Works Published in 2015
Displaying all 7 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing
Angewandte Chemie International Edition, 54(41), 12029–12033.
author keywords: CRISPR-Cas9; DNA; drug delivery; genome editing; nanoparticles
MeSH headings : Animals; CRISPR-Associated Proteins / administration & dosage; CRISPR-Associated Proteins / chemistry; CRISPR-Associated Proteins / genetics; CRISPR-Cas Systems; Cell Line; Clustered Regularly Interspaced Short Palindromic Repeats; DNA / administration & dosage; DNA / chemistry; DNA / genetics; Green Fluorescent Proteins / genetics; Humans; Mice, Nude; Nanoparticles / chemistry; Neoplasms / genetics; Neoplasms / therapy; RNA, Guide, Kinetoplastida / administration & dosage; RNA, Guide, Kinetoplastida / chemistry; RNA, Guide, Kinetoplastida / genetics; Streptococcus pyogenes / chemistry; Streptococcus pyogenes / genetics
TL;DR:
The biologically inspired vehicles were efficiently loaded with Cas9/sgRNA complexes and delivered the complexes to the nuclei of human cells, thus enabling targeted gene disruption while maintaining cell viability.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2015 journal article
Cover Picture: Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing (Angew. Chem. Int. Ed. 41/2015)
Angewandte Chemie International Edition, 54(41), 11877–11877.
Source: Crossref
Added: February 24, 2020
2015 journal article
Isolation and characterization of a 2-methylpropene (isobutylene)-metabolizing bacterium, Mycobacterium sp. ELW1
Applied and Environmental Microbiology, 81, 1966–1976.
Source: NC State University Libraries
Added: February 5, 2019
2015 journal article
Impact of Residual Inducer on Titratable Expression Systems
PLOS ONE, 10(9).
MeSH headings : Arabinose / biosynthesis; Arabinose / genetics; Bacterial Proteins / biosynthesis; Bacterial Proteins / genetics; Escherichia coli; Flow Cytometry; Gene Expression Regulation, Bacterial; Models, Theoretical; Plasmids; Promoter Regions, Genetic; Riboswitch / genetics; Thiamine / genetics; Thiamine Pyrophosphate / biosynthesis; Thiamine Pyrophosphate / genetics
TL;DR:
It is found that residual inducer had a distinct effect on “all-or-none” systems, which exhibited increased sensitivity to the added inducer until becoming fully induced.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Trade-offs in Engineering Sugar Utilization Pathways for Titratable Control
ACS SYNTHETIC BIOLOGY, 4(2), 141–149.
author keywords: carbon catabolism; Escherichia coli; feedback; inducible systems; linearization; systems biology
MeSH headings : Arabinose / metabolism; Carbohydrate Metabolism / physiology; Escherichia coli / metabolism; Metabolic Engineering; Models, Theoretical
TL;DR:
Overall, the findings indicate that there is no ideal set of typical alterations when co-opting natural utilization pathways for titratable control and suggest design rules for manipulating these pathways to advance basic genetic studies and the metabolic engineering of microorganisms for optimized chemical production.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression
NUCLEIC ACIDS RESEARCH, 43(1), 674–681.
MeSH headings : CRISPR-Associated Proteins / genetics; CRISPR-Cas Systems; Cell Engineering; Escherichia coli / genetics; Gene Deletion; Transcription, Genetic
TL;DR:
It is found that deletion of the signature cas3 gene converted this immune system in Escherichia coli into a programmable gene regulator capable of reversible gene silencing of heterologous and endogenous genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Metabolism of 2-Methylpropene (Isobutylene) by the Aerobic Bacterium Mycobacterium sp Strain ELW1
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 81(6), 1966–1976.
MeSH headings : Aerobiosis; Alkenes / metabolism; Carbon / metabolism; Cobalt / metabolism; Coenzymes / metabolism; Culture Media / chemistry; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; DNA, Ribosomal / chemistry; DNA, Ribosomal / genetics; Energy Metabolism; Hydroxybutyrates / metabolism; Molecular Sequence Data; Mycobacterium / isolation & purification; Mycobacterium / metabolism; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA
TL;DR:
The results suggest that, like aerobic MTBE- and TBA-metabolizing bacteria, strain ELW1 utilizes a cobalt/cobalamin-dependent mutase to transform 2-hydroxyisobutyrate, and their impact on the understanding of the microbial metabolism of alkenes and ether oxygenates is interpreted.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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