Modeling the Living Embryo

Works Published in 2017

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Displaying all 6 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2017 journal article

Regulation of cytokinesis during corticogenesis: focus on the midbody

FEBS Letters, 591(24), 4009–4026.

By: C. Johnson  n, C. Wright n & H. Ghashghaei  n

author keywords: abscission; asymmetric; cell division; corticogenesis; cytokinesis; midbody; neurogenesis; symmetric
MeSH headings : Animals; Body Patterning / physiology; Cell Differentiation / physiology; Cell Division / physiology; Cell Movement / physiology; Cerebral Cortex / cytology; Cerebral Cortex / embryology; Cytokinesis / physiology; Humans; Neural Stem Cells / cytology; Neural Stem Cells / physiology; Neurogenesis / physiology
TL;DR: This review describes the midbody and its constituent proteins, as well as the known consequences of their manipulation during cortical development, and the potential functional relevance of midbody mechanisms is discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: February 21, 2020

2017 journal article

Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesis

DEVELOPMENT, 144(15), 2764–2770.

By: M. Pickett n, M. Dush n & N. Nascone-Yoder n

author keywords: Acetylcholinesterase; Morphogenesis; Gut; Intestine; Fibronectin; Xenopus laevis
MeSH headings : Acetylcholine / metabolism; Acetylcholinesterase / genetics; Acetylcholinesterase / metabolism; Animals; Cell Adhesion / physiology; Embryo, Nonmammalian / metabolism; Endoderm / cytology; Endoderm / metabolism; Fibronectins / genetics; Fibronectins / metabolism; Immunohistochemistry; Nervous System / embryology; Nervous System / metabolism; Organogenesis / genetics; Organogenesis / physiology; RNA, Messenger / genetics; Xenopus laevis / embryology; Xenopus laevis / genetics; Xenopus laevis / metabolism
TL;DR: A non-classical function of acetylcholinesterase in the polarization, rearrangement and adhesion of endoderm cells during Xenopus gut morphogenesis is identified and has wide-reaching implications for development and toxicology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Stomach curvature is generated by left-right asymmetric gut morphogenesis

DEVELOPMENT, 144(8), 1477–1483.

By: A. Davis n, N. Amin n, C. Johnson n, K. Bagley n, H. Ghashghaei  n & N. Nascone-Yoder n

author keywords: Left-right; Asymmetry; Stomach; Gut; Morphogenesis; Pitx2; Xenopus; Mouse
MeSH headings : Animals; Body Patterning; Endoderm / embryology; Endoderm / metabolism; Epithelium / embryology; Epithelium / metabolism; Homeodomain Proteins / metabolism; Mice; Rotation; Signal Transduction; Stomach / anatomy & histology; Stomach / embryology; Transcription Factors / metabolism; Xenopus / embryology
TL;DR: It is shown that the mechanisms that drive the curvature of the stomach are intrinsic to the gut tube itself, and this findings have implications for how LR patterning manifests distinct types of morphological asymmetries in different contexts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Mosaic analysis with double markers reveals distinct sequential functions of Lgl1 in neural stem cells

Neuron (Cambridge, Mass.), 94(3), 517-.

By: R. Beattie *, M. Postiglione*, L. Burnett *, S. Laukoter *, C. Streicher*, F. Pauler *, G. Xiao n, O. Klezovitch* ...

MeSH headings : Animals; Cell Polarity; Cell Proliferation / genetics; Embryo, Mammalian / metabolism; Glycoproteins / genetics; Glycoproteins / metabolism; Mice; Mice, Knockout; Microscopy, Confocal; Neocortex / embryology; Neocortex / growth & development; Neocortex / pathology; Neural Stem Cells / cytology; Neural Stem Cells / metabolism; Neurogenesis / genetics; Neuroglia / cytology; Neuroglia / metabolism; Neurons / cytology; Neurons / metabolism
TL;DR: Results suggest that NSC-mediated neuron and glia production is tightly regulated through the concerted interplay of sequential Lgl1-dependent global and cell intrinsic mechanisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury

SCIENTIFIC REPORTS, 7.

By: Y. Ren *, Y. Ao*, . Timothy M. O'Shea *, J. Burda *, A. Bernstein*, A. Brumm*, N. Muthusamy n, H. Ghashghaei  n ...

MeSH headings : Animals; Astrocytes / physiology; Cell Differentiation; Cicatrix / physiopathology; Disease Models, Animal; Ependyma / physiopathology; Mice; Mice, Transgenic; Neural Stem Cells / physiology; Spinal Cord Injuries / physiopathology
TL;DR: It is shown that ependyma contribution of progeny after SCI is minimal, local and dependent on direct ependymal injury, indicating that ependedyma are not a major source of endogenous neural stem cells or neuroprotective astrocytes afterSCI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

NATURE NEUROSCIENCE, 20(1), 20–23.

By: N. Muthusamy n, X. Zhang n, C. Johnson n, P. Yadav* & H. Ghashghaei  n

MeSH headings : Animals; Appetitive Behavior / physiology; Avoidance Learning / physiology; Behavior, Animal / physiology; Conditioning, Classical / physiology; Male; Mice; Neurogenesis / physiology; Neurons / physiology; Olfactory Cortex / physiology; Smell / physiology
TL;DR: It is demonstrated that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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