Works Published in 2021
Displaying works 1 - 20 of 31 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2021 article
Gene regulatory networks for compatible versus incompatible grafts identify a role for SlWOX4 during junction formation
Thomas, H., Broeck, L. V., Spurney, R., Sozzani, R., & Frank, M. (2021, February 27).
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: January 25, 2024
2021 journal article
A hybrid model connecting regulatory interactions with stem cell divisions in the root
Quantitative Plant Biology.
TL;DR:
This work proposes a non-cell autonomous role for WOX5 in the cortex endodermis initial (CEI) and identifies a regulator, ANGUSTIFOLIA (AN3)/GRF-INTERACTING FACTOR 1, that coordinates CEI divisions.
(via Semantic Scholar)
Source: ORCID
Added: January 25, 2024
2021 article
Identifying C. elegans Lifespan Mutants by Screening for Early-Onset Protein Aggregation
Midkiff, D. F., & San-Miguel, A. (2021, December 16).
Source: ORCID
Added: May 31, 2023
2021 article
Endogenous DAF-16 Spatiotemporal Activity Quantitatively Predicts Lifespan Extension Induced by Dietary Restriction
Huayta, J., & San-Miguel, A. (2021, December 21).
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: May 31, 2023
2021 journal article
Antagonistic effects of chemical mixtures on the oxidative stress response are silenced by heat stress and reversed under dietary restriction
Exposome, 1(1).
Source: ORCID
Added: May 31, 2023
2021 article
Antagonistic effects of chemical mixtures on the oxidative stress response are silenced by heat stress and reversed under dietary restriction
Arulalan, K. S., Huayta, J., Stallrich, J. W., & San-Miguel, A. (2021, March 19).
TL;DR:
It is indicated that mixtures drive responses differently than individual components, and that altering environmental conditions, such as increased heat and reduced food availability, result in dramatically different oxidative stress responses mounted by C. elegans.
(via Semantic Scholar)
Source: ORCID
Added: May 31, 2023
2021 chapter
Microfluidic devices for imaging and manipulation of C. elegans
In Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms (pp. 295–321).
Source: ORCID
Added: May 31, 2023
2021 journal article
Cell-by-cell dissection of phloem development links a maturation gradient to cell specialization
SCIENCE, 374(6575), 1577-+.
MeSH headings : Arabidopsis / cytology; Arabidopsis / genetics; Arabidopsis / metabolism; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Cell Differentiation; GTP-Binding Proteins / genetics; GTP-Binding Proteins / metabolism; Meristem / cytology; Phloem / cytology; Phloem / genetics; Phloem / growth & development; Phloem / metabolism; Plant Roots / cytology; Plant Roots / genetics; Plant Roots / growth & development; Plant Roots / metabolism; RNA-Seq; Signal Transduction; Single-Cell Analysis; Transcription Factors / genetics; Transcription Factors / metabolism; Transcriptome
TL;DR:
The ability to connect cellular development such as lineage bifurcation and enucleation to molecular states using scRNA-seq allowed us to uncover genetic mechanisms that coordinate cellular maturation, and revealed the importance of RHO of PLANTS GTPase signaling during early phloem development when the protophloem cell lineage b ifurcates to generate metaphloem sieve element and procambium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID
Added: February 7, 2022
2021 journal article
Mapping the dynamic transfer functions of eukaryotic gene regulation
CELL SYSTEMS, 12(11), 1079-+.
MeSH headings : Chromatin / genetics; Eukaryota / genetics; Gene Expression Regulation / genetics; Promoter Regions, Genetic / genetics; Signal Transduction
TL;DR:
It is determined that chromatin state could be used to tune mutual information and expression levels, as well as completely alter the input-output transfer function of the promoter, which unlocks the information-rich content of eukaryotic gene regulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 31, 2022
2021 journal article
Mapping the residue specificities of epigenome enzymes by yeast surface display
CELL CHEMICAL BIOLOGY, 28(12), 1772-+.
MeSH headings : E1A-Associated p300 Protein / genetics; E1A-Associated p300 Protein / metabolism; Epigenome / genetics; Humans; Saccharomyces cerevisiae / metabolism
TL;DR:
The results show that using yeast surface display to study histone modifications is a useful tool that can advance the understanding of chromatin biology by enabling efficient interrogation of the complexity of epigenome modifications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 3, 2022
2021 article
Epigenetic modification associated with climate regulates betulin biosynthesis in birch
Wang, J., Chen, B., Ali, S., Zhang, T., Wang, Y., Zhang, H., … Zhang, Q. (2021, December 4). JOURNAL OF FORESTRY RESEARCH, Vol. 12.
author keywords: Epigenetics; DNA methylation; Betulin; bHLH9 transcription factor; Hormesis; Climate change; Secondary metabolite
TL;DR:
The role of environmental signals to induce epigenetic changes that result in betulin production is highlighted, possibly helping to develop resilient plants to combat ongoing climate change and enhance secondary metabolite production.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
13. Climate Action
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 13, 2021
2021 review
Solving the puzzle of Fe homeostasis by integrating molecular, mathematical, and societal models
[Review of ]. CURRENT OPINION IN PLANT BIOLOGY, 64.
author keywords: Iron homeostasis; Simulation-based inference (SBI); Inclusivity
MeSH headings : Biological Transport; Gene Expression Regulation, Plant; Homeostasis; Iron / metabolism; Plants / genetics; Plants / metabolism
TL;DR:
This work examines recent advances in the understanding of cellular responses to Fe deficiency and uses intracellular mechanisms of Fe homeostasis to discuss how formalizing cell biology knowledge via a mathematical model can advance discovery even when quantitative data is limited.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 27, 2021
2021 journal article
Integrated omics networks reveal the temporal signaling events of brassinosteroid response in Arabidopsis
NATURE COMMUNICATIONS, 12(1).
