Works Published in 2010
Displaying all 9 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
Retrotransposition and genomic imprinting.
9(4), 340–346.
author keywords: retrotransposition; retrogenes; genomic imprinting; epigenetics
MeSH headings : Animals; DNA Methylation / genetics; Epigenesis, Genetic / genetics; Genomic Imprinting / genetics; Humans; Models, Genetic; Retroelements / genetics
TL;DR:
A distinct class of imprinted genes, which have arisen by retrotransposition, and which have the potential to be used as models for the dissection of the fundamental features and mechanisms required for imprinting are reviewed.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
Source: ORCID
Added: September 28, 2022
2010 chapter
Chemical Carcinogenesis and Mutagenesis
In E. Hodgson (Ed.), Modern Toxicology (4th ed.). New York: J. Wiley and Sons.
Ed(s): E. Hodgson
Sources: NC State University Libraries, ORCID
Added: May 5, 2022
2010 journal article
Ablation of TAK1 Upregulates Reactive Oxygen Species and Selectively Kills Tumor Cells
Cancer Research, 70(21), 8417–8425.
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; Blotting, Western; Carcinogens / toxicity; Cell Proliferation; Gene Deletion; Integrases / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; RNA, Messenger / genetics; RNA, Small Interfering / pharmacology; Reactive Oxygen Species / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Up-Regulation
TL;DR:
TAK1 kinase could be a new and effective molecular target for ROS-based tumor killing and is examined whether ablation of TAK1 in preexisting skin tumors could cause an increase in ROS and result in tumor cell death.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: April 9, 2022
2010 journal article
Maternally-inherited Grb10 reduces placental size and efficiency
Developmental Biology, 337(1), 1–8.
author keywords: Adapter protein; Cell signalling; Epigenetics; Genomic imprinting; Growth factor receptor-bound protein; Growth regulation; IGF; Insulin-like growth factor; Mouse; Placenta
MeSH headings : Alleles; Animals; Endothelium / metabolism; Female; GRB10 Adaptor Protein / analysis; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / physiology; Genomic Imprinting; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Placenta / pathology; Placenta / physiology; Pregnancy
TL;DR:
It is shown that following disruption of the maternal allele in mice, the labyrinthine volume was increased in a manner consistent with a cell-autonomous function of Grb10 and the enlarged placenta was more efficient in supporting foetal growth, becoming the first example of a gene that acts to limit placental size and efficiency.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2010 journal article
Overexpression of Transcription Factor Sp2 Inhibits Epidermal Differentiation and Increases Susceptibility to Wound- and Carcinogen-Induced Tumorigenesis
CANCER RESEARCH, 70(21), 8507–8516.
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Blotting, Western; COS Cells; Carcinogens / toxicity; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cattle; Cell Differentiation; Chlorocebus aethiops; Disease Susceptibility; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Female; Humans; Immunoenzyme Techniques; Keratin-5 / genetics; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Male; Mice; Mice, Transgenic; Promoter Regions, Genetic; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms / etiology; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Sp2 Transcription Factor / physiology; Wounds and Injuries
TL;DR:
It is reported that Sp2 protein abundance in mice increases in concert with the progression of carcinogen-induced murine squamous cell carcinomas, and this results directly support the likelihood that Sp2 overexpression occurring in various human cancers has significant functional effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
RSK-Mediated Phosphorylation in the C/EBP beta Leucine Zipper Regulates DNA Binding, Dimerization, and Growth Arrest Activity
MOLECULAR AND CELLULAR BIOLOGY, 30(11), 2621–2635.
MeSH headings : Amino Acid Sequence; Animals; CCAAT-Enhancer-Binding Protein-beta / chemistry; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / metabolism; Cell Cycle / physiology; Cell Line; DNA / genetics; DNA / metabolism; Growth Substances / metabolism; Humans; Leucine Zippers; MAP Kinase Signaling System / physiology; Mice; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; Phosphorylation; Protein Multimerization; Protein Processing, Post-Translational; Rats; Ribosomal Protein S6 Kinases / antagonists & inhibitors; Ribosomal Protein S6 Kinases / genetics; Ribosomal Protein S6 Kinases / metabolism; Sequence Alignment; Transcriptional Activation; ras Proteins / genetics; ras Proteins / metabolism
TL;DR:
It is shown that C/EBPβ DNA binding is autorepressed and becomes activated by the Ras-Raf-MEK-ERK-p90RSK cascade and RSK-mediated phosphorylation of a bifunctional residue in the leucine zipper that regulates DNA binding and homodimerization and thereby promotes cell cycle arrest.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
C/EBP alpha and C/EBP beta Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin
PLOS ONE, 5(3).
MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / physiology; CCAAT-Enhancer-Binding Protein-beta / physiology; Cell Cycle; Cell Differentiation; Cell Proliferation; Epithelial Cells / cytology; Gene Expression Regulation; Genotype; Homozygote; Immunoblotting; Immunohistochemistry / methods; Keratinocytes / cytology; Mice; Sebaceous Glands / cytology; Skin / cytology
TL;DR:
Results indicate that in adult mouse skin, C/EBPα and C-EBPβ are critically involved in regulating sebocyte differentiation and epidermal homeostasis involving the basal to spinous keratinocyte transition and basal cell cycle withdrawal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Increasing the hydrophobicity and electrospray response of glycans through derivatization with novel cationic hydrazides
CHEMICAL COMMUNICATIONS, 46(2), 237–239.
TL;DR:
Novel tags are used to increase the hydrophobicity of glycans and impart a permanent charge yielding as great as a approximately 5-fold increase in electrospray response from both a standard and complex mixture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
The effects of abundant plasma protein depletion on global glycan profiling using NanoLC FT-ICR mass spectrometry
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 396(4), 1473–1479.
author keywords: HILIC; NanoLCFT-ICRMS; Glycan profiling; N-linked glycans; Protein depletion
MeSH headings : Blood Proteins / chemistry; Blood Proteins / standards; Chromatography, Liquid; Nanotechnology; Polysaccharides / chemistry; Polysaccharides / standards; Proteomics / instrumentation; Proteomics / methods; Reproducibility of Results; Spectroscopy, Fourier Transform Infrared
TL;DR:
Protein depletion was found to marginally effect the abundance of high mannose, hybrid, and large highly sialylated complex species and small fucosylated non-sialylation complex glycans were found to decrease in abundance in the depleted samples.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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