Works Published in 2016
Displaying all 13 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2016 chapter
Microfluidic Platforms for Quantitative Biology Studies in Model Organisms
In C. Lu & S. S. Verbridge (Eds.), Microfluidic Methods for Molecular Biology (pp. 1–18).
Contributors: D. Porto*, T. Rouse*, A. San-Miguel * & H. Lu *
Ed(s): C. Lu * & S. Verbridge
Event: at Cham
TL;DR:
An overview of the current state of the field, the impacts of microfluidics in model organism research, and the outlook, challenges, and opportunities for the future is provided.
(via Semantic Scholar)
Source: ORCID
Added: May 31, 2023
2016 journal article
Endothelial Membrane Modulation by OxLDL: Molecular-Scale Effects of Oxidation Products on Model Membranes
Biophysical Journal, 110(3), 81a.
TL;DR:
A molecular-scale investigation of changes induced in endothelial membranes in the presence of various oxidation products using coarse-grained molecular dynamics simulations may begin to clarify some of the molecular mechanisms underlying endothelial cell dysfunction resulting from exposure to OxLDL.
(via Semantic Scholar)
www.cell.com (publisher PDF)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
Molecular Dynamics Simulations of Kir2.2-Cholesterol Interactions
Biophysical Journal, 110(3), 186a.
TL;DR:
A computational approach which utilizes coarse-grained molecular dynamics simulations - employing the MARTINI force field - to further investigate the spatial and temporal mechanics of cholesterol binding has allowed for a greater range of binding effects, such as binding time, binding instances, changes in channel conformation, and ion flux through the channel.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
Deep phenotyping unveils hidden traits and genetic relations in subtle mutants
NATURE COMMUNICATIONS, 7.
Contributors: A. San-Miguel *, P. Kurshan *, M. Crane *, Y. Zhao*, P. McGrath *, K. Shen *, H. Lu *
MeSH headings : Alleles; Animals; Caenorhabditis elegans / genetics; Caenorhabditis elegans Proteins / genetics; Caenorhabditis elegans Proteins / metabolism; Gene Expression Regulation; Gene Regulatory Networks; Microfluidic Analytical Techniques; Models, Genetic; Quantitative Trait Loci
TL;DR:
This study describes an automated and unbiased multidimensional phenotyping method that relies on machine learning and complex feature computation of imaging data, and identifies weak alleles affecting synapse morphology in live C. elegans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Multi-sample Arabidopsis Growth and Imaging Chamber (MAGIC) for long term imaging in the ZEISS Lightsheet Z.1
Developmental Biology, 419(1), 19–25.
author keywords: Arabidopsis root; Light sheet; 3D printing; Time-lapse imaging
MeSH headings : Arabidopsis / ultrastructure; Arabidopsis Proteins / analysis; Cell Division; Computer-Aided Design; Cyclin B / analysis; Equipment Design; Green Fluorescent Proteins / analysis; Image Processing, Computer-Assisted / methods; Microscopy, Fluorescence / instrumentation; Microscopy, Fluorescence / methods; Plant Roots / ultrastructure; Printing, Three-Dimensional; Recombinant Fusion Proteins / analysis; Time-Lapse Imaging / instrumentation; Time-Lapse Imaging / methods
TL;DR:
A Multi-sample Arabidopsis Growth and Imaging Chamber (MAGIC) is developed that provides near-physiological imaging conditions and allows high-throughput time-course imaging experiments in the ZEISS Lightsheet Z.1, and its imaging capabilities are illustrated by following cell divisions, as an indicator of plant growth and development, over prolonged time periods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Light sheet microscopy reveals more gradual light attenuation in light-green versus dark-green soybean leaves
JOURNAL OF EXPERIMENTAL BOTANY, 67(15), 4697–4709.
author keywords: Chlorophyll; Glycine max; leaf light environment; light sheet microscopy; light use efficiency; photosynthesis; photosynthetic efficiency; soybean
MeSH headings : Chlorophyll / physiology; Chlorophyll / radiation effects; Chloroplasts / physiology; Chloroplasts / radiation effects; Color; Light; Microscopy / methods; Plant Leaves / physiology; Plant Leaves / radiation effects; Soybeans / physiology; Soybeans / radiation effects
TL;DR:
Highlight Light sheet microscopy, a novel approach to quantifying light profiles, showed more gradual light attenuation in light- green soybean leaves compared to dark-green soybean.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 review
The epigenome: the next substrate for engineering
[Review of ]. GENOME BIOLOGY, 17.
