Works Published in 2021
Displaying all 17 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2021 journal article
TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA
NUCLEIC ACIDS RESEARCH, 49(22), 13000–13018.
MeSH headings : Animals; DNA / chemistry; DNA / genetics; DNA / metabolism; HeLa Cells; Humans; Mice, Inbred C57BL; Microscopy, Atomic Force; Nucleic Acid Conformation; Protein Binding; Shelterin Complex / genetics; Shelterin Complex / metabolism; Telomere / genetics; Telomere / metabolism; Telomere-Binding Proteins / genetics; Telomere-Binding Proteins / metabolism; Telomeric Repeat Binding Protein 2 / genetics; Telomeric Repeat Binding Protein 2 / metabolism
TL;DR:
A molecular model in which TIN2 functions as an architectural protein to promote TRF2-mediated trans and cis higher-order nucleic acid structures at telomeres is proposed.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 18, 2022
2021 journal article
Identifying the Best Questions for Rapid Screening of Secondhand Smoke Exposure Among Children
NICOTINE & TOBACCO RESEARCH, 23(7), 1217–1223.
MeSH headings : Child; Child, Preschool; Cotinine / analysis; Humans; Nutrition Surveys; Parents; Saliva / chemistry; Tobacco Smoke Pollution / adverse effects
TL;DR:
Using saliva cotinine concentration levels as a gold standard for determining SHS exposure, an analysis employing elastic net regression identified two questions that served as good classifier for distinguishing children who might be at risk for secondhand smoking exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 3, 2022
2021 journal article
Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis
BMJ GLOBAL HEALTH, 6(9).
author keywords: child health; environmental health; epidemiology; maternal health; nutrition
MeSH headings : Female; Gestational Age; Humans; Infant, Newborn; Pregnancy; Premature Birth / epidemiology; Selenium
TL;DR:
This study observed statistically significant associations between maternal Se concentration and PTB at some sites, but this did not generalise across the entire cohort, and there was a substantial heterogeneity among study cohorts and the random-effect meta-analysis did not achieve statistical significance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 27, 2021
2021 journal article
Transcriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Animals; Body Weight / drug effects; Body Weight / genetics; Cadmium / toxicity; Female; Fetal Development / drug effects; Fetal Development / genetics; Humans; Maternal Exposure; Metabolomics / methods; Mice; Mice, Inbred C57BL; Neurodevelopmental Disorders / chemically induced; Neurodevelopmental Disorders / genetics; Placenta / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Proteomics / methods; Transcriptome / genetics
TL;DR:
The identification of multiple pathways perturbed in the developing brain provides a basis for future studies determining the mechanistic links between maternal Cd exposure and altered neurodevelopment and behavior.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 30, 2021
2021 journal article
DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study
ENVIRONMENTAL HEALTH PERSPECTIVES, 129(5).
MeSH headings : DNA Methylation; Epigenesis, Genetic; Epigenome; Female; Fetal Blood / chemistry; Humans; Infant, Newborn; Maternal Exposure / adverse effects; Pregnancy; Tobacco Smoke Pollution / adverse effects
TL;DR:
It is suggested that even low levels of smoke exposure during pregnancy may be sufficient to alter DNA methylation in distinct sites of mixed umbilical cord blood leukocytes in pathways that are known to be altered in cord blood from pregnant active smokers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 19, 2021
2021 journal article
Implications of Regionalizing Care in the Developing World: Impact of Distance to Referral Center on Compliance to Biopsy Recommendations in a Brazilian Prostate Cancer Screening Cohort
PROSTATE CANCER, 2021.
TL;DR:
In Brazil, where distances to referral centers can be large, greater distance was related to reduced biopsy compliance in a PC screening cohort, and among men who lived within 150 km, distance was unrelated to compliance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 19, 2021
2021 journal article
Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9.
author keywords: dopa decarboxylase; knock-out; imprinting; heart; mouse; human
TL;DR:
Comparative studies in the human developing heart reveal a paternal expression bias with polymorphic imprinting patterns between individual human hearts at DDC_EXON1a, a finding consistent with other imprinted genes in human.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 12, 2021
2021 journal article
Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia
INFECTIOUS AGENTS AND CANCER, 16(1).
author keywords: Cervical intraepithelial neoplasia; Gene methylation; Imprinted gene; Human papillomavirus
TL;DR:
An association between altered DNA methylation at regulatory regions of PEG3 and high grade CIN in high-risk HPV positive cases is suggested in women enrolled at colposcopic evaluation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: June 28, 2021
2021 journal article
Estimating exposure to neighborhood crime by race and ethnicity for public health research
BMC PUBLIC HEALTH, 21(1).
author keywords: Police-reported crime; Race and ethnicity; Crime exposure; Police; Policing
MeSH headings : Crime; Ethnicity; Humans; Infant, Newborn; North Carolina / epidemiology; Police; Public Health; Residence Characteristics; United States
TL;DR:
Dramatic disparities in exposure to crime based on participant race and ethnicity are demonstrated and variability in these disparities is highlighted based on the type of crime and crime measurement method chosen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(Web of Science)
Source: Web Of Science
Added: June 28, 2021
2021 journal article
Smoke-Free Home Rules and Association with Child Secondhand Smoke Exposure among Mother-Child Dyad Relationships
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(10).
author keywords: smoke-free home; smoke-free home rules; child secondhand smoke exposure; salivary cotinine; household smokers; smoking mothers
MeSH headings : Child; Female; Humans; Longitudinal Studies; Mother-Child Relations; North Carolina; Saliva / chemistry; Tobacco Smoke Pollution / analysis
TL;DR:
Smoke-free home rules are not sufficient to fully protect children from secondhand smoke exposure, especially in homes with smokers, and future research should focus on how household members who smoke can facilitate the prevention of child second hand smoke exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 10, 2021
2021 journal article
Opposing Epigenetic Signatures in Human Sperm by Intake of Fast Food Versus Healthy Food
FRONTIERS IN ENDOCRINOLOGY, 12.
