Works Published in 2015
Displaying all 16 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Coadaptation between mother and offspring: why not?
PLoS Biology, 13(3), 1002085,
MeSH headings : Animals; Body Size / genetics; Female; GRB10 Adaptor Protein / genetics
TL;DR:
A Formal Comment has challenged the interpretation of a study into an imprinted gene, maintaining that conflict, rather than mother-offspring co-adaptation, provides a better mechanistic explanation.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 28, 2022
2015 journal article
MP14-11 IS BMI THE BEST ADIPOSITY MEASURE FOR PROSTATE CANCER RISK?
Journal of Urology, 193(4S).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2015 journal article
MP14-06 SELF-REPORTED SEXUAL FUNCTION IS ASSOCIATED WITH PROSTATE CANCER RISK
Journal of Urology, 193(4S).
Source: Crossref
Added: February 24, 2020
2015 journal article
Reagent for Evaluating Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Performance in Bottom-Up Proteomic Experiments
ANALYTICAL CHEMISTRY, 87(23), 11635–11640.
MeSH headings : Amino Acids / chemistry; Chromatography, Liquid / methods; HEK293 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Indicators and Reagents / chemistry; Peptides / chemical synthesis; Peptides / chemistry; Proteomics / methods; Tandem Mass Spectrometry / methods
TL;DR:
A novel proteomic standard for assessing liquid chromatography-tandem mass spectrometry (LC-MS/MS) instrument performance, in terms of chromatographic reproducibility and dynamic range within a single LC- MS/MS injection, is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Genotype-epigenotype interaction at the IGF2 DMR
Genes, 6(3), 777–789.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Correlation between maternal and infant cortisol varies by breastfeeding status
INFANT BEHAVIOR & DEVELOPMENT, 40, 252–258.
author keywords: Breastfeeding; Cortisol; Human milk; Stress
MeSH headings : Adult; Aging / physiology; Body Weight / physiology; Breast Feeding / psychology; Cross-Sectional Studies; Educational Status; Ethnicity; Female; Humans; Hydrocortisone / metabolism; Income; Infant; Infant Food; Linear Models; Male; Mothers; Saliva / chemistry; Saliva / metabolism; Sex Characteristics; Socioeconomic Factors; Stress, Psychological / metabolism
TL;DR:
The data suggest that several factors may contribute to cortisol synchrony observed in mother/infant dyads, including the transfer of cortisol in human milk, physical interaction such as skin-to-skin contact, and shared environment, and household income as a possible contributor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Data-independent-acquisition mass spectrometry for identification of targeted-peptide site-specific modifications
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407(22), 6627–6635.
author keywords: Protein adducts; Toxicoproteomics; Mass spectrometry; Data-independent acquisition; Exposome
MeSH headings : Algorithms; Amino Acids / analysis; Amino Acids / chemistry; Binding Sites; Chromatography, Liquid / methods; Data Mining / methods; Databases, Protein; Peptides / analysis; Peptides / chemistry; Protein Binding; Protein Interaction Mapping / methods; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
A novel strategy based on data-independent acquisition coupled to targeted data extraction for the detection and identification of site-specific modifications of targeted peptides in a completely unbiased manner and an application in profiling adducted peptides derived from abundant proteins in biological fluids with the ultimate objective of detecting biomarkers of exposure to reactive species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Geographic clustering of elevated blood heavy metal levels in pregnant women
BMC PUBLIC HEALTH, 15.
author keywords: Cadmium; Lead; Mercury; Arsenic; Spatial analysis
MeSH headings : Adult; Arsenic / blood; Cadmium / blood; Female; Humans; Lead / blood; Maternal Exposure / statistics & numerical data; Mercury / blood; Metals, Heavy / blood; Pregnancy; Pregnancy Complications / blood; Pregnancy Complications / epidemiology; Prenatal Care / statistics & numerical data; Prenatal Exposure Delayed Effects / prevention & control; Rural Population / statistics & numerical data; United States / epidemiology; Urban Population / statistics & numerical data; Young Adult
TL;DR:
Elevated blood concentrations of Cd and Pb are spatially clustered in this urban environment compared to the surrounding areas and cluster membership was associated with lower education levels and higher pre-pregnancy BMI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 review
Tools for monitoring system suitability in LC MS/MS centric proteomic experiments
[Review of ]. PROTEOMICS, 15(5-6), 891–902.
author keywords: Mass spectrometry; Quality control; Shewhart control charts; Statistical process control; System suitability; Technology
MeSH headings : Chromatography, Liquid / methods; Chromatography, Liquid / standards; Peptides / analysis; Peptides / chemistry; Proteins / analysis; Proteins / chemistry; Proteomics / methods; Proteomics / standards; Quality Control; Tandem Mass Spectrometry / methods; Tandem Mass Spectrometry / standards
TL;DR:
The implementation of a robust system suitability workflow is discussed in terms of metrics, type of standard, and frequency of evaluation along with the obstacles to overcome prior to incorporating a more proactive approach to overall quality control in liquid chromatography coupled to tandem mass spectrometry based proteomic workflows.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Maternal cadmium, iron and zinc levels, DNA methylation and birth weight
BMC Pharmacology & Toxicology, 16.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes
CELL DEATH & DISEASE, 6.
