Synthetic and Systems Biology

Works Published in 2014

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Displaying all 9 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2014 journal article

In Vivo Neuron-Wide Analysis of Synaptic Vesicle Precursor Trafficking

Traffic, 15(3), 273–291.

By: C. Maeder*, A. San-Miguel *, E. Wu*, H. Lu * & K. Shen *

Contributors: C. Maeder*, A. San-Miguel *, E. Wu*, H. Lu * & K. Shen *

MeSH headings : Animals; Axonal Transport; Caenorhabditis elegans / genetics; Caenorhabditis elegans / metabolism; Caenorhabditis elegans Proteins / genetics; Caenorhabditis elegans Proteins / metabolism; Motor Neurons / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Synaptic Vesicles / metabolism
TL;DR: Detailed dissection of speed distributions for wild‐type and unc‐ 104/kif1a mutant animals revealed an unexpected role for UNC‐104/KIF1A in dendritic SVP trafficking, suggesting that polarized SVP transport in concert with local vesicle capturing is necessary for accurate presynapse formation and maintenance. (via Semantic Scholar)
Source: ORCID
Added: May 31, 2023

2014 journal article

Using Targeted Chromatin Regulators to Engineer Combinatorial and Spatial Transcriptional Regulation

Cell, 158(1), 110–120.

By: A. Keung*, C. Bashor *, S. Kiriakov *, J. Collins * & A. Khalil *

MeSH headings : Chromatin / metabolism; Gene Expression Regulation, Fungal; Gene Regulatory Networks; Genes, Reporter; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / chemistry; Saccharomyces cerevisiae Proteins / metabolism; Transcription, Genetic
TL;DR: A synthetic biology approach to decipher the complexity of chromatin regulation by studying emergent transcriptional behaviors from engineered combinatorial, spatial, and temporal patterns of individual CRs. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2014 journal article

Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion.

Journal of Controlled Release : Official Journal of the Controlled Release Society.

Belinda Akpa

author keywords: Lipid emulsion; Local anesthetic; Bupivacaine; Triglyceride; Antidote; Biodetoxification
MeSH headings : Animals; Bupivacaine / pharmacokinetics; Bupivacaine / toxicity; Cardiac Output / drug effects; Cardiotonic Agents / administration & dosage; Cardiotonic Agents / pharmacology; Cardiotonic Agents / therapeutic use; Cardiotoxicity / drug therapy; Cardiotoxicity / metabolism; Cardiotoxicity / physiopathology; Cardiotoxins / pharmacokinetics; Cardiotoxins / toxicity; Emulsions / administration & dosage; Emulsions / pharmacology; Emulsions / therapeutic use; Liver / metabolism; Models, Biological; Muscle, Skeletal / metabolism; Myocardium / metabolism; Phospholipids / administration & dosage; Phospholipids / pharmacology; Phospholipids / therapeutic use; Rats; Soybean Oil / administration & dosage; Soybean Oil / pharmacology; Soybean Oil / therapeutic use; Triglycerides / administration & dosage; Triglycerides / pharmacology; Triglycerides / therapeutic use
TL;DR: An integrated mechanism of reversal of bupivacaine toxicity that includes both transient drug scavenging and a cardiotonic effect that couple to accelerate movement of the toxin away from sites of toxicity is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: May 18, 2019

2014 journal article

Resuscitation with lipid emulsion: dose-dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect.

Anesthesiology, 120(4), 915–925.

