Recent Works

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Sorted by most recent date added to the index first, which may not be the same as publication date order.

2025 journal article

Noninvasive Fibrin Targeting Colloid-Mediated Intra-Articular Repair

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 113(4).

By: G. Scull n, J. Thompson n, M. Osareh n, Y. Rey n, A. Aligwekwe n, S. Finkelstein n, L. Schnabel n, M. Fisher n, A. Brown n

author keywords: ACL injury; biomaterials; clotting; fibrin; microgels; synovial fluid; synthetic platelets
MeSH headings : Fibrin / chemistry; Fibrin / metabolism; Synovial Fluid / metabolism; Tissue Scaffolds / chemistry; Colloids / chemistry; Humans; Animals; Wound Healing / drug effects; Viscosity
topics (OpenAlex): Peripheral Artery Disease Management; Vascular Procedures and Complications; Reconstructive Surgery and Microvascular Techniques
Sources: Web Of Science, NC State University Libraries
Added: April 7, 2025

2025 article

Inhalable Hsa-miR-30a-3p Liposomes Attenuate Pulmonary Fibrosis

Liu, S., Popowski, K. D., Eckhardt, C. M., Zhang, W., Li, J., Jing, Y., … Cheng, K. (2025, March 22). ADVANCED SCIENCE.

By: S. Liu*, K. Popowski n, C. Eckhardt*, W. Zhang*, J. Li*, Y. Jing, D. Silkstone n, E. Belcher n ...

author keywords: CNPY2; idiopathic pulmonary fibrosis; inhalation; miR-30a-3p
topics (OpenAlex): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis; Medical Imaging and Pathology Studies; Extracellular vesicles in disease
Source: Web Of Science
Added: March 31, 2025

2025 journal article

In vivo trafficking of cancer-derived exosomes and their role in metastasis

Extracellular Vesicle.

By: S. Wei, S. Shelton*, Y. Chen & K. Huang*

topics (OpenAlex): Extracellular vesicles in disease; RNA Interference and Gene Delivery; MicroRNA in disease regulation
Source: ORCID
Added: January 18, 2025

2025 journal article

Early degenerative changes are different between partial and complete anterior cruciate ligament injury and associate with joint instability in a skeletally immature porcine model

Osteoarthritis and Cartilage, 33(2), 302–312.

author keywords: Anterior cruciate ligament; Osteoarthritis; Biomechanics; Pediatrics; Orthopedics
MeSH headings : Animals; Joint Instability / physiopathology; Joint Instability / pathology; Anterior Cruciate Ligament Injuries / complications; Anterior Cruciate Ligament Injuries / pathology; Swine; Disease Models, Animal; Magnetic Resonance Imaging; Cartilage, Articular / pathology; Cartilage, Articular / diagnostic imaging; Cartilage, Articular / injuries; Biomechanical Phenomena; Female; Menisci, Tibial / surgery; Menisci, Tibial / pathology
topics (OpenAlex): Knee injuries and reconstruction techniques; Total Knee Arthroplasty Outcomes; Orthopedic Surgery and Rehabilitation
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: February 10, 2025

2024 article

3D Melt Blowing of Elastollan Thermoplastic Polyurethane for Tissue Engineering Applications: A Pilot Study

Pawar, A., Anderson, B., Pourdeyhimi, B., McNulty, A. L., Fisher, M., & Shirwaiker, R. (2024, October). MANUFACTURING LETTERS, Vol. 41, pp. 357–363.

By: A. Pawar*, B. Anderson*, B. Pourdeyhimi*, A. McNulty, M. Fisher* & R. Shirwaiker*

author keywords: tissue engineering; nonwoven; meltblowing; musculoskeletal; scaffolds; thermoplastic polyurethane; Elastollan
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Bone Tissue Engineering Materials; Additive Manufacturing and 3D Printing Technologies
Sources: Web Of Science, NC State University Libraries
Added: January 27, 2025

2024 journal article

Symmetry engineering in 2D bioelectronics facilitating augmented biosensing interfaces

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 121(48).

By: Y. Wu, Y. Liu, Y. Li, Z. Wei, S. Xing, Y. Wang, D. Zhu, Z. Guo ...

co-author countries: China 🇨🇳
author keywords: bioelectronics; symmetry engineering; machine learning; biosensing; logic matrix
MeSH headings : Animals; Biosensing Techniques / methods; Biosensing Techniques / instrumentation; Swine; Microelectrodes; Rats; Mice
topics (OpenAlex): MXene and MAX Phase Materials; Advanced Memory and Neural Computing; Advanced Sensor and Energy Harvesting Materials
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 16, 2024

2024 journal article

Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany).

