Works Published in 2010
Displaying all 5 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
Heterotaxin: A novel TGF-beta signaling inhibitor identified in a multi-phenotype profiling screen in Xenopus embryos
Developmental Biology, 344(1), 526.
TL;DR:
A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a novel pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2010 journal article
An Organotypic Slice Assay for High-Resolution Time-Lapse Imaging of Neuronal Migration in the Postnatal Brain
Journal of Visualized Experiments, (46).
MeSH headings : Animals; Brain / anatomy & histology; Brain / cytology; Cell Movement / physiology; Image Processing, Computer-Assisted / methods; Lateral Ventricles / cytology; Mice; Neural Stem Cells / cytology; Neurogenesis / physiology; Neurons / cytology; Olfactory Bulb / cytology; Organ Culture Techniques / methods
TL;DR:
An organotypic slice assay optimized for postnatal brain tissue, in which the extracellular conditions closely mimic the in vivo environment for migrating neuroblasts within the RMS, is described.
(via Semantic Scholar)
www.ncbi.nlm.nih.gov (repository)
Source: Crossref
Added: July 20, 2019
2010 journal article
Development of a Model of Sacrocaudal Spinal Cord Injury in Cloned Yucatan MiniPigs for Cellular Transplantation Research
CELLULAR REPROGRAMMING, 12(6), 689–697.
MeSH headings : Animals; Behavior, Animal; Cauda Equina / pathology; Cauda Equina / surgery; Cell Culture Techniques; Cells, Cultured; Cloning, Organism; Green Fluorescent Proteins / metabolism; Humans; Models, Animal; Nerve Regeneration / physiology; Nuclear Transfer Techniques; Recovery of Function / physiology; Sacrum; Spinal Cord / pathology; Spinal Cord / surgery; Spinal Cord Injuries / pathology; Stem Cell Transplantation / methods; Swine; Swine, Miniature / surgery
TL;DR:
It is demonstrated that transection of the sacrocaudal spinal cord in Yucatan SCNT clones produces profound, quantifiable neurological deficits restricted to the tail, which represents a powerful research tool to investigate the effect of cellular transplantation on axonal regeneration and functional recovery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Photocaged Morpholino Oligomers for the Light-Regulation of Gene Function in Zebrafish and Xenopus Embryos
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(44), 15644–15650.
MeSH headings : Animals; Cells, Cultured; Embryo, Nonmammalian / metabolism; Gene Expression; Morpholines / chemistry; Oligonucleotides / genetics; Oligonucleotides / metabolism; Ultraviolet Rays; Xenopus laevis / genetics; Xenopus laevis / metabolism; Zebrafish / genetics; Zebrafish / metabolism
TL;DR:
A novel and efficient synthetic route for incorporating photocaged monomeric building blocks directly into morpholino oligomers is reported and the utility of these caged morpholinos in the light-activated control of gene function in both cell culture and living embryos is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gut
DEVELOPMENT, 137(8), 1339–1349.
author keywords: Pitx1; Pitx2; Shroom; Apical constriction; Epithelium; Gut; Xenopus
MeSH headings : Animals; Base Sequence; Blastomeres / physiology; Cell Shape / genetics; Conserved Sequence; DNA Primers; Drosophila / anatomy & histology; Drosophila / physiology; Epithelial Cells / cytology; Epithelial Cells / physiology; Female; Gastrointestinal Tract / embryology; Gastrointestinal Tract / physiology; Gene Expression Regulation, Developmental; Genes, Reporter; Luciferases / genetics; Morphogenesis / physiology; Oligonucleotides, Antisense / pharmacology; Paired Box Transcription Factors / genetics; RNA, Messenger / genetics; Transcription Factors / genetics; Transcription Factors / physiology; Xenopus laevis / embryology
TL;DR:
It is shown in Xenopus that Shroom3 is essential for cell shape changes and morphogenesis in the developing vertebrate gut and thatShroom3 transcription in the gut requires the Pitx1 transcription factor and that ectopic expression of Pitx proteins is sufficient to induce Shrooms3-dependent cytoskeletal reorganization and epithelial cell shape change.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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