By: M. Fettiplace *, B. Akpa* , R. Ripper*, B. Zider*, J. Lang*, I. Rubinstein *, G. Weinberg*

Contributors: M. Fettiplace *, B. Akpa* , R. Ripper*, B. Zider*, J. Lang*, I. Rubinstein *, G. Weinberg*

MeSH headings : Anesthetics, Local / toxicity; Animals; Bupivacaine / toxicity; Cardiotonic Agents / therapeutic use; Disease Models, Animal; Dose-Response Relationship, Drug; Fat Emulsions, Intravenous / therapeutic use; Heart / drug effects; Heart / physiopathology; Heart Arrest / chemically induced; Heart Arrest / therapy; Heart Rate / drug effects; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Resuscitation / methods; Sodium Chloride / administration & dosage; Time Factors; Treatment Outcome
TL;DR: Intravenous lipid emulsion accelerates cardiovascular recovery from bupivacaine toxicity in a dose-dependent manner, which is driven by a cardiotonic response that complements the previously reported sequestration effect. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: May 18, 2019

2014 article

Intercellular Protein Movement: Deciphering the Language of Development

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30, Vol. 30, pp. 207–233.

By: K. Gallagher*, R. Sozzani  n & C. Lee*

author keywords: Arabidopsis development; plasmodesmata; non-cell-autonomous proteins; cell-to-cell signaling
TL;DR: This work reviews some of the transcriptional regulators that traffic between cells, as well as how changes in symplasmic continuity affect and are affected by development, and considers challenges in and new tools for studying protein movement. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 review

Experimental data and computational modeling link auxin gradient and development in the Arabidopsis root

[Review of ]. Frontiers in Plant Science, 5.

By: N. Clark, M. Balaguer & R. Sozzani 

Source: NC State University Libraries
Added: August 6, 2018

2014 review

Omics and modelling approaches for understanding regulation of asymmetric cell divisions in arabidopsis and other angiosperm plants

[Review of ]. ANNALS OF BOTANY, 113(7), 1083–1105.

By: K. Kajala *, P. Ramakrishna *, A. Fisher n, D. Bergmann *, I. De Smet *, R. Sozzani  n, D. Weijers *, S. Brady *

author keywords: Asymmetric cell division; embryo; root; stomata; lateral root; cortex endodermis initial; omics; Arabidopsis thaliana; Zea mays; maize
MeSH headings : Arabidopsis / embryology; Arabidopsis / genetics; Arabidopsis / growth & development; Asymmetric Cell Division; Genomics; Magnoliopsida / embryology; Magnoliopsida / genetics; Magnoliopsida / growth & development; Models, Genetic; Plant Roots / embryology; Plant Roots / genetics; Plant Roots / growth & development; Plant Shoots / embryology; Plant Shoots / genetics; Plant Shoots / growth & development
TL;DR: This review describes how asymmetric cell divisions are regulated during development and in different cell types in both the root and the shoot of plants, and highlights ways in which omics and modelling approaches have been used to elucidate these regulatory mechanisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 review

Advanced imaging techniques for the study of plant growth and development

[Review of ]. TRENDS IN PLANT SCIENCE, 19(5), 304–310.

By: R. Sozzani  n, W. Busch *, E. Spalding * & P. Benfey *

author keywords: imaging techniques; plant growth and development; systems-level modeling.
MeSH headings : Image Processing, Computer-Assisted / methods; Models, Biological; Phenotype; Plant Development; Plants / genetics; Systems Biology; Time Factors
TL;DR: Advances in parallelized and automated image acquisition enable the throughput to capture images from large populations of plants under specific growth conditions, and facilitate the integration of imaging data with genome-wide molecular data to enable systems-level modeling. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 review

Postembryonic control of root meristem growth and development

[Review of ]. CURRENT OPINION IN PLANT BIOLOGY, 17, 7–12.

By: R. Sozzani  n & A. Iyer-Pascuzzi *

MeSH headings : Biological Transport; Cell Differentiation / genetics; Cell Division / genetics; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Indoleacetic Acids / metabolism; Meristem / cytology; Meristem / genetics; Meristem / growth & development; Plant Roots / cytology; Plant Roots / genetics; Plant Roots / growth & development; Stem Cell Niche
TL;DR: Recent advances in the understanding of postembryonic root stem cell maintenance and control of meristem size are reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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