By: G. Offeddu, E. Cambria, S. Shelton, K. Haase, Z. Wan, L. Possenti, H. Nguyen, . Gillrie, D. Hickman, C. Knutson

co-author countries: Canada 🇨🇦 Spain 🇪🇸 Italy 🇮🇹
MeSH headings : Humans; Breast Neoplasms / drug therapy; Breast Neoplasms / pathology; Female; Tumor Microenvironment / drug effects; Drug Delivery Systems / methods; Cell Line, Tumor; Precision Medicine / methods; Hyaluronic Acid / metabolism
topics (OpenAlex): Cancer Cells and Metastasis; Proteoglycans and glycosaminoglycans research; 3D Printing in Biomedical Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 15, 2024

2024 journal article

Transmural Flow Upregulates PD-L1 Expression in Microvascular Networks.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany).

By: Z. Wan, S. Zhang, A. Zhong, L. Xu, M. Coughlin, G. Pavlou, S. Shelton, H. Nguyen ...

co-author countries: China 🇨🇳
MeSH headings : B7-H1 Antigen / metabolism; B7-H1 Antigen / genetics; Up-Regulation; Humans; Microvessels / metabolism; Tumor Microenvironment; Mice; Animals; Endothelial Cells / metabolism
topics (OpenAlex): Phagocytosis and Immune Regulation; Immune cells in cancer; Atherosclerosis and Cardiovascular Diseases
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 15, 2024

2024 journal article

Utilizing convolutional neural networks for discriminating cancer and stromal cells in three-dimensional cell culture images with nuclei counterstain.

Journal of Biomedical Optics.

By: H. Nguyen*, N. Pietraszek*, S. Shelton* & K. Arthur*

MeSH headings : Humans; Neural Networks, Computer; Stromal Cells / cytology; Stromal Cells / pathology; Cell Nucleus; Spheroids, Cellular / pathology; Microscopy, Confocal / methods; Cell Culture Techniques, Three Dimensional / methods; Fibroblasts / cytology; Image Processing, Computer-Assisted / methods; Imaging, Three-Dimensional / methods; Cell Line, Tumor; Neoplasms / diagnostic imaging; Neoplasms / pathology
topics (OpenAlex): Cell Image Analysis Techniques; Image Processing Techniques and Applications; AI in cancer detection
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: ORCID
Added: October 15, 2024

2024 journal article

Extracted Plasma Cell-Free DNA Concentrations Are Elevated in Colic Patients with Systemic Inflammation

VETERINARY SCIENCES, 11(9).

author keywords: equine; systemic inflammatory response syndrome (SIRS); biomarker; gastrointestinal disease
topics (OpenAlex): Cancer Genomics and Diagnostics; Genetic factors in colorectal cancer; Prenatal Screening and Diagnostics
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 15, 2024

2024 review

A Comparative Review of Cytokines and Cytokine Targeting in Sepsis: From Humans to Horses

[Review of ]. CELLS, 13(17).

By: K. Hobbs, R. Bayless & M. Sheats

author keywords: cytokine; sepsis; equine; hemoperfusion
MeSH headings : Horses; Animals; Humans; Cytokines / metabolism; Sepsis / immunology; Sepsis / drug therapy; COVID-19 / immunology; COVID-19 / therapy; SARS-CoV-2 / immunology; Disease Models, Animal
topics (OpenAlex): Immune Response and Inflammation; Sepsis Diagnosis and Treatment; Inflammasome and immune disorders
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 8, 2024

2024 journal article

Inhalable Stem Cell Exosomes Promote Heart Repair After Myocardial Infarction

CIRCULATION, 150(9), 710–723.

By: J. Li n, S. Sun*, D. Zhu*, X. Mei*, Y. Lyu n, K. Huang n, Y. Li n, S. Liu* ...

author keywords: CD36; extracellular vesicles; exosomes; inhalation; myocardial infarction
MeSH headings : Animals; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardial Infarction / physiopathology; Exosomes / metabolism; Mice; Mice, Inbred C57BL; Administration, Inhalation; Disease Models, Animal; Swine; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Male; Ventricular Function, Left; Humans; Myocardium / metabolism; Myocardium / pathology; Stem Cells / metabolism; CD36 Antigens / metabolism; CD36 Antigens / genetics
topics (OpenAlex): Extracellular vesicles in disease; Cardiovascular Effects of Exercise; Tissue Engineering and Regenerative Medicine
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 1, 2024

2024 journal article

Machine identity authentication via unobservable fingerprinting signature: A functional data analysis approach for MQTT 5.0 protocol

JOURNAL OF MANUFACTURING SYSTEMS, 76, 59–74.

