Works Published in 2021

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Displaying works 1 - 20 of 23 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2021 journal article

A Pilot Study Examining the Efficacy of Delivering Colorectal Cancer Screening Messages via Virtual Health Assistants

American Journal of Preventive Medicine, 61(2), 251–255.

By: J. Krieger*, J. Neil*, K. Duke*, M. Zalake*, F. Tavassoli*, M. Vilaro*, D. Wilson-Howard*, S. Chavez* ...

MeSH headings : Adult; Black or African American; Colorectal Neoplasms / diagnosis; Early Detection of Cancer; Humans; Mass Screening; Pilot Projects
TL;DR: Animated virtual healthcare assistants were efficacious compared with the staticvirtual healthcare assistant and attention control conditions and warrants additional investigation in future studies given the potential for virtual healthcare assistant‒assisted interventions to promote colorectal cancer screening within guidelines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Source: ORCID
Added: January 26, 2023

2021 article

To Reduce Healthcare Workload: Identify Critical Sepsis Progression Moments through Deep Reinforcement Learning

2021 IEEE INTERNATIONAL CONFERENCE ON BIG DATA (BIG DATA), pp. 1640–1646.

By: S. Ju n, Y. Kim n, M. Ausin n, M. Mayorga n & M. Chi n

author keywords: Reinforcement Learning; Sepsis; Critical Decision
TL;DR: The Critical-DRL approach, by which decisions are made at critical junctures, is as effective as a fully executed DRL policy and moreover, it enables the critical moments in the septic treatment process, thus greatly reducing burden on medical decision-makers by allowing them to make critical clinical decisions without negatively impacting outcomes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (Web of Science)
16. Peace, Justice and Strong Institutions (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 5, 2022

2021 article

Online Testing of Subgroup Treatment Effects Based on Value Difference

2021 21ST IEEE INTERNATIONAL CONFERENCE ON DATA MINING (ICDM 2021), pp. 1463–1468.

By: M. Yu n, W. Lu n & R. Song n

author keywords: sequential testing; heterogeneous treatment effects
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2021 article

Multi-Objective Model-based Reinforcement Learning for Infectious Disease Control

KDD '21: PROCEEDINGS OF THE 27TH ACM SIGKDD CONFERENCE ON KNOWLEDGE DISCOVERY & DATA MINING, pp. 1634–1644.

By: R. Wan n, X. Zhang n & R. Song n

author keywords: infectious disease control; COVID-19; sequential decision making
TL;DR: A Multi-Objective Model-based Reinforcement Learning framework to facilitate data-driven decision-making and minimize the overall long-term cost is proposed and provides a real-time decision support tool for policymakers. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 14, 2022

2021 article

Statistical inference of the value function for reinforcement learning in infinite-horizon settings

Shi, C., Zhang, S., Lu, W., & Song, R. (2021, December 22). JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, Vol. 12.

By: C. Shi*, S. Zhang n, W. Lu n & R. Song n

author keywords: bidirectional asymptotics; confidence interval; infinite horizons; reinforcement learning; value function
TL;DR: The focus of this paper was to construct confidence intervals (CIs) for a policy’s value in infinite horizon settings where the number of decision points diverges to infinity and it is shown that the proposed CI achieves nominal coverage even in cases where the optimal policy is not unique. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Sources: Web Of Science, ORCID
Added: January 3, 2022

2021 article

Estimation of the odds ratio in a proportional odds model with censored time-lagged outcome in a randomized clinical trial

Tsiatis, A. A., Davidian, M., & Holloway, S. T. (2021, December 17). BIOMETRICS, Vol. 12.

author keywords: augmented inverse probability weighting; censored ordinal categorical outcome; covariate adjustment; COVID-19 treatment; estimating function; marked point process
TL;DR: An estimator for the OR in a proportional odds model with censored, time‐lagged categorical outcome that incorporates additional baseline and time‐dependent covariate information and demonstrates that it can result in considerable gains in efficiency relative to simpler approaches is proposed. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 17, 2021

2021 journal article

Prediction of Sepsis Related Mortality: An Optimization Approach

IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 25(11), 4207–4216.

