Works Published in 2019
Displaying works 1 - 20 of 25 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
Pre-Pregnancy Weight and Symptoms of Attention Deficit Hyperactivity Disorder and Executive Functioning Behaviors in Preschool Children
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 16(4).
author keywords: pregnancy; gestational weight gain; maternal obesity; child development; ADHD
MeSH headings : Adult; Attention Deficit Disorder with Hyperactivity / etiology; Attention Deficit Disorder with Hyperactivity / psychology; Body Mass Index; Child; Child, Preschool; Executive Function; Female; Follow-Up Studies; Gestational Weight Gain; Humans; Male; North Carolina; Pregnancy; Prenatal Exposure Delayed Effects / etiology; Prenatal Exposure Delayed Effects / psychology; Regression Analysis; Risk Factors
TL;DR:
Pre-pregnancy BMI at levels ≥35 was positively associated with higher ADHD symptoms and worse executive self-regulation behaviors (inhibitory control and attention), and a link between maternal weight and child neurodevelopment is supported.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: April 20, 2020
2019 journal article
Mixture designs to investigate adverse effects upon co-exposure to environmental cyanotoxins
Toxicology, 421, 74–83.
author keywords: Cyanotoxins; Mixture design; Interaction; Environmental exposure; Proteomics
MeSH headings : Animals; Bacterial Toxins / toxicity; Cell Line; Cell Survival / drug effects; Cyanobacteria; Drug Interactions; Mice; No-Observed-Adverse-Effect Level; Proteome / drug effects; Risk Assessment / methods; Toxicity Tests / methods
TL;DR:
The results highlight the need to study combinations of cyanotoxins when investigating the link between cyanobacteria and neurodegenerative pathologies and the application of design of experiment (DoE) as an efficient methodology to study mixtures of relevant environmental toxins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, Crossref
Added: April 20, 2020
2019 journal article
Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking
EPIGENOMICS, 11(13), 1487–1500.
author keywords: cigarette smoking; epigenetics; infant; maternal exposure; methylation
MeSH headings : Adult; Cohort Studies; CpG Islands; DNA Methylation; Epigenesis, Genetic; Epigenomics / methods; Female; Humans; Infant, Newborn; Maternal Exposure / adverse effects; Pregnancy; Prenatal Exposure Delayed Effects / epidemiology; Prenatal Exposure Delayed Effects / genetics; Tobacco Smoking / epidemiology; Tobacco Smoking / genetics
TL;DR:
Comparing meta-analyses, numerous signatures specific to newborns along with many shared between newborns and adults were identified and unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 9, 2019
2019 journal article
Associations of maternal diet with infant adiposity at birth, 6 months and 12 months
BMJ OPEN, 9(9).
author keywords: maternal diet; infant adiposity; AHEI-2010; birth weight
MeSH headings : Adiposity; Adult; Birth Weight; Body Composition; Body Mass Index; Diet Records; Diet, Healthy; Female; Fetal Macrosomia; Gestational Age; Humans; Infant; Infant, Low Birth Weight / growth & development; Infant, Newborn; Infant, Small for Gestational Age / growth & development; Linear Models; Maternal Nutritional Physiological Phenomena; Nutrition Assessment; Pregnancy; Prospective Studies; Skinfold Thickness; Southeastern United States; Young Adult
TL;DR:
Although poor maternal diet quality during pregnancy was not associated with infant adiposity in this study, maternal diet during pregnancy may still be an important and modifiable factor of public health importance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: December 9, 2019
2019 journal article
Snacking frequency and dietary intake in toddlers and preschool children
APPETITE, 142.
author keywords: Dietary intake; Diet quality; Preschooler; Snacking; Toddler
MeSH headings : Black People / statistics & numerical data; Child; Child, Preschool; Diet / ethnology; Diet / statistics & numerical data; Diet Surveys; Dietary Carbohydrates / administration & dosage; Dietary Fats / administration & dosage; Dietary Proteins / administration & dosage; Energy Intake / ethnology; Epigenesis, Genetic; Female; Hispanic or Latino / statistics & numerical data; Humans; Infant; Male; Snacks / ethnology; White People / statistics & numerical data
TL;DR:
Snacking frequency was positively and significantly associated with total daily energy intake in both 12-to-24-month-olds and 2- to-6-year-olds as indicated by regression coefficient estimates of snacking frequency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: November 25, 2019
2019 journal article
C/EBP beta suppresses keratinocyte autonomous type 1 IFN response and p53 to increase cell survival and susceptibility to UVB-induced skin cancer
CARCINOGENESIS, 40(9), 1099–1109.