By: P. Koprov*, X. Fang* & B. Starly*

author keywords: Functional data analysis; Machine identity authentication; MQTT Security; Industrial internet of things; Smart manufacturing; Industrial cybersecurity
topics (OpenAlex): User Authentication and Security Systems; IoT and Edge/Fog Computing; Big Data and Digital Economy
Sources: Web Of Science, NC State University Libraries
Added: August 14, 2024

2024 article

Peptide ligands for the universal purification of exosomes by affinity chromatography

Kilgore, R. E., Moore, B. D., Sripada, S. A., Chu, W., Shastry, S., Barbieri, E., … Menegatti, S. (2024, August 4). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 8.

By: R. Kilgore, B. Moore, S. Sripada, W. Chu, S. Shastry, E. Barbieri, S. Hu, W. Tian ...

co-author countries: Denmark 🇩🇰
author keywords: affinity chromatography; bioseparations; exosomes; gene delivery; peptide ligands
MeSH headings : Exosomes / chemistry; Exosomes / metabolism; Chromatography, Affinity / methods; Ligands; Humans; Peptides / chemistry; Peptides / metabolism; Peptides / isolation & purification
topics (OpenAlex): Extracellular vesicles in disease; RNA Interference and Gene Delivery; Inhalation and Respiratory Drug Delivery
Sources: Web Of Science, NC State University Libraries
Added: August 14, 2024

2024 journal article

Optimizing cell therapy by sorting cells with high extracellular vesicle secretion

NATURE COMMUNICATIONS, 15(1).

By: D. Koo*, X. Cheng n, S. Udani*, S. Baghdasarian*, D. Zhu*, J. Li*, B. Hall, N. Tsubamoto* ...

MeSH headings : Extracellular Vesicles / metabolism; Extracellular Vesicles / transplantation; Animals; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / cytology; Mice; Myocardial Infarction / therapy; Myocardial Infarction / metabolism; Humans; Cell- and Tissue-Based Therapy / methods; Mesenchymal Stem Cell Transplantation / methods; Disease Models, Animal; Mice, Inbred C57BL; Cell Separation / methods; Male
topics (OpenAlex): Extracellular vesicles in disease; Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications
Source: Web Of Science
Added: July 8, 2024

2024 review

A gene edited pig model for studying LGR5<SUP>+</SUP> stem cells: implications for future applications in tissue regeneration and biomedical research

[Review of ]. FRONTIERS IN GENOME EDITING, 6.

By: A. Hill, Y. Murphy, K. Polkoff, L. Edwards, D. Walker, A. Moatti, A. Greenbaum, J. Piedrahita

author keywords: LGR5; gene edited pigs; organ stem cells; regenerative medicine; animal models
topics (OpenAlex): Pluripotent Stem Cells Research; Cancer Cells and Metastasis; Neonatal Respiratory Health Research
Sources: Web Of Science, NC State University Libraries
Added: July 1, 2024

2024 journal article

Engineering microvascular networks using a KLF2 reporter to probe flow-dependent endothelial cell function

Biomaterials.

MeSH headings : Kruppel-Like Transcription Factors / metabolism; Kruppel-Like Transcription Factors / genetics; Humans; Microvessels / metabolism; Microvessels / cytology; Tissue Engineering / methods; Endothelial Cells / metabolism; Endothelial Cells / cytology; Human Umbilical Vein Endothelial Cells / metabolism; Animals; Stress, Mechanical
topics (OpenAlex): Kruppel-like factors research; Angiogenesis and VEGF in Cancer; Mesenchymal stem cell research
Source: ORCID
Added: July 1, 2024

2024 journal article

Vascular microphysiological systems

CURRENT OPINION IN HEMATOLOGY, 31(3), 155–161.

By: S. Shelton n

author keywords: endothelial; microfluidic; microphysiological systems; organ-on-chip; vasculature
MeSH headings : Humans; Microphysiological Systems; Microfluidics / methods; Cell Culture Techniques / methods
topics (OpenAlex): 3D Printing in Biomedical Research; Angiogenesis and VEGF in Cancer; Single-cell and spatial transcriptomics
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 1, 2024

2024 journal article

Building a knowledge graph to enrich ChatGPT responses in manufacturing service discovery

JOURNAL OF INDUSTRIAL INFORMATION INTEGRATION, 40.