By: J. Agor*, N. Paramita n & O. Ozaltn n

author keywords: Sepsis; SOFA score; optimization; mixed-integer programming; electronic health records
TL;DR: This study proposes multiple strategies to adjust the SOFA score using mixed-integer programming to improve the in-hospital mortality prediction of septic patients based on Electronic Health Records (EHRs) to take advantage of optimization and data analysis while taking into account the medical expertise. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 23, 2021

2021 journal article

Mapping of critical events in disease progression through binary classification: Application to amyotrophic lateral sclerosis

JOURNAL OF BIOMEDICAL INFORMATICS, 123.

author keywords: Disease progression; Timing of critical events; Binary classification; Amyotrophic lateral sclerosis; Prognosis; Kaplan-Meier analysis
MeSH headings : Amyotrophic Lateral Sclerosis; Disease Progression; Humans; Prospective Studies; Speech; Walking
TL;DR: A novel binary classification approach to map scale scores into disease tollgates to describe disease progression leveraging standard/modified Kaplan-Meier analyses is developed and demonstrated by estimating progression pathways in amyotrophic lateral sclerosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 1, 2021

2021 journal article

Deep learning and regression approaches to forecasting blood glucose levels for type 1 diabetes

BIOMEDICAL SIGNAL PROCESSING AND CONTROL, 69.

author keywords: Neural networks; Regression; Encoder decoder; Time series forecasting; Diabetes
TL;DR: A neural network model using an encoder-decoder architecture has the most stable performance and is able to recover missing dynamics in short time intervals and may enable a feasible solution with low computational cost for the time-dependent adjustment of artificial pancreas for diabetes patients. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 30, 2021

2021 article

Rejoinder: Estimating vaccine efficacy over time after a randomized study is unblinded

Tsiatis, A. A., & Davidian, M. (2021, August 22). BIOMETRICS, Vol. 8.

By: A. Tsiatis n & M. Davidian n

MeSH headings : Randomized Controlled Trials as Topic; Vaccine Efficacy
TL;DR: Responding to the points they raise has enhanced the understanding of the area and the role of the work within it, and all note challenges posed by viral variants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 30, 2021

2021 article

Estimating vaccine efficacy over time after a randomized study is unblinded

Tsiatis, A. A., & Davidian, M. (2021, August 13). BIOMETRICS, Vol. 8.

By: A. Tsiatis n & M. Davidian n

author keywords: crossover; inverse probability weighting; potential outcomes; randomized phase 3 vaccine trial; waning vaccine efficacy
MeSH headings : COVID-19 / prevention & control; COVID-19 Vaccines; Humans; Pandemics / prevention & control; Randomized Controlled Trials as Topic; Research Design; SARS-CoV-2; Vaccine Efficacy
TL;DR: This work focuses on the particular features of the Moderna trial and proposes a statistical framework based on a potential outcomes formulation within which methods for inference on potential waning of VE over time and estimation ofVE at any postvaccination time are developed. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 23, 2021

2021 article

On estimating optimal regime for treatment initiation time based on restricted mean residual lifetime

Chen, X., Song, R., Zhang, J., Adams, S. A., Sun, L., & Lu, W. (2021, August 7). BIOMETRICS, Vol. 8.

author keywords: individualized treatment regime; kernel estimation; optimal treatment initiation time; time-to-event data; value function
MeSH headings : Humans; Models, Statistical; Computer Simulation
TL;DR: This article proposes to use restricted mean residual lifetime as a value function to evaluate the performance of different treatment initiation regimes, and develops a nonparametric estimator for the value function, which is consistent even when treatment initiation times are not completely observable and their distribution is unknown. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 16, 2021

2021 journal article

GEAR: On optimal decision making with auxiliary data

STAT, 10(1).

By: H. Cai n, R. Song n & W. Lu n

author keywords: augmented inverse propensity weighted estimation; auxiliary data; individualized treatment rule; optimal treatment decision making
TL;DR: An auGmented inverse propensity weighted Experimental and Auxiliary sample-based decision Rule (GEAR) is proposed by maximizing the augmented inverse susceptibility weighted value estimator over a class of decision rules using the experimental sample, with the primary outcome being imputed based on the auxiliary sample. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 9, 2021

2021 article

Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study

McDaniel, M., Flores, K. B., & Akpa, B. S. (2021, July 19). DRUGS IN R&D.

By: M. McDaniel n, K. Flores n & B. Akpa*

MeSH headings : Anesthetics, Local / toxicity; Animals; Bupivacaine / toxicity; Cardiotoxicity; Lipids; Rats; Rats, Sprague-Dawley
TL;DR: A mechanistic model predicted a plausible range of treatment outcomes that accurately predicts changes in LD50 when extrapolated to putatively toxic doses of bupivacaine, and causal analysis of the predicted survival outcomes indicated a critical synergy between scavenging and direct cardiotonic mechanisms of ILE action. (via Semantic Scholar)
Source: Web Of Science
Added: July 26, 2021

2021 journal article

Topological data analysis distinguishes parameter regimes in the Anderson-Chaplain model of angiogenesis

PLOS COMPUTATIONAL BIOLOGY, 17(6).