TL;DR:
A p53-C/E BPβ feedback loop, whereby C/EBPβ a transcriptional target of a p53 pathway, functions as a survival factor by negatively regulating p53 apoptotic activity in response to DNA damage is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 18, 2019
2019 journal article
Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood
SCIENTIFIC REPORTS, 9(1).
MeSH headings : Animals; Animals, Newborn; Body Weight / drug effects; Cadmium / adverse effects; Disease Models, Animal; Female; Gene Expression Profiling / methods; Gene Expression Regulation / drug effects; Gene Regulatory Networks / drug effects; Heart / anatomy & histology; Heart / drug effects; Hypotension / chemically induced; Hypotension / genetics; Maternal Exposure / adverse effects; Metabolic Networks and Pathways / drug effects; Mice; Organ Size / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Sequence Analysis, RNA
TL;DR:
It is proposed that a maternal Cd exposure-induced iron deficiency leads to altered cellular metabolic pathways and hypoxic conditions during fetal development; this stress may contribute to increased heart weight at birth and the programming of susceptibility to hypertension in adulthood.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 7, 2019
2019 journal article
Overall gestational weight gain mediates the relationship between maternal and child obesity
BMC PUBLIC HEALTH, 19(1).
author keywords: Obesity; Gestational weight gain; Child obesity; Mediation; Causal inference
MeSH headings : Adult; Child, Preschool; Female; Gestational Weight Gain; Humans; Male; Mothers / statistics & numerical data; Obesity / epidemiology; Pediatric Obesity / epidemiology; Pregnancy; Risk Factors
TL;DR:
GWG mediated the relationship between maternal BMI and childhood adiposity and highlighted an important public health education opportunity to stress the impact of a pre-pregnancy weight and excessive GWG on the risk of child obesity for all mothers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 26, 2019
2019 journal article
Does cesarean delivery impact infant weight gain and adiposity over the first year of life?
INTERNATIONAL JOURNAL OF OBESITY, 43(8), 1549–1555.
MeSH headings : Adiposity; Adult; Birth Weight; Body Size; Body-Weight Trajectory; Cesarean Section / adverse effects; Cesarean Section / methods; Delivery, Obstetric / methods; Female; Gestational Age; Humans; Infant; Infant, Newborn; Linear Models; Male; Pediatric Obesity / pathology; Pregnancy; Prospective Studies; Skinfold Thickness; Socioeconomic Factors; Time Factors; Weight Gain; Young Adult
TL;DR:
Compared to vaginal delivery, cesarean delivery was associated with greater offspring rate of weight gain over the first year and differences in adiposity that appear as early as 3 months of age.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 26, 2019
2019 article
RW-2018-Research Workshop: The Effect of Nutrition on Epigenetic Status, Growth, and Health
Skinner, M., Lumey, L. H., Fleming, T. P., Sapienza, C., Hoyo, C., Aronica, L., … Nichol, P. F. (2019, July). JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, Vol. 43, pp. 627–637.
author keywords: Avy mouse; DOHaD; epigenetics; hormesis; metabolic syndrome; methylome; nutrition; protein malnutrition; xenobiotics
MeSH headings : Animals; Epigenesis, Genetic / physiology; Health Status; Humans; Mice; Nutritional Physiological Phenomena / physiology; Nutritional Status
TL;DR:
The goal of the 2018 ASPEN Research Workshop was to explore the influence of nutrition and dietary exposure to xenobiotics on the epigenome during critical periods in development and how these exposures influence both disease incidence and severity transgenerationally.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: July 29, 2019
2019 journal article
Association of prenatal antibiotics with measures of infant adiposity and the gut microbiome
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS, 18.
