Works Published in 2004

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2004 chapter

Introduction to Biochemical and Molecular Methods in Toxicology

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (pp. 13–22).

By: E. Hodgson n, G. Leblanc n, S. Meyer* & R. Smart n

Ed(s): E. Hodgson n

Sources: Crossref, ORCID
Added: April 10, 2022

2004 chapter

Chemical Carcinogenesis

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (pp. 225–250).

By: R. Smart n

Ed(s): E. Hodgson

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: April 9, 2022

2004 journal article

C/EBP alpha is a DNA damage-inducible p53-regulated mediator of the G(1) checkpoint in keratinocytes


By: K. Yoon n & R. Smart n

MeSH headings : Animals; Blotting, Western; CCAAT-Enhancer-Binding Protein-alpha / metabolism; Caspases / analysis; Cell Line; Cells, Cultured; DNA Damage; Dose-Response Relationship, Radiation; Electrophoretic Mobility Shift Assay; Fibroblasts / drug effects; Fibroblasts / metabolism; Fibroblasts / radiation effects; G1 Phase; Humans; Immunohistochemistry; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Keratinocytes / radiation effects; Kinetics; Methylnitronitrosoguanidine / pharmacology; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mutagens / pharmacology; NIH 3T3 Cells; Precipitin Tests; Rats; Retroviridae / genetics; Skin / metabolism; Time Factors; Tumor Suppressor Protein p53 / deficiency; Tumor Suppressor Protein p53 / metabolism; Ultraviolet Rays
TL;DR: A novel role is uncovered for C/EBPα as a p53-regulated DNA damage-inducible gene that has a critical function in the DNA damage G1 checkpoint response in keratinocytes. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Cell cycle-dependent phosphorylation of C/EBP beta mediates oncogenic cooperativity between C/EBP beta and H-Ras(V12)


By: J. Shuman*, T. Sebastian*, P. Kaldis*, T. Copeland*, S. Zhu n, R. Smart n, P. Johnson*

MeSH headings : Amino Acid Sequence; Animals; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / metabolism; CDC2-CDC28 Kinases / metabolism; Cell Cycle / physiology; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase 2; Enzyme Inhibitors / metabolism; Genes, ras; Mice; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; NIH 3T3 Cells; Phosphorylation; Proto-Oncogene Proteins c-raf / genetics; Proto-Oncogene Proteins c-raf / metabolism; Sequence Alignment; Serine / metabolism; Signal Transduction; Threonine / metabolism; ras Proteins / genetics; ras Proteins / metabolism
TL;DR: It is shown that cell cycle-dependent phosphorylation of C/EBPβ on Ser64 and Thr189 is required to promote Ras-induced transformation of NIH 3T3 cells, and this support a role for C/ EBPβ as a nuclear effector of Ras signaling and transformation. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

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