MeSH headings : Algorithms; Animals; Blood Vessels / anatomy & histology; Blood Vessels / growth & development; Blood Vessels / physiology; Chemotaxis; Computational Biology; Computer Simulation; Humans; Models, Cardiovascular; Neoplasms / blood supply; Neovascularization, Pathologic; Neovascularization, Physiologic; Spatio-Temporal Analysis
TL;DR: This work simulates the Anderson-Chaplain model of angiogenesis at different parameter values, and proposes a topological data analysis (TDA) pipeline for systematic analysis of the model and shows that TDA of model simulation data stratifies parameter space into regions with similar vessel morphology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: July 19, 2021

2021 journal article

Association of Simulated COVID-19 Vaccination and Nonpharmaceutical Interventions With Infections, Hospitalizations, and Mortality

JAMA NETWORK OPEN, 4(6).

By: M. Patel*, E. Rosenstrom n, J. Ivy n, M. Mayorga n, P. Keskinocak*, R. Boyce*, K. Hassmiller Lich*, R. Smith* ...

MeSH headings : Adult; COVID-19 / epidemiology; COVID-19 / prevention & control; COVID-19 / transmission; COVID-19 Vaccines / pharmacology; Communicable Disease Control / methods; Communicable Disease Control / organization & administration; Communicable Disease Control / statistics & numerical data; Computer Simulation; Disease Transmission, Infectious / prevention & control; Female; Hospitalization / statistics & numerical data; Humans; Male; Mass Vaccination / organization & administration; Mass Vaccination / statistics & numerical data; Mortality; North Carolina / epidemiology; Risk Assessment / methods; Risk Assessment / statistics & numerical data; SARS-CoV-2; Treatment Outcome; Vaccination Coverage / organization & administration; Vaccination Coverage / statistics & numerical data
TL;DR: Findings highlight the need for high COVID-19 vaccine coverage and continued adherence to NPIs before safely resuming many prepandemic activities. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2021 journal article

Stoichiometric Ecotoxicology for a Multisubstance World

BIOSCIENCE, 71(2), 132–147.

By: A. Peace*, P. Frost*, N. Wagner*, M. Danger*, C. Accolla*, P. Antczak, B. Brooks*, D. Costello* ...

author keywords: nutrient ratios; elemental imbalances; toxicity; ecotoxicological models; multiple stressors
TL;DR: Stochichiometric ecotoxicology is introduced, a subfield in ecology that examines how contaminant stress, nutrient supply, and elemental constraints interact throughout all levels of biological organization. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: May 24, 2021

2021 review

Learning differential equation models from stochastic agent-based model simulations

[Review of ]. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 18(176).

author keywords: agent-based models; differential equations; equation learning; population dynamics; disease dynamics
MeSH headings : Learning; Models, Biological; Molecular Dynamics Simulation; Monte Carlo Method; Stochastic Processes
TL;DR: This tutorial proposes that methods from the equation learning field provide a promising, novel and unifying approach for agent-based model analysis, and demonstrates that this framework is easy to use, requires few model simulations, and accurately predicts model dynamics in parameter regions where coarse-grained differential equation models fail to do so. (via Semantic Scholar)
Source: Web Of Science
Added: April 12, 2021

2021 journal article

Concordance and Value Information Criteria for Optimal Treatment Decision

Annals of Statistics, 49(1), 49–75.

By: C. Shi*, R. Song* & W. Lu*

author keywords: Concordance and value information criteria; optimal treatment regime; tuning parameter selection; variable selection
TL;DR: This paper studies two information criteria: the concordance and value information criteria, for variable selection in optimal treatment decision making, and considers both fixed-$p$ and high dimensional settings, and shows they are consistent in model/tuning parameter selection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Sources: Web Of Science, ORCID
Added: March 22, 2021

2021 journal article

Assigning spontaneous volunteers to relief efforts under uncertainty in task demand and volunteer availability

OMEGA-INTERNATIONAL JOURNAL OF MANAGEMENT SCIENCE, 99.

By: K. Paret n, M. Mayorga n & E. Lodree*

author keywords: Volunteer management; Disaster operations management; Spontaneous volunteer; Markov decision process; Discrete event simulation
TL;DR: A multi-server queuing model is formulated to represent the dynamics of assigning spontaneous volunteers to tasks in a post-disaster setting and an optimal policy for assigning volunteers to task is generated using a Markov Decision Process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (OpenAlex)
Sources: Web Of Science, ORCID
Added: January 4, 2021

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