author keywords: Gut microbiome; Pediatric obesity; Antibiotic; Child health; Prenatal exposure; Pregnancy
MeSH headings : Adiposity / drug effects; Adult; Anti-Bacterial Agents / adverse effects; Bacteria / classification; Bacteria / drug effects; Bacteria / genetics; Bacteria / isolation & purification; Female; Gastrointestinal Microbiome / drug effects; Humans; Infant; Male; Obesity / etiology; Obesity / microbiology; Obesity / physiopathology; Pregnancy; Prenatal Exposure Delayed Effects / etiology; Prenatal Exposure Delayed Effects / microbiology; Prenatal Exposure Delayed Effects / physiopathology; Prospective Studies; Young Adult
TL;DR:
Prenatal antibiotic exposure in the second trimester was associated with an altered infant gut microbiome composition at 3 and 12 months and with higher infant WFL-z and subscapular skinfold thickness at 12 months.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 8, 2019
2019 journal article
Smoking-associated AHRR demethylation in cord blood DNA: impact of CD235a+nucleated red blood cells
CLINICAL EPIGENETICS, 11.
MeSH headings : Adult; Basic Helix-Loop-Helix Transcription Factors / genetics; CpG Islands; DNA Demethylation; Epigenesis, Genetic; Erythrocyte Count; Erythrocytes / immunology; Female; Fetal Blood / immunology; Glycophorins / metabolism; Humans; Lipopolysaccharide Receptors / metabolism; Male; Maternal Age; Pregnancy; Prenatal Exposure Delayed Effects / genetics; Repressor Proteins / genetics; Sequence Analysis, DNA; Smoking / adverse effects; Smoking / genetics; Young Adult
TL;DR:
Prenatal smoke exposure was highly significantly associated with AHRR methylation in cord blood, CD14+ monocytes, and CD235a+ nRBCs, andCD14+ cells, and robust linear regression models adjusting for estimated cell type composition outperformed those lacking these covariates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 1, 2019
2019 journal article
Epigenome-wide meta-analysis of DNA methylation and childhood asthma
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(6), 2062–2074.
author keywords: Epigenetics; methylation; asthma; childhood; newborn; drug development
MeSH headings : Asthma / genetics; Child; CpG Islands / genetics; Cross-Sectional Studies; DNA Methylation; ERG1 Potassium Channel / genetics; Epigenesis, Genetic; Epigenome / genetics; Genome-Wide Association Study; Humans; Infant, Newborn; Interleukin-5 Receptor alpha Subunit / genetics
TL;DR:
Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age, and Asthma-related differential methylation in blood in children was substantially replicated in eosinophils and respiratory epithelium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 24, 2019
2019 journal article
Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women
CANCER MEDICINE, 8(5), 2503–2513.
author keywords: African ancestry risk; genetic association; ovarian cancer; vitamin D pathway
MeSH headings : Black or African American / genetics; Bayes Theorem; Carcinoma, Ovarian Epithelial / genetics; Carcinoma, Ovarian Epithelial / metabolism; Carcinoma, Ovarian Epithelial / pathology; ErbB Receptors / genetics; Female; Genetic Association Studies; Glucuronosyltransferase / genetics; Humans; Logistic Models; Middle Aged; Neoplasm Grading; Ovarian Neoplasms / genetics; Ovarian Neoplasms / metabolism; Ovarian Neoplasms / pathology; Polymorphism, Single Nucleotide; Receptors, Calcitriol / genetics; Vitamin D / biosynthesis
TL;DR:
Genetic variants in the EGFR and UGT2A1/2 may increase susceptibility of EOC in AA women and the Bayesian False Discovery Probability method was used to evaluate statistical significance of selected SNPs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 17, 2019
2019 review
Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)
[Review of ]. JOURNAL OF ENDOCRINOLOGY, 241(2), R65–R80.
author keywords: vitamin D deficiency; DOHAD; metabolic disorders; autism; neurobehavioral disorders; animal models
TL;DR:
A detailed review and perspective of evidence for the role of maternal VDD in offspring long term health, particularly as it relates to Developmental Origins of Health and Disease (DOHaD), and evidence implicating epigenetic mechanisms as a mediator of this link is explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 17, 2019
2019 journal article
Associations between Maternal Tobacco Smoke Exposure and the Cord Blood CD4(+) DNA Methylome
ENVIRONMENTAL HEALTH PERSPECTIVES, 127(4).
