Prevention for the COVID-19 Response
Public Health Reports, 137(4), 803–812.
author keywords: COVID-19; vulnerability; social vulnerability index; GIS; geographic information systems
MeSH headings : COVID-19 / epidemiology; COVID-19 / prevention & control; Centers for Disease Control and Prevention, U.S.; Humans; Pandemics / prevention & control; Public Health; United States / epidemiology
TL;DR:
The indices can empower local and state public health officials with additional information to focus resources and interventions on disproportionately affected populations to combat the ongoing pandemic and plan for future pandemics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 23, 2022
2022 journal article
Leveraging TOPMed imputation server and constructing a cohort-specific imputation reference panel to enhance genotype imputation among cystic fibrosis patients
HUMAN GENETICS AND GENOMICS ADVANCES, 3(2).
TL;DR:
It is demonstrated that despite having ∼3% the sample size of TOPMed, the CFGP reference panel can still outperform TOPMed when imputing some CF disease-causing variants, likely due to allele and haplotype differences between CF patients and general populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 10, 2022
2022 journal article
The Genome of the Poecilogonous Annelid Streblospio benedicti
GENOME BIOLOGY AND EVOLUTION, 14(2).
author keywords: poecilogony; life-history evolution; developmental genomics; Lophotrochozoa
MeSH headings : Animals; Annelida / genetics; Larva / genetics; Phylogeny; Polychaeta / genetics; Sequence Analysis, DNA
TL;DR:
An annotated chromosomal-level genome assembly of S. benedicti is presented, which is the largest annelid genome to date that has been assembled to chromosomal scaffolds, yet it does not show evidence of extensive gene family expansion, but rather longer intergenic regions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 18, 2022
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