MeSH headings : Animals; Apoptosis / genetics; Apoptosis / radiation effects; Cell Cycle Checkpoints / genetics; Cell Cycle Checkpoints / radiation effects; Cell Line; Cell Proliferation / genetics; Cell Proliferation / radiation effects; DNA Damage / genetics; DNA Damage / radiation effects; Gene Expression Regulation / radiation effects; Humans; Keratinocytes / metabolism; Keratinocytes / pathology; Keratinocytes / radiation effects; Mice; RNA, Long Noncoding / biosynthesis; RNA, Long Noncoding / genetics; Skin / metabolism; Skin / pathology; Skin / radiation effects; Skin Neoplasms / genetics; Skin Neoplasms / pathology; Tumor Suppressor Protein p53 / genetics; Ultraviolet Rays
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST
TOXICOLOGY IN VITRO, 29(3), 544–550.
author keywords: DNA methylation; Epigenetics; Insulin-like growth factor 2 (IGF2); Paternally expressed gene 1/mesoderm specific transcript (PEG1/MEST); Lead acetate; Bisulfite pyrosequencing
MeSH headings : DNA Methylation / drug effects; Gene Expression Regulation / drug effects; HEK293 Cells; Humans; Insulin-Like Growth Factor II / biosynthesis; Insulin-Like Growth Factor II / genetics; Lead / toxicity; Organometallic Compounds / toxicity; Proteins / genetics; Proteins / metabolism
TL;DR:
Pb exposure below reportable/actionable levels increased expression of PEG1/MEST concomitant with decreased methylation, suggesting that Pb exposure can stably alter the regulatory capacity of multiple imprints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Epigenetic regulation of Newborns' imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 69(7), 639–647.
MeSH headings : Birth Weight / genetics; Cohort Studies; DNA Methylation / genetics; Epigenesis, Genetic; Ethnicity / genetics; Fetal Blood / cytology; Fetal Development / genetics; Genomic Imprinting; Humans; Infant, Newborn; North Carolina; Obesity / genetics; Parents; Regression Analysis; Social Class; Time
TL;DR:
The hypothesis that epigenetics may link the observed lower SES during the prenatal period and poor outcomes such as low birth weight is supported; lower birth weight has previously been associated with adult-onset chronic diseases and conditions that include cardiovascular diseases, diabetes, obesity and some cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort
EPIGENETICS, 10(7), 597–606.
author keywords: birth weight; epidemiology; epigenetics; imprinted genes; methylation; physical activity
MeSH headings : Adolescent; Birth Weight / physiology; Cell Cycle Proteins / chemistry; Cell Cycle Proteins / genetics; Cohort Studies; DNA Methylation; Female; Genetic Association Studies; Genomic Imprinting; Humans; Infant, Newborn; Male; Motor Activity / genetics; Pregnancy; Transcription Factors / chemistry; Transcription Factors / genetics; Tumor Suppressor Proteins / chemistry; Tumor Suppressor Proteins / genetics; Young Adult
TL;DR:
This first study to support a role for imprinted gene plasticity in these associations between prenatal PA, birth weight, and newborn DNA methylation levels at differentially methylated regions (DMRs) regulating 4 imprinted genes known to be important in fetal development is confirmed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes
Infectious Agents and Cancer, 10.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Toxicoproteomic analysis of pulmonary carbon nanotube exposure using LC-MS/MS
TOXICOLOGY, 329, 80–87.
author keywords: Carbon nanotube; Label-free proteomics; Pulmonary fibrosis; Toxicoproteomics
MeSH headings : Acute-Phase Proteins / genetics; Acute-Phase Proteins / metabolism; Animals; Bronchoalveolar Lavage Fluid / chemistry; Chromatography, Liquid; Complement C3 / genetics; Complement C3 / metabolism; Complement C4b / genetics; Complement C4b / metabolism; Complement C9 / genetics; Complement C9 / metabolism; Histones / genetics; Histones / metabolism; Lactoferrin / genetics; Lactoferrin / metabolism; Lipocalin-2; Lipocalins / genetics; Lipocalins / metabolism; Lung / drug effects; Lung / metabolism; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Oncogene Proteins / genetics; Oncogene Proteins / metabolism; Peroxidase / genetics; Peroxidase / metabolism; Proteome / metabolism; Pulmonary Surfactant-Associated Protein B / genetics; Pulmonary Surfactant-Associated Protein B / metabolism; Tandem Mass Spectrometry; Toxicity Tests
TL;DR:
The protein secretion profile in lung bronchoalveolar lavage fluid from mice exposed to non-functionalized multi-walled carbon nanotubes or MWCNTs functionalized by nanoscale Al2O3 coatings formed using atomic layer deposition (ALD) was compared.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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