Works Published in 2015
Displaying all 5 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Influence of Desorption Conditions on Analyte Sensitivity and Internal Energy in Discrete Tissue or Whole Body Imaging by IR-MALDESI
Journal of The American Society for Mass Spectrometry, 26(6), 899–910.
author keywords: IR-MALDESI; Mass spectrometry imaging; Laser desorption whole body imaging; Lipids; Xenobiotics
MeSH headings : Anesthetics, Local / analysis; Anesthetics, Local / pharmacokinetics; Animals; Cocaine / analysis; Cocaine / pharmacokinetics; Infrared Rays; Lipid Metabolism; Lipids / analysis; Mice; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Whole Body Imaging / methods
TL;DR:
Optimized desorption conditions have been used to conduct an untargeted lipidomic analysis of whole body sagittal sections of neonate mouse, with enhanced lipid coverage received by varying the laser wavelength used for mass spectrometry imaging (MSI).
(via Semantic Scholar)
link.springer.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Crossref
Added: July 20, 2019
2015 journal article
Transplantation of GABAergic Interneurons into the Neonatal Primary Visual Cortex Reduces Absence Seizures in Stargazer Mice
CEREBRAL CORTEX, 25(9), 2970–2979.
author keywords: absence seizure; MGE transplantation; network activity; Stargazer; visual cortex
MeSH headings : Animals; Calcium Channels / genetics; Calcium Channels / metabolism; Disease Models, Animal; Embryo, Mammalian; Epilepsy, Absence / genetics; Epilepsy, Absence / surgery; GABAergic Neurons / physiology; GABAergic Neurons / transplantation; Glutamate Decarboxylase / metabolism; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; In Vitro Techniques; Median Eminence / cytology; Membrane Potentials / drug effects; Membrane Potentials / physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neocortex / cytology; Nerve Tissue Proteins / metabolism; Proto-Oncogene Proteins c-fos / metabolism; Treatment Outcome; Visual Cortex / transplantation; gamma-Aminobutyric Acid / metabolism
TL;DR:
It is reported that transplantation of MGE cells into the primary visual cortex (V1) of Stg mice significantly reduces AE episodes and lowers mortality and presents MGE grafting in the V1 as a possible clinical approach in the treatment of AE.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging
AGING CELL, 14(5), 764–773.
author keywords: aging; barrier function; Clca3; cerebral cortex; ependymal cells; lipid droplets; mucin; oxidative stress
MeSH headings : Aging / metabolism; Animals; Ependyma / cytology; Ependyma / metabolism; Homeostasis; Intracellular Signaling Peptides and Proteins / deficiency; Intracellular Signaling Peptides and Proteins / metabolism; Lipid Metabolism; Membrane Proteins / deficiency; Membrane Proteins / metabolism; Mice; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Oxidative Stress; Prosencephalon / metabolism
TL;DR:
It is demonstrated that metabolic and barrier functions in ECs decline significantly during aging in mice, and this work constitutes a conceptually new paradigm in the potential role of ECs in the initiation of various conditions and diseases in the aging brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Budgett's frog (Lepidobatrachus laevis): A new amphibian embryo for developmental biology
DEVELOPMENTAL BIOLOGY, 405(2), 291–303.
author keywords: Lepidobatrachus; Xenopus; Amphibian; Embryo; Stages; Scaling
MeSH headings : Amphibians; Animals; Anura / embryology; Cell Lineage; Developmental Biology; Embryonic Development; Immunohistochemistry; Models, Animal; Morphogenesis; Organogenesis; Regeneration; Species Specificity; Xenopus laevis / physiology
TL;DR:
The Budgett's frog is described, an unusual species with eggs that are over twice the diameter of laboratory Xenopus, and embryos that can tolerate higher temperatures to develop into a tadpole four times more rapidly, which substantially accelerates the pace of experimentation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Unique Glycan Signatures Regulate Adeno-Associated Virus Tropism in the Developing Brain
JOURNAL OF VIROLOGY, 89(7), 3976–3987.
MeSH headings : Animals; Brain / virology; Dependovirus / physiology; Mice, Inbred BALB C; Receptors, Virus / metabolism; Sialic Acids / metabolism; Transduction, Genetic; Viral Tropism
TL;DR:
It is postulate that glycan signatures associated with host development can be exploited to redirect novel AAV vectors to specific cell types in the brain and suggest that carbohydrate content can be exploiting to regulate viral transport and tropism in the head.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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