MeSH headings : Chromatin / genetics; Epigenesis, Genetic; Epigenomics; Genome, Human; Humans
TL;DR:
The design and state of epigenome editing tools are reviewed, highlighting the unique regulatory properties afforded by these systems.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Tracking transcription factor mobility and interaction in Arabidopsis roots with fluorescence correlation spectroscopy
Elife, 5.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
ROSY1, a novel regulator of gravitropic response is a stigmasterol binding protein
JOURNAL OF PLANT PHYSIOLOGY, 196-197, 28–40.
Contributors: J. Dalal n, D. Lewis*, O. Tietz*, E. Brown n, C. Brown n, K. Palme *, G. Muday *, H. Sederoff n
author keywords: Gravity; Root; Auxin; Sterol; Lipid; Membrane composition; Arabidopsis
MeSH headings : Amino Acid Sequence; Arabidopsis / genetics; Arabidopsis / growth & development; Arabidopsis / metabolism; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Biological Transport; Carrier Proteins / genetics; Carrier Proteins / metabolism; Gravitropism; Indoleacetic Acids / metabolism; Organ Specificity; Phylogeny; Sequence Alignment; Stigmasterol / metabolism
TL;DR:
The results suggest that ROSY1 plays a role in root gravitropism, possibly by facilitating membrane trafficking and asymmetric cell elongation via its interaction with synaptotagmin-1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 article
The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures
COUNTERMEASURES AGAINST CHEMICAL THREATS, Vol. 1374, pp. 111–122.
Contributors: D. Feinstein *, B. Akpa n , M. Ayee*, A. Boullerne*, D. Braun *, S. Brodsky *, D. Gidalevitz *, Z. Hauck*
author keywords: superwarfarins; brodifacoum; HPLC; lipid membrane; neuropathology; nephrotoxicity; intralipid
MeSH headings : Animals; Anticoagulants / adverse effects; Anticoagulants / analysis; Anticoagulants / chemistry; Biomarkers / analysis; Environmental Exposure / analysis; Humans; Kidney / drug effects; Kidney / pathology; Nervous System / drug effects; Nervous System / pathology; Warfarin / adverse effects; Warfarin / analysis; Warfarin / chemistry; Warfarin / poisoning
TL;DR:
This review summarizes superwarfarin development, biology and pathophysiology, their threat as weapons, and possible therapeutic approaches, including both vitamin K–dependent and –independent effects, which are not mitigated by vitamin K therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Structural perturbation of a dipalmitoylphosphatidylcholine (DPPC) bilayer by warfarin and its bolaamphiphilic analogue: A molecular dynamics study
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 468, 227–237.
Contributors: M. Ayee*, C. Roth* & B. Akpa n
author keywords: Bolaamphiphile; Bilayer; Anticoagulant; Toxicity; Permeation; Phospholipid; Warfarin; Brodifacoum; Defect; Hydroxycoumarin
MeSH headings : 1,2-Dipalmitoylphosphatidylcholine / chemistry; Lipid Bilayers / chemistry; Molecular Dynamics Simulation; Molecular Structure; Surface-Active Agents / chemistry; Warfarin / chemistry
TL;DR:
The consequences of anticoagulant accumulation in a dipalmitoylphosphatidylcholine bilayer are explored and it is found that brodifacoum partitioning into bilayers causes membrane thinning and permeabilization and promotes lipid flip-flop - phenomena that are suspected to play a role in triggering cell death.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 article
A unifying model of epigenetic regulation
Keung, A. J., & Khalil, A. S. (2016, February 12). SCIENCE, Vol. 351, pp. 661–662.
MeSH headings : Animals; Chromatin / metabolism; DNA Methylation; Gene Silencing; Histones / metabolism; Humans
TL;DR:
By studying how individual chromatin regulators (CRs) operate to produce distinct gene expression outputs within individual cells, Bintu et al. find that chromatin's complexity can be reduced into an elegant and unifying model of gene regulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Gene and networks regulating the root stem cell niche of Arabidopsis
Curr Opin Plant Biol, 29, 38–43.
MeSH headings : Arabidopsis / cytology; Arabidopsis / genetics; Arabidopsis / growth & development; Asymmetric Cell Division; Plant Roots / cytology; Plant Roots / genetics; Plant Roots / growth & development; Stem Cells / cytology
TL;DR:
This review will discuss several studies that characterized many of the genetic programs and molecular mechanisms regulating stem cell ACD and their identity in the Arabidopsis root and highlight how the growing use of mathematical modeling provides a comprehensive and quantitative perspective on the design rules governing stemcell ACDs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
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