MeSH headings : Adult; CD4-Positive T-Lymphocytes / chemistry; DNA Methylation / drug effects; Epigenome / drug effects; Female; Fetal Blood / chemistry; Humans; Male; Maternal Exposure; Tobacco Smoke Pollution / analysis; Young Adult
TL;DR:
Maternal tobacco smoke exposure in pregnancy is associated with cord blood CD4+ DNA methylation in key regulatory regions, including enhancers, and a differentially methylated CpG in amino acid transporter SLC7A8 that is highly reproducible, which may be sensitive to cigarette smoke in both cord blood and adultCD4+ cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 28, 2019
2019 journal article
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
NATURE COMMUNICATIONS, 10.
MeSH headings : Adolescent; Adult; Birth Weight / genetics; Body Mass Index; Child; CpG Islands; DNA / genetics; DNA / metabolism; DNA Methylation; Epigenesis, Genetic; Female; Fetal Development / genetics; Fetus; Folic Acid / blood; Genome, Human; Genome-Wide Association Study; Humans; Infant, Newborn; Male; Pregnancy; Prenatal Exposure Delayed Effects / blood; Prenatal Exposure Delayed Effects / etiology; Prenatal Exposure Delayed Effects / genetics; Prenatal Exposure Delayed Effects / physiopathology; Smoking / adverse effects; Smoking / blood; Smoking / genetics
TL;DR:
A meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium finds that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 13, 2019
2019 journal article
Differential methylation values in differential methylation analysis
BIOINFORMATICS, 35(7), 1094–1097.
MeSH headings : DNA Methylation; Linear Models; Research Design
TL;DR:
It is shown that under the condition that M-value linear regression model is correct, the method M-model-coef is the best among the four methods and the M- model-M-mean method works very well too.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 6, 2019
2019 journal article
Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study
EPIGENETICS, 14(4), 325–340.
author keywords: DNA methylation; epigenome-wide association study; maternal obesity; offspring body mass index; offspring blood pressure; cardiometabolic health; ALSPAC; NEST
MeSH headings : Adult; Blood Pressure; Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / genetics; Child; Child, Preschool; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Genome-Wide Association Study; Humans; Infant, Newborn / blood; Infant, Newborn / growth & development; Male; Membrane Transport Proteins / genetics; Metabolic Syndrome / epidemiology; Metabolic Syndrome / genetics; Obesity / epidemiology; Obesity / genetics
TL;DR:
Findings suggest sex-specific effects at CpG sites of the TAPBP gene were associated with BMI z-score and systolic BP percentile in female and syStolic and diastolicBP percentile in male offspring, which, if causal, may explain observed sex- specific effects of maternal obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 29, 2019
2019 journal article
Racial and ethnic differences in predictors of vitamin D among pregnant women in south-eastern USA
JOURNAL OF NUTRITIONAL SCIENCE, 8.
author keywords: Vitamin D; 25-Hydroxyvitamin D; Race; Ethnicity
MeSH headings : Adult; Cohort Studies; Ethnicity; Female; Hispanic or Latino; Humans; Maternal Nutritional Physiological Phenomena; Multivariate Analysis; Pregnancy; Pregnant Women; Prenatal Care; Prevalence; Regression Analysis; Seasons; United States / epidemiology; Vitamin D / analogs & derivatives; Vitamin D / blood; Vitamin D Deficiency / blood; Vitamin D Deficiency / complications; Vitamin D Deficiency / epidemiology; White People
TL;DR:
Although women with darker skin tones are most vulnerable to prenatal vitamin D insufficiency, season may be more strongly associated with insuffsiciency among women with lighter skin tones.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 18, 2019
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