author keywords: nutrition; sperm; imprinted genes; POHaD; TIEGER study; high fat food
MeSH headings : Adolescent; Adult; DNA Methylation; Epigenesis, Genetic; Fast Foods; Genomic Imprinting; Humans; Male; Spermatozoa / metabolism; Young Adult
TL;DR:
Dietary habits are linked to sperm epigenetic outcomes and carried into the next generation paternal unhealthy dietary patterns may result in adverse metabolic conditions and increased risk for chronic diseases in offspring.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 17, 2021
2021 journal article
BMAA and MCLR Interact to Modulate Behavior and Exacerbate Molecular Changes Related to Neurodegeneration in Larval Zebrafish
TOXICOLOGICAL SCIENCES, 179(2), 251–261.
author keywords: cyanotoxins; mixtures; zebrafish; behavior; proteomics
MeSH headings : Amino Acids, Diamino / toxicity; Animals; Cyanobacteria Toxins; Larva; Proteomics; Zebrafish
TL;DR:
This study evaluates the neurotoxic effects of a mixture of two co-occurring cyanotoxins, β-methylamino-L-alanine (BMAA) and microcystin leucine and arginine (MCLR), using the larval zebrafish model to reveal that BMAA and MCLR interact in vivo to enhance neurotoxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 3, 2021
2021 journal article
ALSUntangled 59: Tamoxifen THE ALSUNTANGLED GROUP
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION, 22(7-8), 595–598.
author keywords: Tamoxifen; ALSUntangled; off-label treatment; trials; ethics; therapy; clinical trials
MeSH headings : Amyotrophic Lateral Sclerosis / drug therapy; Humans; Tamoxifen / therapeutic use
TL;DR:
While Tamoxifen cannot yet endorse this as an ALS treatment, there is enough evidence to warrant another larger ALS trial, and it appears reasonably safe, though there is a small risk of developing cancer with long term use.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 15, 2021
2021 journal article
Toxicant exposure during pregnancy increases protective proteins in the dam and a sexually dimorphic response in the fetus
TOXICOLOGY AND APPLIED PHARMACOLOGY, 413.
author keywords: Vinclozolin; Endocrine Disrupting Compounds; Proteomics; Detoxification; Liver
MeSH headings : Adenosine Triphosphate / metabolism; Androgen Antagonists / metabolism; Androgen Antagonists / toxicity; Animals; Endocrine Disruptors / metabolism; Endocrine Disruptors / toxicity; Female; Liver / drug effects; Liver / embryology; Liver / metabolism; Male; Maternal Exposure; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Mice; Oxazoles / metabolism; Oxazoles / toxicity; Oxidative Phosphorylation; Pregnancy; Proteome; Proteomics; Sex Characteristics; Sex Factors
TL;DR:
Proteomic alterations in the livers of mouse dams and their male and female fetuses induced by vinclozolin, a model antiandrogenic EDC, suggest that female Fetuses increase protective mechanisms, whereas male fetuses increase ATP production and upregulate several disease pathways that are indicative of oxidative damage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: March 15, 2021
2021 journal article
Association of birth mode of delivery with infant faecal microbiota, potential pathobionts, and short chain fatty acids: a longitudinal study over the first year of life
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 128(8), 1293–1303.
author keywords: Delivery mode; infant gut microbiome; short-chain fatty acids
MeSH headings : Adult; Bacteroides / isolation & purification; Bifidobacterium / isolation & purification; Butyrates / metabolism; Cesarean Section; Clostridium / isolation & purification; Clostridium perfringens / isolation & purification; Delivery, Obstetric; Fatty Acids, Volatile / metabolism; Feces / chemistry; Feces / microbiology; Female; Gastrointestinal Microbiome; Humans; Infant; Infant, Newborn; Longitudinal Studies; Pregnancy; Prospective Studies; Young Adult
TL;DR:
Examination of birth delivery mode (CS versus vaginal delivery) with the infant gut microbiota and faecal SCFAs measured 3 and 12 months after birth finds CS interrupts mother‐to‐newborn microbial transfer at birth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 22, 2021
2021 journal article
Male obesity impacts DNA methylation reprogramming in sperm
CLINICAL EPIGENETICS, 13(1).
author keywords: Epigenetics; Methylation; Reprogramming; Sperm; Obesity; TIEGER study
MeSH headings : Adolescent; Adult; Age Factors; DNA Methylation; Epigenesis, Genetic; Gametogenesis / genetics; Genomic Imprinting; Healthy Volunteers / statistics & numerical data; Humans; Male; Obesity / complications; Obesity / genetics; Spermatozoa / physiology; Young Adult
TL;DR:
Male obesity is associated with altered sperm DNA methylation profiles that appear to affect reprogramming fidelity in a subset of sperm, suggestive of an influence on the spermatogonia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 15, 2021
2021 journal article
Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort
PEDIATRIC OBESITY, 16(7).
author keywords: cytokines; maternal obesity; childhood obesity
MeSH headings : Black or African American; Body Mass Index; Child; Child, Preschool; Cohort Studies; Cytokines / blood; Female; Humans; Obesity, Maternal / epidemiology; Pediatric Obesity / epidemiology; Pregnancy; White People
TL;DR:
Although maternal systemic inflammation is hypothesized to link maternal pre‐pregnancy obesity to offspring metabolic dysfunction, patient empirical data are limited.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: January 19, 2021
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