Works Published in 2018

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2018 journal article

To scratch an itch: Establishing a mouse model to determine active brain areas involved in acute histaminergic itch

IBRO Reports, 5, 67–73.

By: S. Ehling n, A. Butler n, S. Thi n, H. Ghashghaei n & W. Bäumer n

author keywords: c-fos; Itch; Brain; Medial habenula; Histamine H4 receptor
TL;DR: The specific histamine H4 receptor agonist ST-1006 induces acute itch in mice and selective H4R activation in the skin increases neuronal activity in the medial habenula. (via Semantic Scholar)
Source: Crossref
Added: February 21, 2020

2018 journal article

MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network


By: J. Brudvig*, J. Cain*, R. Sears*, G. Schmidt-Grimminger*, E. Wittchen*, K. Adler n, H. Ghashghaei n, J. Weimer*

MeSH headings : Actins / metabolism; Animals; Cytoskeleton / metabolism; Female; Male; Mice; Mice, Inbred C57BL; Microtubules / metabolism; Myristoylated Alanine-Rich C Kinase Substrate / metabolism; Neurites / metabolism; Neurons / cytology; Neurons / metabolism; Phosphorylation; Primary Cell Culture; Protein Binding; Pseudopodia / metabolism; Signal Transduction; cdc42 GTP-Binding Protein / metabolism
TL;DR: It is proposed that MARCKS is uniquely positioned to regulate CDC42 localization and interactions within specialized cellular compartments, such as nascent neurites. (via Semantic Scholar)
Source: Web Of Science
Added: October 19, 2018

2018 journal article

The left-right asymmetry of liver lobation is generated by Pitx2c-mediated asymmetries in the hepatic diverticulum


By: M. Womble n, N. Amin n & N. Nascone-Yoder n

author keywords: Xenopus; Liver; Left-right asymmetry; Endoderm; Morphogenesis; Pitx2
MeSH headings : Animals; Body Patterning / genetics; Diverticulum / embryology; Diverticulum / metabolism; Embryo, Nonmammalian / metabolism; Gene Expression Regulation, Developmental / genetics; Homeodomain Proteins / metabolism; Homeodomain Proteins / physiology; Liver / embryology; Liver / physiology; Morphogenesis / physiology; Transcription Factors / metabolism; Xenopus / embryology; Xenopus / physiology; Xenopus Proteins / metabolism; Xenopus Proteins / physiology
TL;DR: Side-specific gain- and loss-of-function studies reveal that asymmetric expression of the left-right determinant Pitx2c elicits distinct epithelial morphogenesis events in the left side of the diverticulum. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain


By: N. Muthusamy n, A. Brumm*, X. Zhang n, S. Carmichael* & H. Ghashghaei n

MeSH headings : Animals; Cell Differentiation / physiology; Ependyma / metabolism; Forkhead Transcription Factors / metabolism; Mice; Neurogenesis / physiology; Neuroglia / metabolism; Neurons / metabolism; Prosencephalon / metabolism; Stem Cells / metabolism; Stroke / metabolism
TL;DR: Using a cell specific genetic approach, Foxj1+ ependymal cells are ruled out as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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