MeSH headings : Arabidopsis / metabolism; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Brassinosteroids / metabolism; Cell Division; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Gene Expression Regulation, Plant; Nuclear Proteins / metabolism; Plant Growth Regulators / metabolism; Protein Kinases / genetics; Protein Kinases / metabolism; Proteomics; Seedlings / metabolism; Signal Transduction; Steroids, Heterocyclic; Transcription Factors / metabolism
TL;DR:
By integrating multiple omics datasets and inferring networks, the authors profile BR signaling in Arabidopsis and characterize BRONTOSAURUS, a BR-regulated transcription factor that impacts cell division in roots.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021
2021 journal article
Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids
BMC BIOTECHNOLOGY, 21(1).
author keywords: Human cerebral organoids; Neurodevelopment; Agarose microwells; Microfabrication; RNAseq; Mechanobiology
MeSH headings : Brain; Cell Differentiation; Gene Expression Profiling; Humans; Organoids; Transcriptome
TL;DR:
A role for spatial factors in brain region specification during hCO development is suggested and this work observed that non-spherical shapes showed signs of altered neurodevelopmental kinetics and favored the development of medial ganglionic eminence-associated brain regions and cell types over cortical regions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 26, 2021
2021 article
Spatiotemporal Gene Expression Profiling and Network Inference: A Roadmap for Analysis, Visualization, and Key Gene Identification
MODELING TRANSCRIPTIONAL REGULATION, Vol. 2328, pp. 47–65.
author keywords: Gene regulatory network inference; RNA sequencing; Bioinformatics; Network visualization
MeSH headings : Algorithms; Amino Acid Motifs / genetics; Cluster Analysis; Computational Biology / methods; Gene Expression Profiling / methods; Gene Expression Regulation / genetics; Gene Regulatory Networks / genetics; Multigene Family; RNA-Seq / methods; Software; Spatio-Temporal Analysis; Workflow
TL;DR:
This chapter aims to present a workflow feasible and accessible for plant biologists without a bioinformatics or computer science background and chooses TuxNet, a user-friendly graphical user interface that integrates RNA sequencing data analysis with GRN inference, for the purpose of providing a detailed tutorial.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 4, 2021
2021 journal article
Two distinct trophectoderm lineage stem cells from human pluripotent stem cells
JOURNAL OF BIOLOGICAL CHEMISTRY, 296.
MeSH headings : CDX2 Transcription Factor / metabolism; Cell Culture Techniques; Cell Differentiation; Cell Lineage; Culture Media; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Female; Humans; Placenta / cytology; Placenta / metabolism; Pluripotent Stem Cells / cytology; Pluripotent Stem Cells / metabolism; Pregnancy; Trophoblasts / cytology; Trophoblasts / metabolism
TL;DR:
Derivation of hTSCs and hTESCs from pluripotent stem cells significantly enables construction of models for normal and pathological placental development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: September 7, 2021
2021 review
An Overview of the Practices and Management Methods for Enhancing Seed Production in Conifer Plantations for Commercial Use
[Review of ]. HORTICULTURAE, 7(8).
author keywords: conifers; flowering; seed production; pollination; phytohormones; tree management; nutrient fertilization
TL;DR:
The review revealed that flowering and seed yields in conifers are affected by a variety of factors, such as pollen, temperature, light, water availability, nutrients, etc., and a number of management techniques, including topping off, pruning, fertilization, hormone treatment, supplementary pollination, etc. has been developed for improving cone yields.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021
2021 article
A bioinspired, passive microfluidic lobe filtration system
Clark, A. S., & San-Miguel, A. (2021, August 11). LAB ON A CHIP, Vol. 21.
MeSH headings : Filtration; Microfluidic Analytical Techniques; Microfluidics; Particle Size
TL;DR:
Two microfluidic lobe filters bioinspired by the filtration mechanism of two species of manta ray are developed that enable filTration of particles around 10-30 μm with precise control and high throughput by using two arrays of equally spaced filter lobes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 30, 2021
2021 article
Optogenetics gets the worm
San-Miguel, A. (2021, June 30). SCIENCE ROBOTICS, Vol. 6.
MeSH headings : Animals; Caenorhabditis elegans / genetics; Caenorhabditis elegans Proteins / genetics; Locomotion; Optogenetics
TL;DR:
Analysis of Caenorhabditis elegans natural movement and optogenetic control of its muscle cells enable controlled locomotion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 16, 2021
2021 article
Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study
McDaniel, M., Flores, K. B., & Akpa, B. S. (2021, July 19). DRUGS IN R&D, Vol. 7.
MeSH headings : Anesthetics, Local / toxicity; Animals; Bupivacaine / toxicity; Cardiotoxicity; Lipids; Rats; Rats, Sprague-Dawley
TL;DR:
A mechanistic model predicted a plausible range of treatment outcomes that accurately predicts changes in LD50 when extrapolated to putatively toxic doses of bupivacaine, and causal analysis of the predicted survival outcomes indicated a critical synergy between scavenging and direct cardiotonic mechanisms of ILE action.
(via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 20, 2021
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