By: Y. Li n & B. Starly*

author keywords: Digital supply chain; Knowledge graph; ChatGPT; Manufacturing service discovery
topics (OpenAlex): Data Quality and Management; Advanced Graph Neural Networks; Sentiment Analysis and Opinion Mining
Sources: Web Of Science, NC State University Libraries
Added: May 20, 2024

2024 journal article

Controlled Stiffness of Direct-Write, Near-Field Electrospun Gelatin Fibers Generates Differences in Tenocyte Morphology and Gene Expression

Journal of Biomechanical Engineering, 146(9).

MeSH headings : Gelatin / chemistry; Animals; Horses; Tenocytes / cytology; Tenocytes / metabolism; Tissue Scaffolds / chemistry; Mechanical Phenomena; Gene Expression Regulation; Cell Shape; Biomechanical Phenomena
topics (OpenAlex): Tendon Structure and Treatment; Sports injuries and prevention; Shoulder Injury and Treatment
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, Web Of Science
Added: May 17, 2024

2024 journal article

Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2

NATURE COMMUNICATIONS, 15(1).

By: Z. Wang, S. Hu, K. Popowski, S. Liu, D. Zhu, X. Mei, J. Li, Y. Hu ...

co-author countries: China 🇨🇳
MeSH headings : Cricetinae; Female; Animals; Humans; Mice; SARS-CoV-2; COVID-19; Angiotensin-Converting Enzyme 2; Exosomes; Tissue Distribution; Spike Glycoprotein, Coronavirus; Antibodies, Neutralizing
topics (OpenAlex): Extracellular vesicles in disease; SARS-CoV-2 and COVID-19 Research; COVID-19 Clinical Research Studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2024 journal article

Manufacturing service capability prediction with Graph Neural Networks

JOURNAL OF MANUFACTURING SYSTEMS, 74, 291–301.

By: Y. Li n, X. Liu n & B. Starly*

author keywords: Node classification; Link prediction; Graph neural network; Manufacturing service capability; Manufacturing Service Knowledge Graph
topics (OpenAlex): Industrial Vision Systems and Defect Detection; Anomaly Detection Techniques and Applications; Imbalanced Data Classification Techniques
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 8, 2024

2024 journal article

A Systems Approach to Biomechanics, Mechanobiology, and Biotransport

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 146(4).

MeSH headings : Humans; Biomechanical Phenomena; Bioengineering; Biophysics; Systems Analysis
topics (OpenAlex): Cellular Mechanics and Interactions; 3D Printing in Biomedical Research; Muscle Physiology and Disorders
Source: Web Of Science
Added: April 1, 2024

2024 article

Anticancer Therapy Targeting Cancer-Derived Extracellular Vesicles

Cheng, X., Henick, B. S., & Cheng, K. (2024, February 23). ACS NANO.

author keywords: Extracellular vesicles; Cancer therapy; Nanomedicine; Cancer metastasis; Biomaterials; Drug delivery; Cancer Vaccine; Immunotherapy
MeSH headings : Humans; Neoplasms / pathology; Extracellular Vesicles / metabolism; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Antineoplastic Agents / metabolism; Biological Transport
topics (OpenAlex): Extracellular vesicles in disease; Nanoplatforms for cancer theranostics; MicroRNA in disease regulation
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 1, 2024

2024 article

Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity

Liu, M., Hu, S., Yan, N., Popowski, K. D., & Cheng, K. (2024, January 11). NATURE NANOTECHNOLOGY, Vol. 1.

MeSH headings : Humans; Interleukin-12 / genetics; Lung Neoplasms / genetics; Lung Neoplasms / therapy; RNA, Messenger / genetics; Interferon-gamma / genetics; Cytokines; Extracellular Vesicles; Tumor Microenvironment
topics (OpenAlex): Extracellular vesicles in disease; Inhalation and Respiratory Drug Delivery; Nanoplatforms for cancer theranostics
TL;DR: The delivery of IL-12 mRNA encapsulated in extracellular vesicles to lungs via inhalation is reported on and the immunotherapeutic potential of targeted cytokine mRNA therapy is demonstrated, showing the potential for locally delivered cytokine-based immunotherapies to address orthotopic and metastatic lung tumours. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 29, 2024

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