Works Published in 2012

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Displaying all 2 works

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2012 journal article

A Nestin-cre transgenic mouse is insufficient for recombination in early embryonic neural progenitors

Biology Open, 1(12), 1200–1203.

TL;DR: It is found that the rate of Nestin-cre driven recombination only reaches sufficiently high levels in NSCs and NPCs during late embryonic and early postnatal periods, which is important when commercially available cre lines are considered for directing recombination to embryonic NSCS and NPCs. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2012 journal article

A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos

DEVELOPMENT, 139(2), 437–442.

author keywords: Small-molecule inhibitor; Rho kinase; Photocaging; Xenopus
MeSH headings : Animals; Body Patterning / drug effects; Dioxoles / metabolism; Dioxoles / pharmacology; Embryo, Nonmammalian / metabolism; Immunohistochemistry; Indoles / metabolism; Indoles / pharmacology; Mice; NIH 3T3 Cells; Pyridines / metabolism; Pyridines / pharmacology; Ultraviolet Rays; Xenopus laevis / embryology; Xenopus laevis / metabolism; rho-Associated Kinases / antagonists & inhibitors; rho-Associated Kinases / metabolism
TL;DR: A novel pharmacological agent that can be light activated to achieve spatiotemporally limited inhibition of Rho kinase activity in vivo is developed and application to the spatially heterogeneous problem of embryonic left-right asymmetry revealed a differential requirement for Rho signaling on the left and right sides of the primitive gut tube. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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